UniProtKB - A6NGJ6 (TRI64_HUMAN)
Protein
Tripartite motif-containing protein 64
Gene
TRIM64
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 15 – 56 | RING-typePROSITE-ProRule annotationAdd BLAST | 42 | |
Zinc fingeri | 87 – 128 | B box-typePROSITE-ProRule annotationAdd BLAST | 42 |
GO - Molecular functioni
- ubiquitin protein ligase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- innate immune response Source: GO_Central
- protein ubiquitination Source: GO_Central
- regulation of gene expression Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | A6NGJ6 |
Names & Taxonomyi
Protein namesi | Recommended name: Tripartite motif-containing protein 64 |
Gene namesi | Name:TRIM64 Synonyms:C11orf28 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000204450.7 |
HGNCi | HGNC:14663, TRIM64 |
neXtProti | NX_A6NGJ6 |
Subcellular locationi
Other locations
- cytoplasm Source: GO_Central
Pathology & Biotechi
Organism-specific databases
PharmGKBi | PA25492 |
Miscellaneous databases
Pharosi | A6NGJ6, Tdark |
Polymorphism and mutation databases
BioMutai | TRIM64 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000331574 | 1 – 449 | Tripartite motif-containing protein 64Add BLAST | 449 |
Proteomic databases
MassIVEi | A6NGJ6 |
PeptideAtlasi | A6NGJ6 |
PRIDEi | A6NGJ6 |
ProteomicsDBi | 1132 |
PTM databases
iPTMneti | A6NGJ6 |
PhosphoSitePlusi | A6NGJ6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000204450, Expressed in placenta and 1 other tissue |
Organism-specific databases
HPAi | ENSG00000204450, Group enriched (blood, placenta) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000483764 |
Miscellaneous databases
RNActi | A6NGJ6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 269 – 449 | B30.2/SPRYPROSITE-ProRule annotationAdd BLAST | 181 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 189 – 225 | Sequence analysisAdd BLAST | 37 |
Sequence similaritiesi
Belongs to the TRIM/RBCC family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 15 – 56 | RING-typePROSITE-ProRule annotationAdd BLAST | 42 | |
Zinc fingeri | 87 – 128 | B box-typePROSITE-ProRule annotationAdd BLAST | 42 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000163440 |
HOGENOMi | CLU_013137_0_3_1 |
InParanoidi | A6NGJ6 |
OMAi | IYSEEAC |
OrthoDBi | 704031at2759 |
PhylomeDBi | A6NGJ6 |
Family and domain databases
CDDi | cd00021, BBOX, 1 hit |
Gene3Di | 2.60.120.920, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013320, ConA-like_dom_sf IPR003877, SPRY_dom IPR000315, Znf_B-box IPR018957, Znf_C3HC4_RING-type IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00622, SPRY, 1 hit PF00097, zf-C3HC4, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00336, BBOX, 1 hit SM00184, RING, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A6NGJ6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDSDDLQVFQ NELICCICVN YFIDPVTIDC GHSFCRPCLC LCSEEGRAPM
60 70 80 90 100
RCPSCRKISE KPNFNTNVVL KKLSSLARQT RPQNINSSDN ICVLHEETKE
110 120 130 140 150
LFCEADKRLL CGPCSESPEH MAHSHSPIGW AAEECREKLI KEMDYLWEIN
160 170 180 190 200
QETRNNLNQE TRTFHSLKDY VSVRKRIITI QYQKMPIFLD EEEQRHLQAL
210 220 230 240 250
EREAEELFQQ LQDSQVRMTQ HLERMKDMYR ELWETCHVPD VELLQDVRNV
260 270 280 290 300
SARTDLAQMQ KPQPVNPELT SWCITGVLDM LNNFRVDSAL STEMIPCYIS
310 320 330 340 350
LSEDVRYVIF GDDHLSAPTD PQGVDSFAVW GAQAFTSGKH YWEVDVTLSS
360 370 380 390 400
NWILGVCQDS RTADANFVID SDERFFLISS KRSNHYSLST NSPPLIQYVQ
410 420 430 440
RPLGQVGVFL DYDNGSVSFF DVSKGSLIYG FPPSSFSSPL RPFFCFGCT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP004607 Genomic DNA No translation available. BX093574 mRNA No translation available. |
CCDSi | CCDS73363.1 |
RefSeqi | NP_001129958.1, NM_001136486.1 XP_011540887.1, XM_011542585.2 |
Genome annotation databases
Ensembli | ENST00000533122; ENSP00000483764; ENSG00000204450 |
GeneIDi | 120146 |
KEGGi | hsa:120146 |
UCSCi | uc010rty.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP004607 Genomic DNA No translation available. BX093574 mRNA No translation available. |
CCDSi | CCDS73363.1 |
RefSeqi | NP_001129958.1, NM_001136486.1 XP_011540887.1, XM_011542585.2 |
3D structure databases
SMRi | A6NGJ6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000483764 |
PTM databases
iPTMneti | A6NGJ6 |
PhosphoSitePlusi | A6NGJ6 |
Polymorphism and mutation databases
BioMutai | TRIM64 |
Proteomic databases
MassIVEi | A6NGJ6 |
PeptideAtlasi | A6NGJ6 |
PRIDEi | A6NGJ6 |
ProteomicsDBi | 1132 |
Protocols and materials databases
Antibodypediai | 72942, 64 antibodies |
Genome annotation databases
Ensembli | ENST00000533122; ENSP00000483764; ENSG00000204450 |
GeneIDi | 120146 |
KEGGi | hsa:120146 |
UCSCi | uc010rty.3, human |
Organism-specific databases
CTDi | 120146 |
EuPathDBi | HostDB:ENSG00000204450.7 |
GeneCardsi | TRIM64 |
HGNCi | HGNC:14663, TRIM64 |
HPAi | ENSG00000204450, Group enriched (blood, placenta) |
neXtProti | NX_A6NGJ6 |
PharmGKBi | PA25492 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000163440 |
HOGENOMi | CLU_013137_0_3_1 |
InParanoidi | A6NGJ6 |
OMAi | IYSEEAC |
OrthoDBi | 704031at2759 |
PhylomeDBi | A6NGJ6 |
Enzyme and pathway databases
PathwayCommonsi | A6NGJ6 |
Miscellaneous databases
BioGRID-ORCSi | 120146, 2 hits in 59 CRISPR screens |
GenomeRNAii | 120146 |
Pharosi | A6NGJ6, Tdark |
PROi | PR:A6NGJ6 |
RNActi | A6NGJ6, protein |
Gene expression databases
Bgeei | ENSG00000204450, Expressed in placenta and 1 other tissue |
Family and domain databases
CDDi | cd00021, BBOX, 1 hit |
Gene3Di | 2.60.120.920, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013320, ConA-like_dom_sf IPR003877, SPRY_dom IPR000315, Znf_B-box IPR018957, Znf_C3HC4_RING-type IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00622, SPRY, 1 hit PF00097, zf-C3HC4, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00336, BBOX, 1 hit SM00184, RING, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRI64_HUMAN | |
Accessioni | A6NGJ6Primary (citable) accession number: A6NGJ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | July 1, 2008 | |
Last modified: | December 2, 2020 | |
This is version 109 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM