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Entry version 82 (13 Feb 2019)
Sequence version 4 (29 Apr 2015)
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Protein

Maestro heat-like repeat-containing protein family member 2A

Gene

MROH2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Maestro heat-like repeat-containing protein family member 2A
Alternative name(s):
HEAT repeat-containing protein 7B1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MROH2A
Synonyms:HEATR7B1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000185038.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27936 MROH2A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6NES4

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
339766

Open Targets

More...
OpenTargetsi
ENSG00000185038

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164720351

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MROH2A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003480531 – 1674Maestro heat-like repeat-containing protein family member 2AAdd BLAST1674

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A6NES4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A6NES4

PRoteomics IDEntifications database

More...
PRIDEi
A6NES4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
1010

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6NES4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A6NES4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185038 Expressed in 47 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A6NES4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A6NES4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA052107

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
A6NES4, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A6NES4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati73 – 96HEAT 1Add BLAST24
Repeati97 – 133HEAT 2Add BLAST37
Repeati195 – 234HEAT 3Add BLAST40
Repeati254 – 292HEAT 4Add BLAST39
Repeati382 – 419HEAT 5Add BLAST38
Repeati424 – 461HEAT 6Add BLAST38
Repeati573 – 612HEAT 7Add BLAST40
Repeati615 – 641HEAT 8Add BLAST27
Repeati642 – 679HEAT 9Add BLAST38
Repeati739 – 776HEAT 10Add BLAST38
Repeati993 – 1030HEAT 11Add BLAST38
Repeati1221 – 1263HEAT 12Add BLAST43
Repeati1381 – 1420HEAT 13Add BLAST40
Repeati1627 – 1674HEAT 14Add BLAST48

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2032 Eukaryota
ENOG410XQE8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161309

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000169806

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG100015

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6NES4

TreeFam database of animal gene trees

More...
TreeFami
TF315201

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A6NES4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEAITEAAV ASSEEVSEER DDLGPLELHD SGTFQQVVNL LDIIDSESAK
60 70 80 90 100
TDTTGAGLDM RKTLASVIIM EKATTEPSVV INTLIRCLQV PEISTQRKVN
110 120 130 140 150
IYNILQDIIQ QEGELEEQCV QRLVAIASKE MREIPEMEGY MKAEVASDTL
160 170 180 190 200
VALSRNHFSL VMYELQHHLK PLNLTDEFVI ITLAKLANGN VFEFMPYMGI
210 220 230 240 250
TLATIFTMLR LANEAKIRQA ICSAMETFCE TVQFYLKHLE ESVYPVMTEE
260 270 280 290 300
EFALKVFPMY RYFVTVWLRH YNPEVKLGVI KSLKPMLGLL LPNDDLREQV
310 320 330 340 350
YDYIPLLLAE YQGSLEVLFV TQVLRQILEL SVTTNTPVPQ MQLHTIFTEL
360 370 380 390 400
HVQVCNKAPA QHQYSSQNLM EMVHCFVALA RSYPKELMKF FFSQMETNKE
410 420 430 440 450
AVRVGTLNLI RAIVSADEPR MSIRAIYLAI RVVKNTISDT RSKVRMAILH
460 470 480 490 500
IIGQLALCGY QERIKGWGLK YLSVQLTLST YKLTNRREKF YQRDLEERMV
510 520 530 540 550
HKVTMDTVKI ITSSVSGMTT EFWVRLLCYI METDYVEALT PICISLTNLA
560 570 580 590 600
EHQLHGQDVD VSVAGKSRQV DLPAPQKLLA RLLVLMSSPY KGEGRGIAML
610 620 630 640 650
NLLRTLSQSI APSMADMWEL EIALLVRYLE EHTEFTWDQK AWEDKLIQFL
660 670 680 690 700
RNSLKKTRGS SWSLRLSKEL NNQIASFDSP SLEKGFLYRA LGFTLATGLE
710 720 730 740 750
ASKVEVLLLE LLYKTDYSND FDSEGVIMCF GLCARGQVKT VLNVLHDFEE
760 770 780 790 800
RIQESEQSWQ ISAWRKDHPW RRETVKSALM VMYSCVASYC HPQLLLNLVD
810 820 830 840 850
SPITAKIIHH YVSSCQDICL KMAFMKSVVQ VTKAINNIKD LEDFHFAQKT
860 870 880 890 900
TLTSIIVAVI KAEPTDNLVS PVRALAMEAL SHLSKLKPFY STEENSELMD
910 920 930 940 950
ISIHSVISLQ LPGEDNESIK TLYANALSSL EQLMESLLQR QLDPKGLQEM
960 970 980 990 1000
VQLLEKWILS EKEWEREKAV SLHLYLMWIY VHSTAVCIHL KLGQFGTMVG
1010 1020 1030 1040 1050
LIAPCTCDAH QRTRMASMNV LSSLLDLHAS QTCSLWGPSK QKELEKCKGD
1060 1070 1080 1090 1100
LQSTDVEKIF CASSRIAKVV CMEFSCDEVV SLIQKLCENT GAMNLQHDKA
1110 1120 1130 1140 1150
SVTWIAFFLQ MRAKELEDKV AEILSAILVH LPVVDHPEVR RLLIDGILLL
1160 1170 1180 1190 1200
AHHHQETILT SLLRQPLPME SHLAEVWLAV SENVPFARTM LHSLMGRLQS
1210 1220 1230 1240 1250
RLSPRISATS KADIWRLAAV DPLMTLCTIH LLIQKLDEND KLPDFLPDLI
1260 1270 1280 1290 1300
YTLLLQLGSS HRPEAAPPVL KMWKLVHTTP LPEEMNLQRV TIKSMQLLFK
1310 1320 1330 1340 1350
RVKSQHLAHT LDEQAVWDLL QDGGTFLEGV SLLARLCMQH VEGHRQRLAE
1360 1370 1380 1390 1400
LVLRGMDSEV LSCRISSTAV CFMSGPVLYQ EKLLKPAALL LEKGADQEED
1410 1420 1430 1440 1450
EALRVLSLRA LGNMALGAPK KVKQYRKVLL EKCLGPLREP VSNSVTAEGM
1460 1470 1480 1490 1500
EALTKILAEL REGDVGSSFD AMSEQCRIFF DNESELLRLK AFILFGKLAR
1510 1520 1530 1540 1550
VVGMSKKHFF KGEVKKAWIP LMLHSQDPCS NAAQACMATM FQCVHFWGWK
1560 1570 1580 1590 1600
SLEHPSGPSD TATDDKMTVF QTTMCSILTR KKPAVLYRFL LETMAYVKNN
1610 1620 1630 1640 1650
LSRIRIAACN LAGIIMKQMS THYLKKLDFP ALRNSLQELQ LDPDPGVRRA
1660 1670
ALETLTVLDS CSQHGFLASP QGMS
Length:1,674
Mass (Da):189,561
Last modified:April 29, 2015 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5A72297556939F44
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WT58A0A087WT58_HUMAN
Maestro heat-like repeat-containing...
MROH2A
1,688Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IYW5C9IYW5_HUMAN
Maestro heat-like repeat-containing...
MROH2A
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RMP9A0A1D5RMP9_HUMAN
Maestro heat-like repeat-containing...
MROH2A
9Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04607311A → D. Corresponds to variant dbSNP:rs6431631Ensembl.1
Natural variantiVAR_046074271Y → H. Corresponds to variant dbSNP:rs1500481Ensembl.1
Natural variantiVAR_046075329E → G. Corresponds to variant dbSNP:rs2361503Ensembl.1
Natural variantiVAR_046076489K → N. Corresponds to variant dbSNP:rs11563246Ensembl.1
Natural variantiVAR_046077978W → R. Corresponds to variant dbSNP:rs726016Ensembl.1
Natural variantiVAR_0460781041Q → E. Corresponds to variant dbSNP:rs719418Ensembl.1
Natural variantiVAR_0460791075S → T. Corresponds to variant dbSNP:rs17864722Ensembl.1
Natural variantiVAR_0460801107F → S. Corresponds to variant dbSNP:rs1500480Ensembl.1
Natural variantiVAR_0460811141R → C. Corresponds to variant dbSNP:rs28900688Ensembl.1
Natural variantiVAR_0460821184V → M. Corresponds to variant dbSNP:rs6734083Ensembl.1
Natural variantiVAR_0460851410A → T. Corresponds to variant dbSNP:rs28900693Ensembl.1
Natural variantiVAR_0460861454T → A. Corresponds to variant dbSNP:rs28900694Ensembl.1
Natural variantiVAR_0460871537M → V. Corresponds to variant dbSNP:rs11563074Ensembl.1
Natural variantiVAR_0460881546F → L. Corresponds to variant dbSNP:rs28900700Ensembl.1
Natural variantiVAR_0460891562A → T. Corresponds to variant dbSNP:rs879665Ensembl.1
Natural variantiVAR_0460901569V → I. Corresponds to variant dbSNP:rs879664Ensembl.1
Natural variantiVAR_0460911643P → L. Corresponds to variant dbSNP:rs2270856Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC005538 Genomic DNA No translation available.
AC006985 Genomic DNA No translation available.

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.361778
Hs.736887

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000389758; ENSP00000374408; ENSG00000185038

UCSC genome browser

More...
UCSCi
uc061tvx.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005538 Genomic DNA No translation available.
AC006985 Genomic DNA No translation available.
UniGeneiHs.361778
Hs.736887

3D structure databases

ProteinModelPortaliA6NES4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA6NES4, 1 interactor

PTM databases

iPTMnetiA6NES4
PhosphoSitePlusiA6NES4

Polymorphism and mutation databases

BioMutaiMROH2A

Proteomic databases

jPOSTiA6NES4
PaxDbiA6NES4
PRIDEiA6NES4
ProteomicsDBi1010

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389758; ENSP00000374408; ENSG00000185038
UCSCiuc061tvx.1 human

Organism-specific databases

DisGeNETi339766
EuPathDBiHostDB:ENSG00000185038.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MROH2A
HGNCiHGNC:27936 MROH2A
HPAiHPA052107
neXtProtiNX_A6NES4
OpenTargetsiENSG00000185038
PharmGKBiPA164720351

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2032 Eukaryota
ENOG410XQE8 LUCA
GeneTreeiENSGT00940000161309
HOGENOMiHOG000169806
HOVERGENiHBG100015
InParanoidiA6NES4
TreeFamiTF315201

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A6NES4

Gene expression databases

BgeeiENSG00000185038 Expressed in 47 organ(s), highest expression level in liver
ExpressionAtlasiA6NES4 baseline and differential
GenevisibleiA6NES4 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRO2A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NES4
Secondary accession number(s): F8VUA0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: April 29, 2015
Last modified: February 13, 2019
This is version 82 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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