UniProtKB - A6NFR2 (A6NFR2_HUMAN)
Protein
Voltage-dependent calcium channel gamma-6 subunit
Gene
CACNG6
Organism
Homo sapiens (Human)
Status
Functioni
Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit.UniRule annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
GO - Molecular functioni
- calcium channel activity Source: UniProtKB-KW
- voltage-gated ion channel activity Source: UniProtKB-KW
GO - Biological processi
- regulation of ion transmembrane transport Source: UniProtKB-KW
Keywordsi
Molecular function | Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: Voltage-dependent calcium channel gamma-6 subunitUniRule annotation |
Gene namesi | Name:CACNG6Imported ORF Names:hCG_1648888Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13625, CACNG6 |
VEuPathDBi | HostDB:ENSG00000130433.7 |
Subcellular locationi
Other locations
- Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 41 – 63 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 173 – 195 | HelicalUniRule annotationAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000130433, Expressed in quadriceps femoris and 123 other tissues |
ExpressionAtlasi | A6NFR2, baseline and differential |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 14 – 33 | DisorderedSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationPhylogenomic databases
GeneTreei | ENSGT00390000007786 |
HOGENOMi | CLU_093876_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR004031, PMP22/EMP/MP20/Claudin IPR008370, VDCC_g6su IPR008368, VDCC_gsu |
Pfami | View protein in Pfam PF13903, Claudin_2, 1 hit |
PRINTSi | PR01792, VDCCGAMMA PR01794, VDCCGAMMA6 |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
A6NFR2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMWSNFFLQE ENRRRGAAGR RRAHGQGRSG LTPEREGKVK LALLLAAVGA
60 70 80 90 100
TLAVLSVGTE FWVELNTYKA NGSAVCEAAH LGLWKACTKR LWQADVPVDR
110 120 130 140 150
DTCGPAELPG EANCTYFKFF TTGENARIFQ RTTKKGLLLL VSLEVFRHSV
160 170 180 190 200
RALLQRVSPE PPPAPRLTYE YSWSLGCGVG AGLILLLGAG CFLLLTLPSW
210
PWGSLCPKRG HRAT
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9BXT2 | CCG6_HUMAN | Voltage-dependent calcium channel g... | CACNG6 | 260 | Annotation score: | ||
A6NP74 | A6NP74_HUMAN | Calcium channel, voltage-dependent,... | CACNG6 hCG_1648888 | 189 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008440 Genomic DNA No translation available. CH471135 Genomic DNA Translation: EAW72171.1 |
RefSeqi | NP_665814.1, NM_145815.1 |
Genome annotation databases
Ensembli | ENST00000346968; ENSP00000319097; ENSG00000130433 |
GeneIDi | 59285 |
UCSCi | uc002qcu.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008440 Genomic DNA No translation available. CH471135 Genomic DNA Translation: EAW72171.1 |
RefSeqi | NP_665814.1, NM_145815.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PRIDEi | A6NFR2 |
ProteomicsDBi | 1069 |
Protocols and materials databases
Antibodypediai | 32772, 117 antibodies |
DNASUi | 59285 |
Genome annotation databases
Ensembli | ENST00000346968; ENSP00000319097; ENSG00000130433 |
GeneIDi | 59285 |
UCSCi | uc002qcu.4, human |
Organism-specific databases
CTDi | 59285 |
HGNCi | HGNC:13625, CACNG6 |
OpenTargetsi | ENSG00000130433 |
PharmGKBi | PA26020 |
VEuPathDBi | HostDB:ENSG00000130433.7 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000007786 |
HOGENOMi | CLU_093876_0_0_1 |
Miscellaneous databases
BioGRID-ORCSi | 59285, 16 hits in 981 CRISPR screens |
ChiTaRSi | CACNG6, human |
GenomeRNAii | 59285 |
Gene expression databases
Bgeei | ENSG00000130433, Expressed in quadriceps femoris and 123 other tissues |
ExpressionAtlasi | A6NFR2, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR004031, PMP22/EMP/MP20/Claudin IPR008370, VDCC_g6su IPR008368, VDCC_gsu |
Pfami | View protein in Pfam PF13903, Claudin_2, 1 hit |
PRINTSi | PR01792, VDCCGAMMA PR01794, VDCCGAMMA6 |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A6NFR2_HUMAN | |
Accessioni | A6NFR2Primary (citable) accession number: A6NFR2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 24, 2007 |
Last sequence update: | July 24, 2007 | |
Last modified: | April 7, 2021 | |
This is version 103 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |