UniProtKB - A6NGE4 (DC8L1_HUMAN)
Protein
DDB1- and CUL4-associated factor 8-like protein 1
Gene
DCAF8L1
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: DDB1- and CUL4-associated factor 8-like protein 1Alternative name(s): WD repeat-containing protein 42B |
Gene namesi | Name:DCAF8L1 Synonyms:WDR42B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000226372.2 |
HGNCi | HGNC:31810, DCAF8L1 |
neXtProti | NX_A6NGE4 |
Subcellular locationi
Other locations
- Cul4-RING E3 ubiquitin ligase complex Source: GO_Central
- cytoplasm Source: GO_Central
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000226372 |
PharmGKBi | PA165756552 |
Miscellaneous databases
Pharosi | A6NGE4, Tdark |
Polymorphism and mutation databases
BioMutai | DCAF8L1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000314820 | 1 – 600 | DDB1- and CUL4-associated factor 8-like protein 1Add BLAST | 600 |
Proteomic databases
jPOSTi | A6NGE4 |
MassIVEi | A6NGE4 |
MaxQBi | A6NGE4 |
PaxDbi | A6NGE4 |
PeptideAtlasi | A6NGE4 |
PRIDEi | A6NGE4 |
ProteomicsDBi | 1119 |
PTM databases
iPTMneti | A6NGE4 |
PhosphoSitePlusi | A6NGE4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000226372, Expressed in testis and 4 other tissues |
Organism-specific databases
HPAi | ENSG00000226372, Tissue enriched (testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 126567, 2 interactors |
IntActi | A6NGE4, 1 interactor |
STRINGi | 9606.ENSP00000405222 |
Miscellaneous databases
RNActi | A6NGE4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 194 – 233 | WD 1Add BLAST | 40 | |
Repeati | 237 – 278 | WD 2Add BLAST | 42 | |
Repeati | 284 – 324 | WD 3Add BLAST | 41 | |
Repeati | 332 – 372 | WD 4Add BLAST | 41 | |
Repeati | 388 – 427 | WD 5Add BLAST | 40 | |
Repeati | 435 – 475 | WD 6Add BLAST | 41 | |
Repeati | 479 – 518 | WD 7Add BLAST | 40 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 73 – 115 | Glu-richAdd BLAST | 43 |
Sequence similaritiesi
Belongs to the WD repeat DCAF8 family.Curated
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG1334, Eukaryota |
GeneTreei | ENSGT00950000182900 |
HOGENOMi | CLU_012381_4_1_1 |
InParanoidi | A6NGE4 |
OMAi | KGHRNND |
OrthoDBi | 1270484at2759 |
PhylomeDBi | A6NGE4 |
TreeFami | TF326071 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 3 hits |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
A6NGE4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSHQEGSTGG LPDLVTESLF SSPEEQSGVA AVTAASSDIE MAATEPSTGD
60 70 80 90 100
GGDTRDGGFL NDASTENQNT DSESSSEDVE LESMGEGLFG YPLVGEETER
110 120 130 140 150
EEEEEEMEEE GEEEEQPRMC PRCGGTNHDQ CLLDEDQALE EWISSETSAL
160 170 180 190 200
PRSRWQVLTA LRQRQLGSSA RFVYEACGAR TFVQRFRLQY LLGSHAGSVS
210 220 230 240 250
TIHFNQRGTR LASSGDDLRV IVWDWVRQKP VLNFESGHDI NVIQAKFFPN
260 270 280 290 300
CGDSTLAMCG HDGQVRVAEL INASYCENTK RVAKHRGPAH ELALEPDSPY
310 320 330 340 350
KFLTSGEDAV VFTIDLRQDR PASKVVVTRE NDKKVGLYTI SMNPANIYQF
360 370 380 390 400
AVGGHDQFVR IYDQRRIDKK ENNGVLKKFT PHHLVYCDFP TNITCVVYSH
410 420 430 440 450
DGTELLASYN DEDIYLFNSS LSDGAQYVKR YKGHRNNDTI KCVNFYGPRS
460 470 480 490 500
EFVVSGSDCG HVFFWEKSSS QIIQFMEGDR GDIVNCLEPH PYLPVLATSG
510 520 530 540 550
LDQHVRIWTP TAKTATELTG LKDVIKKNKQ ERDEDNLNYT DSFDNRMLRF
560 570 580 590 600
FVRHLLQRAH QPGWRDHGAE FPDEEELDES SSTSDTSEEE GQDRVQCIPS
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038060 | 549 | R → W. Corresponds to variant dbSNP:rs12388557Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK128123 mRNA Translation: BAG54633.1 AC004553 Genomic DNA No translation available. CH471074 Genomic DNA Translation: EAW99044.1 |
CCDSi | CCDS35222.1 |
RefSeqi | NP_001017930.1, NM_001017930.1 |
Genome annotation databases
Ensembli | ENST00000441525; ENSP00000405222; ENSG00000226372 |
GeneIDi | 139425 |
KEGGi | hsa:139425 |
UCSCi | uc004dbx.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK128123 mRNA Translation: BAG54633.1 AC004553 Genomic DNA No translation available. CH471074 Genomic DNA Translation: EAW99044.1 |
CCDSi | CCDS35222.1 |
RefSeqi | NP_001017930.1, NM_001017930.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 126567, 2 interactors |
IntActi | A6NGE4, 1 interactor |
STRINGi | 9606.ENSP00000405222 |
PTM databases
iPTMneti | A6NGE4 |
PhosphoSitePlusi | A6NGE4 |
Polymorphism and mutation databases
BioMutai | DCAF8L1 |
Proteomic databases
jPOSTi | A6NGE4 |
MassIVEi | A6NGE4 |
MaxQBi | A6NGE4 |
PaxDbi | A6NGE4 |
PeptideAtlasi | A6NGE4 |
PRIDEi | A6NGE4 |
ProteomicsDBi | 1119 |
Protocols and materials databases
Antibodypediai | 50600, 5 antibodies |
Genome annotation databases
Ensembli | ENST00000441525; ENSP00000405222; ENSG00000226372 |
GeneIDi | 139425 |
KEGGi | hsa:139425 |
UCSCi | uc004dbx.2, human |
Organism-specific databases
CTDi | 139425 |
EuPathDBi | HostDB:ENSG00000226372.2 |
GeneCardsi | DCAF8L1 |
HGNCi | HGNC:31810, DCAF8L1 |
HPAi | ENSG00000226372, Tissue enriched (testis) |
neXtProti | NX_A6NGE4 |
OpenTargetsi | ENSG00000226372 |
PharmGKBi | PA165756552 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1334, Eukaryota |
GeneTreei | ENSGT00950000182900 |
HOGENOMi | CLU_012381_4_1_1 |
InParanoidi | A6NGE4 |
OMAi | KGHRNND |
OrthoDBi | 1270484at2759 |
PhylomeDBi | A6NGE4 |
TreeFami | TF326071 |
Enzyme and pathway databases
PathwayCommonsi | A6NGE4 |
SignaLinki | A6NGE4 |
Miscellaneous databases
BioGRID-ORCSi | 139425, 6 hits in 465 CRISPR screens |
GenomeRNAii | 139425 |
Pharosi | A6NGE4, Tdark |
PROi | PR:A6NGE4 |
RNActi | A6NGE4, protein |
Gene expression databases
Bgeei | ENSG00000226372, Expressed in testis and 4 other tissues |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 3 hits |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DC8L1_HUMAN | |
Accessioni | A6NGE4Primary (citable) accession number: A6NGE4 Secondary accession number(s): B3KXX1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | July 24, 2007 | |
Last modified: | December 2, 2020 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations