UniProtKB - A6NE52 (WDR97_HUMAN)
Protein
WD repeat-containing protein 97
Gene
WDR97
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: WD repeat-containing protein 97Imported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000179698.13 |
HGNCi | HGNC:26959, WDR97 |
neXtProti | NX_A6NE52 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000179698 |
Miscellaneous databases
Pharosi | A6NE52, Tdark |
Polymorphism and mutation databases
BioMutai | WDR97 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000332994 | 1 – 1622 | WD repeat-containing protein 97Add BLAST | 1622 |
Proteomic databases
MassIVEi | A6NE52 |
PaxDbi | A6NE52 |
PeptideAtlasi | A6NE52 |
PRIDEi | A6NE52 |
ProteomicsDBi | 959 [A6NE52-1] 960 [A6NE52-2] |
PTM databases
iPTMneti | A6NE52 |
PhosphoSitePlusi | A6NE52 |
Expressioni
Gene expression databases
Bgeei | ENSG00000179698, Expressed in right testis and 105 other tissues |
ExpressionAtlasi | A6NE52, baseline and differential |
Genevisiblei | A6NE52, HS |
Organism-specific databases
HPAi | ENSG00000179698, Group enriched (brain, testis) |
Interactioni
Protein-protein interaction databases
IntActi | A6NE52, 1 interactor |
STRINGi | 9606.ENSP00000320648 |
Miscellaneous databases
RNActi | A6NE52, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 187 – 233 | WD 1Add BLAST | 47 | |
Repeati | 290 – 329 | WD 2Add BLAST | 40 | |
Repeati | 331 – 370 | WD 3Add BLAST | 40 | |
Repeati | 552 – 592 | WD 4Add BLAST | 41 | |
Repeati | 594 – 633 | WD 5Add BLAST | 40 | |
Repeati | 687 – 726 | WD 6Add BLAST | 40 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1094 – 1118 | Sequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1509 – 1605 | Pro-richAdd BLAST | 97 |
Keywords - Domaini
Coiled coil, Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0321, Eukaryota |
GeneTreei | ENSGT00940000164199 |
HOGENOMi | CLU_244603_0_0_1 |
InParanoidi | A6NE52 |
OMAi | LLWLSKP |
OrthoDBi | 313028at2759 |
PhylomeDBi | A6NE52 |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 2 hits PS50294, WD_REPEATS_REGION, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: A6NE52-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEAEVWEAEG YNLVLDSDLY DADGYDVPDP GLLTEKNELT FTEPSQVLPF
60 70 80 90 100
LTSSQQWQSL TPRARARRLW LLLRTSLHEV VEKEKRAELR AARLTHGLEP
110 120 130 140 150
LRRLEVAAGL RSVAQDPVGG RFVVLDGAGR LHLHKEDGWA QETLLAPVRL
160 170 180 190 200
TGLVTVLGPL GAVGRFVGWG PAGLAILRPN LSLLWLSEQG VGRAPGWAPT
210 220 230 240 250
CCLPVPDLRL LLVAEMNSSL ALWQFRSGGR RLVLRGSALH PPPSPTGRLM
260 270 280 290 300
RLAVAPVPPH HVLRCFAAYG SAVLTFDLHA WTLVDVRRDL HKTTISDLAY
310 320 330 340 350
CEEVEAMVTA SRDSTVKVWE ADWQIRMVFV GHTGPVTAMT VLPNTTLVLS
360 370 380 390 400
ASQDGTLRTW DLQAAAQVGE VALGFWGQDK LSRRVGRLLA PVRPGWPVLS
410 420 430 440 450
LCASSMQLWR VRELYSPLAQ LPAKVLHVQV APALPAPAHQ SLPTRLVCAC
460 470 480 490 500
ADGSVYLLSA ATGRIVSSLL LEPEDCAAAV AYCLPREALW LLTRAGHLVR
510 520 530 540 550
ANAARCPMSV LHRVCPPPPP APQPCCLHLY SHLTDLEGAF SSWEIVRQHW
560 570 580 590 600
GELRCSSVAC AWKNKNRYLP VVGHTDGTLS VLEWLSSKTV FQTEAHSPGP
610 620 630 640 650
VVAIASTWNS IVSSGGDLTV KMWRVFPYAE ESLSLLRTFS CCYPAVALCA
660 670 680 690 700
LGRRVTAGFE DPDSATYGLV QFGLGDSPRL DHRPQDDPTD HITGLCCCPT
710 720 730 740 750
LKLYACSSLD CTVRIWTAEN RLLRLLQLNG APQALAFCSN SGDLVLALGS
760 770 780 790 800
RLCLVSHRLY LPTSYLVKKM CRKAPDVVDD PPLPLMSQES LTSAQLQRLT
810 820 830 840 850
NLHGAASLSE ALSLIHRRRA TSQHLVPKED LDAIVARDRD LQQLRLGLVV
860 870 880 890 900
PAAQPPPSWQ QRQEGFDNYL RLIYGSGLLG MQSGRGSQQW SAGTLRVERE
910 920 930 940 950
TRDVCAVPQA AHCLARAEVS TAAQTVPTAL SPQDLGALGQ HFSQSPRVTV
960 970 980 990 1000
PIPPTHRRVH SKASQLLARS SLSHYLGISL DLQLQLEQLR GRTTMALDLP
1010 1020 1030 1040 1050
SSHLQCRIPL LPKRWDKEPL SSLRGFFPAT VQPHKHCLRP ICFPGYVPNS
1060 1070 1080 1090 1100
AVLQQMWLNA EPGASQDALW LWRPRPSQTQ WQRKLLQWMG EKPGEEGEED
1110 1120 1130 1140 1150
KKEEEEEKED EELDWALASL SPHSNQQLDS WELEDQSAVD WTQEPRRRSC
1160 1170 1180 1190 1200
KVARTHPHPW HRHGSLLLDE HYGHLPKFLH FFIYQTWFKK LFPIFSLQAY
1210 1220 1230 1240 1250
PEAGTIEGLA SLLVALLEKT TWVDRVHILQ VLLRLLPNMS SDLQGQLQGL
1260 1270 1280 1290 1300
LVHLLNLDQP PSLQDQTQKK FVILALQLLL ACSLESRDVV LELMSYFLYS
1310 1320 1330 1340 1350
PVHCRPELKK LLHGLGLQDP EGFLFKEMMT WVQGPDLDSK AGLRTCCHQK
1360 1370 1380 1390 1400
LEDMIQELQE TPSQTSVVSG APTRASVIPS GTSWSASGIF GRLSQVSEVP
1410 1420 1430 1440 1450
LMVVSPAEPH SLAPELQAQR MLAPKRSWGT PQLRLRVLSE TLKSFCLEPE
1460 1470 1480 1490 1500
ARLHPAGPAQ LPGEPPPLEE TDWSHSQLLD LGPIDALNFF CEQLRAQQRS
1510 1520 1530 1540 1550
SLQEKAAHPH PPEPYTVAPV PDMVVPPPRE HWYHPILRLQ EAKPQRSARS
1560 1570 1580 1590 1600
AMRLRGPMRS RLCAGRTLDG PIRTLKLPLP RVEPQPFPLD WPMPPRPLPP
1610 1620
RLLQPALQRY FLPADADPDT YS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PKB8 | E9PKB8_HUMAN | WD repeat-containing protein 97 | WDR97 | 837 | Annotation score: |
Sequence cautioni
The sequence BAB47504 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 430 | V → L in BAB47504 (PubMed:11347906).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_043029 | 149 | R → G1 PublicationCorresponds to variant dbSNP:rs4977196Ensembl. | 1 | |
Natural variantiVAR_043030 | 427 | H → Q. Corresponds to variant dbSNP:rs34324679Ensembl. | 1 | |
Natural variantiVAR_043031 | 537 | E → G1 PublicationCorresponds to variant dbSNP:rs13250446Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_033425 | 809 – 837 | SEALS…AIVAR → RSHGGLLSPPGGPPFPLWVG AWRCGALWS in isoform 2. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_033426 | 838 – 1622 | Missing in isoform 2. 1 PublicationAdd BLAST | 785 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB058778 mRNA Translation: BAB47504.1 Sequence problems. AC104592 Genomic DNA No translation available. |
CCDSi | CCDS83334.1 [A6NE52-1] |
RefSeqi | NP_001303238.1, NM_001316309.1 [A6NE52-1] |
Genome annotation databases
Ensembli | ENST00000323662; ENSP00000320648; ENSG00000179698 [A6NE52-1] |
GeneIDi | 340390 |
KEGGi | hsa:340390 |
UCSCi | uc064riy.1, human [A6NE52-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB058778 mRNA Translation: BAB47504.1 Sequence problems. AC104592 Genomic DNA No translation available. |
CCDSi | CCDS83334.1 [A6NE52-1] |
RefSeqi | NP_001303238.1, NM_001316309.1 [A6NE52-1] |
3D structure databases
SMRi | A6NE52 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | A6NE52, 1 interactor |
STRINGi | 9606.ENSP00000320648 |
PTM databases
iPTMneti | A6NE52 |
PhosphoSitePlusi | A6NE52 |
Polymorphism and mutation databases
BioMutai | WDR97 |
Proteomic databases
MassIVEi | A6NE52 |
PaxDbi | A6NE52 |
PeptideAtlasi | A6NE52 |
PRIDEi | A6NE52 |
ProteomicsDBi | 959 [A6NE52-1] 960 [A6NE52-2] |
Protocols and materials databases
Antibodypediai | 71324, 5 antibodies |
Genome annotation databases
Ensembli | ENST00000323662; ENSP00000320648; ENSG00000179698 [A6NE52-1] |
GeneIDi | 340390 |
KEGGi | hsa:340390 |
UCSCi | uc064riy.1, human [A6NE52-1] |
Organism-specific databases
CTDi | 340390 |
EuPathDBi | HostDB:ENSG00000179698.13 |
GeneCardsi | WDR97 |
HGNCi | HGNC:26959, WDR97 |
HPAi | ENSG00000179698, Group enriched (brain, testis) |
neXtProti | NX_A6NE52 |
OpenTargetsi | ENSG00000179698 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0321, Eukaryota |
GeneTreei | ENSGT00940000164199 |
HOGENOMi | CLU_244603_0_0_1 |
InParanoidi | A6NE52 |
OMAi | LLWLSKP |
OrthoDBi | 313028at2759 |
PhylomeDBi | A6NE52 |
Enzyme and pathway databases
PathwayCommonsi | A6NE52 |
SignaLinki | A6NE52 |
Miscellaneous databases
BioGRID-ORCSi | 340390, 1 hit in 44 CRISPR screens |
GenomeRNAii | 340390 |
Pharosi | A6NE52, Tdark |
PROi | PR:A6NE52 |
RNActi | A6NE52, protein |
Gene expression databases
Bgeei | ENSG00000179698, Expressed in right testis and 105 other tissues |
ExpressionAtlasi | A6NE52, baseline and differential |
Genevisiblei | A6NE52, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 2 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | WDR97_HUMAN | |
Accessioni | A6NE52Primary (citable) accession number: A6NE52 Secondary accession number(s): Q96JF2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | May 20, 2008 | |
Last modified: | December 2, 2020 | |
This is version 103 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations