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Entry version 75 (13 Feb 2019)
Sequence version 2 (05 Apr 2011)
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Protein

Uncharacterized protein C2orf72

Gene

C2orf72

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C2orf72
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C2orf72
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000204128.5

Human Gene Nomenclature Database

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HGNCi
HGNC:27418 C2orf72

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6NCS6

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000204128

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C2orf72

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003393001 – 295Uncharacterized protein C2orf72Add BLAST295

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
A6NCS6

MaxQB - The MaxQuant DataBase

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MaxQBi
A6NCS6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
A6NCS6

PRoteomics IDEntifications database

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PRIDEi
A6NCS6

ProteomicsDB human proteome resource

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ProteomicsDBi
859

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6NCS6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
A6NCS6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204128 Expressed in 142 organ(s), highest expression level in right lobe of liver

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A6NCS6 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA044962

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
A6NCS6, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
A6NCS6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A6NCS6

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi63 – 208Ala-richAdd BLAST146

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J5D9 Eukaryota
ENOG4112AI0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003006

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000185157

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG094889

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6NCS6

Identification of Orthologs from Complete Genome Data

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OMAi
AEGTWER

Database of Orthologous Groups

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OrthoDBi
1274440at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A6NCS6

TreeFam database of animal gene trees

More...
TreeFami
TF339232

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027868 DUF4630

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15443 DUF4630, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A6NCS6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERELEALAA RLARPAEPPF QALVEAAGGR GQVLLVGELW EREQSRALLR
60 70 80 90 100
DFARAVFPPE PGAAKPGGAA AEGAGPGAAR GAQRAARAAG AAGAAAAAAR
110 120 130 140 150
AIRSPLVFVL CRASSLAARE PRRRLREMLR DVRGRRRAGA ALVGVLVAEA
160 170 180 190 200
GPEDAVAPGL RLLEALLRAV FGRQAGGPVQ AAAYCPGLPA SCLAVQAAAC
210 220 230 240 250
RALQAAGAGQ PVEGAWERPG LPGLLACFSW GPWSRRKNQD VAACRSSAQE
260 270 280 290
DFQEPEEELP LTAIFPNGDC DDLGRGSKAC DGVVHTPAEP TGDSR
Length:295
Mass (Da):30,481
Last modified:April 5, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA047D9A53A30FA93
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC009407 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS46539.1

NCBI Reference Sequences

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RefSeqi
NP_001138466.1, NM_001144994.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.526596
Hs.551993

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373640; ENSP00000362743; ENSG00000204128

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
257407

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:257407

UCSC genome browser

More...
UCSCi
uc002vrl.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009407 Genomic DNA No translation available.
CCDSiCCDS46539.1
RefSeqiNP_001138466.1, NM_001144994.1
UniGeneiHs.526596
Hs.551993

3D structure databases

ProteinModelPortaliA6NCS6
SMRiA6NCS6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA6NCS6, 1 interactor

PTM databases

iPTMnetiA6NCS6
PhosphoSitePlusiA6NCS6

Polymorphism and mutation databases

BioMutaiC2orf72

Proteomic databases

jPOSTiA6NCS6
MaxQBiA6NCS6
PaxDbiA6NCS6
PRIDEiA6NCS6
ProteomicsDBi859

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373640; ENSP00000362743; ENSG00000204128
GeneIDi257407
KEGGihsa:257407
UCSCiuc002vrl.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
257407
EuPathDBiHostDB:ENSG00000204128.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C2orf72
HGNCiHGNC:27418 C2orf72
HPAiHPA044962
neXtProtiNX_A6NCS6
OpenTargetsiENSG00000204128

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J5D9 Eukaryota
ENOG4112AI0 LUCA
GeneTreeiENSGT00390000003006
HOGENOMiHOG000185157
HOVERGENiHBG094889
InParanoidiA6NCS6
OMAiAEGTWER
OrthoDBi1274440at2759
PhylomeDBiA6NCS6
TreeFamiTF339232

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C2orf72 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
257407

Protein Ontology

More...
PROi
PR:A6NCS6

Gene expression databases

BgeeiENSG00000204128 Expressed in 142 organ(s), highest expression level in right lobe of liver
GenevisibleiA6NCS6 HS

Family and domain databases

InterProiView protein in InterPro
IPR027868 DUF4630
PfamiView protein in Pfam
PF15443 DUF4630, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCB072_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NCS6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: April 5, 2011
Last modified: February 13, 2019
This is version 75 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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