Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

WAS/WASL-interacting protein family member 3

Gene

WIPF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a regulator of cytoskeletal organization. May have a role in spermatogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Developmental protein
Biological processDifferentiation, Spermatogenesis

Enzyme and pathway databases

ReactomeiR-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs

Names & Taxonomyi

Protein namesi
Recommended name:
WAS/WASL-interacting protein family member 3
Alternative name(s):
Corticosteroids and regional expression protein 16 homolog
Gene namesi
Name:WIPF3
Synonyms:CR16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000122574.10
HGNCiHGNC:22004 WIPF3
MIMi612432 gene
neXtProtiNX_A6NGB9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi644150
OpenTargetsiENSG00000122574
PharmGKBiPA162409231

Polymorphism and mutation databases

BioMutaiWIPF3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003379971 – 483WAS/WASL-interacting protein family member 3Add BLAST483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46Asymmetric dimethylarginineCombined sources1
Modified residuei149PhosphoserineCombined sources1
Modified residuei202PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiA6NGB9
PaxDbiA6NGB9
PRIDEiA6NGB9
ProteomicsDBi1115

PTM databases

iPTMnetiA6NGB9
PhosphoSitePlusiA6NGB9

Expressioni

Gene expression databases

BgeeiENSG00000122574
CleanExiHS_WIPF3
ExpressionAtlasiA6NGB9 baseline and differential
GenevisibleiA6NGB9 HS

Organism-specific databases

HPAiHPA041145
HPA041211

Interactioni

Subunit structurei

Interacts with WASL, and monomeric and filamentous actin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi569353, 5 interactors
ELMiA6NGB9
IntActiA6NGB9, 2 interactors
STRINGi9606.ENSP00000386878

Structurei

3D structure databases

ProteinModelPortaliA6NGB9
SMRiA6NGB9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 62WH2PROSITE-ProRule annotationAdd BLAST18

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi3 – 8Profilin-binding motif6
Motifi11 – 16Profilin-binding motif6
Motifi20 – 25Profilin-binding motif6
Motifi58 – 61RLRK4
Motifi424 – 448WASP-binding motifAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi172 – 191Poly-ProAdd BLAST20
Compositional biasi223 – 239Poly-ProAdd BLAST17
Compositional biasi289 – 298Poly-Pro10

Domaini

The WH2 domain is found in a number of putative actin-binding proteins.By similarity
The profilin-binding motif has been implicated in the interaction with profilin and SH3 domains.By similarity
The KLKR motif is essential for G-actin binding and for actin polymerization.By similarity

Sequence similaritiesi

Belongs to the verprolin family.Curated

Phylogenomic databases

eggNOGiENOG410J09R Eukaryota
ENOG410Y0AH LUCA
GeneTreeiENSGT00910000144192
HOGENOMiHOG000090003
HOVERGENiHBG108677
InParanoidiA6NGB9
KOiK19475
OrthoDBiEOG091G0GSL
PhylomeDBiA6NGB9

Family and domain databases

InterProiView protein in InterPro
IPR003124 WH2_dom
PfamiView protein in Pfam
PF02205 WH2, 1 hit
SMARTiView protein in SMART
SM00246 WH2, 1 hit
PROSITEiView protein in PROSITE
PS51082 WH2, 1 hit

Sequencei

Sequence statusi: Complete.

A6NGB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVPPPPPPP LPPPPPPLGA PPPPPPSAPP VSTDTSSLRR ADPKGRSALL
60 70 80 90 100
ADIQQGTRLR KVTQINDRSA PQIESSKGTN KEGGGSANTR GASTPPTLGD
110 120 130 140 150
LFAGGFPVLR PAGQRDVAGG KTGQGPGSRA PSPRLPNKTI SGPLIPPASP
160 170 180 190 200
RLGNTSEAHG AARTAPPRPN VPAPPPPTPP PPPPPLPPPL PSSSPIKTPL
210 220 230 240 250
VSPPGPLTKG NLPVVAPPVP CAPPPPPPPP PPTPPPLPPA SVLSDKAVKP
260 270 280 290 300
QLAPLHLPPI PPPLPLLPPC GYPGLKAEPA SPAQDAQEPP APPPPLPPYA
310 320 330 340 350
SCSPRASLPA PPLPGVNSSS ETPPPLPPKS PSFQAPPQKA GAQALPAPPA
360 370 380 390 400
PPGSQPFLQK KRHGRPGAGG GKLNPPPAPP ARSPTTELSS KSQQATAWTP
410 420 430 440 450
TQQPGGQLRN GSLHIIDDFE SKFTFHSVED FPPPDEYKPC QKIYPSKIPR
460 470 480
SRTPGPWLQA EAVGQSSDDI KGRNSQLSLK TLR
Length:483
Mass (Da):49,458
Last modified:June 26, 2013 - v4
Checksum:i78A600C2FE4F9CCE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043729321E → G. Corresponds to variant dbSNP:rs3750092Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004912 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW93924.1
BX107905 mRNA No translation available.
CCDSiCCDS56472.1
RefSeqiNP_001073998.2, NM_001080529.2
UniGeneiHs.380698

Genome annotation databases

EnsembliENST00000242140; ENSP00000242140; ENSG00000122574
ENST00000409290; ENSP00000386878; ENSG00000122574
GeneIDi644150
KEGGihsa:644150
UCSCiuc022aaz.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiWIPF3_HUMAN
AccessioniPrimary (citable) accession number: A6NGB9
Secondary accession number(s): B8ZZV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 26, 2013
Last modified: July 18, 2018
This is version 93 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health