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UniProtKB - A6NGQ3 (A6NGQ3_HUMAN)

Entry version 125 (29 Sep 2021)
Sequence version 5 (05 Oct 2016)
Previous versions | rss
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Protein

Non-specific serine/threonine protein kinase

Gene

OBSCN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei7454ATPPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseARBA annotation, Transferase
Biological processCell adhesionARBA annotation
LigandATP-bindingPROSITE-ProRule annotationARBA annotation, MagnesiumARBA annotation, Metal-bindingARBA annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		A6NGQ3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OBSCNImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:15719, OBSCN

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000154358

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000154358

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Disulfide bondARBA annotation, PhosphoproteinARBA annotation

Proteomic databases

PeptideAtlas

More...PeptideAtlasi		A6NGQ3

PRoteomics IDEntifications database

More...PRIDEi		A6NGQ3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		1144

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000154358, Expressed in gastrocnemius and 155 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A6NGQ3, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000455507

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 100Ig-likeInterPro annotationAdd BLAST91
Domaini110 – 202Ig-likeInterPro annotationAdd BLAST93
Domaini236 – 322Ig-likeInterPro annotationAdd BLAST87
Domaini331 – 414Ig-likeInterPro annotationAdd BLAST84
Domaini515 – 612Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini701 – 790Ig-likeInterPro annotationAdd BLAST90
Domaini812 – 884Ig-likeInterPro annotationAdd BLAST73
Domaini886 – 974Ig-likeInterPro annotationAdd BLAST89
Domaini978 – 1056Ig-likeInterPro annotationAdd BLAST79
Domaini1070 – 1158Ig-likeInterPro annotationAdd BLAST89
Domaini1162 – 1240Ig-likeInterPro annotationAdd BLAST79
Domaini1254 – 1344Ig-likeInterPro annotationAdd BLAST91
Domaini1346 – 1424Ig-likeInterPro annotationAdd BLAST79
Domaini1438 – 1524Ig-likeInterPro annotationAdd BLAST87
Domaini1530 – 1616Ig-likeInterPro annotationAdd BLAST87
Domaini1622 – 1710Ig-likeInterPro annotationAdd BLAST89
Domaini1714 – 1792Ig-likeInterPro annotationAdd BLAST79
Domaini1806 – 1894Ig-likeInterPro annotationAdd BLAST89
Domaini1898 – 1983Ig-likeInterPro annotationAdd BLAST86
Domaini1997 – 2094Ig-likeInterPro annotationAdd BLAST98
Domaini2098 – 2183Ig-likeInterPro annotationAdd BLAST86
Domaini2198 – 2269Ig-likeInterPro annotationAdd BLAST72
Domaini2271 – 2357Ig-likeInterPro annotationAdd BLAST87
Domaini2362 – 2446Ig-likeInterPro annotationAdd BLAST85
Domaini2540 – 2624Ig-likeInterPro annotationAdd BLAST85
Domaini2718 – 2809Ig-likeInterPro annotationAdd BLAST92
Domaini2897 – 2988Ig-likeInterPro annotationAdd BLAST92
Domaini3075 – 3159Ig-likeInterPro annotationAdd BLAST85
Domaini3255 – 3337Ig-likeInterPro annotationAdd BLAST83
Domaini3349 – 3428Ig-likeInterPro annotationAdd BLAST80
Domaini3524 – 3598Ig-likeInterPro annotationAdd BLAST75
Domaini3613 – 3697Ig-likeInterPro annotationAdd BLAST85
Domaini3702 – 3785Ig-likeInterPro annotationAdd BLAST84
Domaini3788 – 3873Ig-likeInterPro annotationAdd BLAST86
Domaini3878 – 3961Ig-likeInterPro annotationAdd BLAST84
Domaini3966 – 4049Ig-likeInterPro annotationAdd BLAST84
Domaini4054 – 4137Ig-likeInterPro annotationAdd BLAST84
Domaini4142 – 4225Ig-likeInterPro annotationAdd BLAST84
Domaini4230 – 4313Ig-likeInterPro annotationAdd BLAST84
Domaini4318 – 4401Ig-likeInterPro annotationAdd BLAST84
Domaini4406 – 4489Ig-likeInterPro annotationAdd BLAST84
Domaini4494 – 4577Ig-likeInterPro annotationAdd BLAST84
Domaini4582 – 4665Ig-likeInterPro annotationAdd BLAST84
Domaini4670 – 4753Ig-likeInterPro annotationAdd BLAST84
Domaini4758 – 4841Ig-likeInterPro annotationAdd BLAST84
Domaini4847 – 4930Ig-likeInterPro annotationAdd BLAST84
Domaini4935 – 5019Ig-likeInterPro annotationAdd BLAST85
Domaini5025 – 5117Ig-likeInterPro annotationAdd BLAST93
Domaini5205 – 5294Ig-likeInterPro annotationAdd BLAST90
Domaini5482 – 5576Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini5581 – 5671Ig-likeInterPro annotationAdd BLAST91
Domaini5855 – 5946Ig-likeInterPro annotationAdd BLAST92
Domaini6083 – 6172Ig-likeInterPro annotationAdd BLAST90
Domaini6217 – 6306Ig-likeInterPro annotationAdd BLAST90
Domaini6328 – 6424Ig-likeInterPro annotationAdd BLAST97
Domaini6557 – 6624SH3InterPro annotationAdd BLAST68
Domaini6650 – 6834DHInterPro annotationAdd BLAST185
Domaini6852 – 6961PHInterPro annotationAdd BLAST110
Domaini6971 – 7054Ig-likeInterPro annotationAdd BLAST84
Domaini7065 – 7157Ig-likeInterPro annotationAdd BLAST93
Domaini7314 – 7402Ig-likeInterPro annotationAdd BLAST89
Domaini7425 – 7678Protein kinaseInterPro annotationAdd BLAST254
Domaini8420 – 8509Ig-likeInterPro annotationAdd BLAST90
Domaini8514 – 8606Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini8629 – 8879Protein kinaseInterPro annotationAdd BLAST251

