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UniProtKB - A6NI86 (GG6LA_HUMAN)

Entry version 76 (16 Jan 2019)
Sequence version 4 (14 Oct 2015)
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Protein

Golgin subfamily A member 6-like protein 10

Gene

GOLGA6L10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Golgin subfamily A member 6-like protein 10Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GOLGA6L10Imported
Synonyms:GOLGA6L18Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000278662.4

Human Gene Nomenclature Database

More...HGNCi		HGNC:37228 GOLGA6L10

neXtProt; the human protein knowledge platform

More...neXtProti		NX_A6NI86

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165478685

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GOLGA6L10

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003422661 – 522Golgin subfamily A member 6-like protein 10Add BLAST522

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A6NI86

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A6NI86

PRoteomics IDEntifications database

More...PRIDEi		A6NI86

ProteomicsDB human proteome resource

More...ProteomicsDBi		1256
13508

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A6NI86

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A6NI86

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000278662 Expressed in 88 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A6NI86 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		571831, 1 interactor

Protein interaction database and analysis system

More...IntActi		A6NI86, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		A6NI86

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili157 – 328Sequence analysisAdd BLAST172

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GOLGA6 family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4725 Eukaryota
ENOG410ZIE4 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00910000144587

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000218631

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A6NI86

Identification of Orthologs from Complete Genome Data

More...OMAi		KEYWHRK

Database of Orthologous Groups

More...OrthoDBi		414384at7742

TreeFam database of animal gene trees

More...TreeFami		TF316990

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026737 GOLGA6L
IPR024858 Golgin_A

The PANTHER Classification System

More...PANTHERi		PTHR23143 PTHR23143, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15070 GOLGA2L5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A6NI86-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWPQPRLPPH PAMSEKTQQG KLAAAKKKLK AYWQRKSPGI PAGANRKKKV 
        60         70         80         90        100
NGSSPDTATS GGYHSPGDSA TGIYGEGRAS STTLQDLESQ YQELAVALDS 
       110        120        130        140        150
SSAIISQLTE NINSLVRTSK EEKKHEIHLV QKLGRSLFKL KNQTAEPLAP 
       160        170        180        190        200
EPPAGPSKVE QLQDETNHLR KELESVGRQL QAEVENNQML SLLNRRQEER 
       210        220        230        240        250
LREQEERLHE QEERLHEQEE RLCEQEERLR EQEERLCEQE ERLREQEERL 
       260        270        280        290        300
CEQEERLREQ EERLCEQEER LREQEERLRE QEERLCEQEE RLCEQEERLR 
       310        320        330        340        350
EQEERLCEQE ERLCEQEERL CEQEKLPGQE RLLEEVEKLL EQERRQEEQE 
       360        370        380        390        400
RLLERERLLD EVEELLEQER LRQQDERLWQ QETLRELERL RELERLRELE 
       410        420        430        440        450
RMLELGWEAL YEQRAEPRSG FEELNNENKS TLQLEQQVKE LEKSGGAEEP 
       460        470        480        490        500
RGSESAAAAR PVPGAPVPQG AWMCGQAGWT PQEHPGLSGE AVGTGEAAGG 
       510        520 
AEEAACHSFR AAENRELNIT II
Length:522
Mass (Da):60,902
Last modified:October 14, 2015 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i868F54CB58CCEC39
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1J3A0A087X1J3_HUMAN
Golgin subfamily A member 6-like pr...
GOLGA6L10
439Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X0T7A0A087X0T7_HUMAN
Golgin subfamily A member 6-like pr...
GOLGA6L10
475Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YW09A0A0J9YW09_HUMAN
Golgin subfamily A member 6-like pr...
GOLGA6L10
522Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JM30A0A0G2JM30_HUMAN
Golgin subfamily A member 6-like pr...
GOLGA6L10
474Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC243919 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45325.2

NCBI Reference Sequences

More...RefSeqi		NP_001157937.2, NM_001164465.3

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.454625
Hs.498322
Hs.720685

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000610657; ENSP00000479362; ENSG00000278662

Database of genes from NCBI RefSeq genomes

More...GeneIDi		647042

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:647042

UCSC genome browser

More...UCSCi		uc059mng.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC243919 Genomic DNA No translation available.
CCDSiCCDS45325.2
RefSeqiNP_001157937.2, NM_001164465.3
UniGeneiHs.454625
Hs.498322
Hs.720685

3D structure databases

ProteinModelPortaliA6NI86
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi571831, 1 interactor
IntActiA6NI86, 1 interactor

PTM databases

iPTMnetiA6NI86
PhosphoSitePlusiA6NI86

Polymorphism and mutation databases

BioMutaiGOLGA6L10

Proteomic databases

jPOSTiA6NI86
PaxDbiA6NI86
PRIDEiA6NI86
ProteomicsDBi1256
13508

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000610657; ENSP00000479362; ENSG00000278662
GeneIDi647042
KEGGihsa:647042
UCSCiuc059mng.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		647042
EuPathDBiHostDB:ENSG00000278662.4

GeneCards: human genes, protein and diseases

More...GeneCardsi		GOLGA6L10
HGNCiHGNC:37228 GOLGA6L10
neXtProtiNX_A6NI86
PharmGKBiPA165478685

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4725 Eukaryota
ENOG410ZIE4 LUCA
GeneTreeiENSGT00910000144587
HOGENOMiHOG000218631
InParanoidiA6NI86
OMAiKEYWHRK
OrthoDBi414384at7742
TreeFamiTF316990

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		647042

Protein Ontology

More...PROi		PR:A6NI86

Gene expression databases

BgeeiENSG00000278662 Expressed in 88 organ(s), highest expression level in testis
ExpressionAtlasiA6NI86 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR026737 GOLGA6L
IPR024858 Golgin_A
PANTHERiPTHR23143 PTHR23143, 2 hits
PfamiView protein in Pfam
PF15070 GOLGA2L5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGG6LA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NI86
Secondary accession number(s): A0A087WVD5, D6RB28
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: October 14, 2015
Last modified: January 16, 2019
This is version 76 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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