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Entry version 116 (26 Feb 2020)
Sequence version 5 (05 Oct 2016)
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Protein
Submitted name:

Obscurin

Gene

OBSCN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
A6NGQ3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ObscurinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OBSCNImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15719 OBSCN

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000154358

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
1144
41620

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000154358 Expressed in gastrocnemius and 134 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
A6NGQ3 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000455507

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 100Ig-likeInterPro annotationAdd BLAST91
Domaini110 – 202Ig-likeInterPro annotationAdd BLAST93
Domaini236 – 322Ig-likeInterPro annotationAdd BLAST87
Domaini331 – 414Ig-likeInterPro annotationAdd BLAST84
Domaini515 – 612Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini701 – 790Ig-likeInterPro annotationAdd BLAST90
Domaini812 – 884Ig-likeInterPro annotationAdd BLAST73
Domaini886 – 974Ig-likeInterPro annotationAdd BLAST89
Domaini978 – 1056Ig-likeInterPro annotationAdd BLAST79
Domaini1070 – 1158Ig-likeInterPro annotationAdd BLAST89
Domaini1162 – 1240Ig-likeInterPro annotationAdd BLAST79
Domaini1254 – 1344Ig-likeInterPro annotationAdd BLAST91
Domaini1346 – 1424Ig-likeInterPro annotationAdd BLAST79
Domaini1438 – 1524Ig-likeInterPro annotationAdd BLAST87
Domaini1530 – 1616Ig-likeInterPro annotationAdd BLAST87
Domaini1622 – 1710Ig-likeInterPro annotationAdd BLAST89
Domaini1714 – 1792Ig-likeInterPro annotationAdd BLAST79
Domaini1806 – 1894Ig-likeInterPro annotationAdd BLAST89
Domaini1898 – 1983Ig-likeInterPro annotationAdd BLAST86
Domaini1997 – 2094Ig-likeInterPro annotationAdd BLAST98
Domaini2098 – 2183Ig-likeInterPro annotationAdd BLAST86
Domaini2198 – 2269Ig-likeInterPro annotationAdd BLAST72
Domaini2271 – 2357Ig-likeInterPro annotationAdd BLAST87
Domaini2362 – 2446Ig-likeInterPro annotationAdd BLAST85
Domaini2540 – 2624Ig-likeInterPro annotationAdd BLAST85
Domaini2718 – 2809Ig-likeInterPro annotationAdd BLAST92
Domaini2897 – 2988Ig-likeInterPro annotationAdd BLAST92
Domaini3075 – 3159Ig-likeInterPro annotationAdd BLAST85
Domaini3255 – 3337Ig-likeInterPro annotationAdd BLAST83
Domaini3349 – 3428Ig-likeInterPro annotationAdd BLAST80
Domaini3524 – 3598Ig-likeInterPro annotationAdd BLAST75
Domaini3613 – 3697Ig-likeInterPro annotationAdd BLAST85
Domaini3702 – 3785Ig-likeInterPro annotationAdd BLAST84
Domaini3788 – 3873Ig-likeInterPro annotationAdd BLAST86
Domaini3878 – 3961Ig-likeInterPro annotationAdd BLAST84
Domaini3966 – 4049Ig-likeInterPro annotationAdd BLAST84
Domaini4054 – 4137Ig-likeInterPro annotationAdd BLAST84
Domaini4142 – 4225Ig-likeInterPro annotationAdd BLAST84
Domaini4230 – 4313Ig-likeInterPro annotationAdd BLAST84
Domaini4318 – 4401Ig-likeInterPro annotationAdd BLAST84
Domaini4406 – 4489Ig-likeInterPro annotationAdd BLAST84
Domaini4494 – 4577Ig-likeInterPro annotationAdd BLAST84
Domaini4582 – 4665Ig-likeInterPro annotationAdd BLAST84
Domaini4670 – 4753Ig-likeInterPro annotationAdd BLAST84
Domaini4758 – 4841Ig-likeInterPro annotationAdd BLAST84
Domaini4847 – 4930Ig-likeInterPro annotationAdd BLAST84
Domaini4935 – 5019Ig-likeInterPro annotationAdd BLAST85
Domaini5025 – 5117Ig-likeInterPro annotationAdd BLAST93
Domaini5205 – 5294Ig-likeInterPro annotationAdd BLAST90
Domaini5482 – 5576Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini5581 – 5671Ig-likeInterPro annotationAdd BLAST91
Domaini5855 – 5946Ig-likeInterPro annotationAdd BLAST92
Domaini6083 – 6172Ig-likeInterPro annotationAdd BLAST90
Domaini6217 – 6306Ig-likeInterPro annotationAdd BLAST90
Domaini6328 – 6424Ig-likeInterPro annotationAdd BLAST97
Domaini6557 – 6624SH3InterPro annotationAdd BLAST68
Domaini6650 – 6834DHInterPro annotationAdd BLAST185
Domaini6852 – 6961PHInterPro annotationAdd BLAST110
Domaini6971 – 7054Ig-likeInterPro annotationAdd BLAST84
Domaini7065 – 7157Ig-likeInterPro annotationAdd BLAST93
Domaini7314 – 7402Ig-likeInterPro annotationAdd BLAST89
Domaini7425 – 7678Protein kinaseInterPro annotationAdd BLAST254
Domaini8420 – 8509Ig-likeInterPro annotationAdd BLAST90
Domaini8514 – 8606Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini8629 – 8879Protein kinaseInterPro annotationAdd BLAST251

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni228 – 249DisorderedSequence analysisAdd BLAST22
Regioni5706 – 5742DisorderedSequence analysisAdd BLAST37
Regioni5777 – 5817DisorderedSequence analysisAdd BLAST41
Regioni6195 – 6214DisorderedSequence analysisAdd BLAST20
Regioni6511 – 6553DisorderedSequence analysisAdd BLAST43
Regioni7194 – 7253DisorderedSequence analysisAdd BLAST60
Regioni7734 – 7820DisorderedSequence analysisAdd BLAST87
Regioni7909 – 8133DisorderedSequence analysisAdd BLAST225
Regioni8174 – 8229DisorderedSequence analysisAdd BLAST56

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili6793 – 6820Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5706 – 5731PolyampholyteSequence analysisAdd BLAST26
Compositional biasi6531 – 6547PolarSequence analysisAdd BLAST17
Compositional biasi7742 – 7758PolarSequence analysisAdd BLAST17
Compositional biasi8007 – 8021Pro-richSequence analysisAdd BLAST15
Compositional biasi8034 – 8048Pro-richSequence analysisAdd BLAST15
Compositional biasi8072 – 8099PolarSequence analysisAdd BLAST28
Compositional biasi8112 – 8130PolarSequence analysisAdd BLAST19

Keywords - Domaini

Coiled coilSequence analysis, Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154756

Identification of Orthologs from Complete Genome Data

More...
OMAi
CEVAQEK

TreeFam database of animal gene trees

More...
TreeFami
TF331962

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 3 hits
cd00160 RhoGEF, 1 hit
cd12025 SH3_Obscurin_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.60.40.10, 71 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR000048 IQ_motif_EF-hand-BS
IPR011009 Kinase-like_dom_sf
IPR035526 Obscurin_SH3
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 61 hits
PF00612 IQ, 1 hit
PF00069 Pkinase, 2 hits
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 67 hits
SM00408 IGc2, 59 hits
SM00406 IGv, 18 hits
SM00015 IQ, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00220 S_TKc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit
SSF48726 SSF48726, 68 hits
SSF49265 SSF49265, 3 hits
SSF50044 SSF50044, 1 hit
SSF56112 SSF56112, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010 DH_2, 1 hit
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 57 hits
PS00290 IG_MHC, 1 hit
PS50096 IQ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00108 PROTEIN_KINASE_ST, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 14 potential isoforms that are computationally mapped.Show allAlign All

A6NGQ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDQPQFSGAP RFLTRPKAFV VSVGKDATLS CQIVGNPTPQ VSWEKDQQPV
60 70 80 90 100
AAGARFRLAQ DGDLYRLTIL DLALGDSGQY VCRARNAIGE AFAAVGLQVD
110 120 130 140 150
AEAACAEQAP HFLLRPTSIR VREGSEATFR CRVGGSPRPA VSWSKDGRRL
160 170 180 190 200
GEPDGPRVRV EELGEASALR IRAARPRDGG TYEVRAENPL GAASAAAALV
210 220 230 240 250
VDSDAADTAS RPGTSTAALL AHLQRRREAM RAEGAPASPP STGTRTCTVT
260 270 280 290 300
EGKHARLSCY VTGEPKPETV WKKDGQLVTE GRRHVVYEDA QENFVLKILF
310 320 330 340 350
CKQSDRGLYT CTASNLVGQT YSSVLVVVRE PAVPFKKRLQ DLEVREKESA
360 370 380 390 400
TFLCEVPQPS TEAAWFKEET RLWASAKYGI EEEGTERRLT VRNVSADDDA
410 420 430 440 450
VYICETPEGS RTVAELAVQG NLLRKLPRKT AVRVGDTAMF CVELAVPVGP
460 470 480 490 500
VHWLRNQEEV VAGGRVAISA EGTRHTLTIS QCCLEDVGQV AFMAGDCQTS
510 520 530 540 550
TQFCVSAPRK PPLQPPVDPV VKARMESSVI LSWSPPPHGE RPVTIDGYLV
560 570 580 590 600
EKKKLGTYTW IRCHEAEWVA TPELTVADVA EEGNFQFRVS ALNSFGQSPY
610 620 630 640 650
LEFPGTVHLA PKLAVRTPLK AVQAVEGGEV TFSVDLTVAS AGEWFLDGQA
660 670 680 690 700
LKASSVYEIH CDRTRHTLTI REVPASLHGA QLKFVANGIE SSIRMEVRAA
710 720 730 740 750
PGLTANKPPA AAAREVLARL HEEAQLLAEL SDQAAAVTWL KDGRTLSPGP
760 770 780 790 800
KYEVQASAGR RVLLVRDVAR DDAGLYECVS RGGRIAYQLS VQGLARFLHK
810 820 830 840 850
DMAGSCVDAV AGGPAQFECE TSEAHVHVHW YKDGMELGHS GERFLQEDVG
860 870 880 890 900
TRHRLVAATV TRQDEGTYSC RVGEDSVDFR LRVSEPKAVF AKEQPACREV
910 920 930 940 950
QAEVGASATL SCEVAQDQME VTWYKDGKKL SSSSKVHVEA VGCMRRLVVQ
960 970 980 990 1000
QVGQADSGEY SCEARGQRVS FRLDVAEPKV VFAKEQLARR KLQAEAGASA
1010 1020 1030 1040 1050
TLSCEVAQAQ TEVTWYKDGK KLSSSSKVCM EATGCTRRLV VQQAGQADAG
1060 1070 1080 1090 1100
EYSCEAGGQR LSFHLDVKEP KVVFAKDQVA HSEVQAEAGA SATLSCEVAQ
1110 1120 1130 1140 1150
AQTEVMWYKD GKKLSSSLKV HVEAKGCRRR LVVQQAGKTD AGDYSCEARG
1160 1170 1180 1190 1200
QRVSFRLHIT EPKMMFAKEQ SVHNEVQAEA GASAMLSCEV AQAQTEVTWY
1210 1220 1230 1240 1250
KDGKKLSSSS KVGMEVKGCT RRLVLPQAGK ADAGEYSCEA GGQRVSFHLH
1260 1270 1280 1290 1300
ITEPKGVFAK EQSVHNEVQA EAGTTAMLSC EVAQPQTEVT WYKDGKKLSS
1310 1320 1330 1340 1350
SSKVRMEVKG CTRRLVVQQV GKADAGEYSC EAGGQRVSFQ LHITEPKAVF
1360 1370 1380 1390 1400
AKEQLVHNEV RTEAGASATL SCEVAQAQTE VTWYKDGKKL SSSSKVRIEA
1410 1420 1430 1440 1450
AGCMRQLVVQ QAGQADAGEY TCEAGGQRLS FHLDVSEPKA VFAKEQLAHR
1460 1470 1480 1490 1500
KVQAEAGAIA TLSCEVAQAQ TEVTWYKDGK KLSSSSKVRM EAVGCTRRLV
1510 1520 1530 1540 1550
VQQACQADTG EYSCEAGGQR LSFSLDVAEP KVVFAKEQPV HREVQAQAGA
1560 1570 1580 1590 1600
STTLSCEVAQ AQTEVMWYKD GKKLSFSSKV RMEAVGCTRR LVVQQAGQAV
1610 1620 1630 1640 1650
AGEYSCEAGS QRLSFHLHVA EPKAVFAKEQ PAHREVQAEA GASATLSCEV
1660 1670 1680 1690 1700
AQAQTEVTWY KDGKKLSSSL KVHVEAAGCT RRLVVQQAGQ ADTGEYSCEA
1710 1720 1730 1740 1750
GGQQLSFRLQ VAEPKAVFAK EQPASREVQA EAGTSATLSC EVAQAQTEVT
1760 1770 1780 1790 1800
WYKDGKKLSS SSKVRMEAVG CTRRLVVQEA GQADAGEYSC KAGDQRLSFH
1810 1820 1830 1840 1850
LHVAEPKVVF AKEQPAHREV QAEAGASATL SCEVAQAQTE VTWYKDGKKL
1860 1870 1880 1890 1900
SSSSKVRVEA VGCTRRLVVQ QAGQAEAGEY SCEAGGQQLS FRLQVAEPKA
1910 1920 1930 1940 1950
VFAKEQVVFA KDQPVHREVQ AEAGTSTMLS CEVAQAQTEV MWYKDGKKLS
1960 1970 1980 1990 2000
SSSKMRVEAV GCTRRLVVQE AGQADAGEYS CEAGGQRLSF HLHVAEPKVV
2010 2020 2030 2040 2050
FAKEQPACRE VQAEAGASAT LSCEVAQGQM EVTWYKDGKK LSSSSKVHME
2060 2070 2080 2090 2100
ASGYTRRLVV QQAGQADAGE YSCEAGGQRL SFRLHVAELE PQISERPCRR
2110 2120 2130 2140 2150
EPLVVKEHED IILTATLATP SAATVTWLKD GVEIRRSKRH ETASQGDTHT
2160 2170 2180 2190 2200
LTVHGAQVLD SAIYSCRVGA EGQDFPVQVE EVAAKFCRLL EPVCGELGGT
2210 2220 2230 2240 2250
VTLACELSPA CAEVVWRCGN TQLRVGKRFQ MVAEGPVRSL TVLGLRAEDA
2260 2270 2280 2290 2300
GEYVCESRDD HTSAQLTVSV PRVVKFMSGL STVVAEEGGE ATFQCVVSPS
2310 2320 2330 2340 2350
DVAVVWFRDG ALLQPSEKFA ISQSGASHSL TISDLVLEDA GQITVEAEGA
2360 2370 2380 2390 2400
SSSAALRVRE APVLFKKKLE PQTVEERSSV TLEVELTRPW PELRWTRNAT
2410 2420 2430 2440 2450
ALAPGKNVEI HAEGARHRLV LHNVGFADRG FFGCETPDDK TQAKLTVEMR
2460 2470 2480 2490 2500
QVRLVRGLQA VEAREQGTAT MEVQLSHADV DGSWTRDGLR FQQGPTCHLA
2510 2520 2530 2540 2550
VRGPMHTLTL SGLRPEDSGL MVFKAEGVHT SARLVVTELP VSFSRPLQDV
2560 2570 2580 2590 2600
VTTEKEKVTL ECELSRPNVD VRWLKDGVEL RAGKTMAIAA QGACRSLTIY
2610 2620 2630 2640 2650
RCEFADQGVY VCDAHDAQSS ASVKVQGRNI QIVRPLEDVE VMEKDGATFS
2660 2670 2680 2690 2700
CEVSHDEVPG QWFWEGSKLR PTDNVRIRQE GRTYTLIYRR VLAEDAGEIQ
2710 2720 2730 2740 2750
FVAENAESRA QLRVKELPVT LVRPLRDKIA MEKHRGVLEC QVSRASAQVR
2760 2770 2780 2790 2800
WFKGSQELQP GPKYELVSDG LYRKLIISDV HAEDEDTYTC DAGDVKTSAQ
2810 2820 2830 2840 2850
FFVEEQSITI VRGLQDVTVM EPAPAWFECE TSIPSVRPPK WLLGKTVLQA
2860 2870 2880 2890 2900
GGNVGLEQEG TVHRLMLRRT CSTMTGPVHF TVGKSRSSAR LVVSDIPVVL
2910 2920 2930 2940 2950
TRPLEPKTGR ELQSVVLSCD FRPAPKAVQW YKDDTPLSPS EKFKMSLEGQ
2960 2970 2980 2990 3000
MAELRILRLM PADAGVYRCQ AGSAHSSTEV TVEAREVTVT GPLQDAEATE
3010 3020 3030 3040 3050
EGWASFSCEL SHEDEEVEWS LNGMPLYNDS FHEISHKGRR HTLVLKSIQR
3060 3070 3080 3090 3100
ADAGIVRASS LKVSTSARLE VRVKPVVFLK ALDDLSAEER GTLALQCEVS
3110 3120 3130 3140 3150
DPEAHVVWRK DGVQLGPSDK YDFLHTAGTR GLVVHDVSPE DAGLYTCHVG
3160 3170 3180 3190 3200
SEETRARVRV HDLHVGITKR LKTMEVLEGE SCSFECVLSH ESASDPAMWT
3210 3220 3230 3240 3250
VGGKTVGSSS RFQATRQGRK YILVVREAAP SDAGEVVFSV RGLTSKASLI
3260 3270 3280 3290 3300
VRERPAAIIK PLEDQWVAPG EDVELRCELS RAGTPVHWLK DRKAIRKSQK
3310 3320 3330 3340 3350
YDVVCEGTMA MLVIRGASLK DAGEYTCEVE ASKSTASLHV EEKANCFTEE
3360 3370 3380 3390 3400
LTNLQVEEKG TAVFTCKTEH PAATVTWRKG LLELRASGKH QPSQEGLTLR
3410 3420 3430 3440 3450
LTISALEKAD SDTYTCDIGQ AQSRAQLLVQ GRRVHIIEDL EDVDVQEGSS
3460 3470 3480 3490 3500
ATFRCRISPA NYEPVHWFLD KTPLHANELN EIDAQPGGYH VLTLRQLALK
3510 3520 3530 3540 3550
DSGTIYFEAG DQRASAALRV TEKPSVFSRE LTDATITEGE DLTLVCETST
3560 3570 3580 3590 3600
CDIPVCWTKD GKTLRGSARC QLSHEGHRAQ LLITGATLQD SGRYKCEAGG
3610 3620 3630 3640 3650
ACSSSIVRVH ARPVRFQEAL KDLEVLEGGA ATLRCVLSSV AAPVKWCYGN
3660 3670 3680 3690 3700
NVLRPGDKYS LRQEGAMLEL VVRNLRPQDS GRYSCSFGDQ TTSATLTVTA
3710 3720 3730 3740 3750
LPAQFIGKLR NKEATEGATA TLRCELSKAA PVEWRKGSET LRDGDRYCLR
3760 3770 3780 3790 3800
QDGAMCELQI RGLAMVDAAE YSCVCGEERT SASLTIRPMP AHFIGRLRHQ
3810 3820 3830 3840 3850
ESIEGATATL RCELSKAAPV EWRKGRESLR DGDRHSLRQD GAVCELQICG
3860 3870 3880 3890 3900
LAVADAGEYS CVCGEERTSA TLTVKALPAK FTEGLRNEEA VEGATAMLWC
3910 3920 3930 3940 3950
ELSKVAPVEW RKGPENLRDG DRYILRQEGT RCELQICGLA MADAGEYLCV
3960 3970 3980 3990 4000
CGQERTSATL TIRALPARFI EDVKNQEARE GATAVLQCEL NSAAPVEWRK
4010 4020 4030 4040 4050
GSETLRDGDR YSLRQDGTKC ELQIRGLAMA DTGEYSCVCG QERTSAMLTV
4060 4070 4080 4090 4100
RALPIKFTEG LRNEEATEGA TAVLRCELSK MAPVEWWKGH ETLRDGDRHS
4110 4120 4130 4140 4150
LRQDGARCEL QIRGLVAEDA GEYLCMCGKE RTSAMLTVRA MPSKFIEGLR
4160 4170 4180 4190 4200
NEEATEGDTA TLWCELSKAA PVEWRKGHET LRDGDRHSLR QDGSRCELQI
4210 4220 4230 4240 4250
RGLAVVDAGE YSCVCGQERT SATLTVRALP ARFIEDVKNQ EAREGATAVL
4260 4270 4280 4290 4300
QCELSKAAPV EWRKGSETLR GGDRYSLRQD GTRCELQIHG LSVADTGEYS
4310 4320 4330 4340 4350
CVCGQERTSA TLTVRALPAR FTQDLKTKEA SEGATATLQC ELSKVAPVEW
4360 4370 4380 4390 4400
KKGPETLRDG GRYSLKQDGT RCELQIHDLS VADAGEYSCM CGQERTSATL
4410 4420 4430 4440 4450
TVRALPARFT EGLRNEEAME GATATLQCEL SKAAPVEWRK GLEALRDGDK
4460 4470 4480 4490 4500
YSLRQDGAVC ELQIHGLAMA DNGVYSCVCG QERTSATLTV RALPARFIED
4510 4520 4530 4540 4550
MRNQKATEGA TVTLQCKLRK AAPVEWRKGP NTLKDGDRYS LKQDGTSCEL
4560 4570 4580 4590 4600
QIRGLVIADA GEYSCICEQE RTSATLTVRA LPARFIEDVR NHEATEGATA
4610 4620 4630 4640 4650
VLQCELSKAA PVEWRKGSET LRDGDRYSLR QDGTRCELQI RGLAVEDTGE
4660 4670 4680 4690 4700
YLCVCGQERT SATLTVRALP ARFIDNMTNQ EAREGATATL HCELSKVAPV
4710 4720 4730 4740 4750
EWRKGPETLR DGDRHSLRQD GTRCELQIRG LSVADAGEYS CVCGQERTSA
4760 4770 4780 4790 4800
TLTIRALPAK FTKGLRNEEA TEGATAMLQC ELSKVAPVEW RKGPETLRDG
4810 4820 4830 4840 4850
DRYNLRQDGT RCELQIHGLS VADTGEYSCV CGQEKTSATL TVKAPQPVFR
4860 4870 4880 4890 4900
EPLQSLQAEE GSTATLQCEL SEPTATVVWS KGGLQLQANG RREPRLQGCT
4910 4920 4930 4940 4950
AELVLQDLQR EDTGEYTCTC GSQATSATLT VTAAPVRFLR ELQHQEVDEG
4960 4970 4980 4990 5000
GTAHLCCELS RAGASVEWRK GSLQLFPCAK YQMVQDGAAA ELLVRGVEQE
5010 5020 5030 5040 5050
DAGDYTCDTG HTQSMASLSV RVPRPKFKTR LQSLEQETGD IARLCCQLSD
5060 5070 5080 5090 5100
AESGAVVQWL KEGVELHAGP KYEMRSQGAT RELLIHQLEA KDTGEYACVT
5110 5120 5130 5140 5150
GGQKTAASLR VTEPEVTIVR GLVDAEVTAD EDVEFSCEVS RAGATGVQWC
5160 5170 5180 5190 5200
LQGLPLQSNE VTEVAVRDGR IHTLRLKGVT PEDAGTVSFH LGNHASSAQL
5210 5220 5230 5240 5250
TVRAPEVTIL EPLQDVQLSE GQDASFQCRL SRASGQEARW ALGGVPLQAN
5260 5270 5280 5290 5300
EMNDITVEQG TLHLLTLHKV TLEDAGTVSF HVGTCSSEAQ LKVTAKNTVV
5310 5320 5330 5340 5350
RGLENVEALE GGEALFECQL SQPEVAAHTW LLDDEPVHTS ENAEVVFFEN
5360 5370 5380 5390 5400
GLRHLLLLKN LRPQDSCRVT FLAGDMVTSA FLTVRGWRLE ILEPLKNAAV
5410 5420 5430 5440 5450
RAGAQACFTC TLSEAVPVGE ASWYINGAAV QPDDSDWTVT ADGSHHALLL
5460 5470 5480 5490 5500
RSAQPHHAGE VTFACRDAVA SARLTVLGLP DPPEDAEVVA RSSHTVTLSW
5510 5520 5530 5540 5550
AAPMSDGGGG LCGYRVEVKE GATGQWRLCH ELVPGPECVV DGLAPGETYR
5560 5570 5580 5590 5600
FRVAAVGPVG AGEPVHLPQT VRLAEPPKPV PPQPSAPESR QVAAGEDVSL
5610 5620 5630 5640 5650
ELEVVAEAGE VIWHKGMERI QPGGRFEVVS QGRQQMLVIK GFTAEDQGEY
5660 5670 5680 5690 5700
HCGLAQGSIC PAAATFQVAL SPASVDEAPQ PSLPPEAAQE GDLHLLWEAL
5710 5720 5730 5740 5750
ARKRRMSREP TLDSISELPE EDGRSQRLPQ EAEEVAPDLS EGYSTADELA
5760 5770 5780 5790 5800
RTGDADLSHT SSDDESRAGT PSLVTYLKKA GRPGTSPLAS KVGAPAAPSV
5810 5820 5830 5840 5850
KPQQQQEPLA AVRPPLGDLS TKDLGDPSMD KAAVKIQAAF KGYKVRKEMK
5860 5870 5880 5890 5900
QQEGPMFSHT FGDTEAQVGD ALRLECVVAS KADVRARWLK DGVELTDGRH