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni228 – 249DisorderedSequence analysisAdd BLAST22
Regioni5706 – 5742DisorderedSequence analysisAdd BLAST37
Regioni5777 – 5817DisorderedSequence analysisAdd BLAST41
Regioni6195 – 6214DisorderedSequence analysisAdd BLAST20
Regioni6511 – 6553DisorderedSequence analysisAdd BLAST43
Regioni7194 – 7253DisorderedSequence analysisAdd BLAST60
Regioni7734 – 7820DisorderedSequence analysisAdd BLAST87
Regioni7909 – 8133DisorderedSequence analysisAdd BLAST225
Regioni8174 – 8229DisorderedSequence analysisAdd BLAST56

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili6793 – 6820Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5706 – 5731Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi6531 – 6547Polar residuesSequence analysisAdd BLAST17
Compositional biasi7742 – 7758Polar residuesSequence analysisAdd BLAST17
Compositional biasi8007 – 8021Pro residuesSequence analysisAdd BLAST15
Compositional biasi8034 – 8048Pro residuesSequence analysisAdd BLAST15
Compositional biasi8072 – 8099Polar residuesSequence analysisAdd BLAST28
Compositional biasi8112 – 8130Polar residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, Immunoglobulin domainARBA annotation, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0032, Eukaryota
KOG0613, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154756

Identification of Orthologs from Complete Genome Data

More...OMAi		VCELVIH

TreeFam database of animal gene trees

More...TreeFami		TF331962

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063, FN3, 3 hits
cd00160, RhoGEF, 1 hit
cd12025, SH3_Obscurin_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.60.40.10, 71 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set
IPR000048, IQ_motif_EF-hand-BS
IPR011009, Kinase-like_dom_sf
IPR020682, Obscurin
IPR035526, Obscurin_SH3
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR008266, Tyr_kinase_AS

The PANTHER Classification System

More...PANTHERi		PTHR47633:SF2, PTHR47633:SF2, 6 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00041, fn3, 2 hits
PF07679, I-set, 61 hits
PF00612, IQ, 1 hit
PF00069, Pkinase, 2 hits
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060, FN3, 3 hits
SM00409, IG, 67 hits
SM00408, IGc2, 59 hits
SM00406, IGv, 18 hits
SM00015, IQ, 1 hit
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SM00220, S_TKc, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48065, SSF48065, 1 hit
SSF48726, SSF48726, 68 hits
SSF49265, SSF49265, 3 hits
SSF50044, SSF50044, 1 hit
SSF56112, SSF56112, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50010, DH_2, 1 hit
PS50853, FN3, 3 hits
PS50835, IG_LIKE, 57 hits
PS00290, IG_MHC, 1 hit
PS50096, IQ, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 2 hits
PS00108, PROTEIN_KINASE_ST, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 15 potential isoforms that are computationally mapped.Show allAlign All

A6NGQ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDQPQFSGAP RFLTRPKAFV VSVGKDATLS CQIVGNPTPQ VSWEKDQQPV 
        60         70         80         90        100
AAGARFRLAQ DGDLYRLTIL DLALGDSGQY VCRARNAIGE AFAAVGLQVD 
       110        120        130        140        150
AEAACAEQAP HFLLRPTSIR VREGSEATFR CRVGGSPRPA VSWSKDGRRL 
       160        170        180        190        200
GEPDGPRVRV EELGEASALR IRAARPRDGG TYEVRAENPL GAASAAAALV 
       210        220        230        240        250
VDSDAADTAS RPGTSTAALL AHLQRRREAM RAEGAPASPP STGTRTCTVT 
       260        270        280        290        300
EGKHARLSCY VTGEPKPETV WKKDGQLVTE GRRHVVYEDA QENFVLKILF 
       310        320        330        340        350
CKQSDRGLYT CTASNLVGQT YSSVLVVVRE PAVPFKKRLQ DLEVREKESA 
       360        370        380        390        400
TFLCEVPQPS TEAAWFKEET RLWASAKYGI EEEGTERRLT VRNVSADDDA 
       410        420        430        440        450
VYICETPEGS RTVAELAVQG NLLRKLPRKT AVRVGDTAMF CVELAVPVGP 
       460        470        480        490        500
VHWLRNQEEV VAGGRVAISA EGTRHTLTIS QCCLEDVGQV AFMAGDCQTS 
       510        520        530        540        550
TQFCVSAPRK PPLQPPVDPV VKARMESSVI LSWSPPPHGE RPVTIDGYLV 
       560        570        580        590        600
EKKKLGTYTW IRCHEAEWVA TPELTVADVA EEGNFQFRVS ALNSFGQSPY 
       610        620        630        640        650
LEFPGTVHLA PKLAVRTPLK AVQAVEGGEV TFSVDLTVAS AGEWFLDGQA 
       660        670        680        690        700
LKASSVYEIH CDRTRHTLTI REVPASLHGA QLKFVANGIE SSIRMEVRAA 
       710        720        730        740        750
PGLTANKPPA AAAREVLARL HEEAQLLAEL SDQAAAVTWL KDGRTLSPGP 
       760        770        780        790        800
KYEVQASAGR RVLLVRDVAR DDAGLYECVS RGGRIAYQLS VQGLARFLHK 
       810        820        830        840        850
DMAGSCVDAV AGGPAQFECE TSEAHVHVHW YKDGMELGHS GERFLQEDVG 
       860        870        880        890        900
TRHRLVAATV TRQDEGTYSC RVGEDSVDFR LRVSEPKAVF AKEQPACREV 
       910        920        930        940        950
QAEVGASATL SCEVAQDQME VTWYKDGKKL SSSSKVHVEA VGCMRRLVVQ 
       960        970        980        990       1000
QVGQADSGEY SCEARGQRVS FRLDVAEPKV VFAKEQLARR KLQAEAGASA 
      1010       1020       1030       1040       1050
TLSCEVAQAQ TEVTWYKDGK KLSSSSKVCM EATGCTRRLV VQQAGQADAG 
      1060       1070       1080       1090       1100
EYSCEAGGQR LSFHLDVKEP KVVFAKDQVA HSEVQAEAGA SATLSCEVAQ 
      1110       1120       1130       1140       1150
AQTEVMWYKD GKKLSSSLKV HVEAKGCRRR LVVQQAGKTD AGDYSCEARG 
      1160       1170       1180       1190       1200
QRVSFRLHIT EPKMMFAKEQ SVHNEVQAEA GASAMLSCEV AQAQTEVTWY 
      1210       1220       1230       1240       1250
KDGKKLSSSS KVGMEVKGCT RRLVLPQAGK ADAGEYSCEA GGQRVSFHLH 
      1260       1270       1280       1290       1300
ITEPKGVFAK EQSVHNEVQA EAGTTAMLSC EVAQPQTEVT WYKDGKKLSS 
      1310       1320       1330       1340       1350
SSKVRMEVKG CTRRLVVQQV GKADAGEYSC EAGGQRVSFQ LHITEPKAVF 
      1360       1370       1380       1390       1400
AKEQLVHNEV RTEAGASATL SCEVAQAQTE VTWYKDGKKL SSSSKVRIEA 
      1410       1420       1430       1440       1450
AGCMRQLVVQ QAGQADAGEY TCEAGGQRLS FHLDVSEPKA VFAKEQLAHR 
      1460       1470       1480       1490       1500
KVQAEAGAIA TLSCEVAQAQ TEVTWYKDGK KLSSSSKVRM EAVGCTRRLV 
      1510       1520       1530       1540       1550
VQQACQADTG EYSCEAGGQR LSFSLDVAEP KVVFAKEQPV HREVQAQAGA 
      1560       1570       1580       1590       1600
STTLSCEVAQ AQTEVMWYKD GKKLSFSSKV RMEAVGCTRR LVVQQAGQAV 
      1610       1620       1630       1640       1650
AGEYSCEAGS QRLSFHLHVA EPKAVFAKEQ PAHREVQAEA GASATLSCEV 
      1660       1670       1680       1690       1700
AQAQTEVTWY KDGKKLSSSL KVHVEAAGCT RRLVVQQAGQ ADTGEYSCEA 
      1710       1720       1730       1740       1750
GGQQLSFRLQ VAEPKAVFAK EQPASREVQA EAGTSATLSC EVAQAQTEVT 
      1760       1770       1780       1790       1800
WYKDGKKLSS SSKVRMEAVG CTRRLVVQEA GQADAGEYSC KAGDQRLSFH 
      1810       1820       1830       1840       1850
LHVAEPKVVF AKEQPAHREV QAEAGASATL SCEVAQAQTE VTWYKDGKKL 
      1860       1870       1880       1890       1900
SSSSKVRVEA VGCTRRLVVQ QAGQAEAGEY SCEAGGQQLS FRLQVAEPKA 
      1910       1920       1930       1940       1950
