UniProtKB - A6NHG8 (A6NHG8_HUMAN)
Protein
TNF receptor-associated factor
Gene
TRAF3
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.UniRule annotation EC:2.3.2.27
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 135 – 190 | TRAF-typePROSITE-ProRule annotationAdd BLAST | 56 |
GO - Molecular functioni
- tumor necrosis factor receptor binding Source: UniProtKB-UniRule
- zinc ion binding Source: UniProtKB-UniRule
GO - Biological processi
- innate immune response Source: InterPro
- negative regulation of NF-kappaB transcription factor activity Source: InterPro
- regulation of apoptotic process Source: InterPro
- regulation of cytokine production Source: InterPro
- regulation of defense response to virus Source: InterPro
- Toll signaling pathway Source: InterPro
- tumor necrosis factor-mediated signaling pathway Source: InterPro
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:TRAF3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12033, TRAF3 |
VEuPathDBi | HostDB:ENSG00000131323.14 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000131323, Expressed in frontal cortex and 212 other tissues |
ExpressionAtlasi | A6NHG8, baseline and differential |
Interactioni
GO - Molecular functioni
- tumor necrosis factor receptor binding Source: UniProtKB-UniRule
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 53 – 92 | RING-typeInterPro annotationAdd BLAST | 40 | |
Domaini | 135 – 190 | TRAF-typeInterPro annotationAdd BLAST | 56 | |
Domaini | 390 – 535 | MATHInterPro annotationAdd BLAST | 146 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 28 | DisorderedSequence analysisAdd BLAST | 28 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 291 – 311 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 322 – 342 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the TNF receptor-associated factor family.UniRule annotation
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 135 – 190 | TRAF-typePROSITE-ProRule annotationAdd BLAST | 56 |
Keywords - Domaini
Coiled coilSequence analysisARBA annotation, RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000160538 |
Family and domain databases
CDDi | cd03777, MATH_TRAF3, 1 hit |
Gene3Di | 2.60.210.10, 1 hit 3.30.40.10, 2 hits |
InterProi | View protein in InterPro IPR002083, MATH/TRAF_dom IPR043211, TNF_rcpt-assoc_TRAF IPR012227, TNF_rcpt-assoc_TRAF_met IPR008974, TRAF-like IPR027128, TRAF3 IPR037304, TRAF3_MATH IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS IPR001293, Znf_TRAF |
PANTHERi | PTHR10131, PTHR10131, 1 hit PTHR10131:SF76, PTHR10131:SF76, 1 hit |
Pfami | View protein in Pfam PF02176, zf-TRAF, 1 hit |
PIRSFi | PIRSF015614, TRAF, 1 hit |
SMARTi | View protein in SMART SM00061, MATH, 1 hit |
SUPFAMi | SSF49599, SSF49599, 2 hits |
PROSITEi | View protein in PROSITE PS50144, MATH, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit PS50145, ZF_TRAF, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
A6NHG8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESSKKMDSP GALQTNPPLK LHTDRSAGTP VFVPEQGGYK EKFVKTVEDK
60 70 80 90 100
YKCEKCHLVL CSPKQTECGH RFCESCMAAL LSSSSPKCTA CQESIVKDKV
110 120 130 140 150
FKDNCCKREI LALQIYCRNE SRGCAEQLML GHLLVHLKND CHFEELPCVR
160 170 180 190 200
PDCKEKVLRK DLRDHVEKAC KYREATCSHC KSQVPMIALQ KHEDTDCPCV
210 220 230 240 250
VVSCPHKCSV QTLLRSEGTN QQIKAHEASS AVQHVNLLKE WSNSLEKKVS
260 270 280 290 300
LLQNESVEKN KSIQSLHNQI CSFEIEIERQ KEMLRNNESK ILHLQRVIDS
310 320 330 340 350
QAEKLKELDK EIRPFRQNWE EADSMKSSVE SLQNRVTELE SVDKSAGQVA
360 370 380 390 400
RNTGLLESQL SRHDQMLSVH DIRLADMDLR FQVLETASYN GVLIWKIRDY
410 420 430 440 450
KRRKQEAVMG KTLSLYSQPF YTGYFGYKMC ARVYLNGDGM GKGTHLSLFF
460 470 480 490 500
VIMRGEYDAL LPWPFKQKVT LMLMDQGSSR RHLGDAFKPD PNSSSFKKPT
510 520 530 540
GEMNIASGCP VFVAQTVLEN GTYIKDDTIF IKVIVDTSDL PDP
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ13114 | TRAF3_HUMAN | TNF receptor-associated factor 3 | TRAF3 CAP1, CRAF1 | 568 | Annotation score: | ||
H0YL26 | H0YL26_HUMAN | TNF receptor-associated factor 3 | TRAF3 | 290 | Annotation score: | ||
H0YL25 | H0YL25_HUMAN | TNF receptor-associated factor 3 | TRAF3 | 207 | Annotation score: | ||
H0YMI8 | H0YMI8_HUMAN | TNF receptor-associated factor 3 | TRAF3 | 94 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL117209 Genomic DNA No translation available. AL132801 Genomic DNA No translation available. |
RefSeqi | NP_663778.1, NM_145726.2 XP_016877108.1, XM_017021619.1 |
Genome annotation databases
Ensembli | ENST00000347662; ENSP00000328003; ENSG00000131323 ENST00000351691; ENSP00000332468; ENSG00000131323 |
GeneIDi | 7187 |
UCSCi | uc001yme.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL117209 Genomic DNA No translation available. AL132801 Genomic DNA No translation available. |
RefSeqi | NP_663778.1, NM_145726.2 XP_016877108.1, XM_017021619.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | A6NHG8 |
PRIDEi | A6NHG8 |
ProteomicsDBi | 1197 |
Protocols and materials databases
Antibodypediai | 129, 515 antibodies |
Genome annotation databases
Ensembli | ENST00000347662; ENSP00000328003; ENSG00000131323 ENST00000351691; ENSP00000332468; ENSG00000131323 |
GeneIDi | 7187 |
UCSCi | uc001yme.3, human |
Organism-specific databases
CTDi | 7187 |
HGNCi | HGNC:12033, TRAF3 |
OpenTargetsi | ENSG00000131323 |
PharmGKBi | PA36710 |
VEuPathDBi | HostDB:ENSG00000131323.14 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000160538 |
Miscellaneous databases
BioGRID-ORCSi | 7187, 18 hits in 883 CRISPR screens |
ChiTaRSi | TRAF3, human |
GenomeRNAii | 7187 |
Gene expression databases
Bgeei | ENSG00000131323, Expressed in frontal cortex and 212 other tissues |
ExpressionAtlasi | A6NHG8, baseline and differential |
Family and domain databases
CDDi | cd03777, MATH_TRAF3, 1 hit |
Gene3Di | 2.60.210.10, 1 hit 3.30.40.10, 2 hits |
InterProi | View protein in InterPro IPR002083, MATH/TRAF_dom IPR043211, TNF_rcpt-assoc_TRAF IPR012227, TNF_rcpt-assoc_TRAF_met IPR008974, TRAF-like IPR027128, TRAF3 IPR037304, TRAF3_MATH IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS IPR001293, Znf_TRAF |
PANTHERi | PTHR10131, PTHR10131, 1 hit PTHR10131:SF76, PTHR10131:SF76, 1 hit |
Pfami | View protein in Pfam PF02176, zf-TRAF, 1 hit |
PIRSFi | PIRSF015614, TRAF, 1 hit |
SMARTi | View protein in SMART SM00061, MATH, 1 hit |
SUPFAMi | SSF49599, SSF49599, 2 hits |
PROSITEi | View protein in PROSITE PS50144, MATH, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit PS50145, ZF_TRAF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A6NHG8_HUMAN | |
Accessioni | A6NHG8Primary (citable) accession number: A6NHG8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 24, 2007 |
Last sequence update: | July 24, 2007 | |
Last modified: | February 10, 2021 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |