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Protein

Putative keratin-87 protein

Gene

KRT87P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Caution

Could be the product of a pseudogene.Curated

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Putative keratin-87 protein
Alternative name(s):
Keratin, hair, basic pseudogene 4
Keratin-121 pseudogene
Gene namesi
Name:KRT87P
Synonyms:KRT121P, KRTHBP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:30198 KRT87P
neXtProtiNX_A6NCN2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003406611 – 255Putative keratin-87 proteinAdd BLAST255

Proteomic databases

EPDiA6NCN2
PRIDEiA6NCN2
ProteomicsDBi847

PTM databases

SwissPalmiA6NCN2

Expressioni

Organism-specific databases

HPAiHPA049778

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Structurei

3D structure databases

ProteinModelPortaliA6NCN2
SMRiA6NCN2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 255IF rodPROSITE-ProRule annotationAdd BLAST255

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili19 – 81Sequence analysisAdd BLAST63
Coiled coili147 – 227Sequence analysisAdd BLAST81

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiA6NCN2

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR039008 IF_rod_dom
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

A6NCN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEANSGRLAS ELNHVQEVLE GYKKKYEEEV ALRATAENEF VALKKDVDCA
60 70 80 90 100
YLRKSDLEAN VEALTQEIDF LRRLYEEEIR VLQSHISDTS VVVKMDNSRD
110 120 130 140 150
LNMHCVITEI KAQYDDIATR SRAEAESWYR SKCEEMKATV IRHGETLRRT
160 170 180 190 200
KEEINELNRM IQRLTAEVEN AKCQNSKLEA AVAQSEQQGE AALSDARCKL
210 220 230 240 250
AELEGALQKA KQDMACLIRE YQEVMNSKLA WTLRSPPTGA CWRARSRGCV

RALVL
Length:255
Mass (Da):29,117
Last modified:October 31, 2012 - v4
Checksum:i899BC0E5C9D3659D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4N → D in BAG61913 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300121 mRNA Translation: BAG61913.1
AC021066 Genomic DNA No translation available.
UniGeneiHs.584773

Similar proteinsi

Entry informationi

Entry nameiKR87P_HUMAN
AccessioniPrimary (citable) accession number: A6NCN2
Secondary accession number(s): B4DTA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 31, 2012
Last modified: June 20, 2018
This is version 77 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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