UniProtKB - A6NHT5 (HMX3_HUMAN)
Protein
Homeobox protein HMX3
Gene
HMX3
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 227 – 286 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: Ensembl
GO - Biological processi
- brain development Source: Ensembl
- cell differentiation Source: UniProtKB-KW
- embryo implantation Source: Ensembl
- inner ear morphogenesis Source: Ensembl
- maternal process involved in female pregnancy Source: Ensembl
- neuromuscular process controlling balance Source: Ensembl
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Differentiation, Neurogenesis, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | A6NHT5 |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein HMX3Alternative name(s): Homeobox protein H6 family member 3 Homeobox protein Nkx-5.1 |
Gene namesi | Name:HMX3 Synonyms:NKX-5.1, NKX5-1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000188620.9 |
HGNCi | HGNC:5019, HMX3 |
MIMi | 613380, gene |
neXtProti | NX_A6NHT5 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nuclear chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 340784 |
OpenTargetsi | ENSG00000188620 |
PharmGKBi | PA29346 |
Miscellaneous databases
Pharosi | A6NHT5, Tbio |
Polymorphism and mutation databases
BioMutai | HMX3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000341382 | 1 – 357 | Homeobox protein HMX3Add BLAST | 357 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 153 | PhosphoserineCombined sources | 1 | |
Modified residuei | 180 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | A6NHT5 |
jPOSTi | A6NHT5 |
MassIVEi | A6NHT5 |
MaxQBi | A6NHT5 |
PaxDbi | A6NHT5 |
PeptideAtlasi | A6NHT5 |
PRIDEi | A6NHT5 |
ProteomicsDBi | 1225 |
PTM databases
iPTMneti | A6NHT5 |
PhosphoSitePlusi | A6NHT5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000188620, Expressed in hypothalamus and 34 other tissues |
Organism-specific databases
HPAi | ENSG00000188620, Tissue enhanced (brain, intestine) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 131098, 4 interactors |
STRINGi | 9606.ENSP00000350549 |
Miscellaneous databases
RNActi | A6NHT5, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 2 – 52 | Pro-richAdd BLAST | 51 | |
Compositional biasi | 57 – 84 | Ala-richAdd BLAST | 28 | |
Compositional biasi | 319 – 326 | Poly-Ala | 8 |
Sequence similaritiesi
Belongs to the HMX homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0485, Eukaryota |
GeneTreei | ENSGT00940000158286 |
HOGENOMi | CLU_064096_0_0_1 |
InParanoidi | A6NHT5 |
OMAi | DDDKKPC |
OrthoDBi | 1313583at2759 |
PhylomeDBi | A6NHT5 |
TreeFami | TF320562 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A6NHT5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPEPGPDAAG TASAQPQPPP PPPPAPKESP FSIKNLLNGD HHRPPPKPQP
60 70 80 90 100
PPRTLFAPAS AAAAAAAAAA AAAKGALEGA AGFALSQVGD LAFPRFEIPA
110 120 130 140 150
QRFALPAHYL ERSPAWWYPY TLTPAGGHLP RPEASEKALL RDSSPASGTD
160 170 180 190 200
RDSPEPLLKA DPDHKELDSK SPDEIILEES DSEESKKEGE AAPGAAGASV
210 220 230 240 250
GAAAATPGAE DWKKGAESPE KKPACRKKKT RTVFSRSQVF QLESTFDMKR
260 270 280 290 300
YLSSSERAGL AASLHLTETQ VKIWFQNRRN KWKRQLAAEL EAANLSHAAA
310 320 330 340 350
QRIVRVPILY HENSAAEGAA AAAAGAPVPV SQPLLTFPHP VYYSHPVVSS
VPLLRPV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC012391 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49289.1 |
CCDSi | CCDS41575.1 |
RefSeqi | NP_001099044.1, NM_001105574.1 |
Genome annotation databases
Ensembli | ENST00000357878; ENSP00000350549; ENSG00000188620 |
GeneIDi | 340784 |
KEGGi | hsa:340784 |
UCSCi | uc010quc.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC012391 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49289.1 |
CCDSi | CCDS41575.1 |
RefSeqi | NP_001099044.1, NM_001105574.1 |
3D structure databases
SMRi | A6NHT5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 131098, 4 interactors |
STRINGi | 9606.ENSP00000350549 |
PTM databases
iPTMneti | A6NHT5 |
PhosphoSitePlusi | A6NHT5 |
Polymorphism and mutation databases
BioMutai | HMX3 |
Proteomic databases
EPDi | A6NHT5 |
jPOSTi | A6NHT5 |
MassIVEi | A6NHT5 |
MaxQBi | A6NHT5 |
PaxDbi | A6NHT5 |
PeptideAtlasi | A6NHT5 |
PRIDEi | A6NHT5 |
ProteomicsDBi | 1225 |
Protocols and materials databases
Antibodypediai | 32340, 89 antibodies |
Genome annotation databases
Ensembli | ENST00000357878; ENSP00000350549; ENSG00000188620 |
GeneIDi | 340784 |
KEGGi | hsa:340784 |
UCSCi | uc010quc.3, human |
Organism-specific databases
CTDi | 340784 |
DisGeNETi | 340784 |
EuPathDBi | HostDB:ENSG00000188620.9 |
GeneCardsi | HMX3 |
HGNCi | HGNC:5019, HMX3 |
HPAi | ENSG00000188620, Tissue enhanced (brain, intestine) |
MIMi | 613380, gene |
neXtProti | NX_A6NHT5 |
OpenTargetsi | ENSG00000188620 |
PharmGKBi | PA29346 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0485, Eukaryota |
GeneTreei | ENSGT00940000158286 |
HOGENOMi | CLU_064096_0_0_1 |
InParanoidi | A6NHT5 |
OMAi | DDDKKPC |
OrthoDBi | 1313583at2759 |
PhylomeDBi | A6NHT5 |
TreeFami | TF320562 |
Enzyme and pathway databases
PathwayCommonsi | A6NHT5 |
Miscellaneous databases
BioGRID-ORCSi | 340784, 4 hits in 869 CRISPR screens |
GenomeRNAii | 340784 |
Pharosi | A6NHT5, Tbio |
PROi | PR:A6NHT5 |
RNActi | A6NHT5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000188620, Expressed in hypothalamus and 34 other tissues |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HMX3_HUMAN | |
Accessioni | A6NHT5Primary (citable) accession number: A6NHT5 Secondary accession number(s): A8MU06 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | July 24, 2007 | |
Last modified: | December 2, 2020 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM