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UniProtKB - A6NI73 (LIRA5_HUMAN)

Entry version 109 (02 Dec 2020)
Sequence version 1 (24 Jul 2007)
Previous versions | rss
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Protein

Leukocyte immunoglobulin-like receptor subfamily A member 5

Gene

LILRA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processImmunity, Innate immunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		A6NI73

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leukocyte immunoglobulin-like receptor subfamily A member 5
Alternative name(s):
CD85 antigen-like family member F
Immunoglobulin-like transcript 11
Short name:
ILT-11
Leukocyte immunoglobulin-like receptor 9
Short name:
LIR-9
CD_antigen: CD85f
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LILRA5
Synonyms:ILT11, LILRB7, LIR9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000187116.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:16309, LILRA5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606047, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_A6NI73

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini42 – 268ExtracellularSequence analysisAdd BLAST227
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Topological domaini290 – 299CytoplasmicSequence analysis10

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		353514

Open Targets

More...OpenTargetsi		ENSG00000187116

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671547

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		A6NI73, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LILRA5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 41Sequence analysisAdd BLAST41
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031870842 – 299Leukocyte immunoglobulin-like receptor subfamily A member 5Add BLAST258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi67 ↔ 116Combined sources1 Publication
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi162 ↔ 214Combined sources1 Publication
Glycosylationi248N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A6NI73

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		A6NI73

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A6NI73

PeptideAtlas

More...PeptideAtlasi		A6NI73

PRoteomics IDEntifications database

More...PRIDEi		A6NI73

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		1250 [A6NI73-1]
1251 [A6NI73-2]
1252 [A6NI73-3]
1253 [A6NI73-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		A6NI73, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A6NI73

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A6NI73

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed mostly in tissues of the hematopoietic system, including bone marrow, spleen, lymph node and peripheral leukocytes. Among leukocytes, monocytes and neutrophils express the highest level. Expressed in CD14+ monocytes, but not in T-cells, B-cells or natural killer (NK) cells (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000187116, Expressed in blood and 138 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A6NI73, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000187116, Tissue enhanced (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000404236

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A6NI73, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1299
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A6NI73

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		A6NI73

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 136Ig-like C2-type 1Add BLAST86
Domaini142 – 230Ig-like C2-type 2Add BLAST89

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RU0A, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01000000214458

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_021100_1_4_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A6NI73

Identification of Orthologs from Complete Genome Data

More...OMAi		SSHRGTF

Database of Orthologous Groups

More...OrthoDBi		1327293at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A6NI73

TreeFam database of animal gene trees

More...TreeFami		TF336644

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13895, Ig_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409, IG, 2 hits
SM00408, IGc2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A6NI73-1) [UniParc]FASTAAdd to basket
Also known as: LIR9m1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPWSHPSAQ LQPVGGDAVS PALMVLLCLG LSLGPRTHVQ AGNLSKATLW 
        60         70         80         90        100
AEPGSVISRG NSVTIRCQGT LEAQEYRLVK EGSPEPWDTQ NPLEPKNKAR 
       110        120        130        140        150
FSIPSMTEHH AGRYRCYYYS PAGWSEPSDP LELVVTGFYN KPTLSALPSP 
       160        170        180        190        200
VVTSGENVTL QCGSRLRFDR FILTEEGDHK LSWTLDSQLT PSGQFQALFP 
       210        220        230        240        250
VGPVTPSHRW MLRCYGSRRH ILQVWSEPSD LLEIPVSGAA DNLSPSQNKS 
       260        270        280        290 
DSGTASHLQD YAVENLIRMG MAGLILVVLG ILIFQDWHSQ RSPQAAAGR
Length:299
Mass (Da):32,755
Last modified:July 24, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF5EE25361D4E0F02
GO
Isoform 2 (identifier: A6NI73-2) [UniParc]FASTAAdd to basket
Also known as: LIR9m2

The sequence of this isoform differs from the canonical sequence as follows:
     31-42: Missing.

