UniProtKB - A6NI79 (CCD69_HUMAN)
Protein
Coiled-coil domain-containing protein 69
Gene
CCDC69
Organism
Homo sapiens (Human)
Status
Functioni
May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone.1 Publication
GO - Molecular functioni
- microtubule binding Source: GO_Central
GO - Biological processi
- spindle midzone assembly Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | A6NI79 |
Names & Taxonomyi
Protein namesi | Recommended name: Coiled-coil domain-containing protein 69Curated |
Gene namesi | Name:CCDC69Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24487, CCDC69 |
neXtProti | NX_A6NI79 |
VEuPathDBi | HostDB:ENSG00000198624.12 |
Subcellular locationi
Cytoskeleton
- spindle 1 Publication
Other locations
- Midbody 1 Publication
Note: During early anaphase, localizes along overlapping interpolar microtubules between the separating chromosomes. During late anaphase, localizes to the center of spindle midzone. Concentrated at the midbody during telophase.1 Publication
Cytoskeleton
- spindle midzone Source: UniProtKB
Nucleus
- nucleus Source: GO_Central
Other locations
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
DisGeNETi | 26112 |
OpenTargetsi | ENSG00000198624 |
PharmGKBi | PA128394640 |
Miscellaneous databases
Pharosi | A6NI79, Tdark |
Genetic variation databases
BioMutai | CCDC69 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedSequence analysis | |||
ChainiPRO_0000328962 | 2 – 296 | Coiled-coil domain-containing protein 69Add BLAST | 295 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycineSequence analysis | 1 | |
Modified residuei | 154 | PhosphoserineBy similarity | 1 | |
Modified residuei | 241 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Lipoprotein, Myristate, PhosphoproteinProteomic databases
EPDi | A6NI79 |
jPOSTi | A6NI79 |
MassIVEi | A6NI79 |
MaxQBi | A6NI79 |
PaxDbi | A6NI79 |
PeptideAtlasi | A6NI79 |
PRIDEi | A6NI79 |
ProteomicsDBi | 1255 |
TopDownProteomicsi | A6NI79 |
PTM databases
iPTMneti | A6NI79 |
PhosphoSitePlusi | A6NI79 |
SwissPalmi | A6NI79 |
Expressioni
Tissue specificityi
Highly expressed in duodenum, esophagus, pancreas, prostate, salivary gland, thymus and urinary bladder.1 Publication
Gene expression databases
Bgeei | ENSG00000198624, Expressed in lower esophagus and 232 other tissues |
ExpressionAtlasi | A6NI79, baseline and differential |
Genevisiblei | A6NI79, HS |
Organism-specific databases
HPAi | ENSG00000198624, Tissue enhanced (breast) |
Interactioni
GO - Molecular functioni
- microtubule binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 117558, 23 interactors |
IntActi | A6NI79, 6 interactors |
MINTi | A6NI79 |
STRINGi | 9606.ENSP00000347586 |
Miscellaneous databases
RNActi | A6NI79, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 48 – 272 | Sequence analysisAdd BLAST | 225 |
Sequence similaritiesi
Belongs to the CCDC69 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502RYPP, Eukaryota |
GeneTreei | ENSGT00950000183026 |
HOGENOMi | CLU_079661_0_0_1 |
InParanoidi | A6NI79 |
OMAi | HERHVEE |
OrthoDBi | 1278490at2759 |
PhylomeDBi | A6NI79 |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
A6NI79-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGCRHSRLSS CKPPKKKRQE PEPEQPPRPE PHELGPLNGD TAITVQLCAS
60 70 80 90 100
EEAERHQKDI TRILQQHEEE KKKWAQQVEK ERELELRDRL DEQQRVLEGK
110 120 130 140 150
NEEALQVLRA SYEQEKEALT HSFREASSTQ QETIDRLTSQ LEAFQAKMKR
160 170 180 190 200
VEESILSRNY KKHIQDYGSP SQFWEQELES LHFVIEMKNE RIHELDRRLI
210 220 230 240 250
LMETVKEKNL ILEEKITTLQ QENEDLHVRS RNQVVLSRQL SEDLLLTREA
260 270 280 290
LEKEVQLRRQ LQQEKEELLY RVLGANASPA FPLAPVTPTE VSFLAT
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YBY5 | H0YBY5_HUMAN | Coiled-coil domain-containing prote... | CCDC69 | 186 | Annotation score: | ||
H0YB32 | H0YB32_HUMAN | Coiled-coil domain-containing prote... | CCDC69 | 88 | Annotation score: | ||
E5RK59 | E5RK59_HUMAN | Coiled-coil domain-containing prote... | CCDC69 | 47 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_042584 | 197 | R → K1 PublicationCorresponds to variant dbSNP:rs248427Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK292841 mRNA Translation: BAF85530.1 AC011342 Genomic DNA No translation available. |
CCDSi | CCDS4312.1 |
RefSeqi | NP_056436.2, NM_015621.2 |
Genome annotation databases
Ensembli | ENST00000355417; ENSP00000347586; ENSG00000198624 |
GeneIDi | 26112 |
KEGGi | hsa:26112 |
UCSCi | uc003ltq.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK292841 mRNA Translation: BAF85530.1 AC011342 Genomic DNA No translation available. |
CCDSi | CCDS4312.1 |
RefSeqi | NP_056436.2, NM_015621.2 |
3D structure databases
SMRi | A6NI79 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117558, 23 interactors |
IntActi | A6NI79, 6 interactors |
MINTi | A6NI79 |
STRINGi | 9606.ENSP00000347586 |
PTM databases
iPTMneti | A6NI79 |
PhosphoSitePlusi | A6NI79 |
SwissPalmi | A6NI79 |
Genetic variation databases
BioMutai | CCDC69 |
Proteomic databases
EPDi | A6NI79 |
jPOSTi | A6NI79 |
MassIVEi | A6NI79 |
MaxQBi | A6NI79 |
PaxDbi | A6NI79 |
PeptideAtlasi | A6NI79 |
PRIDEi | A6NI79 |
ProteomicsDBi | 1255 |
TopDownProteomicsi | A6NI79 |
Protocols and materials databases
Antibodypediai | 28179, 144 antibodies |
Genome annotation databases
Ensembli | ENST00000355417; ENSP00000347586; ENSG00000198624 |
GeneIDi | 26112 |
KEGGi | hsa:26112 |
UCSCi | uc003ltq.4, human |
Organism-specific databases
CTDi | 26112 |
DisGeNETi | 26112 |
GeneCardsi | CCDC69 |
HGNCi | HGNC:24487, CCDC69 |
HPAi | ENSG00000198624, Tissue enhanced (breast) |
neXtProti | NX_A6NI79 |
OpenTargetsi | ENSG00000198624 |
PharmGKBi | PA128394640 |
VEuPathDBi | HostDB:ENSG00000198624.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RYPP, Eukaryota |
GeneTreei | ENSGT00950000183026 |
HOGENOMi | CLU_079661_0_0_1 |
InParanoidi | A6NI79 |
OMAi | HERHVEE |
OrthoDBi | 1278490at2759 |
PhylomeDBi | A6NI79 |
Enzyme and pathway databases
PathwayCommonsi | A6NI79 |
Miscellaneous databases
BioGRID-ORCSi | 26112, 5 hits in 875 CRISPR screens |
ChiTaRSi | CCDC69, human |
GenomeRNAii | 26112 |
Pharosi | A6NI79, Tdark |
PROi | PR:A6NI79 |
RNActi | A6NI79, protein |
Gene expression databases
Bgeei | ENSG00000198624, Expressed in lower esophagus and 232 other tissues |
ExpressionAtlasi | A6NI79, baseline and differential |
Genevisiblei | A6NI79, HS |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCD69_HUMAN | |
Accessioni | A6NI79Primary (citable) accession number: A6NI79 Secondary accession number(s): A8K9X6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | July 24, 2007 | |
Last modified: | February 10, 2021 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM