PGP

Functionⁱ

Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear (PubMed:26755581). In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP (By similarity).By similarity1 Publication

Catalytic activityⁱ

Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.By similarity

Glycerol 1-phosphate + H₂O = glycerol + phosphate.1 Publication

Cofactorⁱ

Mg²⁺By similarityNote: Binds 1 Mg²⁺ ion per subunit.By similarity

Kineticsⁱ

Given the respective intracellular concentrations of glycerol-3-phosphate and 2-phosphoglycolate, glycerol-3-phosphate with a concentration of 2 to 10 mM is most probably the physiological substrate.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	34	NucleophileBy similarity	1
Metal bindingⁱ	34	MagnesiumBy similarity	1
Active siteⁱ	36	Proton donorBy similarity	1
Metal bindingⁱ	36	Magnesium; via carbonyl oxygenBy similarity	1
Siteⁱ	204	Important for substrate specificityBy similarity	1
Metal bindingⁱ	260	MagnesiumBy similarity	1

GO - Molecular functionⁱ

glycerol-1-phosphatase activity Source: UniProtKB-EC
glycerol-3-phosphatase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 26755581
magnesium ion binding Source: UniProtKB
nucleotide phosphatase activity, acting on free nucleotides Source: UniProtKB
phosphatase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phosphoglycolate phosphatase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 26755581
phosphoprotein phosphatase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein tyrosine phosphatase activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

dephosphorylation Source: UniProtKB
glycerol biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 26755581
glycerophospholipid metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 26755581
negative regulation of gluconeogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 26755581
peptidyl-tyrosine dephosphorylation Source: UniProtKB
protein dephosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protein phosphatase
Biological process	Carbohydrate metabolism
Ligand	Magnesium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-70171 Glycolysis

Reactomeⁱ

R-HSA-70171 Glycolysis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glycerol-3-phosphate phosphataseCurated (EC:3.1.3.211 Publication) Short name: G3PP1 Publication Alternative name(s): Aspartate-based ubiquitous Mg(2+)-dependent phosphatase1 Publication (EC:3.1.3.48By similarity) Short name: AUM1 Publication Phosphoglycolate phosphatase1 Publication Short name: PGP1 Publication
Gene namesⁱ	Name:PGPImported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000184207.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8909 PGP
MIMⁱ	172280 gene
neXtProtⁱ	NX_A6NDG6

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	283871
Open Targets More...OpenTargetsⁱ	ENSG00000184207
PharmGKBⁱ	PA33246

Polymorphism and mutation databases

BioMutaⁱ	PGP

BioMutaⁱ

PGP

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000316888	1 – 321	Glycerol-3-phosphate phosphataseAdd BLAST		321

Proteomic databases

EPDⁱ	A6NDG6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A6NDG6
PaxDbⁱ	A6NDG6
PRIDEⁱ	A6NDG6
ProteomicsDBⁱ	907

PTM databases

DEPODⁱ	A6NDG6
iPTMnetⁱ	A6NDG6
PhosphoSitePlusⁱ	A6NDG6

Expressionⁱ

Tissue specificityⁱ

Detected in all tissues including red cells, lymphocytes and cultured fibroblasts (at protein level). The highest activities occur in skeletal muscle and cardiac muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000184207 Expressed in 194 organ(s), highest expression level in testis
CleanExⁱ	HS_PGP
ExpressionAtlasⁱ	A6NDG6 baseline and differential
Genevisibleⁱ	A6NDG6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043096 HPA046739

HPAⁱ

HPA043096
HPA046739

Interactionⁱ

Subunit structureⁱ

Homodimer.By similarity

Protein-protein interaction databases

BioGridⁱ	129694, 8 interactors
STRINGⁱ	9606.ENSP00000330918

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A6NDG6
SMRⁱ	A6NDG6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2882 Eukaryota COG0647 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000047020
HOGENOMⁱ	HOG000068104
HOVERGENⁱ	HBG049429
InParanoidⁱ	A6NDG6
KEGG Orthology (KO) More...KOⁱ	K19269
OMAⁱ	VFGTAYC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I92
PhylomeDBⁱ	A6NDG6
TreeFamⁱ	TF314344

Family and domain databases

Gene3Dⁱ	3.40.50.1000, 2 hits
InterProⁱ	View protein in InterPro IPR036412 HAD-like_sf IPR006357 HAD-SF_hydro_IIA IPR023214 HAD_sf IPR006349 PGP_euk
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13344 Hydrolase_6, 1 hit
PIRSFⁱ	PIRSF000915 PGP-type_phosphatase, 1 hit
SUPFAMⁱ	SSF56784 SSF56784, 1 hit
TIGRFAMsⁱ	TIGR01460 HAD-SF-IIA, 1 hit TIGR01452 PGP_euk, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

A6NDG6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAAAEAGGDD ARCVRLSAER AQALLADVDT LLFDCDGVLW RGETAVPGAP 
        60         70         80         90        100
EALRALRARG KRLGFITNNS SKTRAAYAEK LRRLGFGGPA GPGASLEVFG 
       110        120        130        140        150
TAYCTALYLR QRLAGAPAPK AYVLGSPALA AELEAVGVAS VGVGPEPLQG 
       160        170        180        190        200
EGPGDWLHAP LEPDVRAVVV GFDPHFSYMK LTKALRYLQQ PGCLLVGTNM 
       210        220        230        240        250
DNRLPLENGR FIAGTGCLVR AVEMAAQRQA DIIGKPSRFI FDCVSQEYGI 
       260        270        280        290        300
NPERTVMVGD RLDTDILLGA TCGLKTILTL TGVSTLGDVK NNQESDCVSK 
       310        320 
KKMVPDFYVD SIADLLPALQ G

Length:321

Mass (Da):34,006

Last modified:July 24, 2007 - v1

Checksum:ⁱ6277550764EAAF91

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H3BV17	H3BV17_HUMAN		Glycerol-3-phosphate phosphatase Glycerol-3-phosphate phosphatase	PGP	57	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC009065 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85534.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42104.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001035830.1, NM_001042371.2
UniGeneⁱ	Hs.442634

Genome annotation databases

Ensemblⁱ	ENST00000333503; ENSP00000330918; ENSG00000184207
GeneIDⁱ	283871
KEGGⁱ	hsa:283871
UCSC genome browser More...UCSCⁱ	uc002cpk.2 human

Protein	Similar proteins		Species	Score	Length	Source
A6NDG6	Uncharacterized protein		PAPAN		326	UniRef90_A6NDG6
Uncharacterized protein		COLAP		122
Uncharacterized protein		PANPA		122
Uncharacterized protein		GORGO		122
Uncharacterized protein		MACFA		322
+16

Protein	Similar proteins		Species	Score	Length	Source
A6NDG6	Glycerol-3-phosphate phosphatase		CHICK		312	UniRef50_A6NDG6
Glycerol-3-phosphate phosphatase		BOVIN		321
Uncharacterized protein		PAPAN		326
Uncharacterized protein		COLAP		122
Uncharacterized protein		PANPA		122
+84

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC009065 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85534.1
CCDSⁱ	CCDS42104.1
RefSeqⁱ	NP_001035830.1, NM_001042371.2
UniGeneⁱ	Hs.442634

3D structure databases

ProteinModelPortalⁱ	A6NDG6
SMRⁱ	A6NDG6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	129694, 8 interactors
STRINGⁱ	9606.ENSP00000330918

PTM databases

DEPODⁱ	A6NDG6
iPTMnetⁱ	A6NDG6
PhosphoSitePlusⁱ	A6NDG6

Polymorphism and mutation databases

BioMutaⁱ	PGP

BioMutaⁱ

PGP

Proteomic databases

EPDⁱ	A6NDG6
MaxQBⁱ	A6NDG6
PaxDbⁱ	A6NDG6
PRIDEⁱ	A6NDG6
ProteomicsDBⁱ	907

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	283871
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000333503; ENSP00000330918; ENSG00000184207
GeneIDⁱ	283871
KEGGⁱ	hsa:283871
UCSCⁱ	uc002cpk.2 human

Organism-specific databases

CTDⁱ	283871
DisGeNETⁱ	283871
EuPathDBⁱ	HostDB:ENSG00000184207.8
GeneCardsⁱ	PGP
HGNCⁱ	HGNC:8909 PGP
HPAⁱ	HPA043096 HPA046739
MIMⁱ	172280 gene
neXtProtⁱ	NX_A6NDG6
OpenTargetsⁱ	ENSG00000184207
PharmGKBⁱ	PA33246
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2882 Eukaryota COG0647 LUCA
GeneTreeⁱ	ENSGT00510000047020
HOGENOMⁱ	HOG000068104
HOVERGENⁱ	HBG049429
InParanoidⁱ	A6NDG6
KOⁱ	K19269
OMAⁱ	VFGTAYC
OrthoDBⁱ	EOG091G0I92
PhylomeDBⁱ	A6NDG6
TreeFamⁱ	TF314344

Enzyme and pathway databases

Reactomeⁱ	R-HSA-70171 Glycolysis

Reactomeⁱ

R-HSA-70171 Glycolysis

Miscellaneous databases

ChiTaRSⁱ	PGP human
GenomeRNAiⁱ	283871
Protein Ontology More...PROⁱ	PR:A6NDG6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000184207 Expressed in 194 organ(s), highest expression level in testis
CleanExⁱ	HS_PGP
ExpressionAtlasⁱ	A6NDG6 baseline and differential
Genevisibleⁱ	A6NDG6 HS

Family and domain databases

Gene3Dⁱ	3.40.50.1000, 2 hits
InterProⁱ	View protein in InterPro IPR036412 HAD-like_sf IPR006357 HAD-SF_hydro_IIA IPR023214 HAD_sf IPR006349 PGP_euk
Pfamⁱ	View protein in Pfam PF13344 Hydrolase_6, 1 hit
PIRSFⁱ	PIRSF000915 PGP-type_phosphatase, 1 hit
SUPFAMⁱ	SSF56784 SSF56784, 1 hit
TIGRFAMsⁱ	TIGR01460 HAD-SF-IIA, 1 hit TIGR01452 PGP_euk, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PGP_HUMAN
Accessionⁱ	A6NDG6Primary (citable) accession number: A6NDG6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
	Last sequence update:	July 24, 2007
	Last modified:	November 7, 2018
	This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniParc

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UniProtKB - A6NDG6 (PGP_HUMAN)

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Glycerol-3-phosphate phosphatase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Kineticsⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