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Protein

Putative olfactory receptor 2W5

Gene

OR2W5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Odorant receptor.Curated

Caution

Could be the product of a pseudogene.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Putative olfactory receptor 2W5
Gene namesi
Name:OR2W5
Synonyms:OR2W5P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:15424 OR2W5
neXtProtiNX_A6NFC9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32218

Polymorphism and mutation databases

BioMutaiOR2W5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003454181 – 320Putative olfactory receptor 2W5Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiA6NFC9
ProteomicsDBi1041

PTM databases

iPTMnetiA6NFC9
PhosphoSitePlusiA6NFC9

Expressioni

Gene expression databases

CleanExiHS_OR2W5

Structurei

3D structure databases

ProteinModelPortaliA6NFC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiA6NFC9
PhylomeDBiA6NFC9

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

A6NFC9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKDNASYLQ AFILVGSSDR PGLEKILFAV ILIFCILTLV GNTAIILLLV
60 70 80 90 100
MDVRLHTPMY FFLGNLSFLD LCFTASIAPQ LLWNLGGPEK TITYHGCVAQ
110 120 130 140 150
LYIYMMLGST ECVLLVVMSH DRYVAVCRSL HYMAVMRPHL CLQLVTVAWC
160 170 180 190 200
CGFLNSFIMC PQTMQLSRCG RRRVDHFLCE MPALIAMSCE ETMLVEAIHL
210 220 230 240 250
CPGGGSPPGA ALPHPHLLWR DCSRGAEDEV SSRAKESLPH LLFSPHSGLS
260 270 280 290 300
LLRNHHLRVP EAGQQLLPRS GEVPDSLLHH RHSQHQPPHL HFEEQGCEGD
310 320
HEETSGVGER GWGASTRGTL
Length:320
Mass (Da):35,528
Last modified:July 24, 2007 - v1
Checksum:iBB7F97B2C06564D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606804 Genomic DNA No translation available.
BC137203 mRNA Translation: AAI37204.1
BC137204 mRNA Translation: AAI37205.1
RefSeqiNP_001004698.1, NM_001004698.2
UniGeneiHs.591526

Genome annotation databases

GeneIDi441932
KEGGihsa:441932

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606804 Genomic DNA No translation available.
BC137203 mRNA Translation: AAI37204.1
BC137204 mRNA Translation: AAI37205.1
RefSeqiNP_001004698.1, NM_001004698.2
UniGeneiHs.591526

3D structure databases

ProteinModelPortaliA6NFC9
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiA6NFC9
PhosphoSitePlusiA6NFC9

Polymorphism and mutation databases

BioMutaiOR2W5

Proteomic databases

PRIDEiA6NFC9
ProteomicsDBi1041

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi441932
KEGGihsa:441932

Organism-specific databases

CTDi441932
GeneCardsiOR2W5
HGNCiHGNC:15424 OR2W5
neXtProtiNX_A6NFC9
PharmGKBiPA32218
GenAtlasiSearch...

Phylogenomic databases

InParanoidiA6NFC9
PhylomeDBiA6NFC9

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GenomeRNAii441932

Gene expression databases

CleanExiHS_OR2W5

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR2W5_HUMAN
AccessioniPrimary (citable) accession number: A6NFC9
Secondary accession number(s): B9EH85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 24, 2007
Last modified: June 20, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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