UniProtKB - A6NDG6 (PGP_HUMAN)
Glycerol-3-phosphate phosphatase
PGP
Functioni
Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear (PubMed:26755581).
In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP (By similarity).
By similarity1 PublicationCatalytic activityi
Cofactori
Kineticsi
- KM=1.4 mM for glycerol-3-phosphate1 Publication
- KM=1.5 mM for 2-phosphoglycolate1 Publication
- Vmax=100 nmol/min/mg enzyme with glycerol-3-phosphate as substrate1 Publication
- Vmax=500 nmol/min/mg enzyme with 2-phosphoglycolate as substrate1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 34 | NucleophileBy similarity | 1 | |
Metal bindingi | 34 | MagnesiumBy similarity | 1 | |
Active sitei | 36 | Proton donorBy similarity | 1 | |
Metal bindingi | 36 | Magnesium; via carbonyl oxygenBy similarity | 1 | |
Sitei | 204 | Important for substrate specificityBy similarity | 1 | |
Metal bindingi | 260 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- glycerol-1-phosphatase activity Source: UniProtKB-EC
- glycerol-3-phosphatase activity Source: UniProtKB
- magnesium ion binding Source: UniProtKB
- nucleotide phosphatase activity, acting on free nucleotides Source: UniProtKB
- phosphatase activity Source: GO_Central
- phosphoglycolate phosphatase activity Source: UniProtKB
- protein tyrosine phosphatase activity Source: UniProtKB
GO - Biological processi
- dephosphorylation Source: UniProtKB
- glycerol biosynthetic process Source: UniProtKB
- glycerophospholipid metabolic process Source: UniProtKB
- negative regulation of gluconeogenesis Source: UniProtKB
- peptidyl-tyrosine dephosphorylation Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Biological process | Carbohydrate metabolism |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | A6NDG6 |
Reactomei | R-HSA-70171, Glycolysis |
SignaLinki | A6NDG6 |
Names & Taxonomyi
Protein namesi | Recommended name: Glycerol-3-phosphate phosphataseCurated (EC:3.1.3.211 Publication)Short name: G3PP1 Publication Alternative name(s): Aspartate-based ubiquitous Mg(2+)-dependent phosphatase1 Publication (EC:3.1.3.48By similarity) Short name: AUM1 Publication Phosphoglycolate phosphatase1 Publication Short name: PGP1 Publication |
Gene namesi | Name:PGPImported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8909, PGP |
MIMi | 172280, gene |
neXtProti | NX_A6NDG6 |
VEuPathDBi | HostDB:ENSG00000184207 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 283871 |
OpenTargetsi | ENSG00000184207 |
PharmGKBi | PA33246 |
Miscellaneous databases
Pharosi | A6NDG6, Tbio |
Genetic variation databases
BioMutai | PGP |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000316888 | 1 – 321 | Glycerol-3-phosphate phosphataseAdd BLAST | 321 |
Proteomic databases
EPDi | A6NDG6 |
jPOSTi | A6NDG6 |
MassIVEi | A6NDG6 |
MaxQBi | A6NDG6 |
PaxDbi | A6NDG6 |
PeptideAtlasi | A6NDG6 |
PRIDEi | A6NDG6 |
ProteomicsDBi | 907 |
PTM databases
DEPODi | PGP |
GlyGeni | A6NDG6, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | A6NDG6 |
MetOSitei | A6NDG6 |
PhosphoSitePlusi | A6NDG6 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000184207, Expressed in testis and 209 other tissues |
ExpressionAtlasi | A6NDG6, baseline and differential |
Genevisiblei | A6NDG6, HS |
Organism-specific databases
HPAi | ENSG00000184207, Tissue enhanced (testis) |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
BioGRIDi | 129694, 18 interactors |
IntActi | A6NDG6, 5 interactors |
STRINGi | 9606.ENSP00000330918 |
Miscellaneous databases
RNActi | A6NDG6, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2882, Eukaryota |
GeneTreei | ENSGT00940000160577 |
HOGENOMi | CLU_043473_0_1_1 |
InParanoidi | A6NDG6 |
OMAi | PPMHRET |
OrthoDBi | 982374at2759 |
PhylomeDBi | A6NDG6 |
TreeFami | TF314344 |
Family and domain databases
Gene3Di | 3.40.50.1000, 2 hits |
InterProi | View protein in InterPro IPR036412, HAD-like_sf IPR006357, HAD-SF_hydro_IIA IPR023214, HAD_sf IPR006349, PGP_euk |
Pfami | View protein in Pfam PF13344, Hydrolase_6, 1 hit |
PIRSFi | PIRSF000915, PGP-type_phosphatase, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit |
TIGRFAMsi | TIGR01460, HAD-SF-IIA, 1 hit TIGR01452, PGP_euk, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MAAAEAGGDD ARCVRLSAER AQALLADVDT LLFDCDGVLW RGETAVPGAP
60 70 80 90 100
EALRALRARG KRLGFITNNS SKTRAAYAEK LRRLGFGGPA GPGASLEVFG
110 120 130 140 150
TAYCTALYLR QRLAGAPAPK AYVLGSPALA AELEAVGVAS VGVGPEPLQG
160 170 180 190 200
EGPGDWLHAP LEPDVRAVVV GFDPHFSYMK LTKALRYLQQ PGCLLVGTNM
210 220 230 240 250
DNRLPLENGR FIAGTGCLVR AVEMAAQRQA DIIGKPSRFI FDCVSQEYGI
260 270 280 290 300
NPERTVMVGD RLDTDILLGA TCGLKTILTL TGVSTLGDVK NNQESDCVSK
310 320
KKMVPDFYVD SIADLLPALQ G
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH3BV17 | H3BV17_HUMAN | Glycerol-3-phosphate phosphatase | PGP | 57 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC009065 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85534.1 |
CCDSi | CCDS42104.1 |
RefSeqi | NP_001035830.1, NM_001042371.2 |
Genome annotation databases
Ensembli | ENST00000333503.8; ENSP00000330918.7; ENSG00000184207.9 |
GeneIDi | 283871 |
KEGGi | hsa:283871 |
MANE-Selecti | ENST00000333503.8; ENSP00000330918.7; NM_001042371.3; NP_001035830.1 |
UCSCi | uc002cpk.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC009065 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85534.1 |
CCDSi | CCDS42104.1 |
RefSeqi | NP_001035830.1, NM_001042371.2 |
3D structure databases
AlphaFoldDBi | A6NDG6 |
SMRi | A6NDG6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129694, 18 interactors |
IntActi | A6NDG6, 5 interactors |
STRINGi | 9606.ENSP00000330918 |
PTM databases
DEPODi | PGP |
GlyGeni | A6NDG6, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | A6NDG6 |
MetOSitei | A6NDG6 |
PhosphoSitePlusi | A6NDG6 |
Genetic variation databases
BioMutai | PGP |
Proteomic databases
EPDi | A6NDG6 |
jPOSTi | A6NDG6 |
MassIVEi | A6NDG6 |
MaxQBi | A6NDG6 |
PaxDbi | A6NDG6 |
PeptideAtlasi | A6NDG6 |
PRIDEi | A6NDG6 |
ProteomicsDBi | 907 |
Protocols and materials databases
Antibodypediai | 54763, 146 antibodies from 25 providers |
DNASUi | 283871 |
Genome annotation databases
Ensembli | ENST00000333503.8; ENSP00000330918.7; ENSG00000184207.9 |
GeneIDi | 283871 |
KEGGi | hsa:283871 |
MANE-Selecti | ENST00000333503.8; ENSP00000330918.7; NM_001042371.3; NP_001035830.1 |
UCSCi | uc002cpk.2, human |
Organism-specific databases
CTDi | 283871 |
DisGeNETi | 283871 |
GeneCardsi | PGP |
HGNCi | HGNC:8909, PGP |
HPAi | ENSG00000184207, Tissue enhanced (testis) |
MIMi | 172280, gene |
neXtProti | NX_A6NDG6 |
OpenTargetsi | ENSG00000184207 |
PharmGKBi | PA33246 |
VEuPathDBi | HostDB:ENSG00000184207 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2882, Eukaryota |
GeneTreei | ENSGT00940000160577 |
HOGENOMi | CLU_043473_0_1_1 |
InParanoidi | A6NDG6 |
OMAi | PPMHRET |
OrthoDBi | 982374at2759 |
PhylomeDBi | A6NDG6 |
TreeFami | TF314344 |
Enzyme and pathway databases
PathwayCommonsi | A6NDG6 |
Reactomei | R-HSA-70171, Glycolysis |
SignaLinki | A6NDG6 |
Miscellaneous databases
BioGRID-ORCSi | 283871, 79 hits in 1092 CRISPR screens |
ChiTaRSi | PGP, human |
GenomeRNAii | 283871 |
Pharosi | A6NDG6, Tbio |
PROi | PR:A6NDG6 |
RNActi | A6NDG6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000184207, Expressed in testis and 209 other tissues |
ExpressionAtlasi | A6NDG6, baseline and differential |
Genevisiblei | A6NDG6, HS |
Family and domain databases
Gene3Di | 3.40.50.1000, 2 hits |
InterProi | View protein in InterPro IPR036412, HAD-like_sf IPR006357, HAD-SF_hydro_IIA IPR023214, HAD_sf IPR006349, PGP_euk |
Pfami | View protein in Pfam PF13344, Hydrolase_6, 1 hit |
PIRSFi | PIRSF000915, PGP-type_phosphatase, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit |
TIGRFAMsi | TIGR01460, HAD-SF-IIA, 1 hit TIGR01452, PGP_euk, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PGP_HUMAN | |
Accessioni | A6NDG6Primary (citable) accession number: A6NDG6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | July 24, 2007 | |
Last modified: | May 25, 2022 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families