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Protein

Transmembrane protein 8B

Gene

TMEM8B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cell-matrix adhesion Source: HGNC
  • regulation of growth Source: UniProtKB-KW
  • regulation of mitotic cell cycle Source: HGNC

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Growth regulation

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.N.2.1.7 the myoblast fusion complex (mfc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 8B
Alternative name(s):
Nasopharyngeal carcinoma-associated gene 6 protein
Protein NAG-5
Protein NGX6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM8B
Synonyms:C9orf127, NGX6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000137103.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21427 TMEM8B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6NDV4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 233ExtracellularSequence analysisAdd BLAST233
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 257CytoplasmicSequence analysis3
Transmembranei258 – 277HelicalSequence analysisAdd BLAST20
Topological domaini278 – 292ExtracellularSequence analysisAdd BLAST15
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Topological domaini314 – 315CytoplasmicSequence analysis2
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Topological domaini337 – 342ExtracellularSequence analysis6
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Topological domaini364 – 379CytoplasmicSequence analysisAdd BLAST16
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Topological domaini401 – 405ExtracellularSequence analysis5
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Topological domaini427 – 472CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51754

Open Targets

More...
OpenTargetsi
ENSG00000137103

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165586305

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM8B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003330391 – 472Transmembrane protein 8BAdd BLAST472

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi186 ↔ 196By similarity
Disulfide bondi190 ↔ 209By similarity
Disulfide bondi211 ↔ 220By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoform 2 is N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A6NDV4

PRoteomics IDEntifications database

More...
PRIDEi
A6NDV4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
931
932 [A6NDV4-2]
933 [A6NDV4-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
A6NDV4-2 [A6NDV4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6NDV4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A6NDV4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Isoform 2 is down-regulated in nasopharyngeal carcinoma cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137103 Expressed in 159 organ(s), highest expression level in esophagus

CleanEx database of gene expression profiles

More...
CleanExi
HS_C9orf127

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A6NDV4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA052130
HPA062701

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 2 (via its cytoplasmic part) interacts with EZR.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119714, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000367227

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A6NDV4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini182 – 221EGF-likeAdd BLAST40

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM8 family.Curated

Keywords - Domaini

EGF-like domain, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHJ3 Eukaryota
ENOG4111FA8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157861

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6NDV4

Identification of Orthologs from Complete Genome Data

More...
OMAi
TTACENG

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0KZA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A6NDV4

TreeFam database of animal gene trees

More...
TreeFami
TF331003

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR021910 NGX6/PGAP6/MYMK

The PANTHER Classification System

More...
PANTHERi
PTHR14319 PTHR14319, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12036 DUF3522, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: A6NDV4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNMPQSLGNQ PLPPEPPSLG TPAEGPGTTS PPEHCWPVRP TLRNELDTFS
60 70 80 90 100
VHFYIFFGPS VALPPERPAV FAMRLLPVLD SGGVLSLELQ LNASSVRQEN
110 120 130 140 150
VTVFGCLTHE VPLSLGDAAV TCSKESLAGF LLSVSATTRV ARLRIPFPQT
160 170 180 190 200
GTWFLALRSL CGVGPRFVRC RNATAEVRMR TFLSPCVDDC GPYGQCKLLR
210 220 230 240 250
THNYLYAACE CKAGWRGWGC TDSADALTYG FQLLSTLLLC LSNLMFLPPV
260 270 280 290 300
VLAIRSRYVL EAAVYTFTMF FSTFYHACDQ PGIVVFCIMD YDVLQFCDFL
310 320 330 340 350
GSLMSVWVTV IAMARLQPVV KQVLYLLGAM LLSMALQLDR HGLWNLLGPS
360 370 380 390 400
LFALGILATA WTVRSVRRRH CYPPTWRRWL FYLCPGSLIA GSAVLLYAFV
410 420 430 440 450
ETRDNYFYIH SIWHMLIAGS VGFLLPPRAK TDHGVPSGAR ARGCGYQLCI
460 470
NEQEELGLVG PGGATVSSIC AS
Length:472
Mass (Da):51,941
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3E5EA4495CF54389
GO
Isoform 2 (identifier: A6NDV4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     274-337: FYHACDQPGI...GAMLLSMALQ → VCGGVCILSL...GHFCKTHWSK
     338-472: Missing.

Show »
Length:338
Mass (Da):36,844
Checksum:iBBB601E2F7ADAF3E
GO
Isoform 3 (identifier: A6NDV4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.
     82-93: GGVLSLELQLNA → MWRPHFHTCPPQ
     274-337: FYHACDQPGI...GAMLLSMALQ → VCGGVCILSL...GHFCKTHWSK
     338-472: Missing.

Note: No experimental confirmation available.
Show »
Length:257
Mass (Da):28,336
Checksum:iA482F1C8662472A8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y2M5A0A2R8Y2M5_HUMAN
Transmembrane protein 8B
TMEM8B
924Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC28644 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAF34820 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAF34820 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti178R → W in AAH98296 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0334501 – 81Missing in isoform 3. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_03345182 – 93GGVLS…LQLNA → MWRPHFHTCPPQ in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_033452274 – 337FYHAC…SMALQ → VCGGVCILSLGACAWWWVTV CISTTFSEGLGMSVPSLCLL QTETAVLPKLSCIDNGHFCK THWSK in isoform 2 and isoform 3. 4 PublicationsAdd BLAST64
Alternative sequenceiVSP_033453338 – 472Missing in isoform 2 and isoform 3. 4 PublicationsAdd BLAST135

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF149297 mRNA Translation: AAF34820.1 Sequence problems.
AF188239 mRNA Translation: AAG29055.1
AF070572 mRNA Translation: AAC28644.1 Different initiation.
AK074844 mRNA Translation: BAG52015.1
AL133410 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58325.1
BC041377 mRNA No translation available.
BC098265 mRNA Translation: AAH98265.1
BC098296 mRNA Translation: AAH98296.1
BC099733 mRNA Translation: AAH99733.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43800.1 [A6NDV4-1]
CCDS6595.1 [A6NDV4-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001036054.1, NM_001042589.2 [A6NDV4-1]
NP_001036055.1, NM_001042590.2
NP_057530.2, NM_016446.3 [A6NDV4-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.493808
Hs.9187

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000377988; ENSP00000367227; ENSG00000137103 [A6NDV4-1]
ENST00000377991; ENSP00000367230; ENSG00000137103 [A6NDV4-1]
ENST00000377996; ENSP00000367235; ENSG00000137103 [A6NDV4-2]
ENST00000439587; ENSP00000395810; ENSG00000137103 [A6NDV4-2]
ENST00000650015; ENSP00000497766; ENSG00000137103 [A6NDV4-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51754

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51754

UCSC genome browser

More...
UCSCi
uc003zyk.4 human [A6NDV4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF149297 mRNA Translation: AAF34820.1 Sequence problems.
AF188239 mRNA Translation: AAG29055.1
AF070572 mRNA Translation: AAC28644.1 Different initiation.
AK074844 mRNA Translation: BAG52015.1
AL133410 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58325.1
BC041377 mRNA No translation available.
BC098265 mRNA Translation: AAH98265.1
BC098296 mRNA Translation: AAH98296.1
BC099733 mRNA Translation: AAH99733.1
CCDSiCCDS43800.1 [A6NDV4-1]
CCDS6595.1 [A6NDV4-2]
RefSeqiNP_001036054.1, NM_001042589.2 [A6NDV4-1]
NP_001036055.1, NM_001042590.2
NP_057530.2, NM_016446.3 [A6NDV4-2]
UniGeneiHs.493808
Hs.9187

3D structure databases

ProteinModelPortaliA6NDV4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119714, 2 interactors
STRINGi9606.ENSP00000367227

Protein family/group databases

TCDBi1.N.2.1.7 the myoblast fusion complex (mfc) family

PTM databases

iPTMnetiA6NDV4
PhosphoSitePlusiA6NDV4

Polymorphism and mutation databases

BioMutaiTMEM8B

Proteomic databases

PaxDbiA6NDV4
PRIDEiA6NDV4
ProteomicsDBi931
932 [A6NDV4-2]
933 [A6NDV4-3]
TopDownProteomicsiA6NDV4-2 [A6NDV4-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377988; ENSP00000367227; ENSG00000137103 [A6NDV4-1]
ENST00000377991; ENSP00000367230; ENSG00000137103 [A6NDV4-1]
ENST00000377996; ENSP00000367235; ENSG00000137103 [A6NDV4-2]
ENST00000439587; ENSP00000395810; ENSG00000137103 [A6NDV4-2]
ENST00000650015; ENSP00000497766; ENSG00000137103 [A6NDV4-1]
GeneIDi51754
KEGGihsa:51754
UCSCiuc003zyk.4 human [A6NDV4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51754
DisGeNETi51754
EuPathDBiHostDB:ENSG00000137103.16

GeneCards: human genes, protein and diseases

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GeneCardsi
TMEM8B
HGNCiHGNC:21427 TMEM8B
HPAiHPA052130
HPA062701
neXtProtiNX_A6NDV4
OpenTargetsiENSG00000137103
PharmGKBiPA165586305

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IHJ3 Eukaryota
ENOG4111FA8 LUCA
GeneTreeiENSGT00940000157861
InParanoidiA6NDV4
OMAiTTACENG
OrthoDBiEOG091G0KZA
PhylomeDBiA6NDV4
TreeFamiTF331003

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TMEM8B human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
C9orf127

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51754

Protein Ontology

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PROi
PR:A6NDV4

Gene expression databases

BgeeiENSG00000137103 Expressed in 159 organ(s), highest expression level in esophagus
CleanExiHS_C9orf127
GenevisibleiA6NDV4 HS

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR021910 NGX6/PGAP6/MYMK
PANTHERiPTHR14319 PTHR14319, 1 hit
PfamiView protein in Pfam
PF12036 DUF3522, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMM8B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NDV4
Secondary accession number(s): B3KQF3
, O75539, Q49AB1, Q4KMX5, Q5TCW5, Q9HBY2, Q9P0U7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 15, 2008
Last modified: December 5, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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