Show »
Length:287
Mass (Da):31,538
Checksum:iB2CDEEDDD148FF85
GO
Isoform 3 (identifier: A6NI73-3) [UniParc]FASTAAdd to basket
Also known as: LIR9s1

The sequence of this isoform differs from the canonical sequence as follows:
     239-299: AADNLSPSQN...QRSPQAAAGR → EEATVFSSTIQGSQTGCGELYRQGSPC

Show »
Length:265
Mass (Da):29,070
Checksum:i0BAF42BF24CBDA10
GO
Isoform 4 (identifier: A6NI73-4) [UniParc]FASTAAdd to basket
Also known as: LIR9s2

The sequence of this isoform differs from the canonical sequence as follows:
     31-42: Missing.
     239-299: AADNLSPSQN...QRSPQAAAGR → EEATVFSSTIQGSQTGCGELYRQGSPC

Show »
Length:253
Mass (Da):27,852
Checksum:iC34EF35D5C05BCFE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti100R → G in AAF73849 (PubMed:10941842).Curated1
Sequence conflicti220H → R in AAF73849 (PubMed:10941842).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03127631 – 42Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_031277239 – 299AADNL…AAAGR → EEATVFSSTIQGSQTGCGEL YRQGSPC in isoform 3 and isoform 4. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF212842 mRNA Translation: AAF73849.1
AF324830 mRNA Translation: AAK52451.1
AF499916 mRNA Translation: AAN27925.1
AF499917 mRNA Translation: AAN27926.1
AF499918 mRNA Translation: AAN27927.1
AF499919 mRNA Translation: AAN27928.1
AC008984 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72226.1
CH471135 Genomic DNA Translation: EAW72227.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12888.1 [A6NI73-1]
CCDS12889.1 [A6NI73-2]

NCBI Reference Sequences

More...RefSeqi		NP_067073.1, NM_021250.3 [A6NI73-1]
NP_870994.1, NM_181879.2 [A6NI73-3]
NP_871714.1, NM_181985.3 [A6NI73-2]
NP_871715.1, NM_181986.2 [A6NI73-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000432233; ENSP00000404236; ENSG00000187116 [A6NI73-1]
ENST00000486742; ENSP00000484372; ENSG00000187116 [A6NI73-2]
ENST00000611164; ENSP00000482658; ENSG00000278355 [A6NI73-2]
ENST00000612266; ENSP00000480436; ENSG00000274914 [A6NI73-4]
ENST00000612621; ENSP00000484785; ENSG00000278355 [A6NI73-1]
ENST00000613559; ENSP00000484775; ENSG00000274914 [A6NI73-3]
ENST00000614299; ENSP00000483992; ENSG00000274914 [A6NI73-2]
ENST00000615820; ENSP00000480204; ENSG00000274113 [A6NI73-2]
ENST00000616133; ENSP00000484062; ENSG00000275404 [A6NI73-4]
ENST00000618711; ENSP00000478354; ENSG00000274914 [A6NI73-1]
ENST00000619516; ENSP00000480382; ENSG00000278355 [A6NI73-4]
ENST00000620091; ENSP00000480458; ENSG00000274113 [A6NI73-1]
ENST00000620692; ENSP00000483958; ENSG00000275404 [A6NI73-3]
ENST00000620898; ENSP00000484869; ENSG00000275404 [A6NI73-2]
ENST00000621042; ENSP00000482882; ENSG00000275404 [A6NI73-1]
ENST00000621482; ENSP00000477785; ENSG00000278355 [A6NI73-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		353514

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:353514

UCSC genome browser

More...UCSCi		uc032idp.1, human [A6NI73-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212842 mRNA Translation: AAF73849.1
AF324830 mRNA Translation: AAK52451.1
AF499916 mRNA Translation: AAN27925.1
AF499917 mRNA Translation: AAN27926.1
AF499918 mRNA Translation: AAN27927.1
AF499919 mRNA Translation: AAN27928.1
AC008984 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72226.1
CH471135 Genomic DNA Translation: EAW72227.1
CCDSiCCDS12888.1 [A6NI73-1]
CCDS12889.1 [A6NI73-2]
RefSeqiNP_067073.1, NM_021250.3 [A6NI73-1]
NP_870994.1, NM_181879.2 [A6NI73-3]
NP_871714.1, NM_181985.3 [A6NI73-2]
NP_871715.1, NM_181986.2 [A6NI73-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D3VX-ray1.85A42-237[»]
SMRiA6NI73
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000404236

PTM databases

GlyGeniA6NI73, 3 sites
iPTMnetiA6NI73
PhosphoSitePlusiA6NI73

Polymorphism and mutation databases

BioMutaiLILRA5

Proteomic databases

jPOSTiA6NI73
MassIVEiA6NI73
PaxDbiA6NI73
PeptideAtlasiA6NI73
PRIDEiA6NI73
ProteomicsDBi1250 [A6NI73-1]
1251 [A6NI73-2]
1252 [A6NI73-3]
1253 [A6NI73-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		46350, 150 antibodies

The DNASU plasmid repository

More...DNASUi		353514

Genome annotation databases

EnsembliENST00000432233; ENSP00000404236; ENSG00000187116 [A6NI73-1]
ENST00000486742; ENSP00000484372; ENSG00000187116 [A6NI73-2]
ENST00000611164; ENSP00000482658; ENSG00000278355 [A6NI73-2]
ENST00000612266; ENSP00000480436; ENSG00000274914 [A6NI73-4]
ENST00000612621; ENSP00000484785; ENSG00000278355 [A6NI73-1]
ENST00000613559; ENSP00000484775; ENSG00000274914 [A6NI73-3]
ENST00000614299; ENSP00000483992; ENSG00000274914 [A6NI73-2]
ENST00000615820; ENSP00000480204; ENSG00000274113 [A6NI73-2]
ENST00000616133; ENSP00000484062; ENSG00000275404 [A6NI73-4]
ENST00000618711; ENSP00000478354; ENSG00000274914 [A6NI73-1]
ENST00000619516; ENSP00000480382; ENSG00000278355 [A6NI73-4]
ENST00000620091; ENSP00000480458; ENSG00000274113 [A6NI73-1]
ENST00000620692; ENSP00000483958; ENSG00000275404 [A6NI73-3]
ENST00000620898; ENSP00000484869; ENSG00000275404 [A6NI73-2]
ENST00000621042; ENSP00000482882; ENSG00000275404 [A6NI73-1]
ENST00000621482; ENSP00000477785; ENSG00000278355 [A6NI73-3]
GeneIDi353514
KEGGihsa:353514
UCSCiuc032idp.1, human [A6NI73-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		353514
DisGeNETi353514
EuPathDBiHostDB:ENSG00000187116.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		LILRA5
HGNCiHGNC:16309, LILRA5
HPAiENSG00000187116, Tissue enhanced (blood, lymphoid tissue)
MIMi606047, gene
neXtProtiNX_A6NI73
OpenTargetsiENSG00000187116
PharmGKBiPA142671547

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RU0A, Eukaryota
GeneTreeiENSGT01000000214458
HOGENOMiCLU_021100_1_4_1
InParanoidiA6NI73
OMAiSSHRGTF
OrthoDBi1327293at2759
PhylomeDBiA6NI73
TreeFamiTF336644

Enzyme and pathway databases

PathwayCommonsiA6NI73
ReactomeiR-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		353514, 3 hits in 837 CRISPR screens
EvolutionaryTraceiA6NI73

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		353514
PharosiA6NI73, Tbio

Protein Ontology

More...PROi		PR:A6NI73
RNActiA6NI73, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000187116, Expressed in blood and 138 other tissues
GenevisibleiA6NI73, HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
PfamiView protein in Pfam
PF13895, Ig_2, 1 hit
SMARTiView protein in SMART
SM00409, IG, 2 hits
SM00408, IGc2, 1 hit
SUPFAMiSSF48726, SSF48726, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIRA5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NI73
Secondary accession number(s): A6NHI3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 24, 2007
Last modified: December 2, 2020
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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