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Entry version 92 (02 Jun 2021)
Sequence version 3 (02 Sep 2008)
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Protein

Coiled-coil domain-containing protein 160

Gene

CCDC160

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
A6NGH7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 160
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC160
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:37286, CCDC160

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6NGH7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000203952.9

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000203952

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165756450

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
A6NGH7, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC160

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003459511 – 325Coiled-coil domain-containing protein 160Add BLAST325

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
A6NGH7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A6NGH7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A6NGH7

PeptideAtlas

More...
PeptideAtlasi
A6NGH7

PRoteomics IDEntifications database

More...
PRIDEi
A6NGH7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
1127

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6NGH7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A6NGH7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000203952, Expressed in saliva-secreting gland and 116 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A6NGH7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000203952, Tissue enhanced (salivary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
131441, 1 interactor

Protein interaction database and analysis system

More...
IntActi
A6NGH7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000427951

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
A6NGH7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A6NGH7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni18 – 45DisorderedSequence analysisAdd BLAST28
Regioni81 – 123DisorderedSequence analysisAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili144 – 288Sequence analysisAdd BLAST145

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi20 – 45Polar residuesSequence analysisAdd BLAST26
Compositional biasi89 – 123Polar residuesSequence analysisAdd BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CCDC160 family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RVAM, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013938

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_058746_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6NGH7

Identification of Orthologs from Complete Genome Data

More...
OMAi
HFTGDFF

Database of Orthologous Groups

More...
OrthoDBi
1366530at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A6NGH7

TreeFam database of animal gene trees

More...
TreeFami
TF351883

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026789, Ccdc160

The PANTHER Classification System

More...
PANTHERi
PTHR11636:SF71, PTHR11636:SF71, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A6NGH7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDARRKHWKE NMFTPFFSAQ DVLEETSEPE SSSEQTTADS SKGMEEIYNL
60 70 80 90 100
SSRKFQEESK FKRKKYIFQL NEIEQEQNLR ENKRNISKNE TDTNSASYES
110 120 130 140 150
SNVDVTTEES FNSTEDNSTC STDNLPALLR QDIRKKFMER MSPKLCLNLL
160 170 180 190 200
NEELEELNMK YRKIEEEFEN AEKELLHYKK EIFTKPLNFQ ETETDASKSD
210 220 230 240 250
YELQALRNDL SEKATNVKNL SEQLQQAKEV IHKLNLENRN LKEAVRKLKH
260 270 280 290 300
QTEVGNVLLK EEMKSYYELE MAKIRGELSV IKNELRTEKT LQARNNRALE
310 320
LLRKYYASSM VTSSSILDHF TGDFF
Length:325
Mass (Da):38,277
Last modified:September 2, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i63E95ACBF5A6910C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC004409 Genomic DNA No translation available.
CH471107 Genomic DNA Translation: EAX11768.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS48171.1

NCBI Reference Sequences

More...
RefSeqi
NP_001094827.1, NM_001101357.1
XP_005262466.1, XM_005262409.4
XP_005262467.1, XM_005262410.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000370809; ENSP00000359845; ENSG00000203952
ENST00000517294; ENSP00000427951; ENSG00000203952

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
347475

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:347475

UCSC genome browser

More...
UCSCi
uc011mvj.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004409 Genomic DNA No translation available.
CH471107 Genomic DNA Translation: EAX11768.1
CCDSiCCDS48171.1
RefSeqiNP_001094827.1, NM_001101357.1
XP_005262466.1, XM_005262409.4
XP_005262467.1, XM_005262410.4

3D structure databases

SMRiA6NGH7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi131441, 1 interactor
IntActiA6NGH7, 1 interactor
STRINGi9606.ENSP00000427951

PTM databases

iPTMnetiA6NGH7
PhosphoSitePlusiA6NGH7

Genetic variation databases

BioMutaiCCDC160

Proteomic databases

MassIVEiA6NGH7
MaxQBiA6NGH7
PaxDbiA6NGH7
PeptideAtlasiA6NGH7
PRIDEiA6NGH7
ProteomicsDBi1127

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
50575, 9 antibodies

The DNASU plasmid repository

More...
DNASUi
347475

Genome annotation databases

EnsembliENST00000370809; ENSP00000359845; ENSG00000203952
ENST00000517294; ENSP00000427951; ENSG00000203952
GeneIDi347475
KEGGihsa:347475
UCSCiuc011mvj.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
347475

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC160
HGNCiHGNC:37286, CCDC160
HPAiENSG00000203952, Tissue enhanced (salivary)
neXtProtiNX_A6NGH7
OpenTargetsiENSG00000203952
PharmGKBiPA165756450
VEuPathDBiHostDB:ENSG00000203952.9

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RVAM, Eukaryota
GeneTreeiENSGT00390000013938
HOGENOMiCLU_058746_0_0_1
InParanoidiA6NGH7
OMAiHFTGDFF
OrthoDBi1366530at2759
PhylomeDBiA6NGH7
TreeFamiTF351883

Enzyme and pathway databases

PathwayCommonsiA6NGH7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
347475, 8 hits in 606 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CCDC160, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
347475
PharosiA6NGH7, Tdark

Protein Ontology

More...
PROi
PR:A6NGH7
RNActiA6NGH7, protein

Gene expression databases

BgeeiENSG00000203952, Expressed in saliva-secreting gland and 116 other tissues
GenevisibleiA6NGH7, HS

Family and domain databases

InterProiView protein in InterPro
IPR026789, Ccdc160
PANTHERiPTHR11636:SF71, PTHR11636:SF71, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC160_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NGH7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: June 2, 2021
This is version 92 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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