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Protein

Transmembrane protein 8B

Gene

TMEM8B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion.4 Publications

GO - Biological processi

  • cell-matrix adhesion Source: HGNC
  • regulation of growth Source: UniProtKB-KW
  • regulation of mitotic cell cycle Source: HGNC

Keywordsi

Biological processCell adhesion, Growth regulation

Protein family/group databases

TCDBi1.N.2.1.7 the myoblast fusion complex (mfc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 8B
Alternative name(s):
Nasopharyngeal carcinoma-associated gene 6 protein
Protein NAG-5
Protein NGX6
Gene namesi
Name:TMEM8B
Synonyms:C9orf127, NGX6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000137103.16
HGNCiHGNC:21427 TMEM8B
neXtProtiNX_A6NDV4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 233ExtracellularSequence analysisAdd BLAST233
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 257CytoplasmicSequence analysis3
Transmembranei258 – 277HelicalSequence analysisAdd BLAST20
Topological domaini278 – 292ExtracellularSequence analysisAdd BLAST15
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Topological domaini314 – 315CytoplasmicSequence analysis2
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Topological domaini337 – 342ExtracellularSequence analysis6
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Topological domaini364 – 379CytoplasmicSequence analysisAdd BLAST16
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Topological domaini401 – 405ExtracellularSequence analysis5
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Topological domaini427 – 472CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51754
OpenTargetsiENSG00000137103
PharmGKBiPA165586305

Polymorphism and mutation databases

BioMutaiTMEM8B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003330391 – 472Transmembrane protein 8BAdd BLAST472

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi186 ↔ 196By similarity
Disulfide bondi190 ↔ 209By similarity
Disulfide bondi211 ↔ 220By similarity

Post-translational modificationi

Isoform 2 is N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NDV4
PRIDEiA6NDV4
ProteomicsDBi931
932 [A6NDV4-2]
933 [A6NDV4-3]
TopDownProteomicsiA6NDV4-2 [A6NDV4-2]

PTM databases

iPTMnetiA6NDV4
PhosphoSitePlusiA6NDV4

Expressioni

Inductioni

Isoform 2 is down-regulated in nasopharyngeal carcinoma cells.1 Publication

Gene expression databases

BgeeiENSG00000137103 Expressed in 159 organ(s), highest expression level in esophagus
CleanExiHS_C9orf127
GenevisibleiA6NDV4 HS

Organism-specific databases

HPAiHPA052130
HPA062701

Interactioni

Subunit structurei

Isoform 2 (via its cytoplasmic part) interacts with EZR.2 Publications

Protein-protein interaction databases

BioGridi119714, 2 interactors
STRINGi9606.ENSP00000367227

Structurei

3D structure databases

ProteinModelPortaliA6NDV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 221EGF-likeAdd BLAST40

Sequence similaritiesi

Belongs to the TMEM8 family.Curated

Keywords - Domaini

EGF-like domain, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHJ3 Eukaryota
ENOG4111FA8 LUCA
GeneTreeiENSGT00390000004668
InParanoidiA6NDV4
OMAiACLTHEV
OrthoDBiEOG091G0KZA
PhylomeDBiA6NDV4
TreeFamiTF331003

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR021910 NGX6/PGAP6/MYMK
PANTHERiPTHR14319 PTHR14319, 1 hit
PfamiView protein in Pfam
PF12036 DUF3522, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: A6NDV4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNMPQSLGNQ PLPPEPPSLG TPAEGPGTTS PPEHCWPVRP TLRNELDTFS
60 70 80 90 100
VHFYIFFGPS VALPPERPAV FAMRLLPVLD SGGVLSLELQ LNASSVRQEN
110 120 130 140 150
VTVFGCLTHE VPLSLGDAAV TCSKESLAGF LLSVSATTRV ARLRIPFPQT
160 170 180 190 200
GTWFLALRSL CGVGPRFVRC RNATAEVRMR TFLSPCVDDC GPYGQCKLLR
210 220 230 240 250
THNYLYAACE CKAGWRGWGC TDSADALTYG FQLLSTLLLC LSNLMFLPPV
260 270 280 290 300
VLAIRSRYVL EAAVYTFTMF FSTFYHACDQ PGIVVFCIMD YDVLQFCDFL
310 320 330 340 350
GSLMSVWVTV IAMARLQPVV KQVLYLLGAM LLSMALQLDR HGLWNLLGPS
360 370 380 390 400
LFALGILATA WTVRSVRRRH CYPPTWRRWL FYLCPGSLIA GSAVLLYAFV
410 420 430 440 450
ETRDNYFYIH SIWHMLIAGS VGFLLPPRAK TDHGVPSGAR ARGCGYQLCI
460 470
NEQEELGLVG PGGATVSSIC AS
Length:472
Mass (Da):51,941
Last modified:January 15, 2008 - v2
Checksum:i3E5EA4495CF54389
GO
Isoform 2 (identifier: A6NDV4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     274-337: FYHACDQPGI...GAMLLSMALQ → VCGGVCILSL...GHFCKTHWSK
     338-472: Missing.

Show »
Length:338
Mass (Da):36,844
Checksum:iBBB601E2F7ADAF3E
GO
Isoform 3 (identifier: A6NDV4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.
     82-93: GGVLSLELQLNA → MWRPHFHTCPPQ
     274-337: FYHACDQPGI...GAMLLSMALQ → VCGGVCILSL...GHFCKTHWSK
     338-472: Missing.

Note: No experimental confirmation available.
Show »
Length:257
Mass (Da):28,336
Checksum:iA482F1C8662472A8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y2M5A0A2R8Y2M5_HUMAN
Transmembrane protein 8B
TMEM8B
924Annotation score:

Sequence cautioni

The sequence AAC28644 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAF34820 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAF34820 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti178R → W in AAH98296 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0334501 – 81Missing in isoform 3. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_03345182 – 93GGVLS…LQLNA → MWRPHFHTCPPQ in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_033452274 – 337FYHAC…SMALQ → VCGGVCILSLGACAWWWVTV CISTTFSEGLGMSVPSLCLL QTETAVLPKLSCIDNGHFCK THWSK in isoform 2 and isoform 3. 4 PublicationsAdd BLAST64
Alternative sequenceiVSP_033453338 – 472Missing in isoform 2 and isoform 3. 4 PublicationsAdd BLAST135

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF149297 mRNA Translation: AAF34820.1 Sequence problems.
AF188239 mRNA Translation: AAG29055.1
AF070572 mRNA Translation: AAC28644.1 Different initiation.
AK074844 mRNA Translation: BAG52015.1
AL133410 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58325.1
BC041377 mRNA No translation available.
BC098265 mRNA Translation: AAH98265.1
BC098296 mRNA Translation: AAH98296.1
BC099733 mRNA Translation: AAH99733.1
CCDSiCCDS43800.1 [A6NDV4-1]
CCDS6595.1 [A6NDV4-2]
RefSeqiNP_001036054.1, NM_001042589.2 [A6NDV4-1]
NP_001036055.1, NM_001042590.2
NP_057530.2, NM_016446.3 [A6NDV4-2]
UniGeneiHs.493808
Hs.9187

Genome annotation databases

EnsembliENST00000377988; ENSP00000367227; ENSG00000137103 [A6NDV4-1]
ENST00000377991; ENSP00000367230; ENSG00000137103 [A6NDV4-1]
ENST00000377996; ENSP00000367235; ENSG00000137103 [A6NDV4-2]
ENST00000439587; ENSP00000395810; ENSG00000137103 [A6NDV4-2]
GeneIDi51754
KEGGihsa:51754
UCSCiuc003zyk.4 human [A6NDV4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF149297 mRNA Translation: AAF34820.1 Sequence problems.
AF188239 mRNA Translation: AAG29055.1
AF070572 mRNA Translation: AAC28644.1 Different initiation.
AK074844 mRNA Translation: BAG52015.1
AL133410 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58325.1
BC041377 mRNA No translation available.
BC098265 mRNA Translation: AAH98265.1
BC098296 mRNA Translation: AAH98296.1
BC099733 mRNA Translation: AAH99733.1
CCDSiCCDS43800.1 [A6NDV4-1]
CCDS6595.1 [A6NDV4-2]
RefSeqiNP_001036054.1, NM_001042589.2 [A6NDV4-1]
NP_001036055.1, NM_001042590.2
NP_057530.2, NM_016446.3 [A6NDV4-2]
UniGeneiHs.493808
Hs.9187

3D structure databases

ProteinModelPortaliA6NDV4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119714, 2 interactors
STRINGi9606.ENSP00000367227

Protein family/group databases

TCDBi1.N.2.1.7 the myoblast fusion complex (mfc) family

PTM databases

iPTMnetiA6NDV4
PhosphoSitePlusiA6NDV4

Polymorphism and mutation databases

BioMutaiTMEM8B

Proteomic databases

PaxDbiA6NDV4
PRIDEiA6NDV4
ProteomicsDBi931
932 [A6NDV4-2]
933 [A6NDV4-3]
TopDownProteomicsiA6NDV4-2 [A6NDV4-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377988; ENSP00000367227; ENSG00000137103 [A6NDV4-1]
ENST00000377991; ENSP00000367230; ENSG00000137103 [A6NDV4-1]
ENST00000377996; ENSP00000367235; ENSG00000137103 [A6NDV4-2]
ENST00000439587; ENSP00000395810; ENSG00000137103 [A6NDV4-2]
GeneIDi51754
KEGGihsa:51754
UCSCiuc003zyk.4 human [A6NDV4-1]

Organism-specific databases

CTDi51754
DisGeNETi51754
EuPathDBiHostDB:ENSG00000137103.16
GeneCardsiTMEM8B
HGNCiHGNC:21427 TMEM8B
HPAiHPA052130
HPA062701
neXtProtiNX_A6NDV4
OpenTargetsiENSG00000137103
PharmGKBiPA165586305
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHJ3 Eukaryota
ENOG4111FA8 LUCA
GeneTreeiENSGT00390000004668
InParanoidiA6NDV4
OMAiACLTHEV
OrthoDBiEOG091G0KZA
PhylomeDBiA6NDV4
TreeFamiTF331003

Miscellaneous databases

ChiTaRSiTMEM8B human
GeneWikiiC9orf127
GenomeRNAii51754
PROiPR:A6NDV4

Gene expression databases

BgeeiENSG00000137103 Expressed in 159 organ(s), highest expression level in esophagus
CleanExiHS_C9orf127
GenevisibleiA6NDV4 HS

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR021910 NGX6/PGAP6/MYMK
PANTHERiPTHR14319 PTHR14319, 1 hit
PfamiView protein in Pfam
PF12036 DUF3522, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMM8B_HUMAN
AccessioniPrimary (citable) accession number: A6NDV4
Secondary accession number(s): B3KQF3
, O75539, Q49AB1, Q4KMX5, Q5TCW5, Q9HBY2, Q9P0U7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 15, 2008
Last modified: October 10, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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