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UniProtKB - A6NGE4 (DC8L1_HUMAN)

Entry version 99 (11 Dec 2019)
Sequence version 1 (24 Jul 2007)
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Protein

DDB1- and CUL4-associated factor 8-like protein 1

Gene

DCAF8L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		A6NGE4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 8-like protein 1
Alternative name(s):
WD repeat-containing protein 42B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCAF8L1
Synonyms:WDR42B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000226372.2

Human Gene Nomenclature Database

More...HGNCi		HGNC:31810 DCAF8L1

neXtProt; the human protein knowledge platform

More...neXtProti		NX_A6NGE4

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000226372

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165756552

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		A6NGE4 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DCAF8L1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003148201 – 600DDB1- and CUL4-associated factor 8-like protein 1Add BLAST600

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A6NGE4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		A6NGE4

MaxQB - The MaxQuant DataBase

More...MaxQBi		A6NGE4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A6NGE4

PRoteomics IDEntifications database

More...PRIDEi		A6NGE4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		1119

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A6NGE4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A6NGE4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000226372 Expressed in 4 organ(s), highest expression level in right testis

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA043787

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		126567, 1 interactor

Protein interaction database and analysis system

More...IntActi		A6NGE4, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000405222

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A6NGE4 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati194 – 233WD 1Add BLAST40
Repeati237 – 278WD 2Add BLAST42
Repeati284 – 324WD 3Add BLAST41
Repeati332 – 372WD 4Add BLAST41
Repeati388 – 427WD 5Add BLAST40
Repeati435 – 475WD 6Add BLAST41
Repeati479 – 518WD 7Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi73 – 115Glu-richAdd BLAST43

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat DCAF8 family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1334 Eukaryota
ENOG410XQZP LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182900

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000243561

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A6NGE4

KEGG Orthology (KO)

More...KOi		K11804

Identification of Orthologs from Complete Genome Data

More...OMAi		KGHRNND

Database of Orthologous Groups

More...OrthoDBi		737753at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A6NGE4

TreeFam database of animal gene trees

More...TreeFami		TF326071

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00400 WD40, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00320 WD40, 7 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A6NGE4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHQEGSTGG LPDLVTESLF SSPEEQSGVA AVTAASSDIE MAATEPSTGD 
        60         70         80         90        100
GGDTRDGGFL NDASTENQNT DSESSSEDVE LESMGEGLFG YPLVGEETER 
       110        120        130        140        150
EEEEEEMEEE GEEEEQPRMC PRCGGTNHDQ CLLDEDQALE EWISSETSAL 
       160        170        180        190        200
PRSRWQVLTA LRQRQLGSSA RFVYEACGAR TFVQRFRLQY LLGSHAGSVS 
       210        220        230        240        250
TIHFNQRGTR LASSGDDLRV IVWDWVRQKP VLNFESGHDI NVIQAKFFPN 
       260        270        280        290        300
CGDSTLAMCG HDGQVRVAEL INASYCENTK RVAKHRGPAH ELALEPDSPY 
       310        320        330        340        350
KFLTSGEDAV VFTIDLRQDR PASKVVVTRE NDKKVGLYTI SMNPANIYQF 
       360        370        380        390        400
AVGGHDQFVR IYDQRRIDKK ENNGVLKKFT PHHLVYCDFP TNITCVVYSH 
       410        420        430        440        450
DGTELLASYN DEDIYLFNSS LSDGAQYVKR YKGHRNNDTI KCVNFYGPRS 
       460        470        480        490        500
EFVVSGSDCG HVFFWEKSSS QIIQFMEGDR GDIVNCLEPH PYLPVLATSG 
       510        520        530        540        550
LDQHVRIWTP TAKTATELTG LKDVIKKNKQ ERDEDNLNYT DSFDNRMLRF 
       560        570        580        590        600
FVRHLLQRAH QPGWRDHGAE FPDEEELDES SSTSDTSEEE GQDRVQCIPS
Length:600
Mass (Da):67,373
Last modified:July 24, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB74F2E7A625C6C9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038060549R → W. Corresponds to variant dbSNP:rs12388557Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK128123 mRNA Translation: BAG54633.1
AC004553 Genomic DNA No translation available.
CH471074 Genomic DNA Translation: EAW99044.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35222.1

NCBI Reference Sequences

More...RefSeqi		NP_001017930.1, NM_001017930.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000441525; ENSP00000405222; ENSG00000226372

Database of genes from NCBI RefSeq genomes

More...GeneIDi		139425

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:139425

UCSC genome browser

More...UCSCi		uc004dbx.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128123 mRNA Translation: BAG54633.1
AC004553 Genomic DNA No translation available.
CH471074 Genomic DNA Translation: EAW99044.1
CCDSiCCDS35222.1
RefSeqiNP_001017930.1, NM_001017930.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi126567, 1 interactor
IntActiA6NGE4, 1 interactor
STRINGi9606.ENSP00000405222

PTM databases

iPTMnetiA6NGE4
PhosphoSitePlusiA6NGE4

Polymorphism and mutation databases

BioMutaiDCAF8L1

Proteomic databases

jPOSTiA6NGE4
MassIVEiA6NGE4
MaxQBiA6NGE4
PaxDbiA6NGE4
PRIDEiA6NGE4
ProteomicsDBi1119

Genome annotation databases

EnsembliENST00000441525; ENSP00000405222; ENSG00000226372
GeneIDi139425
KEGGihsa:139425
UCSCiuc004dbx.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		139425
EuPathDBiHostDB:ENSG00000226372.2

GeneCards: human genes, protein and diseases

More...GeneCardsi		DCAF8L1
HGNCiHGNC:31810 DCAF8L1
HPAiHPA043787
neXtProtiNX_A6NGE4
OpenTargetsiENSG00000226372
PharmGKBiPA165756552

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1334 Eukaryota
ENOG410XQZP LUCA
GeneTreeiENSGT00950000182900
HOGENOMiHOG000243561
InParanoidiA6NGE4
KOiK11804
OMAiKGHRNND
OrthoDBi737753at2759
PhylomeDBiA6NGE4
TreeFamiTF326071

Enzyme and pathway databases

SignaLinkiA6NGE4

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		139425
PharosiA6NGE4 Tdark

Protein Ontology

More...PROi		PR:A6NGE4
RNActiA6NGE4 protein

Gene expression databases

BgeeiENSG00000226372 Expressed in 4 organ(s), highest expression level in right testis

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDC8L1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NGE4
Secondary accession number(s): B3KXX1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 24, 2007
Last modified: December 11, 2019
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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