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Entry version 109 (12 Aug 2020)
Sequence version 2 (26 Feb 2008)
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Protein

Maestro heat-like repeat-containing protein family member 6

Gene

MROH6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
A6NGR9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Maestro heat-like repeat-containing protein family member 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MROH6
Synonyms:C8orf73
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000204839.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27814, MROH6

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6NGR9

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
642475

Open Targets

More...
OpenTargetsi
ENSG00000204839

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672336

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
A6NGR9, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MROH6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003209221 – 719Maestro heat-like repeat-containing protein family member 6Add BLAST719

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A6NGR9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A6NGR9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
A6NGR9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A6NGR9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A6NGR9

PeptideAtlas

More...
PeptideAtlasi
A6NGR9

PRoteomics IDEntifications database

More...
PRIDEi
A6NGR9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
1146

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6NGR9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A6NGR9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204839, Expressed in lower esophagus mucosa and 187 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A6NGR9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A6NGR9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000204839, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
567998, 3 interactors

Protein interaction database and analysis system

More...
IntActi
A6NGR9, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000381857

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
A6NGR9, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati356 – 393HEAT 1Add BLAST38
Repeati397 – 434HEAT 2Add BLAST38
Repeati436 – 473HEAT 3Add BLAST38
Repeati477 – 514HEAT 4Add BLAST38
Repeati527 – 563HEAT 5Add BLAST37
Repeati594 – 631HEAT 6Add BLAST38
Repeati633 – 674HEAT 7Add BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi340 – 539Leu-richAdd BLAST200

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SUFR, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162472

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_030549_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6NGR9

Identification of Orthologs from Complete Genome Data

More...
OMAi
ESSEWTL

Database of Orthologous Groups

More...
OrthoDBi
429115at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A6NGR9

TreeFam database of animal gene trees

More...
TreeFami
TF343191

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A6NGR9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGGVWGRSR AREAPVGALT LTALTEGIRA RQGQPQGPPS AGPQPKSWEV
60 70 80 90 100
KPEAEPQTQA LTAPSEAEPG RGATVPEAGS EPCSLNSALE PAPEGPHQVP
110 120 130 140 150
QSSWEEGVLA DLALYTAACL EEAGFAGTQA TVLTLSSALE ARGERLEDQV
160 170 180 190 200
HALVRGLLAQ VPSLAEGRPW RAALRVLSAL ALEHARDVVC ALLPRSLPAD
210 220 230 240 250
RVAAELWRSL SRNQRVNGQV LVQLLWALKG ASGPEPQALA ATRALGEMLA
260 270 280 290 300
VSGCVGATRG FYPHLLLALV TQLHKLARSP CSPDMPKIWV LSHRGPPHSH
310 320 330 340 350
ASCAVEALKA LLTGDGGRMV VTCMEQAGGW RRLVGAHTHL EGVLLLASAM
360 370 380 390 400
VAHADHHLRG LFADLLPRLR SADDPQRLTA MAFFTGLLQS RPTARLLREE
410 420 430 440 450
VILERLLTWQ GDPEPTVRWL GLLGLGHLAL NRRKVRHVST LLPALLGALG
460 470 480 490 500
EGDARLVGAA LGALRRLLLR PRAPVRLLSA ELGPRLPPLL DDTRDSIRAS
510 520 530 540 550
AVGLLGTLVR RGRGGLRLGL RGPLRKLVLQ SLVPLLLRLH DPSRDAAESS
560 570 580 590 600
EWTLARCDHA FCWGLLEELV TVAHYDSPEA LSHLCCRLVQ RYPGHVPNFL
610 620 630 640 650
SQTQGYLRSP QDPLRRAAAV LIGFLVHHAS PGCVNQDLLD SLFQDLGRLQ
660 670 680 690 700
SDPKPAVAAA AHVSAQQVAM LARARGCPRG PRLLRIAPRP ARPPPVFADS
710
PFQRRSVAGR WGCSGPRRA
Length:719
Mass (Da):77,186
Last modified:February 26, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE934473EF64302AC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PJR4E9PJR4_HUMAN
Maestro heat-like repeat-containing...
MROH6
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPP7E9PPP7_HUMAN
Maestro heat-like repeat-containing...
MROH6
548Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03930597H → Q. Corresponds to variant dbSNP:rs4873803Ensembl.1
Natural variantiVAR_039306132V → A. Corresponds to variant dbSNP:rs4874153Ensembl.1
Natural variantiVAR_039307134T → I. Corresponds to variant dbSNP:rs10866911Ensembl.1
Natural variantiVAR_061595619A → T. Corresponds to variant dbSNP:rs13255489Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC067930 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47928.1

NCBI Reference Sequences

More...
RefSeqi
NP_001094348.1, NM_001100878.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000398882; ENSP00000381857; ENSG00000204839
ENST00000618551; ENSP00000479227; ENSG00000277781

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
642475

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:642475

UCSC genome browser

More...
UCSCi
uc010mff.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067930 Genomic DNA No translation available.
CCDSiCCDS47928.1
RefSeqiNP_001094348.1, NM_001100878.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi567998, 3 interactors
IntActiA6NGR9, 2 interactors
STRINGi9606.ENSP00000381857

PTM databases

iPTMnetiA6NGR9
PhosphoSitePlusiA6NGR9

Polymorphism and mutation databases

BioMutaiMROH6

Proteomic databases

EPDiA6NGR9
jPOSTiA6NGR9
MassIVEiA6NGR9
MaxQBiA6NGR9
PaxDbiA6NGR9
PeptideAtlasiA6NGR9
PRIDEiA6NGR9
ProteomicsDBi1146

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
76664, 7 antibodies

Genome annotation databases

EnsembliENST00000398882; ENSP00000381857; ENSG00000204839
ENST00000618551; ENSP00000479227; ENSG00000277781
GeneIDi642475
KEGGihsa:642475
UCSCiuc010mff.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
642475
DisGeNETi642475
EuPathDBiHostDB:ENSG00000204839.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MROH6
HGNCiHGNC:27814, MROH6
HPAiENSG00000204839, Low tissue specificity
neXtProtiNX_A6NGR9
OpenTargetsiENSG00000204839
PharmGKBiPA142672336

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502SUFR, Eukaryota
GeneTreeiENSGT00940000162472
HOGENOMiCLU_030549_0_0_1
InParanoidiA6NGR9
OMAiESSEWTL
OrthoDBi429115at2759
PhylomeDBiA6NGR9
TreeFamiTF343191

Enzyme and pathway databases

PathwayCommonsiA6NGR9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
642475, 16 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MROH6, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
642475
PharosiA6NGR9, Tdark

Protein Ontology

More...
PROi
PR:A6NGR9
RNActiA6NGR9, protein

Gene expression databases

BgeeiENSG00000204839, Expressed in lower esophagus mucosa and 187 other tissues
ExpressionAtlasiA6NGR9, baseline and differential
GenevisibleiA6NGR9, HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMROH6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NGR9
Secondary accession number(s): A8MWB1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: August 12, 2020
This is version 109 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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