5910 5920 5930 5940 5950
HHIDQLGDGT CSLLITGLDR ADAGCYTCQV SNKFGQVTHS ACVVVSGSES
5960 5970 5980 5990 6000
EAESSSGGEL DDAFRRAARR LHRLFRTKSP AEVSDEELFL SADEGPAEPE
6010 6020 6030 6040 6050
EPADWQTYRE DEHFICIRFE ALTEARQAVT RFQEMFATLG IGVEIKLVEQ
6060 6070 6080 6090 6100
GPRRVEMCIS KETPAPVVPP EPLPSLLTSD AAPVFLTELQ NQEVQDGYPV
6110 6120 6130 6140 6150
SFDCVVTGQP MPSVRWFKDG KLLEEDDHYM INEDQQGGHQ LIITAVVPAD
6160 6170 6180 6190 6200
MGVYRCLAEN SMGVSSTKAE LRVDLTSTDY DTAADATESS SYFSAQGYLS
6210 6220 6230 6240 6250
SREQEGTEST TDEGQLPQVV EELRDLQVAP GTRLAKFQLK VKGYPAPRLY
6260 6270 6280 6290 6300
WFKDGQPLTA SAHIRMTDKK ILHTLEIISV TREDSGQYAA YISNAMGAAY
6310 6320 6330 6340 6350
SSARLLVRGP DEPEEKPASD VHEQLVPPRM LERFTPKKVK KGSSITFSVK
6360 6370 6380 6390 6400
VEGRPVPTVH WLREEAERGV LWIGPDTPGY TVASSAQQHS LVLLDVGRQH
6410 6420 6430 6440 6450
QGTYTCIASN AAGQALCSAS LHVSGLPKVE EQEKVKEALI STFLQGTTQA
6460 6470 6480 6490 6500
ISAQGLETAS FADLGGQRKE EPLAAKEALG HLSLAEVGTE EFLQKLTSQI
6510 6520 6530 6540 6550
TEMVSAKITQ AKLQVPGGDS DEDSKTPSAS PRHGRSRPSS SIQESSSESE
6560 6570 6580 6590 6600
DGDARGEIFD IYVVTADYLP LGAEQDAITL REGQYVEVLD AAHPLRWLVR
6610 6620 6630 6640 6650
TKPTKSSPSR QGWVSPAYLD RRLKLSPEWG AAEAPEFPGE AVSEDEYKAR
6660 6670 6680 6690 6700
LSSVIQELLS SEQAFVEELQ FLQSHHLQHL ERCPHVPIAV AGQKAVIFRN
6710 6720 6730 6740 6750
VRDIGRFHSS FLQELQQCDT DDDVAMCFIK NQAAFEQYLE FLVGRVQAES
6760 6770 6780 6790 6800
VVVSTAIQEF YKKYAEEALL AGDPSQPPPP PLQHYLEQPV ERVQRYQALL
6810 6820 6830 6840 6850
KELIRNKARN RQNCALLEQA YAVVSALPQR AENKLHVSLM ENYPGTLQAL
6860 6870 6880 6890 6900
GEPIRQGHFI VWEGAPGARM PWKGHNRHVF LFRNHLVICK PRRDSRTDTV
6910 6920 6930 6940 6950
SYVFRNMMKL SSIDLNDQVE GDDRAFEVWQ EREDSVRKYL LQARTAIIKS
6960 6970 6980 6990 7000
SWVKEICGIQ QRLALPVWRP PDFEEELADC TAELGETVKL ACRVTGTPKP
7010 7020 7030 7040 7050
VISWYKDGKA VQVDPHHILI EDPDGSCALI LDSLTGVDSG QYMCFAASAA
7060 7070 7080 7090 7100
GNCSTLGKIL VQVPPRFVNK VRASPFVEGE DAQFTCTIEG APYPQIRWYK
7110 7120 7130 7140 7150
DGALLTTGNK FQTLSEPRSG LLVLVIRAAS KEDLGLYECE LVNRLGSARA
7160 7170 7180 7190 7200
SAELRIQSPM LQAQEQCHRE QLVAAVEDTT LERADQEVTS VLKRLLGPKA
7210 7220 7230 7240 7250
PGPSTGDLTG PGPCPRGAPA LQETGSQPPV TGTSEAPAVP PRVPQPLLHE
7260 7270 7280 7290 7300
GPEQEPEAIA RAQEWTVPIR MEGAAWPGAG TGELLWDVHS HVVRETTQRT
7310 7320 7330 7340 7350
YTYQAIDTHT ARPPSMQVTI EDVQAQTGGT AQFEAIIEGD PQPSVTWYKD
7360 7370 7380 7390 7400
SVQLVDSTRL SQQQEGTTYS LVLRHVASKD AGVYTCLAQN TGGQVLCKAE
7410 7420 7430 7440 7450
LLVLGGDNEP DSEKQSHRRK LHSFYEVKEE IGRGVFGFVK RVQHKGNKIL
7460 7470 7480 7490 7500
CAAKFIPLRS RTRAQAYRER DILAALSHPL VTGLLDQFET RKTLILILEL
7510 7520 7530 7540 7550
CSSEELLDRL YRKGVVTEAE VKVYIQQLVE GLHYLHSHGV LHLDIKPSNI
7560 7570 7580 7590 7600
LMVHPAREDI KICDFGFAQN ITPAELQFSQ YGSPEFVSPE IIQQNPVSEA
7610 7620 7630 7640 7650
SDIWAMGVIS YLSLTCSSPF AGESDRATLL NVLEGRVSWS SPMAAHLSED
7660 7670 7680 7690 7700
AKDFIKATLQ RAPQARPSAA QCLSHPWFLK SMPAEEAHFI NTKQLKFLLA
7710 7720 7730 7740 7750
RSRWQRSLMS YKSILVMRSI PELLRGPPDS PSLGVARHLC RDTGGSSSSS
7760 7770 7780 7790 7800
SSSDNELAPF ARAKSLPPSP VTHSPLLHPR GFLRPSASLP EEAEASERST
7810 7820 7830 7840 7850
EAPAPPASPE GAGPPAAQGC VPRHSVIRSL FYHQAGESPE HGALAPGSRR
7860 7870 7880 7890 7900
HPARRRHLLK GGYIAGALPG LREPLMEHRV LEEEAAREEQ ATLLAKAPSF
7910 7920 7930 7940 7950
ETALRLPASG THLAPGHSHS LEHDSPSTPR PSSEACGEAQ RLPSAPSGGA
7960 7970 7980 7990 8000
PIRDMGHPQG SKQLPSTGGH PGTAQPERPS PDSPWGQPAP FCHPKQGSAP
8010 8020 8030 8040 8050
QEGCSPHPAV APCPPGSFPP GSCKEAPLVP SSPFLGQPQA PPAPAKASPP
8060 8070 8080 8090 8100
LDSKMGPGDI SLPGRPKPGP CSSPGSASQA SSSQVSSLRV GSSQVGTEPG
8110 8120 8130 8140 8150
PSLDAEGWTQ EAEDLSDSTP TLQRPQEQAT MRKFSLGGRG GYAGVAGYGT
8160 8170 8180 8190 8200
FAFGGDAGGM LGQGPMWARI AWAVSQSEEE EQEEARAESQ SEEQQEARAE
8210 8220 8230 8240 8250
SPLPQVSARP VPEVGRAPTR SSPEPTPWED IGQVSLVQIR DLSGDAEAAD
8260 8270 8280 8290 8300
TISLDISEVD PAYLNLSDLY DIKYLPFEFM IFRKVPKSAQ PEPPSPMAEE
8310 8320 8330 8340 8350
ELAEFPEPTW PWPGELGPHA GLEITEESED VDALLAEAAV GRKRKWSSPS
8360 8370 8380 8390 8400
RSLFHFPGRH LPLDEPAELG LRERVKASVE HISRILKGRP EGLEKEGPPR
8410 8420 8430 8440 8450
KKPGLASFRL SGLKSWDRAP TFLRELSDET VVLGQSVTLA CQVSAQPAAQ
8460 8470 8480 8490 8500
ATWSKDGAPL ESSSRVLISA TLKNFQLLTI LVVVAEDLGV YTCSVSNALG
8510 8520 8530 8540 8550
TVTTTGVLRK AERPSSSPCP DIGEVYADGV LLVWKPVESY GPVTYIVQCS
8560 8570 8580 8590 8600
LEGGSWTTLA SDIFDCCYLT SKLSRGGTYT FRTACVSKAG MGPYSSPSEQ
8610 8620 8630 8640 8650
VLLGGPSHLA SEEESQGRSA QPLPSTKTFA FQTQIQRGRF SVVRQCWEKA
8660 8670 8680 8690 8700
SGRALAAKII PYHPKDKTAV LREYEALKGL RHPHLAQLHA AYLSPRHLVL
8710 8720 8730 8740 8750
ILELCSGPEL LPCLAERASY SESEVKDYLW QMLSATQYLH NQHILHLDLR
8760 8770 8780 8790 8800
SENMIITEYN LLKVVDLGNA QSLSQEKVLP SDKFKDYLET MELLEGQGAV
8810 8820 8830 8840 8850
PQTDIWAIGV TAFIMLSAEY PVSSEGARDL QRGLRKGLVR LSRCYAGLSG
8860 8870 8880 8890 8900
GAVAFLRSTL CAQPWGRPCA SSCLQCPWLT EEGPACSRPA PVTFPTARLR
8910 8920
VFVRNREKRR ALLYKRHNLA QVR
Length:8,923
Mass (Da):973,004
Last modified:October 5, 2016 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD1AA2309EAD437C9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VST9OBSCN_HUMAN
Obscurin
OBSCN KIAA1556, KIAA1639
7,968Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJJ2A0A590UJJ2_HUMAN
Obscurin
OBSCN
406Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJ10A0A590UJ10_HUMAN
Obscurin
OBSCN
3,010Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJ65A0A590UJ65_HUMAN
Obscurin
OBSCN
503Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQA7H3BQA7_HUMAN
Obscurin
OBSCN
639Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRI8A0A0A0MRI8_HUMAN
Obscurin
OBSCN
858Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJD5A0A590UJD5_HUMAN
Obscurin
OBSCN
721Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UKA5A0A590UKA5_HUMAN
Obscurin
OBSCN
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPW6H3BPW6_HUMAN
Obscurin
OBSCN
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJ33A0A590UJ33_HUMAN
Obscurin
OBSCN
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL353593 Genomic DNA No translation available.
AL359510 Genomic DNA No translation available.
AL670729 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001258152.2, NM_001271223.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000366707; ENSP00000355668; ENSG00000154358
ENST00000570156; ENSP00000455507; ENSG00000154358

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84033

UCSC genome browser

More...
UCSCi
uc001hsq.2 human
uc057qea.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353593 Genomic DNA No translation available.
AL359510 Genomic DNA No translation available.
AL670729 Genomic DNA No translation available.
RefSeqiNP_001258152.2, NM_001271223.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000455507

Proteomic databases

ProteomicsDBi1144
41620

Genome annotation databases

EnsembliENST00000366707; ENSP00000355668; ENSG00000154358
ENST00000570156; ENSP00000455507; ENSG00000154358
GeneIDi84033
UCSCiuc001hsq.2 human
uc057qea.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84033
HGNCiHGNC:15719 OBSCN
OpenTargetsiENSG00000154358

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000154756
OMAiCEVAQEK
TreeFamiTF331962

Enzyme and pathway databases

SignaLinkiA6NGQ3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
OBSCN human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84033

Gene expression databases

BgeeiENSG00000154358 Expressed in gastrocnemius and 134 other tissues
ExpressionAtlasiA6NGQ3 baseline and differential

Family and domain databases

CDDicd00063 FN3, 3 hits
cd00160 RhoGEF, 1 hit
cd12025 SH3_Obscurin_like, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.60.40.10, 71 hits
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR000048 IQ_motif_EF-hand-BS
IPR011009 Kinase-like_dom_sf
IPR035526 Obscurin_SH3
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 61 hits
PF00612 IQ, 1 hit
PF00069 Pkinase, 2 hits
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 67 hits
SM00408 IGc2, 59 hits
SM00406 IGv, 18 hits
SM00015 IQ, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00220 S_TKc, 2 hits
SUPFAMiSSF48065 SSF48065, 1 hit
SSF48726 SSF48726, 68 hits
SSF49265 SSF49265, 3 hits
SSF50044 SSF50044, 1 hit
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 57 hits
PS00290 IG_MHC, 1 hit
PS50096 IQ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00108 PROTEIN_KINASE_ST, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA6NGQ3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NGQ3
Secondary accession number(s): H3BPX2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: October 5, 2016
Last modified: February 26, 2020
This is version 116 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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