UniProtKB - A6NI79 (CCD69_HUMAN)

BLAST

>sp|A6NI79|CCD69_HUMAN Coiled-coil domain-containing protein 69 OS=Homo sapiens OX=9606 GN=CCDC69 PE=1 SV=1
MGCRHSRLSSCKPPKKKRQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDI
TRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALT
HSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQELES
LHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQL
SEDLLLTREALEKEVQLRRQLQQEKEELLYRVLGANASPAFPLAPVTPTEVSFLAT

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History
Entry version 87 (07 Nov 2018)
Sequence version 1 (24 Jul 2007)
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Protein

Coiled-coil domain-containing protein 69

Gene

CCDC69

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone.1 Publication

GO - Molecular functionⁱ

microtubule binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

spindle midzone assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20962590

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Coiled-coil domain-containing protein 69Curated
Gene namesⁱ	Name:CCDC69Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000198624.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24487 CCDC69
neXtProtⁱ	NX_A6NI79

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000198624
PharmGKBⁱ	PA128394640

Polymorphism and mutation databases

BioMutaⁱ	CCDC69

BioMutaⁱ

CCDC69

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedSequence analysis
ChainⁱPRO_0000328962	2 – 296	Coiled-coil domain-containing protein 69Add BLAST		295

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Lipidationⁱ	2	N-myristoyl glycineSequence analysis	1
Modified residueⁱ	154	PhosphoserineBy similarity	1
Modified residueⁱ	241	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDⁱ	A6NI79
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A6NI79
PaxDbⁱ	A6NI79
PRIDEⁱ	A6NI79
ProteomicsDBⁱ	1255
TopDownProteomicsⁱ	A6NI79

PTM databases

iPTMnetⁱ	A6NI79
PhosphoSitePlusⁱ	A6NI79
SwissPalmⁱ	A6NI79

Expressionⁱ

Tissue specificityⁱ

Highly expressed in duodenum, esophagus, pancreas, prostate, salivary gland, thymus and urinary bladder.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000198624 Expressed in 217 organ(s), highest expression level in lower esophagus
CleanExⁱ	HS_CCDC69
ExpressionAtlasⁱ	A6NI79 baseline and differential
Genevisibleⁱ	A6NI79 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043648 HPA052896

HPAⁱ

HPA043648
HPA052896

Interactionⁱ

GO - Molecular functionⁱ

microtubule binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	117558, 23 interactors
IntActⁱ	A6NI79, 6 interactors
Molecular INTeraction database More...MINTⁱ	A6NI79
STRINGⁱ	9606.ENSP00000347586

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A6NI79
SMRⁱ	A6NI79
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	48 – 272	Sequence analysisAdd BLAST		225

Sequence similaritiesⁱ

Belongs to the CCDC69 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IYDA Eukaryota ENOG4111TAG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006245
HOGENOMⁱ	HOG000111431
HOVERGENⁱ	HBG107610
InParanoidⁱ	A6NI79
OMAⁱ	FWESEQE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DE4
PhylomeDBⁱ	A6NI79

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

A6NI79-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGCRHSRLSS CKPPKKKRQE PEPEQPPRPE PHELGPLNGD TAITVQLCAS 
        60         70         80         90        100
EEAERHQKDI TRILQQHEEE KKKWAQQVEK ERELELRDRL DEQQRVLEGK 
       110        120        130        140        150
NEEALQVLRA SYEQEKEALT HSFREASSTQ QETIDRLTSQ LEAFQAKMKR 
       160        170        180        190        200
VEESILSRNY KKHIQDYGSP SQFWEQELES LHFVIEMKNE RIHELDRRLI 
       210        220        230        240        250
LMETVKEKNL ILEEKITTLQ QENEDLHVRS RNQVVLSRQL SEDLLLTREA 
       260        270        280        290 
LEKEVQLRRQ LQQEKEELLY RVLGANASPA FPLAPVTPTE VSFLAT