VFAKEQVVFA KDQPVHREVQ AEAGTSTMLS CEVAQAQTEV MWYKDGKKLS 
      1960       1970       1980       1990       2000
SSSKMRVEAV GCTRRLVVQE AGQADAGEYS CEAGGQRLSF HLHVAEPKVV 
      2010       2020       2030       2040       2050
FAKEQPACRE VQAEAGASAT LSCEVAQGQM EVTWYKDGKK LSSSSKVHME 
      2060       2070       2080       2090       2100
ASGYTRRLVV QQAGQADAGE YSCEAGGQRL SFRLHVAELE PQISERPCRR 
      2110       2120       2130       2140       2150
EPLVVKEHED IILTATLATP SAATVTWLKD GVEIRRSKRH ETASQGDTHT 
      2160       2170       2180       2190       2200
LTVHGAQVLD SAIYSCRVGA EGQDFPVQVE EVAAKFCRLL EPVCGELGGT 
      2210       2220       2230       2240       2250
VTLACELSPA CAEVVWRCGN TQLRVGKRFQ MVAEGPVRSL TVLGLRAEDA 
      2260       2270       2280       2290       2300
GEYVCESRDD HTSAQLTVSV PRVVKFMSGL STVVAEEGGE ATFQCVVSPS 
      2310       2320       2330       2340       2350
DVAVVWFRDG ALLQPSEKFA ISQSGASHSL TISDLVLEDA GQITVEAEGA 
      2360       2370       2380       2390       2400
SSSAALRVRE APVLFKKKLE PQTVEERSSV TLEVELTRPW PELRWTRNAT 
      2410       2420       2430       2440       2450
ALAPGKNVEI HAEGARHRLV LHNVGFADRG FFGCETPDDK TQAKLTVEMR 
      2460       2470       2480       2490       2500
QVRLVRGLQA VEAREQGTAT MEVQLSHADV DGSWTRDGLR FQQGPTCHLA 
      2510       2520       2530       2540       2550
VRGPMHTLTL SGLRPEDSGL MVFKAEGVHT SARLVVTELP VSFSRPLQDV 
      2560       2570       2580       2590       2600
VTTEKEKVTL ECELSRPNVD VRWLKDGVEL RAGKTMAIAA QGACRSLTIY 
      2610       2620       2630       2640       2650
RCEFADQGVY VCDAHDAQSS ASVKVQGRNI QIVRPLEDVE VMEKDGATFS 
      2660       2670       2680       2690       2700
CEVSHDEVPG QWFWEGSKLR PTDNVRIRQE GRTYTLIYRR VLAEDAGEIQ 
      2710       2720       2730       2740       2750
FVAENAESRA QLRVKELPVT LVRPLRDKIA MEKHRGVLEC QVSRASAQVR 
      2760       2770       2780       2790       2800
WFKGSQELQP GPKYELVSDG LYRKLIISDV HAEDEDTYTC DAGDVKTSAQ 
      2810       2820       2830       2840       2850
FFVEEQSITI VRGLQDVTVM EPAPAWFECE TSIPSVRPPK WLLGKTVLQA 
      2860       2870       2880       2890       2900
GGNVGLEQEG TVHRLMLRRT CSTMTGPVHF TVGKSRSSAR LVVSDIPVVL 
      2910       2920       2930       2940       2950
TRPLEPKTGR ELQSVVLSCD FRPAPKAVQW YKDDTPLSPS EKFKMSLEGQ 
      2960       2970       2980       2990       3000
MAELRILRLM PADAGVYRCQ AGSAHSSTEV TVEAREVTVT GPLQDAEATE 
      3010       3020       3030       3040       3050
EGWASFSCEL SHEDEEVEWS LNGMPLYNDS FHEISHKGRR HTLVLKSIQR 
      3060       3070       3080       3090       3100
ADAGIVRASS LKVSTSARLE VRVKPVVFLK ALDDLSAEER GTLALQCEVS 
      3110       3120       3130       3140       3150
DPEAHVVWRK DGVQLGPSDK YDFLHTAGTR GLVVHDVSPE DAGLYTCHVG 
      3160       3170       3180       3190       3200
SEETRARVRV HDLHVGITKR LKTMEVLEGE SCSFECVLSH ESASDPAMWT 
      3210       3220       3230       3240       3250
VGGKTVGSSS RFQATRQGRK YILVVREAAP SDAGEVVFSV RGLTSKASLI 
      3260       3270       3280       3290       3300
VRERPAAIIK PLEDQWVAPG EDVELRCELS RAGTPVHWLK DRKAIRKSQK 
      3310       3320       3330       3340       3350
YDVVCEGTMA MLVIRGASLK DAGEYTCEVE ASKSTASLHV EEKANCFTEE 
      3360       3370       3380       3390       3400
LTNLQVEEKG TAVFTCKTEH PAATVTWRKG LLELRASGKH QPSQEGLTLR 
      3410       3420       3430       3440       3450
LTISALEKAD SDTYTCDIGQ AQSRAQLLVQ GRRVHIIEDL EDVDVQEGSS 
      3460       3470       3480       3490       3500
ATFRCRISPA NYEPVHWFLD KTPLHANELN EIDAQPGGYH VLTLRQLALK 
      3510       3520       3530       3540       3550
DSGTIYFEAG DQRASAALRV TEKPSVFSRE LTDATITEGE DLTLVCETST 
      3560       3570       3580       3590       3600
CDIPVCWTKD GKTLRGSARC QLSHEGHRAQ LLITGATLQD SGRYKCEAGG 
      3610       3620       3630       3640       3650
ACSSSIVRVH ARPVRFQEAL KDLEVLEGGA ATLRCVLSSV AAPVKWCYGN 
      3660       3670       3680       3690       3700
NVLRPGDKYS LRQEGAMLEL VVRNLRPQDS GRYSCSFGDQ TTSATLTVTA 
      3710       3720       3730       3740       3750
LPAQFIGKLR NKEATEGATA TLRCELSKAA PVEWRKGSET LRDGDRYCLR 
      3760       3770       3780       3790       3800
QDGAMCELQI RGLAMVDAAE YSCVCGEERT SASLTIRPMP AHFIGRLRHQ 
      3810       3820       3830       3840       3850
ESIEGATATL RCELSKAAPV EWRKGRESLR DGDRHSLRQD GAVCELQICG 
      3860       3870       3880       3890       3900
LAVADAGEYS CVCGEERTSA TLTVKALPAK FTEGLRNEEA VEGATAMLWC 
      3910       3920       3930       3940       3950
ELSKVAPVEW RKGPENLRDG DRYILRQEGT RCELQICGLA MADAGEYLCV 
      3960       3970       3980       3990       4000
CGQERTSATL TIRALPARFI EDVKNQEARE GATAVLQCEL NSAAPVEWRK 
      4010       4020       4030       4040       4050
GSETLRDGDR YSLRQDGTKC ELQIRGLAMA DTGEYSCVCG QERTSAMLTV 
      4060       4070       4080       4090       4100
RALPIKFTEG LRNEEATEGA TAVLRCELSK MAPVEWWKGH ETLRDGDRHS 
      4110       4120       4130       4140       4150
LRQDGARCEL QIRGLVAEDA GEYLCMCGKE RTSAMLTVRA MPSKFIEGLR 
      4160       4170       4180       4190       4200
NEEATEGDTA TLWCELSKAA PVEWRKGHET LRDGDRHSLR QDGSRCELQI 
      4210       4220       4230       4240       4250
RGLAVVDAGE YSCVCGQERT SATLTVRALP ARFIEDVKNQ EAREGATAVL 
      4260       4270       4280       4290       4300
QCELSKAAPV EWRKGSETLR GGDRYSLRQD GTRCELQIHG LSVADTGEYS 
      4310       4320       4330       4340       4350
CVCGQERTSA TLTVRALPAR FTQDLKTKEA SEGATATLQC ELSKVAPVEW 
      4360       4370       4380       4390       4400
KKGPETLRDG GRYSLKQDGT RCELQIHDLS VADAGEYSCM CGQERTSATL 
      4410       4420       4430       4440       4450
TVRALPARFT EGLRNEEAME GATATLQCEL SKAAPVEWRK GLEALRDGDK 
      4460       4470       4480       4490       4500
YSLRQDGAVC ELQIHGLAMA DNGVYSCVCG QERTSATLTV RALPARFIED 
      4510       4520       4530       4540       4550
MRNQKATEGA TVTLQCKLRK AAPVEWRKGP NTLKDGDRYS LKQDGTSCEL 
      4560       4570       4580       4590       4600
QIRGLVIADA GEYSCICEQE RTSATLTVRA LPARFIEDVR NHEATEGATA 
      4610       4620       4630       4640       4650
VLQCELSKAA PVEWRKGSET LRDGDRYSLR QDGTRCELQI RGLAVEDTGE 
      4660       4670       4680       4690       4700
YLCVCGQERT SATLTVRALP ARFIDNMTNQ EAREGATATL HCELSKVAPV 
      4710       4720       4730       4740       4750
EWRKGPETLR DGDRHSLRQD GTRCELQIRG LSVADAGEYS CVCGQERTSA 
      4760       4770       4780       4790       4800
TLTIRALPAK FTKGLRNEEA TEGATAMLQC ELSKVAPVEW RKGPETLRDG 
      4810       4820       4830       4840       4850
DRYNLRQDGT RCELQIHGLS VADTGEYSCV CGQEKTSATL TVKAPQPVFR 
      4860       4870       4880       4890       4900
EPLQSLQAEE GSTATLQCEL SEPTATVVWS KGGLQLQANG RREPRLQGCT 
      4910       4920       4930       4940       4950
AELVLQDLQR EDTGEYTCTC GSQATSATLT VTAAPVRFLR ELQHQEVDEG 
      4960       4970       4980       4990       5000
GTAHLCCELS RAGASVEWRK GSLQLFPCAK YQMVQDGAAA ELLVRGVEQE 
      5010       5020       5030       5040       5050
DAGDYTCDTG HTQSMASLSV RVPRPKFKTR LQSLEQETGD IARLCCQLSD 
      5060       5070       5080       5090       5100
AESGAVVQWL KEGVELHAGP KYEMRSQGAT RELLIHQLEA KDTGEYACVT 
      5110       5120       5130       5140       5150
GGQKTAASLR VTEPEVTIVR GLVDAEVTAD EDVEFSCEVS RAGATGVQWC 
      5160       5170       5180       5190       5200
LQGLPLQSNE VTEVAVRDGR IHTLRLKGVT PEDAGTVSFH LGNHASSAQL 
      5210       5220       5230       5240       5250
TVRAPEVTIL EPLQDVQLSE GQDASFQCRL SRASGQEARW ALGGVPLQAN 
      5260       5270       5280       5290       5300
EMNDITVEQG TLHLLTLHKV TLEDAGTVSF HVGTCSSEAQ LKVTAKNTVV 
      5310       5320       5330       5340       5350
RGLENVEALE GGEALFECQL SQPEVAAHTW LLDDEPVHTS ENAEVVFFEN 
      5360       5370       5380       5390       5400
GLRHLLLLKN LRPQDSCRVT FLAGDMVTSA FLTVRGWRLE ILEPLKNAAV 
      5410       5420       5430       5440       5450
RAGAQACFTC TLSEAVPVGE ASWYINGAAV QPDDSDWTVT ADGSHHALLL 
      5460       5470       5480       5490       5500
RSAQPHHAGE VTFACRDAVA SARLTVLGLP DPPEDAEVVA RSSHTVTLSW 
      5510       5520       5530       5540       5550
AAPMSDGGGG LCGYRVEVKE GATGQWRLCH ELVPGPECVV DGLAPGETYR 
      5560       5570       5580       5590       5600
FRVAAVGPVG AGEPVHLPQT VRLAEPPKPV PPQPSAPESR QVAAGEDVSL 
      5610       5620       5630       5640       5650
ELEVVAEAGE VIWHKGMERI QPGGRFEVVS QGRQQMLVIK GFTAEDQGEY 
      5660       5670       5680       5690       5700
HCGLAQGSIC PAAATFQVAL SPASVDEAPQ PSLPPEAAQE GDLHLLWEAL 
      5710       5720       5730       5740       5750
ARKRRMSREP TLDSISELPE EDGRSQRLPQ EAEEVAPDLS EGYSTADELA 
      5760       5770       5780       5790       5800
RTGDADLSHT SSDDESRAGT PSLVTYLKKA GRPGTSPLAS KVGAPAAPSV 
      5810       5820       5830       5840       5850
KPQQQQEPLA AVRPPLGDLS TKDLGDPSMD KAAVKIQAAF KGYKVRKEMK 
      5860       5870       5880       5890       5900
QQEGPMFSHT FGDTEAQVGD ALRLECVVAS KADVRARWLK DGVELTDGRH 
      5910       5920       5930       5940       5950
HHIDQLGDGT CSLLITGLDR ADAGCYTCQV SNKFGQVTHS ACVVVSGSES 
      5960       5970       5980       5990       6000
EAESSSGGEL DDAFRRAARR LHRLFRTKSP AEVSDEELFL SADEGPAEPE 
      6010       6020       6030       6040       6050
EPADWQTYRE DEHFICIRFE ALTEARQAVT RFQEMFATLG IGVEIKLVEQ 
      6060       6070       6080       6090       6100
GPRRVEMCIS KETPAPVVPP EPLPSLLTSD AAPVFLTELQ NQEVQDGYPV 
      6110       6120       6130       6140       6150
SFDCVVTGQP MPSVRWFKDG KLLEEDDHYM INEDQQGGHQ LIITAVVPAD 
      6160       6170       6180       6190       6200
MGVYRCLAEN SMGVSSTKAE LRVDLTSTDY DTAADATESS SYFSAQGYLS 
      6210       6220       6230       6240       6250
SREQEGTEST TDEGQLPQVV EELRDLQVAP GTRLAKFQLK VKGYPAPRLY 
      6260       6270       6280       6290       6300
WFKDGQPLTA SAHIRMTDKK ILHTLEIISV TREDSGQYAA YISNAMGAAY 
      6310       6320       6330       6340       6350
SSARLLVRGP DEPEEKPASD VHEQLVPPRM LERFTPKKVK KGSSITFSVK 
      6360       6370       6380       6390       6400
VEGRPVPTVH WLREEAERGV LWIGPDTPGY TVASSAQQHS LVLLDVGRQH 
      6410       6420       6430       6440       6450
QGTYTCIASN AAGQALCSAS LHVSGLPKVE EQEKVKEALI STFLQGTTQA 
      6460       6470       6480       6490       6500
ISAQGLETAS FADLGGQRKE EPLAAKEALG HLSLAEVGTE EFLQKLTSQI 
      6510       6520       6530       6540       6550
TEMVSAKITQ AKLQVPGGDS DEDSKTPSAS PRHGRSRPSS SIQESSSESE 
      6560       6570       6580       6590       6600
DGDARGEIFD IYVVTADYLP LGAEQDAITL REGQYVEVLD AAHPLRWLVR 
      6610       6620       6630       6640       6650
TKPTKSSPSR QGWVSPAYLD RRLKLSPEWG AAEAPEFPGE AVSEDEYKAR 
      6660       6670       6680       6690       6700
LSSVIQELLS SEQAFVEELQ FLQSHHLQHL ERCPHVPIAV AGQKAVIFRN 
      6710       6720       6730       6740       6750
VRDIGRFHSS FLQELQQCDT DDDVAMCFIK NQAAFEQYLE FLVGRVQAES 
      6760       6770       6780       6790       6800
VVVSTAIQEF YKKYAEEALL AGDPSQPPPP PLQHYLEQPV ERVQRYQALL 
      6810       6820       6830       6840       6850
KELIRNKARN RQNCALLEQA YAVVSALPQR AENKLHVSLM ENYPGTLQAL 
      6860       6870       6880       6890       6900
GEPIRQGHFI VWEGAPGARM PWKGHNRHVF LFRNHLVICK PRRDSRTDTV 
      6910       6920       6930       6940       6950
SYVFRNMMKL SSIDLNDQVE GDDRAFEVWQ EREDSVRKYL LQARTAIIKS 
      6960       6970       6980       6990       7000
SWVKEICGIQ QRLALPVWRP PDFEEELADC TAELGETVKL ACRVTGTPKP 
      7010       7020       7030       7040       7050
VISWYKDGKA VQVDPHHILI EDPDGSCALI LDSLTGVDSG QYMCFAASAA 
      7060       7070       7080       7090       7100
GNCSTLGKIL VQVPPRFVNK VRASPFVEGE DAQFTCTIEG APYPQIRWYK 
      7110       7120       7130       7140       7150
DGALLTTGNK FQTLSEPRSG LLVLVIRAAS KEDLGLYECE LVNRLGSARA 
      7160       7170       7180       7190       7200
SAELRIQSPM LQAQEQCHRE QLVAAVEDTT LERADQEVTS VLKRLLGPKA 
      7210       7220       7230       7240       7250
PGPSTGDLTG PGPCPRGAPA LQETGSQPPV TGTSEAPAVP PRVPQPLLHE 
      7260       7270       7280       7290       7300
GPEQEPEAIA RAQEWTVPIR MEGAAWPGAG TGELLWDVHS HVVRETTQRT 
      7310       7320       7330       7340       7350
YTYQAIDTHT ARPPSMQVTI EDVQAQTGGT AQFEAIIEGD PQPSVTWYKD 
      7360       7370       7380       7390       7400
SVQLVDSTRL SQQQEGTTYS LVLRHVASKD AGVYTCLAQN TGGQVLCKAE 
      7410       7420       7430       7440       7450
LLVLGGDNEP DSEKQSHRRK LHSFYEVKEE IGRGVFGFVK RVQHKGNKIL 
      7460       7470       7480       7490       7500
CAAKFIPLRS RTRAQAYRER DILAALSHPL VTGLLDQFET RKTLILILEL 
      7510       7520       7530       7540       7550
CSSEELLDRL YRKGVVTEAE VKVYIQQLVE GLHYLHSHGV LHLDIKPSNI 
      7560       7570       7580       7590       7600
LMVHPAREDI KICDFGFAQN ITPAELQFSQ YGSPEFVSPE IIQQNPVSEA 
      7610       7620       7630       7640       7650
SDIWAMGVIS YLSLTCSSPF AGESDRATLL NVLEGRVSWS SPMAAHLSED 
      7660       7670       7680       7690       7700
AKDFIKATLQ RAPQARPSAA QCLSHPWFLK SMPAEEAHFI NTKQLKFLLA 
      7710       7720       7730       7740       7750
RSRWQRSLMS YKSILVMRSI PELLRGPPDS PSLGVARHLC RDTGGSSSSS 
      7760       7770       7780       7790       7800
SSSDNELAPF ARAKSLPPSP VTHSPLLHPR GFLRPSASLP EEAEASERST 
      7810       7820       7830       7840       7850
EAPAPPASPE GAGPPAAQGC VPRHSVIRSL FYHQAGESPE HGALAPGSRR 
      7860       7870       7880       7890       7900
HPARRRHLLK GGYIAGALPG LREPLMEHRV LEEEAAREEQ ATLLAKAPSF 
      7910       7920       7930       7940       7950
ETALRLPASG THLAPGHSHS LEHDSPSTPR PSSEACGEAQ RLPSAPSGGA 
      7960       7970       7980       7990       8000
PIRDMGHPQG SKQLPSTGGH PGTAQPERPS PDSPWGQPAP FCHPKQGSAP 
      8010       8020       8030       8040       8050
QEGCSPHPAV APCPPGSFPP GSCKEAPLVP SSPFLGQPQA PPAPAKASPP 
      8060       8070       8080       8090       8100
LDSKMGPGDI SLPGRPKPGP CSSPGSASQA SSSQVSSLRV GSSQVGTEPG 
      8110       8120       8130       8140       8150
PSLDAEGWTQ EAEDLSDSTP TLQRPQEQAT MRKFSLGGRG GYAGVAGYGT 
      8160       8170       8180       8190       8200
FAFGGDAGGM LGQGPMWARI AWAVSQSEEE EQEEARAESQ SEEQQEARAE 
      8210       8220       8230       8240       8250
SPLPQVSARP VPEVGRAPTR SSPEPTPWED IGQVSLVQIR DLSGDAEAAD 
      8260       8270       8280       8290       8300
TISLDISEVD PAYLNLSDLY DIKYLPFEFM IFRKVPKSAQ PEPPSPMAEE 
      8310       8320       8330       8340       8350
ELAEFPEPTW PWPGELGPHA GLEITEESED VDALLAEAAV GRKRKWSSPS 
      8360       8370       8380       8390       8400
RSLFHFPGRH LPLDEPAELG LRERVKASVE HISRILKGRP EGLEKEGPPR 
      8410       8420       8430       8440       8450
KKPGLASFRL SGLKSWDRAP TFLRELSDET VVLGQSVTLA CQVSAQPAAQ 
      8460       8470       8480       8490       8500
ATWSKDGAPL ESSSRVLISA TLKNFQLLTI LVVVAEDLGV YTCSVSNALG 
      8510       8520       8530       8540       8550
TVTTTGVLRK AERPSSSPCP DIGEVYADGV LLVWKPVESY GPVTYIVQCS 
      8560       8570       8580       8590       8600
LEGGSWTTLA SDIFDCCYLT SKLSRGGTYT FRTACVSKAG MGPYSSPSEQ 
      8610       8620       8630       8640       8650
VLLGGPSHLA SEEESQGRSA QPLPSTKTFA FQTQIQRGRF SVVRQCWEKA 
      8660       8670       8680       8690       8700
SGRALAAKII PYHPKDKTAV LREYEALKGL RHPHLAQLHA AYLSPRHLVL 
      8710       8720       8730       8740       8750
ILELCSGPEL LPCLAERASY SESEVKDYLW QMLSATQYLH NQHILHLDLR 
      8760       8770       8780       8790       8800
SENMIITEYN LLKVVDLGNA QSLSQEKVLP SDKFKDYLET MELLEGQGAV 
      8810       8820       8830       8840       8850
PQTDIWAIGV TAFIMLSAEY PVSSEGARDL QRGLRKGLVR LSRCYAGLSG 
      8860       8870       8880       8890       8900
GAVAFLRSTL CAQPWGRPCA SSCLQCPWLT EEGPACSRPA PVTFPTARLR 
      8910       8920 
VFVRNREKRR ALLYKRHNLA QVR
Length:8,923
Mass (Da):973,004
Last modified:October 5, 2016 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD1AA2309EAD437C9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VST9OBSCN_HUMAN
Obscurin
OBSCN KIAA1556, KIAA1639
7,968Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0Z489A0A7P0Z489_HUMAN
Non-specific serine/threonine prote...
OBSCN
8,925Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJJ2A0A590UJJ2_HUMAN
Non-specific serine/threonine prote...
OBSCN
406Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQA7H3BQA7_HUMAN
Obscurin
OBSCN
639Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRI8A0A0A0MRI8_HUMAN
Obscurin
OBSCN
858Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJ10A0A590UJ10_HUMAN
Obscurin
OBSCN
3,010Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJ65A0A590UJ65_HUMAN
Obscurin
OBSCN
503Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJH9A0A590UJH9_HUMAN
Obscurin
OBSCN
296Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJD0A0A590UJD0_HUMAN
Obscurin
OBSCN
237Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJD5A0A590UJD5_HUMAN
Obscurin
OBSCN
721Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL353593 Genomic DNA No translation available.
AL359510 Genomic DNA No translation available.
AL670729 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_001258152.2, NM_001271223.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000570156; ENSP00000455507; ENSG00000154358

Database of genes from NCBI RefSeq genomes

More...GeneIDi		84033

UCSC genome browser

More...UCSCi		uc001hsq.2, human
uc057qea.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353593 Genomic DNA No translation available.
AL359510 Genomic DNA No translation available.
AL670729 Genomic DNA No translation available.
RefSeqiNP_001258152.2, NM_001271223.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000455507

Proteomic databases

PeptideAtlasiA6NGQ3
PRIDEiA6NGQ3
ProteomicsDBi1144

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11615, 39 antibodies

The DNASU plasmid repository

More...DNASUi		84033

Genome annotation databases

EnsembliENST00000570156; ENSP00000455507; ENSG00000154358
GeneIDi84033
UCSCiuc001hsq.2, human
uc057qea.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84033
HGNCiHGNC:15719, OBSCN
OpenTargetsiENSG00000154358
VEuPathDBiHostDB:ENSG00000154358

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0032, Eukaryota
KOG0613, Eukaryota
GeneTreeiENSGT00940000154756
OMAiVCELVIH
TreeFamiTF331962

Enzyme and pathway databases

SignaLinkiA6NGQ3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		84033, 8 hits in 1046 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		OBSCN, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		84033

Gene expression databases

BgeeiENSG00000154358, Expressed in gastrocnemius and 155 other tissues
ExpressionAtlasiA6NGQ3, baseline and differential

Family and domain databases

CDDicd00063, FN3, 3 hits
cd00160, RhoGEF, 1 hit
cd12025, SH3_Obscurin_like, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.60.40.10, 71 hits
InterProiView protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set
IPR000048, IQ_motif_EF-hand-BS
IPR011009, Kinase-like_dom_sf
IPR020682, Obscurin
IPR035526, Obscurin_SH3
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR008266, Tyr_kinase_AS
PANTHERiPTHR47633:SF2, PTHR47633:SF2, 6 hits
PfamiView protein in Pfam
PF00041, fn3, 2 hits
PF07679, I-set, 61 hits
PF00612, IQ, 1 hit
PF00069, Pkinase, 2 hits
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00060, FN3, 3 hits
SM00409, IG, 67 hits
SM00408, IGc2, 59 hits
SM00406, IGv, 18 hits
SM00015, IQ, 1 hit
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SM00220, S_TKc, 2 hits
SUPFAMiSSF48065, SSF48065, 1 hit
SSF48726, SSF48726, 68 hits
SSF49265, SSF49265, 3 hits
SSF50044, SSF50044, 1 hit
SSF56112, SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50010, DH_2, 1 hit
PS50853, FN3, 3 hits
PS50835, IG_LIKE, 57 hits
PS00290, IG_MHC, 1 hit
PS50096, IQ, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 2 hits
PS00108, PROTEIN_KINASE_ST, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA6NGQ3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NGQ3
Secondary accession number(s): H3BPX2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: October 5, 2016
Last modified: September 29, 2021
This is version 125 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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