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Entry version 74 (13 Feb 2019)
Sequence version 2 (11 Jan 2011)
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Protein

Single-pass membrane and coiled-coil domain-containing protein 2

Gene

SMCO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Single-pass membrane and coiled-coil domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SMCO2
Synonyms:C12orf70
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000165935.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:34448 SMCO2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6NFE2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei284 – 304HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000165935

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SMCO2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003406991 – 343Single-pass membrane and coiled-coil domain-containing protein 2Add BLAST343

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A6NFE2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A6NFE2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A6NFE2

PRoteomics IDEntifications database

More...
PRIDEi
A6NFE2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
1045

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6NFE2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A6NFE2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165935 Expressed in 75 organ(s), highest expression level in lower esophagus mucosa

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A6NFE2 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA014366

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000387617

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A6NFE2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili152 – 238Sequence analysisAdd BLAST87

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IKWD Eukaryota
ENOG41115SD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153380

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111772

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG101057

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6NFE2

Identification of Orthologs from Complete Genome Data

More...
OMAi
MWELREI

Database of Orthologous Groups

More...
OrthoDBi
1093587at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A6NFE2

TreeFam database of animal gene trees

More...
TreeFami
TF338250

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026617 SMCO2/5

The PANTHER Classification System

More...
PANTHERi
PTHR22422 PTHR22422, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14992 TMCO5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A6NFE2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALTPTNLNN KMSLQMKMDC QEQQLTKKNN GFFQKLNVTE GAMQDLLKEI
60 70 80 90 100
IKVDHILDRS DDEDDISSEN PQTDFLHKGM LELEAEHDQD LSKQDKQETD
110 120 130 140 150
VDEDPQASTS LQFSKKNLLE LCLKGMFLKL NYWNTKIGLQ VKELGADYID
160 170 180 190 200
GTEKIDNIIK KINVTENTVK SLLKDMLTLK GQIEKLEDRG LDLDQGTSTE
210 220 230 240 250
VNTCNEVYEL KKKVIERLED LCKNVELLSA KLRMYQMEAE DTDSHSSEEI
260 270 280 290 300
DTEEMEALLP QAPASFLVQK SPPRNTAWKR ALRIFIMFDV LTVTGLLCYI
310 320 330 340
LFFGATFLFE RVLLRMLGCR TTWDLREMRE PFLNLEVEAL LPS
Length:343
Mass (Da):39,487
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i80CF8FAD3758B66B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KNC3J3KNC3_HUMAN
Single-pass membrane and coiled-coi...
SMCO2
293Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti129K → M in DY654457 (Ref. 2) Curated1
Sequence conflicti165T → P in DY654457 (Ref. 2) Curated1
Sequence conflicti175D → E in DY654457 (Ref. 2) Curated1
Sequence conflicti180K → R in DY654457 (Ref. 2) Curated1
Sequence conflicti198 – 199ST → CA in DY654457 (Ref. 2) Curated2
Sequence conflicti212K → N in DY654457 (Ref. 2) Curated1
Sequence conflicti216E → Q in DY654457 (Ref. 2) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC068794 Genomic DNA No translation available.
DY654457 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44852.1

NCBI Reference Sequences

More...
RefSeqi
NP_001138482.1, NM_001145010.1
XP_011518936.1, XM_011520634.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.282121

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000416383; ENSP00000387617; ENSG00000165935
ENST00000535986; ENSP00000441688; ENSG00000165935

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
341346

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:341346

UCSC genome browser

More...
UCSCi
uc010sjq.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068794 Genomic DNA No translation available.
DY654457 mRNA No translation available.
CCDSiCCDS44852.1
RefSeqiNP_001138482.1, NM_001145010.1
XP_011518936.1, XM_011520634.2
UniGeneiHs.282121

3D structure databases

ProteinModelPortaliA6NFE2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000387617

PTM databases

iPTMnetiA6NFE2
PhosphoSitePlusiA6NFE2

Polymorphism and mutation databases

BioMutaiSMCO2

Proteomic databases

EPDiA6NFE2
jPOSTiA6NFE2
PaxDbiA6NFE2
PRIDEiA6NFE2
ProteomicsDBi1045

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000416383; ENSP00000387617; ENSG00000165935
ENST00000535986; ENSP00000441688; ENSG00000165935
GeneIDi341346
KEGGihsa:341346
UCSCiuc010sjq.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
341346
EuPathDBiHostDB:ENSG00000165935.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SMCO2
HGNCiHGNC:34448 SMCO2
HPAiHPA014366
neXtProtiNX_A6NFE2
OpenTargetsiENSG00000165935

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IKWD Eukaryota
ENOG41115SD LUCA
GeneTreeiENSGT00940000153380
HOGENOMiHOG000111772
HOVERGENiHBG101057
InParanoidiA6NFE2
OMAiMWELREI
OrthoDBi1093587at2759
PhylomeDBiA6NFE2
TreeFamiTF338250

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
341346

Protein Ontology

More...
PROi
PR:A6NFE2

Gene expression databases

BgeeiENSG00000165935 Expressed in 75 organ(s), highest expression level in lower esophagus mucosa
ExpressionAtlasiA6NFE2 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR026617 SMCO2/5
PANTHERiPTHR22422 PTHR22422, 1 hit
PfamiView protein in Pfam
PF14992 TMCO5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMCO2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NFE2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 11, 2011
Last modified: February 13, 2019
This is version 74 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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