Length:296

Mass (Da):34,796

Last modified:July 24, 2007 - v1

Checksum:ⁱ083A804AFAE45C8E

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YBY5	H0YBY5_HUMAN	Coiled-coil domain-containing prote... Coiled-coil domain-containing protein 69	CCDC69	186	Annotation score:
H0YB32	H0YB32_HUMAN	Coiled-coil domain-containing prote... Coiled-coil domain-containing protein 69	CCDC69	88	Annotation score:
E5RK59	E5RK59_HUMAN	Coiled-coil domain-containing prote... Coiled-coil domain-containing protein 69	CCDC69	47	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_042584	197	R → K1 PublicationCorresponds to variant dbSNP:rs248427Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK292841 mRNA Translation: BAF85530.1 AC011342 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4312.1
NCBI Reference Sequences More...RefSeqⁱ	NP_056436.2, NM_015621.2
UniGeneⁱ	Hs.655336

Genome annotation databases

Ensemblⁱ	ENST00000355417; ENSP00000347586; ENSG00000198624
GeneIDⁱ	26112
KEGGⁱ	hsa:26112
UCSC genome browser More...UCSCⁱ	uc003ltq.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A6NI79	Uncharacterized protein		COLAP		296	UniRef90_A6NI79
Uncharacterized protein		RHIRO		296
CCDC69 isoform 1		PONAB		296
Uncharacterized protein		PAPAN		296
Uncharacterized protein		RHIBE		296
+21

Protein	Similar proteins		Species	Score	Length	Source
A6NI79	Coiled-coil domain-containing protein 69		BOVIN		294	UniRef50_A6NI79
Uncharacterized protein		NOMLE		296
Uncharacterized protein		PAPAN		296
Uncharacterized protein		MACNE		296
Uncharacterized protein		RHIBE		296
+63

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK292841 mRNA Translation: BAF85530.1 AC011342 Genomic DNA No translation available.
CCDSⁱ	CCDS4312.1
RefSeqⁱ	NP_056436.2, NM_015621.2
UniGeneⁱ	Hs.655336

3D structure databases

ProteinModelPortalⁱ	A6NI79
SMRⁱ	A6NI79
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117558, 23 interactors
IntActⁱ	A6NI79, 6 interactors
MINTⁱ	A6NI79
STRINGⁱ	9606.ENSP00000347586

PTM databases

iPTMnetⁱ	A6NI79
PhosphoSitePlusⁱ	A6NI79
SwissPalmⁱ	A6NI79

Polymorphism and mutation databases

BioMutaⁱ	CCDC69

BioMutaⁱ

CCDC69

Proteomic databases

EPDⁱ	A6NI79
MaxQBⁱ	A6NI79
PaxDbⁱ	A6NI79
PRIDEⁱ	A6NI79
ProteomicsDBⁱ	1255
TopDownProteomicsⁱ	A6NI79

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000355417; ENSP00000347586; ENSG00000198624
GeneIDⁱ	26112
KEGGⁱ	hsa:26112
UCSCⁱ	uc003ltq.4 human

Organism-specific databases

CTDⁱ	26112
EuPathDBⁱ	HostDB:ENSG00000198624.12
GeneCardsⁱ	CCDC69
HGNCⁱ	HGNC:24487 CCDC69
HPAⁱ	HPA043648 HPA052896
neXtProtⁱ	NX_A6NI79
OpenTargetsⁱ	ENSG00000198624
PharmGKBⁱ	PA128394640
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IYDA Eukaryota ENOG4111TAG LUCA
GeneTreeⁱ	ENSGT00390000006245
HOGENOMⁱ	HOG000111431
HOVERGENⁱ	HBG107610
InParanoidⁱ	A6NI79
OMAⁱ	FWESEQE
OrthoDBⁱ	EOG091G0DE4
PhylomeDBⁱ	A6NI79

Miscellaneous databases

ChiTaRSⁱ	CCDC69 human
GenomeRNAiⁱ	26112
Protein Ontology More...PROⁱ	PR:A6NI79

Gene expression databases

Bgeeⁱ	ENSG00000198624 Expressed in 217 organ(s), highest expression level in lower esophagus
CleanExⁱ	HS_CCDC69
ExpressionAtlasⁱ	A6NI79 baseline and differential
Genevisibleⁱ	A6NI79 HS

Family and domain databases

ProtoNetⁱ	Search...

ProtoNetⁱ

Search...

Entry informationⁱ

Entry nameⁱ	CCD69_HUMAN
Accessionⁱ	A6NI79Primary (citable) accession number: A6NI79 Secondary accession number(s): A8K9X6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
	Last sequence update:	July 24, 2007
	Last modified:	November 7, 2018
	This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A6NI79 (CCD69_HUMAN)

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Coiled-coil domain-containing protein 69

CCDC69

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