Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 6C74

Gene

OR6C74

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6C74
Gene namesi
Name:OR6C74
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000197706.3
HGNCiHGNC:31303 OR6C74
neXtProtiNX_A6NCV1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 63CytoplasmicSequence analysisAdd BLAST19
Transmembranei64 – 84Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini85 – 95ExtracellularSequence analysisAdd BLAST11
Transmembranei96 – 116Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini117 – 140CytoplasmicSequence analysisAdd BLAST24
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 194ExtracellularSequence analysisAdd BLAST33
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 237CytoplasmicSequence analysisAdd BLAST22
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 269ExtracellularSequence analysisAdd BLAST11
Transmembranei270 – 290Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini291 – 312CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134897737

Polymorphism and mutation databases

BioMutaiOR6C74

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003096191 – 312Olfactory receptor 6C74Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 177PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NCV1
PRIDEiA6NCV1
ProteomicsDBi864
TopDownProteomicsiA6NCV1

PTM databases

iPTMnetiA6NCV1
PhosphoSitePlusiA6NCV1

Expressioni

Gene expression databases

CleanExiHS_OR6C74
ExpressionAtlasiA6NCV1 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000342836

Structurei

3D structure databases

ProteinModelPortaliA6NCV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIV6 Eukaryota
ENOG411142A LUCA
GeneTreeiENSGT00900000140821
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiA6NCV1
KOiK04257
OMAiTDTDIIE
OrthoDBiEOG091G0F9F
PhylomeDBiA6NCV1
TreeFamiTF336833

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

A6NCV1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRNHTTVANF ILLGLTDDPQ LQVIIFLLLF FTYMLSITGN LTIITLTLLD
60 70 80 90 100
LHLKTPMYFF LRNFSFLEVS FTTVYIPKFL VSMATGDKTI SYNDCAAQLF
110 120 130 140 150
FTILLGATEF FLLAAMSYER YVAICKPLHY TTIMSSRVCS LLVFASWMAG
160 170 180 190 200
FLIIFPPLLM GLQLDFCAAN TVDHFFCDVS PILQLSCTDT DIIELMMLLS
210 220 230 240 250
AILTLLVTLV LVILSYTNII RTILKIPSSQ QRKKAFSTCS SHMVVVSISY
260 270 280 290 300
GSCIFMYVKP SAKERVSLNK GIALLSTSVA PMLNPFIYTL RNKQVKDVFK
310
HTVKKIELFS MK
Length:312
Mass (Da):35,253
Last modified:July 24, 2007 - v1
Checksum:i90C62992CA8844AA
GO

Sequence cautioni

The sequence AAI40755 differs from that shown. Reason: Erroneous termination at position 62. Translated as Arg.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0369812R → G1 PublicationCorresponds to variant dbSNP:rs7301705Ensembl.1
Natural variantiVAR_03698261L → F. Corresponds to variant dbSNP:rs11171388Ensembl.1
Natural variantiVAR_03698375Y → C1 PublicationCorresponds to variant dbSNP:rs4388990Ensembl.1
Natural variantiVAR_03698486G → D1 PublicationCorresponds to variant dbSNP:rs6581025Ensembl.1
Natural variantiVAR_036985120R → C. Corresponds to variant dbSNP:rs4321039Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122684 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96805.1
BC140754 mRNA Translation: AAI40755.1 Sequence problems.
CCDSiCCDS31816.1
RefSeqiNP_001005490.1, NM_001005490.1
XP_016874615.1, XM_017019126.1
UniGeneiHs.554556

Genome annotation databases

EnsembliENST00000343870; ENSP00000342836; ENSG00000197706
GeneIDi254783
KEGGihsa:254783
UCSCiuc010spg.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122684 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96805.1
BC140754 mRNA Translation: AAI40755.1 Sequence problems.
CCDSiCCDS31816.1
RefSeqiNP_001005490.1, NM_001005490.1
XP_016874615.1, XM_017019126.1
UniGeneiHs.554556

3D structure databases

ProteinModelPortaliA6NCV1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000342836

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiA6NCV1
PhosphoSitePlusiA6NCV1

Polymorphism and mutation databases

BioMutaiOR6C74

Proteomic databases

PaxDbiA6NCV1
PRIDEiA6NCV1
ProteomicsDBi864
TopDownProteomicsiA6NCV1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343870; ENSP00000342836; ENSG00000197706
GeneIDi254783
KEGGihsa:254783
UCSCiuc010spg.3 human

Organism-specific databases

CTDi254783
EuPathDBiHostDB:ENSG00000197706.3
GeneCardsiOR6C74
HGNCiHGNC:31303 OR6C74
neXtProtiNX_A6NCV1
PharmGKBiPA134897737
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIV6 Eukaryota
ENOG411142A LUCA
GeneTreeiENSGT00900000140821
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiA6NCV1
KOiK04257
OMAiTDTDIIE
OrthoDBiEOG091G0F9F
PhylomeDBiA6NCV1
TreeFamiTF336833

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GenomeRNAii254783
PROiPR:A6NCV1

Gene expression databases

CleanExiHS_OR6C74
ExpressionAtlasiA6NCV1 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO6C74_HUMAN
AccessioniPrimary (citable) accession number: A6NCV1
Secondary accession number(s): B9EIN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: October 10, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again