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Protein

Glycerol-3-phosphate phosphatase

Gene

PGP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear (PubMed:26755581). In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP (By similarity).By similarity1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.By similarity
Glycerol 1-phosphate + H2O = glycerol + phosphate.1 Publication

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Kineticsi

Given the respective intracellular concentrations of glycerol-3-phosphate and 2-phosphoglycolate, glycerol-3-phosphate with a concentration of 2 to 10 mM is most probably the physiological substrate.1 Publication
  1. KM=1.4 mM for glycerol-3-phosphate1 Publication
  2. KM=1.5 mM for 2-phosphoglycolate1 Publication
  1. Vmax=100 nmol/min/mg enzyme with glycerol-3-phosphate as substrate1 Publication
  2. Vmax=500 nmol/min/mg enzyme with 2-phosphoglycolate as substrate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei34NucleophileBy similarity1
Metal bindingi34MagnesiumBy similarity1
Active sitei36Proton donorBy similarity1
Metal bindingi36Magnesium; via carbonyl oxygenBy similarity1
Sitei204Important for substrate specificityBy similarity1
Metal bindingi260MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCarbohydrate metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-70171 Glycolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate phosphataseCurated (EC:3.1.3.211 Publication)
Short name:
G3PP1 Publication
Alternative name(s):
Aspartate-based ubiquitous Mg(2+)-dependent phosphatase1 Publication (EC:3.1.3.48By similarity)
Short name:
AUM1 Publication
Phosphoglycolate phosphatase1 Publication
Short name:
PGP1 Publication
Gene namesi
Name:PGPImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000184207.8
HGNCiHGNC:8909 PGP
MIMi172280 gene
neXtProtiNX_A6NDG6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi283871
OpenTargetsiENSG00000184207
PharmGKBiPA33246

Polymorphism and mutation databases

BioMutaiPGP

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003168881 – 321Glycerol-3-phosphate phosphataseAdd BLAST321

Proteomic databases

EPDiA6NDG6
MaxQBiA6NDG6
PaxDbiA6NDG6
PRIDEiA6NDG6
ProteomicsDBi907

PTM databases

DEPODiA6NDG6
iPTMnetiA6NDG6
PhosphoSitePlusiA6NDG6

Expressioni

Tissue specificityi

Detected in all tissues including red cells, lymphocytes and cultured fibroblasts (at protein level). The highest activities occur in skeletal muscle and cardiac muscle.1 Publication

Gene expression databases

BgeeiENSG00000184207 Expressed in 194 organ(s), highest expression level in testis
CleanExiHS_PGP
ExpressionAtlasiA6NDG6 baseline and differential
GenevisibleiA6NDG6 HS

Organism-specific databases

HPAiHPA043096
HPA046739

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi129694, 8 interactors
STRINGi9606.ENSP00000330918

Structurei

3D structure databases

ProteinModelPortaliA6NDG6
SMRiA6NDG6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2882 Eukaryota
COG0647 LUCA
GeneTreeiENSGT00510000047020
HOGENOMiHOG000068104
HOVERGENiHBG049429
InParanoidiA6NDG6
KOiK19269
OMAiVFGTAYC
OrthoDBiEOG091G0I92
PhylomeDBiA6NDG6
TreeFamiTF314344

Family and domain databases

Gene3Di3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR006357 HAD-SF_hydro_IIA
IPR023214 HAD_sf
IPR006349 PGP_euk
PfamiView protein in Pfam
PF13344 Hydrolase_6, 1 hit
PIRSFiPIRSF000915 PGP-type_phosphatase, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR01460 HAD-SF-IIA, 1 hit
TIGR01452 PGP_euk, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A6NDG6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAEAGGDD ARCVRLSAER AQALLADVDT LLFDCDGVLW RGETAVPGAP
60 70 80 90 100
EALRALRARG KRLGFITNNS SKTRAAYAEK LRRLGFGGPA GPGASLEVFG
110 120 130 140 150
TAYCTALYLR QRLAGAPAPK AYVLGSPALA AELEAVGVAS VGVGPEPLQG
160 170 180 190 200
EGPGDWLHAP LEPDVRAVVV GFDPHFSYMK LTKALRYLQQ PGCLLVGTNM
210 220 230 240 250
DNRLPLENGR FIAGTGCLVR AVEMAAQRQA DIIGKPSRFI FDCVSQEYGI
260 270 280 290 300
NPERTVMVGD RLDTDILLGA TCGLKTILTL TGVSTLGDVK NNQESDCVSK
310 320
KKMVPDFYVD SIADLLPALQ G
Length:321
Mass (Da):34,006
Last modified:July 24, 2007 - v1
Checksum:i6277550764EAAF91
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BV17H3BV17_HUMAN
Glycerol-3-phosphate phosphatase
PGP
57Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009065 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85534.1
CCDSiCCDS42104.1
RefSeqiNP_001035830.1, NM_001042371.2
UniGeneiHs.442634

Genome annotation databases

EnsembliENST00000333503; ENSP00000330918; ENSG00000184207
GeneIDi283871
KEGGihsa:283871
UCSCiuc002cpk.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009065 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85534.1
CCDSiCCDS42104.1
RefSeqiNP_001035830.1, NM_001042371.2
UniGeneiHs.442634

3D structure databases

ProteinModelPortaliA6NDG6
SMRiA6NDG6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129694, 8 interactors
STRINGi9606.ENSP00000330918

PTM databases

DEPODiA6NDG6
iPTMnetiA6NDG6
PhosphoSitePlusiA6NDG6

Polymorphism and mutation databases

BioMutaiPGP

Proteomic databases

EPDiA6NDG6
MaxQBiA6NDG6
PaxDbiA6NDG6
PRIDEiA6NDG6
ProteomicsDBi907

Protocols and materials databases

DNASUi283871
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333503; ENSP00000330918; ENSG00000184207
GeneIDi283871
KEGGihsa:283871
UCSCiuc002cpk.2 human

Organism-specific databases

CTDi283871
DisGeNETi283871
EuPathDBiHostDB:ENSG00000184207.8
GeneCardsiPGP
HGNCiHGNC:8909 PGP
HPAiHPA043096
HPA046739
MIMi172280 gene
neXtProtiNX_A6NDG6
OpenTargetsiENSG00000184207
PharmGKBiPA33246
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2882 Eukaryota
COG0647 LUCA
GeneTreeiENSGT00510000047020
HOGENOMiHOG000068104
HOVERGENiHBG049429
InParanoidiA6NDG6
KOiK19269
OMAiVFGTAYC
OrthoDBiEOG091G0I92
PhylomeDBiA6NDG6
TreeFamiTF314344

Enzyme and pathway databases

ReactomeiR-HSA-70171 Glycolysis

Miscellaneous databases

ChiTaRSiPGP human
GenomeRNAii283871
PROiPR:A6NDG6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184207 Expressed in 194 organ(s), highest expression level in testis
CleanExiHS_PGP
ExpressionAtlasiA6NDG6 baseline and differential
GenevisibleiA6NDG6 HS

Family and domain databases

Gene3Di3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR006357 HAD-SF_hydro_IIA
IPR023214 HAD_sf
IPR006349 PGP_euk
PfamiView protein in Pfam
PF13344 Hydrolase_6, 1 hit
PIRSFiPIRSF000915 PGP-type_phosphatase, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR01460 HAD-SF-IIA, 1 hit
TIGR01452 PGP_euk, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPGP_HUMAN
AccessioniPrimary (citable) accession number: A6NDG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 24, 2007
Last modified: November 7, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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