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Protein

Golgin subfamily A member 6B

Gene

GOLGA6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Maps to a duplicated region on chromosome 15; the gene is present in at least 4 almost identical copies.Curated

GO - Biological processi

  • Golgi organization Source: GO_Central
  • spindle assembly Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 6B
Gene namesi
Name:GOLGA6B
Synonyms:GOLGA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000215186.6
HGNCiHGNC:32205 GOLGA6B
neXtProtiNX_A6NDN3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000215186
PharmGKBiPA162389878

Polymorphism and mutation databases

BioMutaiGOLGA6B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003322481 – 693Golgin subfamily A member 6BAdd BLAST693

Proteomic databases

PaxDbiA6NDN3
PRIDEiA6NDN3
ProteomicsDBi919

PTM databases

iPTMnetiA6NDN3
PhosphoSitePlusiA6NDN3

Expressioni

Gene expression databases

BgeeiENSG00000215186 Expressed in 57 organ(s), highest expression level in testis
GenevisibleiA6NDN3 HS

Organism-specific databases

HPAiHPA044978
HPA050087

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000408132

Structurei

3D structure databases

ProteinModelPortaliA6NDN3
SMRiA6NDN3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili77 – 611Sequence analysisAdd BLAST535

Sequence similaritiesi

Belongs to the GOLGA6 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4725 Eukaryota
ENOG410ZIE4 LUCA
GeneTreeiENSGT00530000062932
HOGENOMiHOG000218631
HOVERGENiHBG051752
InParanoidiA6NDN3
OMAiPGPQELG
OrthoDBiEOG091G0DDT
PhylomeDBiA6NDN3
TreeFamiTF316990

Family and domain databases

InterProiView protein in InterPro
IPR024858 Golgin_A
PANTHERiPTHR10881 PTHR10881, 1 hit
PfamiView protein in Pfam
PF15070 GOLGA2L5, 3 hits

Sequencei

Sequence statusi: Complete.

A6NDN3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWPQPYLPPH PMMLEESRQN KLAAAKKKLK EYQQRKSPGI PAGAKTKKKK
60 70 80 90 100
TDSSPETTTS GGGHSPGDSQ YQELAVALES SSVTISQLNE NIESLKQQKK
110 120 130 140 150
QVEHQLEEAK KTNNEIHKAQ MERLETINIL TLEKADLKTT LYHTKRAARH
160 170 180 190 200
FEEESKDLAG RLQYSLQRIQ ELERALCAVS TQQQEEDRSS SCREAVLHRR
210 220 230 240 250
LQQTIKERAL LNAHVTQVTE SLKQVQLERD EYAKHIKGER ARWQERMWKM
260 270 280 290 300
SVEARTLKEE KKRDIHRIQE LERSLSELKN QMAKPPSLAP PAVTSVVEQL
310 320 330 340 350
QDEAKHLRQE VEGLEGKLQS QVENNQALSL LSKEQKQRLQ EQEEMLREQE
360 370 380 390 400
VQRVREQERL CEQNERLREQ QKTLQEQGER LRKQEQRLRK QEERLRKEEE
410 420 430 440 450
RLQKQEKRLW DQEERLWKKE ERLQKQEERL ALSQNHKLDK QLAEPQCSFE
460 470 480 490 500
DLNNEKKSAL QLEQQVKELQ EKLDEEHLEA ASQQNQQLET QLSLVALPGE
510 520 530 540 550
GDGGQHLDSE EEEAPRPTPN IPEDLESREA TSSFMDLPKE KADGTEQVER
560 570 580 590 600
RELGFVQPSG VTDGMRESFT VYESQGAVPN TRHQEMEDVI RLAQKEEEMK
610 620 630 640 650
VKLLELQELV LPLVGNHEGH GKFLIAAQNP ADEPTPGAPA PQELGAAGEQ
660 670 680 690
DDFYEVSLDN NVEPAPGAAR EGSPHDNPTV QQIVQLSPVM QDT
Length:693
Mass (Da):79,913
Last modified:April 29, 2008 - v3
Checksum:i462832EB3A4DB159
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042994200R → W. Corresponds to variant dbSNP:rs2081561Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009712 Genomic DNA No translation available.
AC100827 Genomic DNA No translation available.
CCDSiCCDS10245.2
RefSeqiNP_061122.4, NM_018652.4
UniGeneiHs.546408

Genome annotation databases

EnsembliENST00000421285; ENSP00000408132; ENSG00000215186
GeneIDi55889
KEGGihsa:55889
UCSCiuc010uks.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009712 Genomic DNA No translation available.
AC100827 Genomic DNA No translation available.
CCDSiCCDS10245.2
RefSeqiNP_061122.4, NM_018652.4
UniGeneiHs.546408

3D structure databases

ProteinModelPortaliA6NDN3
SMRiA6NDN3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000408132

PTM databases

iPTMnetiA6NDN3
PhosphoSitePlusiA6NDN3

Polymorphism and mutation databases

BioMutaiGOLGA6B

Proteomic databases

PaxDbiA6NDN3
PRIDEiA6NDN3
ProteomicsDBi919

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000421285; ENSP00000408132; ENSG00000215186
GeneIDi55889
KEGGihsa:55889
UCSCiuc010uks.2 human

Organism-specific databases

CTDi55889
EuPathDBiHostDB:ENSG00000215186.6
GeneCardsiGOLGA6B
HGNCiHGNC:32205 GOLGA6B
HPAiHPA044978
HPA050087
neXtProtiNX_A6NDN3
OpenTargetsiENSG00000215186
PharmGKBiPA162389878
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4725 Eukaryota
ENOG410ZIE4 LUCA
GeneTreeiENSGT00530000062932
HOGENOMiHOG000218631
HOVERGENiHBG051752
InParanoidiA6NDN3
OMAiPGPQELG
OrthoDBiEOG091G0DDT
PhylomeDBiA6NDN3
TreeFamiTF316990

Miscellaneous databases

GenomeRNAii55889
PROiPR:A6NDN3

Gene expression databases

BgeeiENSG00000215186 Expressed in 57 organ(s), highest expression level in testis
GenevisibleiA6NDN3 HS

Family and domain databases

InterProiView protein in InterPro
IPR024858 Golgin_A
PANTHERiPTHR10881 PTHR10881, 1 hit
PfamiView protein in Pfam
PF15070 GOLGA2L5, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGOG6B_HUMAN
AccessioniPrimary (citable) accession number: A6NDN3
Secondary accession number(s): A8MYY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: November 7, 2018
This is version 73 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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