UniProtKB - A6NDY0 (EPAB2_HUMAN)
Protein
Embryonic polyadenylate-binding protein 2
Gene
PABPN1L
Organism
Homo sapiens (Human)
Status
Functioni
Binds the poly(A) tail of mRNA.By similarity
GO - Molecular functioni
- RNA binding Source: UniProtKB-KW
Keywordsi
Molecular function | RNA-binding |
Enzyme and pathway databases
PathwayCommonsi | A6NDY0 |
Names & Taxonomyi
Protein namesi | Recommended name: Embryonic polyadenylate-binding protein 2Short name: Embryonic poly(A)-binding protein 2 Short name: ePABP-2 Short name: ePABP2 Alternative name(s): Embryonic poly(A)-binding protein type II Poly(A)-binding protein nuclear-like 1 |
Gene namesi | Name:PABPN1L Synonyms:EPABP2, PABPNL1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:37237, PABPN1L |
neXtProti | NX_A6NDY0 |
VEuPathDBi | HostDB:ENSG00000205022.9 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 390748 |
OpenTargetsi | ENSG00000205022 |
Miscellaneous databases
Pharosi | A6NDY0, Tdark |
Genetic variation databases
BioMutai | PABPN1L |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000349172 | 1 – 278 | Embryonic polyadenylate-binding protein 2Add BLAST | 278 |
Proteomic databases
jPOSTi | A6NDY0 |
MassIVEi | A6NDY0 |
MaxQBi | A6NDY0 |
PaxDbi | A6NDY0 |
PeptideAtlasi | A6NDY0 |
PRIDEi | A6NDY0 |
ProteomicsDBi | 940 [A6NDY0-1] 941 [A6NDY0-2] 942 [A6NDY0-3] 943 [A6NDY0-4] |
TopDownProteomicsi | A6NDY0-3 [A6NDY0-3] |
PTM databases
iPTMneti | A6NDY0 |
PhosphoSitePlusi | A6NDY0 |
Expressioni
Tissue specificityi
Expressed in various adult tissues.1 Publication
Gene expression databases
Bgeei | ENSG00000205022, Expressed in right adrenal gland and 72 other tissues |
ExpressionAtlasi | A6NDY0, baseline and differential |
Organism-specific databases
HPAi | ENSG00000205022, Tissue enhanced (adrenal gland, bone marrow, brain) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000408598 |
Miscellaneous databases
RNActi | A6NDY0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 147 – 224 | RRMPROSITE-ProRule annotationAdd BLAST | 78 |
Phylogenomic databases
eggNOGi | KOG4209, Eukaryota |
GeneTreei | ENSGT00940000161325 |
HOGENOMi | CLU_012062_23_2_1 |
InParanoidi | A6NDY0 |
OMAi | MWPFLSH |
OrthoDBi | 1412946at2759 |
PhylomeDBi | A6NDY0 |
TreeFami | TF105907 |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: A6NDY0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MWPFPSRSLF PPPTQAWLQT VSSDPEAQGW GAWNETKEIL GPEGGEGKEE
60 70 80 90 100
KEEEEDAEED QDGDAGFLLS LLEQENLAEC PLPDQELEAI KMKVCAMEQA
110 120 130 140 150
EGTPRPPGVQ QQAEEEEGTA AGQLLSPETV GCPLSGTPEE KVEADHRSVY
160 170 180 190 200
VGNVDYGGSA EELEAHFSRC GEVHRVTILC DKFSGHPKGY AYIEFATKGS
210 220 230 240 250
VQAAVELDQS LFRGRVIKVL PKRTNFPGIS STDRGGLRGH PGSRGAPFPH
260 270
SGLQGRPRLR PQGQNRARGK FSPWFSPY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1C7CYY8 | A0A1C7CYY8_HUMAN | Embryonic polyadenylate-binding pro... | PABPN1L | 266 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035211 | 154 | V → LCLHRVCHQGLRAGRRGAGP EPLPGPGHQGAAEKNQLPWD QLHRPRGPSRTPRLQGGTLP PQRPPGQAPAQTTRAEPGPW KILTMVFTVLKGRPDFERGA GAWIRSKPLVLHPG in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_035212 | 155 – 278 | Missing in isoform 3. 1 PublicationAdd BLAST | 124 | |
Alternative sequenceiVSP_035213 | 190 | Y → CCRKEPTSLGSAPQTAGAFE DTQAPGGHPSPTAASRAGPG SDHKGRTGPVENSHHGFHRI KGKTRF in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_035214 | 191 – 278 | Missing in isoform 2. 1 PublicationAdd BLAST | 88 | |
Alternative sequenceiVSP_040501 | 267 – 278 | ARGKF…WFSPY → TPAALTPLWARPLPWVVVSH VIK in isoform 4. CuratedAdd BLAST | 12 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC092384 Genomic DNA No translation available. BC130001 mRNA Translation: AAI30002.1 BC130002 mRNA Translation: AAI30003.1 |
CCDSi | CCDS45547.2 [A6NDY0-1] CCDS73925.1 [A6NDY0-2] |
RefSeqi | NP_001073956.2, NM_001080487.2 [A6NDY0-1] NP_001281257.1, NM_001294328.1 [A6NDY0-2] XP_016878719.1, XM_017023230.1 [A6NDY0-1] |
Genome annotation databases
Ensembli | ENST00000411789; ENSP00000405259; ENSG00000205022 [A6NDY0-2] ENST00000419291; ENSP00000408598; ENSG00000205022 [A6NDY0-1] |
GeneIDi | 390748 |
KEGGi | hsa:390748 |
UCSCi | uc002fmi.4, human [A6NDY0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC092384 Genomic DNA No translation available. BC130001 mRNA Translation: AAI30002.1 BC130002 mRNA Translation: AAI30003.1 |
CCDSi | CCDS45547.2 [A6NDY0-1] CCDS73925.1 [A6NDY0-2] |
RefSeqi | NP_001073956.2, NM_001080487.2 [A6NDY0-1] NP_001281257.1, NM_001294328.1 [A6NDY0-2] XP_016878719.1, XM_017023230.1 [A6NDY0-1] |
3D structure databases
SMRi | A6NDY0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000408598 |
PTM databases
iPTMneti | A6NDY0 |
PhosphoSitePlusi | A6NDY0 |
Genetic variation databases
BioMutai | PABPN1L |
Proteomic databases
jPOSTi | A6NDY0 |
MassIVEi | A6NDY0 |
MaxQBi | A6NDY0 |
PaxDbi | A6NDY0 |
PeptideAtlasi | A6NDY0 |
PRIDEi | A6NDY0 |
ProteomicsDBi | 940 [A6NDY0-1] 941 [A6NDY0-2] 942 [A6NDY0-3] 943 [A6NDY0-4] |
TopDownProteomicsi | A6NDY0-3 [A6NDY0-3] |
Protocols and materials databases
Antibodypediai | 50156, 59 antibodies |
DNASUi | 390748 |
Genome annotation databases
Ensembli | ENST00000411789; ENSP00000405259; ENSG00000205022 [A6NDY0-2] ENST00000419291; ENSP00000408598; ENSG00000205022 [A6NDY0-1] |
GeneIDi | 390748 |
KEGGi | hsa:390748 |
UCSCi | uc002fmi.4, human [A6NDY0-1] |
Organism-specific databases
CTDi | 390748 |
DisGeNETi | 390748 |
GeneCardsi | PABPN1L |
HGNCi | HGNC:37237, PABPN1L |
HPAi | ENSG00000205022, Tissue enhanced (adrenal gland, bone marrow, brain) |
neXtProti | NX_A6NDY0 |
OpenTargetsi | ENSG00000205022 |
VEuPathDBi | HostDB:ENSG00000205022.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4209, Eukaryota |
GeneTreei | ENSGT00940000161325 |
HOGENOMi | CLU_012062_23_2_1 |
InParanoidi | A6NDY0 |
OMAi | MWPFLSH |
OrthoDBi | 1412946at2759 |
PhylomeDBi | A6NDY0 |
TreeFami | TF105907 |
Enzyme and pathway databases
PathwayCommonsi | A6NDY0 |
Miscellaneous databases
BioGRID-ORCSi | 390748, 73 hits in 979 CRISPR screens |
GenomeRNAii | 390748 |
Pharosi | A6NDY0, Tdark |
PROi | PR:A6NDY0 |
RNActi | A6NDY0, protein |
Gene expression databases
Bgeei | ENSG00000205022, Expressed in right adrenal gland and 72 other tissues |
ExpressionAtlasi | A6NDY0, baseline and differential |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EPAB2_HUMAN | |
Accessioni | A6NDY0Primary (citable) accession number: A6NDY0 Secondary accession number(s): A1L3B3, A2VDI2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | July 24, 2007 | |
Last modified: | April 7, 2021 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM