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Protein

Coiled-coil domain-containing protein 69

Gene

CCDC69

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone.1 Publication

GO - Molecular functioni

  • microtubule binding Source: GO_Central

GO - Biological processi

  • spindle midzone assembly Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 69Curated
Gene namesi
Name:CCDC69Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000198624.12
HGNCiHGNC:24487 CCDC69
neXtProtiNX_A6NI79

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198624
PharmGKBiPA128394640

Polymorphism and mutation databases

BioMutaiCCDC69

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00003289622 – 296Coiled-coil domain-containing protein 69Add BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1
Modified residuei154PhosphoserineBy similarity1
Modified residuei241PhosphoserineCombined sources1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiA6NI79
MaxQBiA6NI79
PaxDbiA6NI79
PRIDEiA6NI79
ProteomicsDBi1255
TopDownProteomicsiA6NI79

PTM databases

iPTMnetiA6NI79
PhosphoSitePlusiA6NI79
SwissPalmiA6NI79

Expressioni

Tissue specificityi

Highly expressed in duodenum, esophagus, pancreas, prostate, salivary gland, thymus and urinary bladder.1 Publication

Gene expression databases

BgeeiENSG00000198624 Expressed in 217 organ(s), highest expression level in lower esophagus
CleanExiHS_CCDC69
ExpressionAtlasiA6NI79 baseline and differential
GenevisibleiA6NI79 HS

Organism-specific databases

HPAiHPA043648
HPA052896

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117558, 23 interactors
IntActiA6NI79, 6 interactors
MINTiA6NI79
STRINGi9606.ENSP00000347586

Structurei

3D structure databases

ProteinModelPortaliA6NI79
SMRiA6NI79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili48 – 272Sequence analysisAdd BLAST225

Sequence similaritiesi

Belongs to the CCDC69 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IYDA Eukaryota
ENOG4111TAG LUCA
GeneTreeiENSGT00390000006245
HOGENOMiHOG000111431
HOVERGENiHBG107610
InParanoidiA6NI79
OMAiFWESEQE
OrthoDBiEOG091G0DE4
PhylomeDBiA6NI79

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A6NI79-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGCRHSRLSS CKPPKKKRQE PEPEQPPRPE PHELGPLNGD TAITVQLCAS
60 70 80 90 100
EEAERHQKDI TRILQQHEEE KKKWAQQVEK ERELELRDRL DEQQRVLEGK
110 120 130 140 150
NEEALQVLRA SYEQEKEALT HSFREASSTQ QETIDRLTSQ LEAFQAKMKR
160 170 180 190 200
VEESILSRNY KKHIQDYGSP SQFWEQELES LHFVIEMKNE RIHELDRRLI
210 220 230 240 250
LMETVKEKNL ILEEKITTLQ QENEDLHVRS RNQVVLSRQL SEDLLLTREA
260 270 280 290
LEKEVQLRRQ LQQEKEELLY RVLGANASPA FPLAPVTPTE VSFLAT
Length:296
Mass (Da):34,796
Last modified:July 24, 2007 - v1
Checksum:i083A804AFAE45C8E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBY5H0YBY5_HUMAN
Coiled-coil domain-containing prote...
CCDC69
186Annotation score:
H0YB32H0YB32_HUMAN
Coiled-coil domain-containing prote...
CCDC69
88Annotation score:
E5RK59E5RK59_HUMAN
Coiled-coil domain-containing prote...
CCDC69
47Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042584197R → K1 PublicationCorresponds to variant dbSNP:rs248427Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292841 mRNA Translation: BAF85530.1
AC011342 Genomic DNA No translation available.
CCDSiCCDS4312.1
RefSeqiNP_056436.2, NM_015621.2
UniGeneiHs.655336

Genome annotation databases

EnsembliENST00000355417; ENSP00000347586; ENSG00000198624
GeneIDi26112
KEGGihsa:26112
UCSCiuc003ltq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292841 mRNA Translation: BAF85530.1
AC011342 Genomic DNA No translation available.
CCDSiCCDS4312.1
RefSeqiNP_056436.2, NM_015621.2
UniGeneiHs.655336

3D structure databases

ProteinModelPortaliA6NI79
SMRiA6NI79
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117558, 23 interactors
IntActiA6NI79, 6 interactors
MINTiA6NI79
STRINGi9606.ENSP00000347586

PTM databases

iPTMnetiA6NI79
PhosphoSitePlusiA6NI79
SwissPalmiA6NI79

Polymorphism and mutation databases

BioMutaiCCDC69

Proteomic databases

EPDiA6NI79
MaxQBiA6NI79
PaxDbiA6NI79
PRIDEiA6NI79
ProteomicsDBi1255
TopDownProteomicsiA6NI79

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355417; ENSP00000347586; ENSG00000198624
GeneIDi26112
KEGGihsa:26112
UCSCiuc003ltq.4 human

Organism-specific databases

CTDi26112
EuPathDBiHostDB:ENSG00000198624.12
GeneCardsiCCDC69
HGNCiHGNC:24487 CCDC69
HPAiHPA043648
HPA052896
neXtProtiNX_A6NI79
OpenTargetsiENSG00000198624
PharmGKBiPA128394640
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYDA Eukaryota
ENOG4111TAG LUCA
GeneTreeiENSGT00390000006245
HOGENOMiHOG000111431
HOVERGENiHBG107610
InParanoidiA6NI79
OMAiFWESEQE
OrthoDBiEOG091G0DE4
PhylomeDBiA6NI79

Miscellaneous databases

ChiTaRSiCCDC69 human
GenomeRNAii26112
PROiPR:A6NI79

Gene expression databases

BgeeiENSG00000198624 Expressed in 217 organ(s), highest expression level in lower esophagus
CleanExiHS_CCDC69
ExpressionAtlasiA6NI79 baseline and differential
GenevisibleiA6NI79 HS

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCCD69_HUMAN
AccessioniPrimary (citable) accession number: A6NI79
Secondary accession number(s): A8K9X6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 24, 2007
Last modified: November 7, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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