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Entry version 80 (13 Feb 2019)
Sequence version 4 (22 Jul 2008)
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Protein

Coiled-coil domain-containing protein 154

Gene

CCDC154

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Overexpression suppresses cell proliferation by inducing G2/M arrest.1 Publication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 154Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC154Imported
Synonyms:C16orf29Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000197599.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:34454 CCDC154

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6NI56

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
645811

Open Targets

More...
OpenTargetsi
ENSG00000197599

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC154

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003322701 – 674Coiled-coil domain-containing protein 154Add BLAST674

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A6NI56

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A6NI56

PRoteomics IDEntifications database

More...
PRIDEi
A6NI56

ProteomicsDB human proteome resource

More...
ProteomicsDBi
1246

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6NI56

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A6NI56

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197599 Expressed in 85 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A6NI56 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041158
HPA043535
HPA048237

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
570763, 3 interactors

Protein interaction database and analysis system

More...
IntActi
A6NI56, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A6NI56

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A6NI56

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili76 – 182Sequence analysisAdd BLAST107
Coiled coili215 – 302Sequence analysisAdd BLAST88
Coiled coili393 – 419Sequence analysisAdd BLAST27
Coiled coili466 – 530Sequence analysisAdd BLAST65

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IE6K Eukaryota
ENOG41121FM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002278

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000082432

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107604

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6NI56

Identification of Orthologs from Complete Genome Data

More...
OMAi
VRWLQWK

Database of Orthologous Groups

More...
OrthoDBi
516409at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A6NI56

TreeFam database of animal gene trees

More...
TreeFami
TF351158

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029512 CCDC154

The PANTHER Classification System

More...
PANTHERi
PTHR35153 PTHR35153, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15450 CCDC154, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A6NI56-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSELADSGPS GASAPSQLRA VTLEDLGLLL AGGLASPEPL SLEELSERYE
60 70 80 90 100
SSHPTSTASV PEQDTAKHWN QLEQWVVELQ AEVACLREHK QRCERATRSL
110 120 130 140 150
LRELLQVRAR VQLQGSELRQ LQQEARPAAQ APEKEAPEFS GLQNQMQALD
160 170 180 190 200
KRLVEVREAL TRLRRRQVQQ EAERRGAEQE AGLRLAKLTD LLQQEEQGRE
210 220 230 240 250
VACGALQKNQ EDSSRRVDLE VARMQAQVTK LGEEVSLRFL KREAKLCGFL
260 270 280 290 300
QKSFLALEKR MKASESSRLK LEGSLRGELE SRWEKLRGLM EERLRALQGQ
310 320 330 340 350
HEVGPGGRRA EESHLLEQCQ GLDAAVAQLT KFVQQNQASL NRVLLAEEKA
360 370 380 390 400
WDAKGRLEES RAGELAAYVQ ENLEAAQLAG ELARQEMHGE LVLLREKSRA
410 420 430 440 450
LEASVAQLAG QLKELSGHLP ALSSRLDLQE QMLGLRLSEA KTEWEGAERK
460 470 480 490 500
SLEDLARWRK EVTEHLRGVR EKVDGLPQQI ESVSDKCLLH KSDSDLRISA
510 520 530 540 550
EGKAREFKVG ALRQELATLL SSVQLLKEDN PGRKIAEMQG KLATNQIMKL
560 570 580 590 600
ENCVQANKTI QNLRFNTEAR LRTQEMATLW ESVLRLWSEE GPRTPLGSWK
610 620 630 640 650
ALPSLVRPRV FIKDMAPGKV VPMNCWGVYQ AVRWLRWKAS LIKLRALRRP
660 670
GGVLEKPHSQ EQVQQLTPSL FIQK
Length:674
Mass (Da):76,013
Last modified:July 22, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i90B3F8A43B63A16F
GO
Isoform 2 (identifier: A6NI56-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     302-310: Missing.
     544-544: T → TFQ

Show »
Length:667
Mass (Da):75,408
Checksum:i0D022F9B7049C8FD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZBA8B7ZBA8_HUMAN
Coiled-coil domain-containing prote...
CCDC154
522Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BS06H3BS06_HUMAN
Coiled-coil domain-containing prote...
CCDC154
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_047467302 – 310Missing in isoform 2. 1 Publication9
Alternative sequenceiVSP_047468544T → TFQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JN935901 mRNA Translation: AEW67365.1
AL031600 Genomic DNA No translation available.
AL032819 Genomic DNA No translation available.
AL137252 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001137452.1, NM_001143980.1 [A6NI56-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.355232

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000389176; ENSP00000373828; ENSG00000197599 [A6NI56-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
645811

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:645811

UCSC genome browser

More...
UCSCi
uc059oxj.1 human [A6NI56-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JN935901 mRNA Translation: AEW67365.1
AL031600 Genomic DNA No translation available.
AL032819 Genomic DNA No translation available.
AL137252 Genomic DNA No translation available.
RefSeqiNP_001137452.1, NM_001143980.1 [A6NI56-2]
UniGeneiHs.355232

3D structure databases

ProteinModelPortaliA6NI56
SMRiA6NI56
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi570763, 3 interactors
IntActiA6NI56, 1 interactor

PTM databases

iPTMnetiA6NI56
PhosphoSitePlusiA6NI56

Polymorphism and mutation databases

BioMutaiCCDC154

Proteomic databases

jPOSTiA6NI56
PaxDbiA6NI56
PRIDEiA6NI56
ProteomicsDBi1246

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389176; ENSP00000373828; ENSG00000197599 [A6NI56-1]
GeneIDi645811
KEGGihsa:645811
UCSCiuc059oxj.1 human [A6NI56-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
645811
DisGeNETi645811
EuPathDBiHostDB:ENSG00000197599.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC154
HGNCiHGNC:34454 CCDC154
HPAiHPA041158
HPA043535
HPA048237
neXtProtiNX_A6NI56
OpenTargetsiENSG00000197599

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IE6K Eukaryota
ENOG41121FM LUCA
GeneTreeiENSGT00390000002278
HOGENOMiHOG000082432
HOVERGENiHBG107604
InParanoidiA6NI56
OMAiVRWLQWK
OrthoDBi516409at2759
PhylomeDBiA6NI56
TreeFamiTF351158

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
645811

Protein Ontology

More...
PROi
PR:A6NI56

Gene expression databases

BgeeiENSG00000197599 Expressed in 85 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiA6NI56 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR029512 CCDC154
PANTHERiPTHR35153 PTHR35153, 1 hit
PfamiView protein in Pfam
PF15450 CCDC154, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC154_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NI56
Secondary accession number(s): G9JV18
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 22, 2008
Last modified: February 13, 2019
This is version 80 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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