Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 79 (16 Jan 2019)
Sequence version 3 (05 Apr 2011)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Leucine-rich repeat-containing protein 14B

Gene

LRRC14B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 14BCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRC14BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000185028.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:37268 LRRC14B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6NHZ5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000185028

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LRRC14B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003442401 – 514Leucine-rich repeat-containing protein 14BAdd BLAST514

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A6NHZ5

PRoteomics IDEntifications database

More...
PRIDEi
A6NHZ5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
1234

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6NHZ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A6NHZ5

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
A6NHZ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185028 Expressed in 41 organ(s), highest expression level in muscle of leg

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A6NHZ5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038046
HPA038047

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A6NHZ5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati104 – 141LRR 1; degenerateBy similarityAdd BLAST38
Repeati185 – 209LRR 2; degenerateBy similarityAdd BLAST25
Repeati238 – 277LRR 4; degenerateBy similarityAdd BLAST40
Repeati278 – 302LRR 5By similarityAdd BLAST25
Repeati303 – 334LRR 6By similarityAdd BLAST32
Repeati335 – 350LRR 7By similarityAdd BLAST16
Repeati359 – 386LRR 8By similarityAdd BLAST28
Repeati387 – 411LRR 9By similarityAdd BLAST25

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PRAME family. LRRC14 subfamily.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHBR Eukaryota
ENOG410Z0VD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153199

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113360

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG083227

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6NHZ5

Identification of Orthologs from Complete Genome Data

More...
OMAi
WPLEEFR

Database of Orthologous Groups

More...
OrthoDBi
563553at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A6NHZ5

TreeFam database of animal gene trees

More...
TreeFami
TF332708

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032675 LRR_dom_sf

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A6NHZ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTMRSLRFI SAEALVSHPQ VARQSLDSVA HNLYPLLFKA SYLLEQAEVT
60 70 80 90 100
RAVLGRWPLE EFRLGALLGP GADHPQDLRD RTCRACLEAL VRGLADHVLQ
110 120 130 140 150
DRSRRRLRVA DLTGIRDVQV QRCPCGRALG RWGRTQLLAR TCCELQAEPL
160 170 180 190 200
AAGRPVEVLA DLFVTEGNFE AVVQALRPAG PAPLRVHCPS FRADSLSPSQ
210 220 230 240 250
LLHVLRLAGP GALRKLEVVH NVRLHAGHVQ QLLAQVGFPR LASLTLPTKA
260 270 280 290 300
FDAPPTYAST PDGEDPLLAS IARELSKMAQ LTELSVAFST LTGKIPTLLG
310 320 330 340 350
PLQTPLRVLD LANCALNHTD MAFLADCAHA AHLEVLDLSG HNLVSLYPST
360 370 380 390 400
FFRLLSQASR TLRILTLEEC GIVDSHVGML ILGLSPCHRL RQLKFLGNPL
410 420 430 440 450
SARALRRLFT ALCELPELRC IEFPVPKDCY PEGAAYPQDE LAMSKFNQQK
460 470 480 490 500
YDEIAEELRA VLLRADREDI QVSTPLFGSF DPDIQETSNE LGAFLLQAFK
510
TALENFSRAL KQIE
Length:514
Mass (Da):56,758
Last modified:April 5, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i61F7F004766CF7C9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC021087 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47184.1

NCBI Reference Sequences

More...
RefSeqi
NP_001073947.1, NM_001080478.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.103142

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000328278; ENSP00000327675; ENSG00000185028

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
389257

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:389257

UCSC genome browser

More...
UCSCi
uc003jal.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC021087 Genomic DNA No translation available.
CCDSiCCDS47184.1
RefSeqiNP_001073947.1, NM_001080478.2
UniGeneiHs.103142

3D structure databases

ProteinModelPortaliA6NHZ5
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiA6NHZ5
PhosphoSitePlusiA6NHZ5
SwissPalmiA6NHZ5

Polymorphism and mutation databases

BioMutaiLRRC14B

Proteomic databases

PaxDbiA6NHZ5
PRIDEiA6NHZ5
ProteomicsDBi1234

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
389257
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328278; ENSP00000327675; ENSG00000185028
GeneIDi389257
KEGGihsa:389257
UCSCiuc003jal.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
389257
EuPathDBiHostDB:ENSG00000185028.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LRRC14B
HGNCiHGNC:37268 LRRC14B
HPAiHPA038046
HPA038047
neXtProtiNX_A6NHZ5
OpenTargetsiENSG00000185028

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHBR Eukaryota
ENOG410Z0VD LUCA
GeneTreeiENSGT00940000153199
HOGENOMiHOG000113360
HOVERGENiHBG083227
InParanoidiA6NHZ5
OMAiWPLEEFR
OrthoDBi563553at2759
PhylomeDBiA6NHZ5
TreeFamiTF332708

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
389257

Protein Ontology

More...
PROi
PR:A6NHZ5

Gene expression databases

BgeeiENSG00000185028 Expressed in 41 organ(s), highest expression level in muscle of leg
GenevisibleiA6NHZ5 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLR14B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NHZ5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: April 5, 2011
Last modified: January 16, 2019
This is version 79 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again