UniProtKB - A6NI56 (CC154_HUMAN)
Protein
Coiled-coil domain-containing protein 154
Gene
CCDC154
Organism
Homo sapiens (Human)
Status
Functioni
Miscellaneous
Overexpression suppresses cell proliferation by inducing G2/M arrest.1 Publication
Enzyme and pathway databases
PathwayCommonsi | A6NI56 |
Names & Taxonomyi
Protein namesi | Recommended name: Coiled-coil domain-containing protein 154Curated |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000197599.12 |
HGNCi | HGNC:34454, CCDC154 |
MIMi | 618740, gene |
neXtProti | NX_A6NI56 |
Subcellular locationi
Endosome
- Early endosome 1 Publication
Endosome
- early endosome Source: UniProtKB-SubCell
Keywords - Cellular componenti
EndosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 645811 |
Miscellaneous databases
Pharosi | A6NI56, Tdark |
Polymorphism and mutation databases
BioMutai | CCDC154 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000332270 | 1 – 667 | Coiled-coil domain-containing protein 154Add BLAST | 667 |
Proteomic databases
PaxDbi | A6NI56 |
PeptideAtlasi | A6NI56 |
PRIDEi | A6NI56 |
PTM databases
iPTMneti | A6NI56 |
PhosphoSitePlusi | A6NI56 |
Expressioni
Gene expression databases
Bgeei | ENSG00000197599, Expressed in right hemisphere of cerebellum and 110 other tissues |
Organism-specific databases
HPAi | ENSG00000197599, Tissue enhanced (testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 570763, 4 interactors |
IntActi | A6NI56, 1 interactor |
STRINGi | 9606.ENSP00000373828 |
Miscellaneous databases
RNActi | A6NI56, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 76 – 182 | Sequence analysisAdd BLAST | 107 | |
Coiled coili | 215 – 302 | Sequence analysisAdd BLAST | 88 | |
Coiled coili | 384 – 410 | Sequence analysisAdd BLAST | 27 | |
Coiled coili | 457 – 521 | Sequence analysisAdd BLAST | 65 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502RF80, Eukaryota |
InParanoidi | A6NI56 |
OrthoDBi | 516409at2759 |
PhylomeDBi | A6NI56 |
TreeFami | TF351158 |
Family and domain databases
InterProi | View protein in InterPro IPR029512, CCDC154 |
PANTHERi | PTHR35153, PTHR35153, 1 hit |
Pfami | View protein in Pfam PF15450, CCDC154, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
A6NI56-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSELADSGPS GASAPSQLRA VTLEDLGLLL AGGLASPEPL SLEELSERYE
60 70 80 90 100
SSHPTSTASV PEQDTAKHWN QLEQWVVELQ AEVACLREHK QRCERATRSL
110 120 130 140 150
LRELLQVRAR VQLQGSELRQ LQQEARPAAQ APEKEAPEFS GLQNQMQALD
160 170 180 190 200
KRLVEVREAL TRLRRRQVQQ EAERRGAEQE AGLRLAKLTD LLQQEEQGRE
210 220 230 240 250
VACGALQKNQ EDSSRRVDLE VARMQAQVTK LGEEVSLRFL KREAKLCGFL
260 270 280 290 300
QKSFLALEKR MKASESSRLK LEGSLRGELE SRWEKLRGLM EERLRALQGQ
310 320 330 340 350
HEESHLLEQC QGLDAAVAQL TKFVQQNQAS LNRVLLAEEK AWDAKGRLEE
360 370 380 390 400
SRAGELAAYV QENLEAAQLA GELARQEMHG ELVLLREKSR ALEASVAQLA
410 420 430 440 450
GQLKELSGHL PALSSRLDLQ EQMLGLRLSE AKTEWEGAER KSLEDLARWR
460 470 480 490 500
KEVTEHLRGV REKVDGLPQQ IESVSDKCLL HKSDSDLRIS AEGKAREFKV
510 520 530 540 550
GALRQELATL LSSVQLLKED NPGRKIAEMQ GKLATFQNQI MKLENCVQAN
560 570 580 590 600
KTIQNLRFNT EARLRTQEMA TLWESVLRLW SEEGPRTPLG SWKALPSLVR
610 620 630 640 650
PRVFIKDMAP GKVVPMNCWG VYQAVRWLRW KASLIKLRAL RRPGGVLEKP
660
HSQEQVQQLT PSLFIQK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A590PWR5 | A0A590PWR5_HUMAN | Coiled-coil domain-containing prote... | CCDC154 | 674 | Annotation score: | ||
B7ZBA8 | B7ZBA8_HUMAN | Coiled-coil domain-containing prote... | CCDC154 | 522 | Annotation score: | ||
H3BS06 | H3BS06_HUMAN | Coiled-coil domain-containing prote... | CCDC154 | 99 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JN935901 mRNA Translation: AEW67365.1 AL031600 Genomic DNA No translation available. AL032819 Genomic DNA No translation available. AL137252 Genomic DNA No translation available. |
RefSeqi | NP_001137452.1, NM_001143980.1 |
Genome annotation databases
GeneIDi | 645811 |
KEGGi | hsa:645811 |
UCSCi | uc059oxj.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JN935901 mRNA Translation: AEW67365.1 AL031600 Genomic DNA No translation available. AL032819 Genomic DNA No translation available. AL137252 Genomic DNA No translation available. |
RefSeqi | NP_001137452.1, NM_001143980.1 |
3D structure databases
SMRi | A6NI56 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 570763, 4 interactors |
IntActi | A6NI56, 1 interactor |
STRINGi | 9606.ENSP00000373828 |
PTM databases
iPTMneti | A6NI56 |
PhosphoSitePlusi | A6NI56 |
Polymorphism and mutation databases
BioMutai | CCDC154 |
Proteomic databases
PaxDbi | A6NI56 |
PeptideAtlasi | A6NI56 |
PRIDEi | A6NI56 |
Genome annotation databases
GeneIDi | 645811 |
KEGGi | hsa:645811 |
UCSCi | uc059oxj.1, human |
Organism-specific databases
CTDi | 645811 |
DisGeNETi | 645811 |
EuPathDBi | HostDB:ENSG00000197599.12 |
GeneCardsi | CCDC154 |
HGNCi | HGNC:34454, CCDC154 |
HPAi | ENSG00000197599, Tissue enhanced (testis) |
MIMi | 618740, gene |
neXtProti | NX_A6NI56 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RF80, Eukaryota |
InParanoidi | A6NI56 |
OrthoDBi | 516409at2759 |
PhylomeDBi | A6NI56 |
TreeFami | TF351158 |
Enzyme and pathway databases
PathwayCommonsi | A6NI56 |
Miscellaneous databases
BioGRID-ORCSi | 645811, 1 hit in 118 CRISPR screens |
GenomeRNAii | 645811 |
Pharosi | A6NI56, Tdark |
PROi | PR:A6NI56 |
RNActi | A6NI56, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197599, Expressed in right hemisphere of cerebellum and 110 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR029512, CCDC154 |
PANTHERi | PTHR35153, PTHR35153, 1 hit |
Pfami | View protein in Pfam PF15450, CCDC154, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CC154_HUMAN | |
Accessioni | A6NI56Primary (citable) accession number: A6NI56 Secondary accession number(s): G9JV18 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | September 18, 2019 | |
Last modified: | December 2, 2020 | |
This is version 93 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM