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Protein

Protein FAM186A

Gene

FAM186A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM186A
Gene namesi
Name:FAM186A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000185958.9
HGNCiHGNC:26980 FAM186A
neXtProtiNX_A6NE01

Pathology & Biotechi

Organism-specific databases

DisGeNETi121006
OpenTargetsiENSG00000185958
PharmGKBiPA164719869

Polymorphism and mutation databases

BioMutaiFAM186A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003322011 – 2351Protein FAM186AAdd BLAST2351

Proteomic databases

EPDiA6NE01
PaxDbiA6NE01
PRIDEiA6NE01
ProteomicsDBi951

PTM databases

iPTMnetiA6NE01
PhosphoSitePlusiA6NE01

Expressioni

Gene expression databases

BgeeiENSG00000185958
ExpressionAtlasiA6NE01 baseline and differential
GenevisibleiA6NE01 HS

Organism-specific databases

HPAiHPA047128

Interactioni

Protein-protein interaction databases

BioGridi125703, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliA6NE01
SMRiA6NE01
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili296 – 340Sequence analysisAdd BLAST45
Coiled coili812 – 860Sequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi913 – 916Poly-Glu4
Compositional biasi1814 – 1943Pro-richAdd BLAST130

Sequence similaritiesi

Belongs to the FAM186 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J3XI Eukaryota
ENOG4111YPH LUCA
GeneTreeiENSGT00580000081635
HOGENOMiHOG000112459
InParanoidiA6NE01
OMAiFTTKKFQ
OrthoDBiEOG091G00PG
PhylomeDBiA6NE01
TreeFamiTF338344

Sequencei

Sequence statusi: Complete.

A6NE01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFFKMKNEID NDPESEKCIK DSTIMRREPQ NILSPLMLPN LEIPFSVKDI
60 70 80 90 100
ISRIERAQLH RAREDIDMQL SEIMNNVHRI MTRYTLVFNS SSERNVSLTE
110 120 130 140 150
HKKKQRTNFL EKMATYAKTI EIREKTLANI LAWLEEWNDV LSEMTLMDVD
160 170 180 190 200
EHHHWIAQME LLPDTLKAIE NNVKILSRFS TSFLDEKKKQ KKKILSRGTL
210 220 230 240 250
WKSWKERVIK RPSTARALRP DQMISDQLAT NTKVSEIQGM LQELIGTTMF
260 270 280 290 300
STLENNAIKY ISSTIVNLST ALSMLNDELK CVNFQSSTVY AHETSEAEKE
310 320 330 340 350
LSLKIIRDLS NENEMLQQKL QDAEEKCEQL IRSKIVIEQL YAKLSTSSTL
360 370 380 390 400
KVLPGPSPQS SRAIIKVGDT EDNMDNILDK ELENIVDEVQ RKETKDSGIK
410 420 430 440 450
WDSTISYTAQ AERTPDLTEL RQQPVASEDI SEDSTKDNVS LKKGDFYQED
460 470 480 490 500
ETDEYQSWKR SHKKATYVYE TSGPNLSDNK SGQKVSEAKP SQYYELQVLK
510 520 530 540 550
KKRKEMKSFS EDKSKSPTEA KRKHLSLTET KSQGGKSGTS MMMLEQFRKV
560 570 580 590 600
KRESPFDKRP TAAEIKVEPT TESLDKEGKG EIRSLVEPLS MIQFDDTAEP
610 620 630 640 650
QKGKIKGKKH HISSGTITSK EEKTEEKEEL TKQVKSHQLV KSLSRVAKET
660 670 680 690 700
SESTRVLESP DGKSEQSNLE EFQEAIMAFL KQKIDNIGKA FDKKTVPKEE
710 720 730 740 750
ELLKRAEAEK LGIIKAKMEE YFQKVAETVT KILRKYKDTK KEEQVGEKPI
760 770 780 790 800
KQKKVVSFMP GLHFQKSPIS AKSESSTLLS YESTDPVINN LIQMILAEIE
810 820 830 840 850
SERDIPTVST VQKDHKEKEK QRQEQYLQEG QEQMSGMSLK QQLLGERNLL
860 870 880 890 900
KEHYEKISEN WEEKKAWLQM KEGKQEQQSQ KQWQEEEMWK EEQKQATPKQ
910 920 930 940 950
AEQEEKQKQR GQEEEELPKS SLQRLEEGTQ KMKTQGLLLE KENGQMRQIQ
960 970 980 990 1000
KEAKHLGPHR RREKGKEKQK PERGLEDLER QIKTKDQMQM KETQPKELEK
1010 1020 1030 1040 1050
MVIQTPMTLS PRWKSVLKDV QRSYEGKEFQ RNLKTLENLP DEKEPISITP
1060 1070 1080 1090 1100
PPSLQYSLPG ALPISGQPLT KCIHLTPQQA QEVGITLTPQ QAQAQGITLT
1110 1120 1130 1140 1150
LQQAQELGIP LTPQQAQALE ILFTPQQAQA LGIPLTPQQT QVQGITLTPQ
1160 1170 1180 1190 1200
QDQAPGISLT TQQAQKLGIP LTPQQAQALG IPLTPQQAQE LGIPLTPQQA
1210 1220 1230 1240 1250
QALRVSLTPQ QAQELGIPLT PQQAQALGIT LTLQQAQQLG IPLTPQQAQA
1260 1270 1280 1290 1300
LGITLTPKQV QELGIPLTPQ QAQALGITLT PKQAQELGIP LNPQQAQTLG
1310 1320 1330 1340 1350
IPLTPKQAQA LGIPFTPQQA QALGIPLTPQ QAQTQEITLT PQQAQALGMP
1360 1370 1380 1390 1400
LTTQQAQELG IPLTPQHAQA LGMPLTTQQA QELGIPLTPQ QAQALGMPLT
1410 1420 1430 1440 1450
TQQAQELGIP LTPQQAQELG IPFTPQQAQA QEITLTPQQA QALGMPLTAQ
1460 1470 1480 1490 1500
QAQELGITLT PQQAQELGIP LTPQQAQALG IPLIPPQAQE LGIPLTPQQA
1510 1520 1530 1540 1550
QALGILLIPP QAQELGIPLT PQQAQALGIP LIPPQAQELG IPLTPQQVQA
1560 1570 1580 1590 1600
LGIPLIPPQA QELEIPLTPQ QAQALGIPLT PQQAQELGIP LTPQQAQELG
1610 1620 1630 1640 1650
IPLTPQQAQA QGIPLTPQQA QALGISLTPQ QAQAQGITLT PQQAQALGVP
1660 1670 1680 1690 1700
ITPVNAWVSA VTLTSEQTHA LESPMNLEQA QEQLLKLGVP LTLDKAHTLG
1710 1720 1730 1740 1750
SPLTLKQVQW SHRPFQKSKA SLPTGQSIIS RLSPSLRLSL ASSAPTAEKS
1760 1770 1780 1790 1800
SIFGVSSTPL QISRVPLNQG PFAPGKPLEM GILSEPGKLG APQTLRSSGQ
1810 1820 1830 1840 1850
TLVYGGQSTS AQFPAPQAPP SPGQLPISRA PPTPGQPFIA GVPPTSGQIP
1860 1870 1880 1890 1900
SLWAPLSPGQ PLVPEASSIP GDLLESGPLT FSEQLQEFQP PATAEQSPYL
1910 1920 1930 1940 1950
QAPSTPGQHL ATWTLPGRAS SLWIPPTSRH PPTLWPSPAP GKPQKSWSPS
1960 1970 1980 1990 2000
VAKKRLAIIS SLKSKSVLIH PSAPDFKVAQ VPFTTKKFQM SEVSDTSEET
2010 2020 2030 2040 2050
QILRDTFAIE SFRTFQSHFT KYRTPVYQTP YTDERALLTL MKPTTSPSSL
2060 2070 2080 2090 2100
TTLLRTSQIS PLEWYQKSRF PPIDKPWILS SVSDTKKPKV MVPPSSPQEL
2110 2120 2130 2140 2150
EEKRYFVDVE AQKKNLILLN QAIKTCGLPS QLHTMARTLI IEILHMDTVQ
2160 2170 2180 2190 2200
LGYLFRKYIA YRLIQHARNN IMKRLKAIQN TGKGYEARNL HMMLSRLDDY
2210 2220 2230 2240 2250
GKKVMQVWTE KQKSLGQKRN QCLKKMIHVF NQLKKIHELN LSQPIPLIIE
2260 2270 2280 2290 2300
EKQIPASTTF VQKPFLKLLM EEDRTSDICK KFRQQEDQTE AIWNVDLSTS
2310 2320 2330 2340 2350
SYPIAEKTSM HSLWAQLGGY PDIPRLLQLE VQSTFRKSLA SLQSRVKKIP

K
Length:2,351
Mass (Da):262,758
Last modified:February 10, 2009 - v3
Checksum:i290E59F3CC9085B4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti165T → M in AL833333 (PubMed:17974005).Curated1
Sequence conflicti463 – 465KKA → TKG in AL833333 (PubMed:17974005).Curated3
Sequence conflicti935Q → R in AL833333 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054419187K → Q1 PublicationCorresponds to variant dbSNP:rs12303082Ensembl.1
Natural variantiVAR_0544201204R → G. Corresponds to variant dbSNP:rs10876024Ensembl.1
Natural variantiVAR_0544211233L → P. Corresponds to variant dbSNP:rs10876023Ensembl.1
Natural variantiVAR_0544222166H → Y. Corresponds to variant dbSNP:rs7296291Ensembl.1
Natural variantiVAR_0544232193M → I. Corresponds to variant dbSNP:rs6580742Ensembl.1
Natural variantiVAR_0544242228H → Q1 PublicationCorresponds to variant dbSNP:rs6580741Ensembl.1
Natural variantiVAR_0544252316Q → E. Corresponds to variant dbSNP:rs12809349Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090058 Genomic DNA No translation available.
AC140061 Genomic DNA No translation available.
AL833333 mRNA No translation available.
BX099768 mRNA No translation available.
CCDSiCCDS44878.1
RefSeqiNP_001138947.1, NM_001145475.1
UniGeneiHs.133187

Genome annotation databases

EnsembliENST00000327337; ENSP00000329995; ENSG00000185958
GeneIDi121006
KEGGihsa:121006
UCSCiuc001rwl.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiF186A_HUMAN
AccessioniPrimary (citable) accession number: A6NE01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 10, 2009
Last modified: June 20, 2018
This is version 64 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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