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Entry version 81 (13 Feb 2019)
Sequence version 1 (24 Jul 2007)
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Protein

Golgin subfamily A member 6C

Gene

GOLGA6C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Maps to a duplicated region on chromosome 15; the gene is present in at least 4 almost identical copies.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • Golgi organization Source: GO_Central
  • spindle assembly Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Golgin subfamily A member 6C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GOLGA6C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000167195.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:32206 GOLGA6C

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6NDK9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162389919

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GOLGA6C

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003322491 – 693Golgin subfamily A member 6CAdd BLAST693

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A6NDK9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A6NDK9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A6NDK9

PRoteomics IDEntifications database

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PRIDEi
A6NDK9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
914

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6NDK9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A6NDK9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167195 Expressed in 16 organ(s), highest expression level in testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A6NDK9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044978
HPA050087

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A6NDK9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A6NDK9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili73 – 611Sequence analysisAdd BLAST539

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GOLGA6 family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4725 Eukaryota
ENOG410ZIE4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000062932

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000218631

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051752

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6NDK9

Identification of Orthologs from Complete Genome Data

More...
OMAi
NARINDT

Database of Orthologous Groups

More...
OrthoDBi
358120at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A6NDK9

TreeFam database of animal gene trees

More...
TreeFami
TF316990

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024858 Golgin_A

The PANTHER Classification System

More...
PANTHERi
PTHR10881 PTHR10881, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15070 GOLGA2L5, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A6NDK9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWPQPYLPPH PMMLEESRQN KLAAAKKKLK EYQQRKSPGI PAGAKTKKKK
60 70 80 90 100
TDSSPETTTS GGGHSPGDSQ YQELAVALES SSVTINQLNE NIESLKQQKK
110 120 130 140 150
QVEHQLEEAK KTNNEIHKAQ MEQLETINIL TLEKADLKTT LYHTKRAARH
160 170 180 190 200
FEEESKDLAG RLQYSLQRIQ ELERALSAVS TQQQEEDRSS SCREAVLQRR
210 220 230 240 250
LQQTIKERAL LNAHVTQVTE SLKQVQLERD EYAKHIKGER ARWQERMWKM
260 270 280 290 300
SVEARTLKEE KKRDIHRIQE LERSLSELKN QMAEPPSLAP PAVTSVVEQL
310 320 330 340 350
QDEAKHLRQE VEGLEGKLQS QVENNQALSL LSKEQKQRLQ EQEEMLREQE
360 370 380 390 400
AQRVREQERL CEQNERLREQ QKTLQEQGER LRKQEQRLRK QEERLRKEEE
410 420 430 440 450
RLQKQEKRLW DQEERLWKKE ERLQKQEERL ALSQNHKLDK QLAEPQCSFE
460 470 480 490 500
DLNNEKKSAL QLEQQVKELQ EKLDEEHLEA ASQRNQQLET QLSLVALPGE
510 520 530 540 550
GDGGQHLDSE EEEAPRPTPN IPEDLESREA TSSFMDLPKE KADGTEQVER
560 570 580 590 600
RELGFVQPSG VTDGMRESFT VYESQGAVPN TRHQEMEDVI RLAQKEEEMK
610 620 630 640 650
VKLLELQELV LPLVGNHEGH GKFLIAAQNP ADEPTPGAPA PQELGAAGEQ
660 670 680 690
DDFYEVSLDN NVEPAPGAAR EGSPHDNPPV QQIVQLSPVM QDT
Length:693
Mass (Da):79,884
Last modified:July 24, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBEA09FD2D471FB8D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC068338 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS58388.1

NCBI Reference Sequences

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RefSeqi
NP_001157876.1, NM_001164404.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.540230

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000300576; ENSP00000300576; ENSG00000167195

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
653641

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:653641

UCSC genome browser

More...
UCSCi
uc002azs.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068338 Genomic DNA No translation available.
CCDSiCCDS58388.1
RefSeqiNP_001157876.1, NM_001164404.1
UniGeneiHs.540230

3D structure databases

ProteinModelPortaliA6NDK9
SMRiA6NDK9
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiA6NDK9
PhosphoSitePlusiA6NDK9

Polymorphism and mutation databases

BioMutaiGOLGA6C

Proteomic databases

EPDiA6NDK9
jPOSTiA6NDK9
PaxDbiA6NDK9
PRIDEiA6NDK9
ProteomicsDBi914

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300576; ENSP00000300576; ENSG00000167195
GeneIDi653641
KEGGihsa:653641
UCSCiuc002azs.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
653641
EuPathDBiHostDB:ENSG00000167195.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GOLGA6C
HGNCiHGNC:32206 GOLGA6C
HPAiHPA044978
HPA050087
neXtProtiNX_A6NDK9
PharmGKBiPA162389919

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4725 Eukaryota
ENOG410ZIE4 LUCA
GeneTreeiENSGT00530000062932
HOGENOMiHOG000218631
HOVERGENiHBG051752
InParanoidiA6NDK9
OMAiNARINDT
OrthoDBi358120at2759
PhylomeDBiA6NDK9
TreeFamiTF316990

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
653641

Protein Ontology

More...
PROi
PR:A6NDK9

Gene expression databases

BgeeiENSG00000167195 Expressed in 16 organ(s), highest expression level in testis
GenevisibleiA6NDK9 HS

Family and domain databases

InterProiView protein in InterPro
IPR024858 Golgin_A
PANTHERiPTHR10881 PTHR10881, 2 hits
PfamiView protein in Pfam
PF15070 GOLGA2L5, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGOG6C_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NDK9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 24, 2007
Last modified: February 13, 2019
This is version 81 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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