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Protein

Cilia- and flagella-associated protein 73

Gene

CFAP73

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cilia- and flagella-associated protein 73Curated
Alternative name(s):
Coiled-coil domain-containing protein 42BImported
Gene namesi
Name:CFAP73Imported
Synonyms:CCDC42BImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000186710.11
HGNCiHGNC:37100 CFAP73
neXtProtiNX_A6NFT4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186710

Polymorphism and mutation databases

BioMutaiCCDC42B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003437151 – 308Cilia- and flagella-associated protein 73Add BLAST308

Proteomic databases

PaxDbiA6NFT4
PRIDEiA6NFT4
ProteomicsDBi1076

Expressioni

Gene expression databases

BgeeiENSG00000186710 Expressed in 147 organ(s), highest expression level in right uterine tube
ExpressionAtlasiA6NFT4 baseline and differential
GenevisibleiA6NFT4 HS

Organism-specific databases

HPAiHPA048539

Interactioni

Protein-protein interaction databases

IntActiA6NFT4, 1 interactor
MINTiA6NFT4

Structurei

3D structure databases

ProteinModelPortaliA6NFT4
SMRiA6NFT4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili34 – 143Sequence analysisAdd BLAST110
Coiled coili175 – 233Sequence analysisAdd BLAST59

Sequence similaritiesi

Belongs to the CFAP73 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG5M Eukaryota
ENOG4111NGK LUCA
GeneTreeiENSGT00390000018178
HOGENOMiHOG000067751
HOVERGENiHBG058037
InParanoidiA6NFT4
OMAiNLFQLVC
OrthoDBiEOG091G0B7C
PhylomeDBiA6NFT4
TreeFamiTF327270

Family and domain databases

InterProiView protein in InterPro
IPR025252 DUF4200
PfamiView protein in Pfam
PF13863 DUF4200, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A6NFT4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVPWEEYFR LALQEKLSTK LPEQAEDHVP PVLRLLEKRQ ELVDADQALQ
60 70 80 90 100
AQKEVFRTKT AALKQRWEQL EQKERELKGS FIRFDKFLQD SEARRNRALR
110 120 130 140 150
RAAEERHQAG RREVEALRLW TQLQELRREH ARLQRRLKRL EPCARLLEQA
160 170 180 190 200
LELLPGFQEV PELVARFDGL AETQAALRLR EREQLAELEA ARARLQQLRD
210 220 230 240 250
AWPDEVLAQG QRRAQLQERL EAARERTLQW ESKWIQIQNT AAEKTLLLGR
260 270 280 290 300
SRMAVLNLFQ LVCQHQGQPP TLDIEDTEGQ LEHVKLFMQD LSAMLAGLGQ

AEPAAPAS
Length:308
Mass (Da):35,914
Last modified:January 11, 2011 - v3
Checksum:iBB0972AFC8C8B077
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YHK5H0YHK5_HUMAN
Cilia- and flagella-associated prot...
CFAP73
124Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC089999 Genomic DNA No translation available.
EG327787 mRNA No translation available.
CCDSiCCDS44983.1
RefSeqiNP_001138344.1, NM_001144872.1
UniGeneiHs.486856

Genome annotation databases

EnsembliENST00000335621; ENSP00000333915; ENSG00000186710
GeneIDi387885
KEGGihsa:387885
UCSCiuc010sys.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC089999 Genomic DNA No translation available.
EG327787 mRNA No translation available.
CCDSiCCDS44983.1
RefSeqiNP_001138344.1, NM_001144872.1
UniGeneiHs.486856

3D structure databases

ProteinModelPortaliA6NFT4
SMRiA6NFT4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA6NFT4, 1 interactor
MINTiA6NFT4

Polymorphism and mutation databases

BioMutaiCCDC42B

Proteomic databases

PaxDbiA6NFT4
PRIDEiA6NFT4
ProteomicsDBi1076

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335621; ENSP00000333915; ENSG00000186710
GeneIDi387885
KEGGihsa:387885
UCSCiuc010sys.2 human

Organism-specific databases

CTDi387885
EuPathDBiHostDB:ENSG00000186710.11
GeneCardsiCFAP73
HGNCiHGNC:37100 CFAP73
HPAiHPA048539
neXtProtiNX_A6NFT4
OpenTargetsiENSG00000186710
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG5M Eukaryota
ENOG4111NGK LUCA
GeneTreeiENSGT00390000018178
HOGENOMiHOG000067751
HOVERGENiHBG058037
InParanoidiA6NFT4
OMAiNLFQLVC
OrthoDBiEOG091G0B7C
PhylomeDBiA6NFT4
TreeFamiTF327270

Miscellaneous databases

GenomeRNAii387885
PROiPR:A6NFT4

Gene expression databases

BgeeiENSG00000186710 Expressed in 147 organ(s), highest expression level in right uterine tube
ExpressionAtlasiA6NFT4 baseline and differential
GenevisibleiA6NFT4 HS

Family and domain databases

InterProiView protein in InterPro
IPR025252 DUF4200
PfamiView protein in Pfam
PF13863 DUF4200, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCFA73_HUMAN
AccessioniPrimary (citable) accession number: A6NFT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: January 11, 2011
Last modified: November 7, 2018
This is version 65 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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