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Entry version 66 (16 Jan 2019)
Sequence version 3 (09 Jan 2013)
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Protein

Golgin subfamily A member 6-like protein 4

Gene

GOLGA6L4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Golgin subfamily A member 6-like protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000184206.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27256 GOLGA6L4

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6NEF3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GOLGA6L4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003322641 – 574Golgin subfamily A member 6-like protein 4Add BLAST574

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A6NEF3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A6NEF3

PRoteomics IDEntifications database

More...
PRIDEi
A6NEF3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
981

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6NEF3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A6NEF3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184206 Expressed in 89 organ(s), highest expression level in left ovary

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A6NEF3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A6NEF3 HS

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A6NEF3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A6NEF3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili157 – 496Sequence analysisAdd BLAST340

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GOLGA6 family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4725 Eukaryota
ENOG410ZIE4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00910000144587

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000218631

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6NEF3

Identification of Orthologs from Complete Genome Data

More...
OMAi
VERIHEQ

Database of Orthologous Groups

More...
OrthoDBi
414384at7742

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A6NEF3

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026737 GOLGA6L
IPR024858 Golgin_A

The PANTHER Classification System

More...
PANTHERi
PTHR23143 PTHR23143, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15070 GOLGA2L5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A6NEF3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWPQPRFPPH PAMSEKTQQG KLAAAKKKLK AYWQRKSPGI PAGANRKKKI
60 70 80 90 100
NGSSPDTATS GGYHSPGDSA TGIYGEGRAS STTLEDLESQ YQELAVALDS
110 120 130 140 150
SSAIISQLTE NINSLVRTSK EEKKHEIHLV QKLGRSLFKL KNQTAEPLAP
160 170 180 190 200
EPPAGPSKVE QLQDETNHLR KELESVGRQL QAEVENNQML SLLNRRQEER
210 220 230 240 250
LREQEERLRE QEERLREQED RLHEQEERLR EQEERLCEQE ERLREHEERL
260 270 280 290 300
CEQEERLCEQ EERLREQEER LHEQEERLRE QEERLCEQEE RLREQEERLC
310 320 330 340 350
EQEERLREQE ERLCEQEKLP GQERLLEEVE KLLEQERRQE EQERLLERER
360 370 380 390 400
LLEEVEKLLE QERQQEEQER LLERERLLEE VEKLLEQERR QEEQERLLER
410 420 430 440 450
ERLLDEVEEL LDEVEELLEQ ERLRQQDERL WQQETLQELE RLRELERLRE
460 470 480 490 500
LERMLELGWE ALYEQRAEPR SGFEELNNEN KSTLQLEQQV KELKKSGGAE
510 520 530 540 550
EPRGSESAAA ARPVAGAPVP QGAWMCGQAG WTPQEHPGLS GEAVGTGEAA
560 570
GGAGEAACHS FRAAENRELN ITII
Length:574
Mass (Da):67,563
Last modified:January 9, 2013 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1B501FFBE38A1020
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQ80J3KQ80_HUMAN
Golgin subfamily A member 6-like pr...
GOLGA6L4
438Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YA86H0YA86_HUMAN
Golgin subfamily A member 6-like pr...
GOLGA6L4
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC136698 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS73774.1

NCBI Reference Sequences

More...
RefSeqi
NP_001254465.2, NM_001267536.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.498345
Hs.534573
Hs.742301

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000510439; ENSP00000421586; ENSG00000184206

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
643707

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:643707

UCSC genome browser

More...
UCSCi
uc059mrg.1 human

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136698 Genomic DNA No translation available.
CCDSiCCDS73774.1
RefSeqiNP_001254465.2, NM_001267536.2
UniGeneiHs.498345
Hs.534573
Hs.742301

3D structure databases

ProteinModelPortaliA6NEF3
SMRiA6NEF3
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiA6NEF3
PhosphoSitePlusiA6NEF3

Polymorphism and mutation databases

BioMutaiGOLGA6L4

Proteomic databases

jPOSTiA6NEF3
PaxDbiA6NEF3
PRIDEiA6NEF3
ProteomicsDBi981

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000510439; ENSP00000421586; ENSG00000184206
GeneIDi643707
KEGGihsa:643707
UCSCiuc059mrg.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
643707
EuPathDBiHostDB:ENSG00000184206.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GOLGA6L4
HGNCiHGNC:27256 GOLGA6L4
neXtProtiNX_A6NEF3

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4725 Eukaryota
ENOG410ZIE4 LUCA
GeneTreeiENSGT00910000144587
HOGENOMiHOG000218631
InParanoidiA6NEF3
OMAiVERIHEQ
OrthoDBi414384at7742
PhylomeDBiA6NEF3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GOLGA6L4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
643707

Protein Ontology

More...
PROi
PR:A6NEF3

Gene expression databases

BgeeiENSG00000184206 Expressed in 89 organ(s), highest expression level in left ovary
ExpressionAtlasiA6NEF3 baseline and differential
GenevisibleiA6NEF3 HS

Family and domain databases

InterProiView protein in InterPro
IPR026737 GOLGA6L
IPR024858 Golgin_A
PANTHERiPTHR23143 PTHR23143, 4 hits
PfamiView protein in Pfam
PF15070 GOLGA2L5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGG6L4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NEF3
Secondary accession number(s): D6REZ9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 9, 2013
Last modified: January 16, 2019
This is version 66 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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