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UniProtKB - A6NI56 (CC154_HUMAN)

Entry version 89 (26 Feb 2020)
Sequence version 5 (18 Sep 2019)
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Protein

Coiled-coil domain-containing protein 154

Gene

CCDC154

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Overexpression suppresses cell proliferation by inducing G2/M arrest.1 Publication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 154Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC154Imported
Synonyms:C16orf29Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:34454 CCDC154

neXtProt; the human protein knowledge platform

More...neXtProti		NX_A6NI56

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		645811

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		A6NI56 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CCDC154

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003322701 – 667Coiled-coil domain-containing protein 154Add BLAST667

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A6NI56

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A6NI56

PRoteomics IDEntifications database

More...PRIDEi		A6NI56

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A6NI56

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A6NI56

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000197599 Expressed in right hemisphere of cerebellum and 84 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A6NI56 baseline and differential

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA041158
HPA043535
HPA048237

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		570763, 4 interactors

Protein interaction database and analysis system

More...IntActi		A6NI56, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000373828

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A6NI56 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A6NI56

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili76 – 182Sequence analysisAdd BLAST107
Coiled coili215 – 302Sequence analysisAdd BLAST88
Coiled coili384 – 410Sequence analysisAdd BLAST27
Coiled coili457 – 521Sequence analysisAdd BLAST65

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IE6K Eukaryota
ENOG41121FM LUCA

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A6NI56

Identification of Orthologs from Complete Genome Data

More...OMAi		VRWLQWK

Database of Orthologous Groups

More...OrthoDBi		516409at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A6NI56

TreeFam database of animal gene trees

More...TreeFami		TF351158

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029512 CCDC154

The PANTHER Classification System

More...PANTHERi		PTHR35153 PTHR35153, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15450 CCDC154, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A6NI56-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSELADSGPS GASAPSQLRA VTLEDLGLLL AGGLASPEPL SLEELSERYE 
        60         70         80         90        100
SSHPTSTASV PEQDTAKHWN QLEQWVVELQ AEVACLREHK QRCERATRSL 
       110        120        130        140        150
LRELLQVRAR VQLQGSELRQ LQQEARPAAQ APEKEAPEFS GLQNQMQALD 
       160        170        180        190        200
KRLVEVREAL TRLRRRQVQQ EAERRGAEQE AGLRLAKLTD LLQQEEQGRE 
       210        220        230        240        250
VACGALQKNQ EDSSRRVDLE VARMQAQVTK LGEEVSLRFL KREAKLCGFL 
       260        270        280        290        300
QKSFLALEKR MKASESSRLK LEGSLRGELE SRWEKLRGLM EERLRALQGQ 
       310        320        330        340        350
HEESHLLEQC QGLDAAVAQL TKFVQQNQAS LNRVLLAEEK AWDAKGRLEE 
       360        370        380        390        400
SRAGELAAYV QENLEAAQLA GELARQEMHG ELVLLREKSR ALEASVAQLA 
       410        420        430        440        450
GQLKELSGHL PALSSRLDLQ EQMLGLRLSE AKTEWEGAER KSLEDLARWR 
       460        470        480        490        500
KEVTEHLRGV REKVDGLPQQ IESVSDKCLL HKSDSDLRIS AEGKAREFKV 
       510        520        530        540        550
GALRQELATL LSSVQLLKED NPGRKIAEMQ GKLATFQNQI MKLENCVQAN 
       560        570        580        590        600
KTIQNLRFNT EARLRTQEMA TLWESVLRLW SEEGPRTPLG SWKALPSLVR 
       610        620        630        640        650
PRVFIKDMAP GKVVPMNCWG VYQAVRWLRW KASLIKLRAL RRPGGVLEKP 
       660 
HSQEQVQQLT PSLFIQK
Length:667
Mass (Da):75,408
Last modified:September 18, 2019 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D022F9B7049C8FD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A590PWR5A0A590PWR5_HUMAN
Coiled-coil domain-containing prote...
CCDC154
674Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZBA8B7ZBA8_HUMAN
Coiled-coil domain-containing prote...
CCDC154
522Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BS06H3BS06_HUMAN
Coiled-coil domain-containing prote...
CCDC154
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
JN935901 mRNA Translation: AEW67365.1
AL031600 Genomic DNA No translation available.
AL032819 Genomic DNA No translation available.
AL137252 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_001137452.1, NM_001143980.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		645811

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:645811

UCSC genome browser

More...UCSCi		uc059oxj.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JN935901 mRNA Translation: AEW67365.1
AL031600 Genomic DNA No translation available.
AL032819 Genomic DNA No translation available.
AL137252 Genomic DNA No translation available.
RefSeqiNP_001137452.1, NM_001143980.1

3D structure databases

SMRiA6NI56
ModBaseiSearch...

Protein-protein interaction databases

BioGridi570763, 4 interactors
IntActiA6NI56, 1 interactor
STRINGi9606.ENSP00000373828

PTM databases

iPTMnetiA6NI56
PhosphoSitePlusiA6NI56

Polymorphism and mutation databases

BioMutaiCCDC154

Proteomic databases

jPOSTiA6NI56
PaxDbiA6NI56
PRIDEiA6NI56

Genome annotation databases

GeneIDi645811
KEGGihsa:645811
UCSCiuc059oxj.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		645811
DisGeNETi645811

GeneCards: human genes, protein and diseases

More...GeneCardsi		CCDC154
HGNCiHGNC:34454 CCDC154
HPAiHPA041158
HPA043535
HPA048237
neXtProtiNX_A6NI56

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IE6K Eukaryota
ENOG41121FM LUCA
InParanoidiA6NI56
OMAiVRWLQWK
OrthoDBi516409at2759
PhylomeDBiA6NI56
TreeFamiTF351158

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		645811
PharosiA6NI56 Tdark

Protein Ontology

More...PROi		PR:A6NI56
RNActiA6NI56 protein

Gene expression databases

BgeeiENSG00000197599 Expressed in right hemisphere of cerebellum and 84 other tissues
ExpressionAtlasiA6NI56 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR029512 CCDC154
PANTHERiPTHR35153 PTHR35153, 1 hit
PfamiView protein in Pfam
PF15450 CCDC154, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC154_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NI56
Secondary accession number(s): G9JV18
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 18, 2019
Last modified: February 26, 2020
This is version 89 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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