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Protein

Ig-like V-type domain-containing protein FAM187A

Gene

FAM187A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Ig-like V-type domain-containing protein FAM187A
Gene namesi
Name:FAM187A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000214447.4
HGNCiHGNC:35153 FAM187A
neXtProtiNX_A6NFU0

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 376ExtracellularSequence analysisAdd BLAST359
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Topological domaini398 – 413CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000034065418 – 413Ig-like V-type domain-containing protein FAM187AAdd BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi289 ↔ 345PROSITE-ProRule annotation
Glycosylationi317N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NFU0
PRIDEiA6NFU0
ProteomicsDBi1077

Expressioni

Gene expression databases

BgeeiENSG00000214447
GenevisibleiA6NFU0 HS

Organism-specific databases

HPAiHPA022794

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000329499

Structurei

3D structure databases

ProteinModelPortaliA6NFU0
SMRiA6NFU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini267 – 361Ig-like V-typeAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi398 – 408Cys-richAdd BLAST11

Sequence similaritiesi

Belongs to the FAM187 family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE2U Eukaryota
ENOG410XNRD LUCA
GeneTreeiENSGT00390000004038
HOGENOMiHOG000155662
HOVERGENiHBG108742
InParanoidiA6NFU0
OMAiSMRVFID
OrthoDBiEOG091G07MV
PhylomeDBiA6NFU0
TreeFamiTF332178

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR039311 FAM187A/B
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013106 Ig_V-set
PANTHERiPTHR32178 PTHR32178, 1 hit
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6NFU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLALTTVLL WAWGLQAFEI VEKENIFQRT PCPAFLMFEN AAYLADMSFE
60 70 80 90 100
LPCHCKPEEV PAVVWFYQKH LGSSHTKVLT DFDGRVLTEA AQVRVGSDML
110 120 130 140 150
TRFSIRMFSL LVFRAQSEDS GLYFCGTRKG DYFYAYDVDI QNSEGMVATF
160 170 180 190 200
QDKGQEPFAD EYYGHLHVFT TFWEWTPCDR CGVRGEQWRI GLCYLQSPDL
210 220 230 240 250
SPRYLKAVPD VVSCGSRAVP RKLRTKARDH TPEVLVRSCL VPCEKTKTIR
260 270 280 290 300
EGVLAIINYV SKVGSRPWVP QVPIQFHQQR LGHGLIISCP GARPEHAVAW
310 320 330 340 350
DKDRQHLYRT QYLKGVNRSM RVFIDHGNQL HIRFTQLDDR GIYYCWRQGV
360 370 380 390 400
LVAGFRLGVT SHGHYPASFS DPETRSAVEL TLIGYLLITA VFVTIHFCRC
410
CCYLFHCCPS FSP
Length:413
Mass (Da):47,349
Last modified:July 24, 2007 - v1
Checksum:i580178965D3F9631
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015936 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000331733; ENSP00000329499; ENSG00000214447
UCSCiuc002ihp.2 human

Similar proteinsi

Entry informationi

Entry nameiF187A_HUMAN
AccessioniPrimary (citable) accession number: A6NFU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 24, 2007
Last modified: July 18, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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