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Protein

RNA binding protein fox-1 homolog 3

Gene

RBFOX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD).By similarity

GO - Molecular functioni

  • DNA binding Source: Ensembl
  • mRNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA binding protein fox-1 homolog 3
Alternative name(s):
Fox-1 homolog C
Neuronal nuclei antigen
Short name:
NeuN antigen
Gene namesi
Name:RBFOX3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000167281.18
HGNCiHGNC:27097 RBFOX3
MIMi616999 gene
neXtProtiNX_A6NFN3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi146713
MalaCardsiRBFOX3
OpenTargetsiENSG00000167281

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003492071 – 312RNA binding protein fox-1 homolog 3Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei223Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei223Omega-N-methylarginine; alternateBy similarity1
Modified residuei272Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

EPDiA6NFN3
MaxQBiA6NFN3
PaxDbiA6NFN3
PRIDEiA6NFN3
ProteomicsDBi1060

PTM databases

iPTMnetiA6NFN3
PhosphoSitePlusiA6NFN3

Expressioni

Gene expression databases

BgeeiENSG00000167281 Expressed in 111 organ(s), highest expression level in cerebellar vermis
ExpressionAtlasiA6NFN3 baseline and differential

Organism-specific databases

HPAiCAB078782
HPA030790

Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei100Interaction with RNABy similarity1
Sitei108Interaction with RNABy similarity1
Sitei109Interaction with RNABy similarity1
Sitei133Interaction with RNABy similarity1
Sitei138Interaction with RNABy similarity1
Sitei142Interaction with RNABy similarity1
Sitei166Interaction with RNABy similarity1
Sitei176Interaction with RNABy similarity1

Protein-protein interaction databases

BioGridi127004, 11 interactors
STRINGi9606.ENSP00000393262

Structurei

3D structure databases

ProteinModelPortaliA6NFN3
SMRiA6NFN3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 175RRMPROSITE-ProRule annotationAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 40Pro-richAdd BLAST37
Compositional biasi277 – 282Poly-Ala6

Phylogenomic databases

eggNOGiKOG0125 Eukaryota
ENOG4111WJT LUCA
GeneTreeiENSGT00390000013767
HOGENOMiHOG000230971
HOVERGENiHBG000044
InParanoidiA6NFN3
KOiK14946
PhylomeDBiA6NFN3
TreeFamiTF315942

Family and domain databases

CDDicd12407 RRM_FOX1_like, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR025670 Fox-1_C_dom
IPR034237 FOX1_RRM
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR017325 RNA-bd_Fox-1
IPR000504 RRM_dom
PfamiView protein in Pfam
PF12414 Fox-1_C, 1 hit
PF00076 RRM_1, 1 hit
PIRSFiPIRSF037932 Ataxin_2_bd_A2BP, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A6NFN3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQPYPPAQY PPPPQNGIPA EYAPPPPHPT QDYSGQTPVP TEHGMTLYTP
60 70 80 90 100
AQTHPEQPGS EASTQPIAGT QTVPQTDEAA QTDSQPLHPS DPTEKQQPKR
110 120 130 140 150
LHVSNIPFRF RDPDLRQMFG QFGKILDVEI IFNERGSKGF GFVTFETSSD
160 170 180 190 200
ADRAREKLNG TIVEGRKIEV NNATARVMTN KKTGNPYTNG WKLNPVVGAV
210 220 230 240 250
YGPEFYAVTG FPYPTTGTAV AYRGAHLRGR GRAVYNTFRA APPPPPIPTY
260 270 280 290 300
GAVVYQDGFY GAEIYGGYAA YRYAQPAAAA AAYSDSYGRV YAAADPYHHT
310
IGPAATYSIG TM
Length:312
Mass (Da):33,873
Last modified:February 8, 2011 - v4
Checksum:i62D564F8A7862862
GO
Isoform 2 (identifier: A6NFN3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-312: M → MVRSPGPPSPGCQS

Note: No experimental confirmation available.
Show »
Length:325
Mass (Da):35,123
Checksum:i53ECD61C4CC86F5B
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QRF4J3QRF4_HUMAN
RNA binding protein fox-1 homolog
RBFOX3
358Annotation score:
J3QQZ2J3QQZ2_HUMAN
RNA binding protein fox-1 homolog
RBFOX3
328Annotation score:
K7ESF7K7ESF7_HUMAN
RNA-binding protein fox-1 homolog 3
RBFOX3
131Annotation score:
K7EJX6K7EJX6_HUMAN
RNA-binding protein fox-1 homolog 3
RBFOX3
75Annotation score:
K7EQK7K7EQK7_HUMAN
RNA-binding protein fox-1 homolog 3
RBFOX3
52Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056241312M → MVRSPGPPSPGCQS in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293617 mRNA Translation: BAG57077.1
AK293905 mRNA Translation: BAG57290.1
AC020689 Genomic DNA No translation available.
AC021534 Genomic DNA No translation available.
AC027824 Genomic DNA No translation available.
AC055858 Genomic DNA No translation available.
AC073624 Genomic DNA No translation available.
AC142247 Genomic DNA No translation available.
CCDSiCCDS45805.1 [A6NFN3-1]
RefSeqiNP_001076044.1, NM_001082575.2 [A6NFN3-1]
XP_016879699.1, XM_017024210.1 [A6NFN3-1]
UniGeneiHs.135229
Hs.574437

Genome annotation databases

EnsembliENST00000580155; ENSP00000463653; ENSG00000167281 [A6NFN3-1]
ENST00000584778; ENSP00000462007; ENSG00000167281 [A6NFN3-2]
GeneIDi146713
KEGGihsa:146713
UCSCiuc010dhs.5 human [A6NFN3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293617 mRNA Translation: BAG57077.1
AK293905 mRNA Translation: BAG57290.1
AC020689 Genomic DNA No translation available.
AC021534 Genomic DNA No translation available.
AC027824 Genomic DNA No translation available.
AC055858 Genomic DNA No translation available.
AC073624 Genomic DNA No translation available.
AC142247 Genomic DNA No translation available.
CCDSiCCDS45805.1 [A6NFN3-1]
RefSeqiNP_001076044.1, NM_001082575.2 [A6NFN3-1]
XP_016879699.1, XM_017024210.1 [A6NFN3-1]
UniGeneiHs.135229
Hs.574437

3D structure databases

ProteinModelPortaliA6NFN3
SMRiA6NFN3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127004, 11 interactors
STRINGi9606.ENSP00000393262

PTM databases

iPTMnetiA6NFN3
PhosphoSitePlusiA6NFN3

Proteomic databases

EPDiA6NFN3
MaxQBiA6NFN3
PaxDbiA6NFN3
PRIDEiA6NFN3
ProteomicsDBi1060

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000580155; ENSP00000463653; ENSG00000167281 [A6NFN3-1]
ENST00000584778; ENSP00000462007; ENSG00000167281 [A6NFN3-2]
GeneIDi146713
KEGGihsa:146713
UCSCiuc010dhs.5 human [A6NFN3-1]

Organism-specific databases

CTDi146713
DisGeNETi146713
EuPathDBiHostDB:ENSG00000167281.18
GeneCardsiRBFOX3
HGNCiHGNC:27097 RBFOX3
HPAiCAB078782
HPA030790
MalaCardsiRBFOX3
MIMi616999 gene
neXtProtiNX_A6NFN3
OpenTargetsiENSG00000167281
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0125 Eukaryota
ENOG4111WJT LUCA
GeneTreeiENSGT00390000013767
HOGENOMiHOG000230971
HOVERGENiHBG000044
InParanoidiA6NFN3
KOiK14946
PhylomeDBiA6NFN3
TreeFamiTF315942

Miscellaneous databases

ChiTaRSiRBFOX3 human
GenomeRNAii146713
PROiPR:A6NFN3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167281 Expressed in 111 organ(s), highest expression level in cerebellar vermis
ExpressionAtlasiA6NFN3 baseline and differential

Family and domain databases

CDDicd12407 RRM_FOX1_like, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR025670 Fox-1_C_dom
IPR034237 FOX1_RRM
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR017325 RNA-bd_Fox-1
IPR000504 RRM_dom
PfamiView protein in Pfam
PF12414 Fox-1_C, 1 hit
PF00076 RRM_1, 1 hit
PIRSFiPIRSF037932 Ataxin_2_bd_A2BP, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRFOX3_HUMAN
AccessioniPrimary (citable) accession number: A6NFN3
Secondary accession number(s): B4DEG6, B4DF29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: February 8, 2011
Last modified: November 7, 2018
This is version 89 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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