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Entry version 87 (08 May 2019)
Sequence version 1 (24 Jul 2007)
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Protein

Protein FAM181B

Gene

FAM181B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM181B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM181B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:28512 FAM181B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6NEQ2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000182103

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162387593

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM181B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003243021 – 426Protein FAM181BAdd BLAST426

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
A6NEQ2

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
A6NEQ2

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
A6NEQ2

PRoteomics IDEntifications database

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PRIDEi
A6NEQ2

ProteomicsDB human proteome resource

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ProteomicsDBi
1002

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
A6NEQ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
A6NEQ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000182103 Expressed in 114 organ(s), highest expression level in substantia nigra

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
A6NEQ2 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA066861

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000365295

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi120 – 217Ala-richAdd BLAST98
Compositional biasi177 – 275Gly-richAdd BLAST99
Compositional biasi300 – 388Pro-richAdd BLAST89

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM181 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IZ30 Eukaryota
ENOG4111N0D LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154730

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000035118

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A6NEQ2

Identification of Orthologs from Complete Genome Data

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OMAi
FTEPANC

Database of Orthologous Groups

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OrthoDBi
950012at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
A6NEQ2

TreeFam database of animal gene trees

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TreeFami
TF333276

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029359 FAM181

The PANTHER Classification System

More...
PANTHERi
PTHR33766 PTHR33766, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15238 FAM181, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A6NEQ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVQAALLST HPFVPFGFGG SPDGLGGAFG ALDKGCCFED DETGAPAGAL
60 70 80 90 100
LSGAEGGDVR EATRDLLSFI DSASSNIKLA LDKPGKSKRK VNHRKYLQKQ
110 120 130 140 150
IKRCSGLMGA APPGPPSPSA ADTPAKRPLA APSAPTVAAP AHGKAAPRRE
160 170 180 190 200
ASQAAAAASL QSRSLAALFD SLRHVPGGAE PAGGEVAAPA AGLGGAGTGG
210 220 230 240 250
AGGDVAGPAG ATAIPGARKV PLRARNLPPS FFTEPSRAGG GGCGPSGPDV
260 270 280 290 300
SLGDLEKGAE AVEFFELLGP DYGAGTEAAV LLAAEPLDVF PAGASVLRGP
310 320 330 340 350
PELEPGLFEP PPAVVGNLLY PEPWSVPGCS PTKKSPLTAP RGGLTLNEPL
360 370 380 390 400
SPLYPAAADS PGGEDGRGHL ASFAPFFPDC ALPPPPPPHQ VSYDYSAGYS
410 420
RTAYSSLWRS DGVWEGAPGE EGAHRD
Length:426
Mass (Da):42,657
Last modified:July 24, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3B3E0116C8029D16
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti394D → N in AAI50622 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039694186V → L. Corresponds to variant dbSNP:rs986097Ensembl.1
Natural variantiVAR_039695367R → P. Corresponds to variant dbSNP:rs6592081Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AP002796 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW75073.1
BC150621 mRNA Translation: AAI50622.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31648.1

NCBI Reference Sequences

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RefSeqi
NP_787081.2, NM_175885.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000329203; ENSP00000365295; ENSG00000182103

Database of genes from NCBI RefSeq genomes

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GeneIDi
220382

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:220382

UCSC genome browser

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UCSCi
uc001ozp.4 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002796 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW75073.1
BC150621 mRNA Translation: AAI50622.1
CCDSiCCDS31648.1
RefSeqiNP_787081.2, NM_175885.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000365295

PTM databases

iPTMnetiA6NEQ2
PhosphoSitePlusiA6NEQ2

Polymorphism and mutation databases

BioMutaiFAM181B

Proteomic databases

EPDiA6NEQ2
jPOSTiA6NEQ2
PaxDbiA6NEQ2
PRIDEiA6NEQ2
ProteomicsDBi1002

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329203; ENSP00000365295; ENSG00000182103
GeneIDi220382
KEGGihsa:220382
UCSCiuc001ozp.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
220382

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM181B

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0009983
HGNCiHGNC:28512 FAM181B
HPAiHPA066861
neXtProtiNX_A6NEQ2
OpenTargetsiENSG00000182103
PharmGKBiPA162387593

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IZ30 Eukaryota
ENOG4111N0D LUCA
GeneTreeiENSGT00940000154730
HOGENOMiHOG000035118
InParanoidiA6NEQ2
OMAiFTEPANC
OrthoDBi950012at2759
PhylomeDBiA6NEQ2
TreeFamiTF333276

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
220382

Protein Ontology

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PROi
PR:A6NEQ2

Gene expression databases

BgeeiENSG00000182103 Expressed in 114 organ(s), highest expression level in substantia nigra
GenevisibleiA6NEQ2 HS

Family and domain databases

InterProiView protein in InterPro
IPR029359 FAM181
PANTHERiPTHR33766 PTHR33766, 1 hit
PfamiView protein in Pfam
PF15238 FAM181, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF181B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NEQ2
Secondary accession number(s): B2RWP1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 24, 2007
Last modified: May 8, 2019
This is version 87 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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