Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 90 (16 Jan 2019)
Sequence version 3 (03 Apr 2013)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Ankyrin repeat and death domain-containing protein 1B

Gene

ANKDD1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat and death domain-containing protein 1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANKDD1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000189045.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:32525 ANKDD1B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6NHY2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
728780

Open Targets

More...
OpenTargetsi
ENSG00000189045

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANKDD1B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003321601 – 528Ankyrin repeat and death domain-containing protein 1BAdd BLAST528

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A6NHY2

PRoteomics IDEntifications database

More...
PRIDEi
A6NHY2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
1232

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6NHY2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A6NHY2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000189045 Expressed in 87 organ(s), highest expression level in right uterine tube

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA059722

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000471417

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A6NHY2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A6NHY2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati67 – 96ANK 1Add BLAST30
Repeati100 – 129ANK 2Add BLAST30
Repeati133 – 162ANK 3Add BLAST30
Repeati166 – 197ANK 4Add BLAST32
Repeati201 – 230ANK 5Add BLAST30
Repeati234 – 263ANK 6Add BLAST30
Repeati267 – 296ANK 7Add BLAST30
Repeati300 – 329ANK 8Add BLAST30
Repeati333 – 362ANK 9Add BLAST30
Repeati366 – 395ANK 10Add BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini427 – 515DeathPROSITE-ProRule annotationAdd BLAST89

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4177 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154170

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG100885

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6NHY2

Identification of Orthologs from Complete Genome Data

More...
OMAi
QWQDINE

Database of Orthologous Groups

More...
OrthoDBi
1073550at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039194 AKD1A/AKD1B
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain

The PANTHER Classification System

More...
PANTHERi
PTHR24125 PTHR24125, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 6 hits
PS50017 DEATH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A6NHY2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPAGRARGQ GATAGGLLLR AAAAAKGLRE DLWGAAALPW RSLSRIPKRE
60 70 80 90 100
GLGEEDTAVA GHELLLPNER SFQNAAKSNN LDLMEKLFEK KVNINVVNNM
110 120 130 140 150
NRTALHFAVG RNHLSAVDFL LKHKARVDVA DKHGLTVIHL AAWSGSLEVM
160 170 180 190 200
LMLVKAGADQ RAKNQDGMSA LHFATQSNHV RIVEYLIQDL HLKDLNQPDE
210 220 230 240 250
KGRKPFLLAA ERGHVEMIEK LTFLNLHTSE KDKGGNTALH LAAKHGHSPA
260 270 280 290 300
VQVLLAQWQD INEMNELNIS SLQIATRNGH ASLVNFLLSE NVDLHQKVEP
310 320 330 340 350
KESPLHLVVI NNHITVVNSL LSAQHDIDIL NQKQQTPLHV AADRGNVELV
360 370 380 390 400
ETLLKAGCDL KAVDKQGKTA LAVASRSNHS LVVGMLIKAE RYYAWREEHH
410 420 430 440 450
ESIRDPSTGF TLTFKQDHSL ETRHIRTLLW DLAYHQLKAN EWQRLARSWN
460 470 480 490 500
FTDDQIRAIE EQWSGNESFR EHGHRALLIW LHGTLMTQGD PAKQLYEELV
510 520
HAGFPKLAEK TRHFKSKTDS NSKKCVVS
Length:528
Mass (Da):59,088
Last modified:April 3, 2013 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5C3FF9A1A2A54859
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC010245 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS64180.1

NCBI Reference Sequences

More...
RefSeqi
NP_001263642.1, NM_001276713.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.370455

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000601380; ENSP00000471417; ENSG00000189045

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
728780

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:728780

UCSC genome browser

More...
UCSCi
uc031ski.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010245 Genomic DNA No translation available.
CCDSiCCDS64180.1
RefSeqiNP_001263642.1, NM_001276713.1
UniGeneiHs.370455

3D structure databases

ProteinModelPortaliA6NHY2
SMRiA6NHY2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000471417

PTM databases

iPTMnetiA6NHY2
PhosphoSitePlusiA6NHY2

Polymorphism and mutation databases

BioMutaiANKDD1B

Proteomic databases

PaxDbiA6NHY2
PRIDEiA6NHY2
ProteomicsDBi1232

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000601380; ENSP00000471417; ENSG00000189045
GeneIDi728780
KEGGihsa:728780
UCSCiuc031ski.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
728780
DisGeNETi728780
EuPathDBiHostDB:ENSG00000189045.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ANKDD1B
HGNCiHGNC:32525 ANKDD1B
HPAiHPA059722
neXtProtiNX_A6NHY2
OpenTargetsiENSG00000189045

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4177 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000154170
HOVERGENiHBG100885
InParanoidiA6NHY2
OMAiQWQDINE
OrthoDBi1073550at2759

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
728780

Protein Ontology

More...
PROi
PR:A6NHY2

Gene expression databases

BgeeiENSG00000189045 Expressed in 87 organ(s), highest expression level in right uterine tube

Family and domain databases

CDDicd00204 ANK, 3 hits
Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR039194 AKD1A/AKD1B
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
PANTHERiPTHR24125 PTHR24125, 2 hits
PfamiView protein in Pfam
PF12796 Ank_2, 3 hits
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 10 hits
SUPFAMiSSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 6 hits
PS50017 DEATH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAKD1B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NHY2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 3, 2013
Last modified: January 16, 2019
This is version 90 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again