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Entry version 70 (08 May 2019)
Sequence version 3 (05 Apr 2011)
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Protein

Uncharacterized protein C2orf78

Gene

C2orf78

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C2orf78
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C2orf78
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:34349 C2orf78

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6NCI8

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000187833

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C2orf78

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003194221 – 922Uncharacterized protein C2orf78Add BLAST922

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
A6NCI8

PRoteomics IDEntifications database

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PRIDEi
A6NCI8

ProteomicsDB human proteome resource

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ProteomicsDBi
838

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
A6NCI8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
A6NCI8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000187833 Expressed in 6 organ(s), highest expression level in right testis

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
A6NCI8, 3 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000387124

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili872 – 899Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi11 – 141Ser-richAdd BLAST131
Compositional biasi546 – 621Lys-richAdd BLAST76

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IVAP Eukaryota
ENOG41115RW LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000014208

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000060273

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6NCI8

Identification of Orthologs from Complete Genome Data

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OMAi
YRASAHQ

Database of Orthologous Groups

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OrthoDBi
669317at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A6NCI8

TreeFam database of animal gene trees

More...
TreeFami
TF337929

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR040292 C2orf78-like
IPR027898 DUF4629

The PANTHER Classification System

More...
PANTHERi
PTHR31466 PTHR31466, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15442 DUF4629, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A6NCI8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHWLASATQT SASIVSSSLL SAVDVSSSLT MSEYFQNTSL PGTANSRQFS
60 70 80 90 100
LPVVSNAAFL TGSISNFSRA SAPAISSAWL QPSASGTSFQ PLMGSAYLYQ
110 120 130 140 150
HSSTTMLSGV TGQSHICTSA ASYPGVFEWD STASTVKKSS SLRDFTVTVI
160 170 180 190 200
DQNTAVSSMS MTAQYYKTSD TNTMVPLYPS LSASLVQGTL TQIPNQQGHN
210 220 230 240 250
LSLPCQIGSQ VYYYNQGTLG PQLSCLQSYG SVSYTGYRAS AHQPEMVMVL
260 270 280 290 300
KEVQPTNVLP PVSTSGMYYS VSSQPITETS VQVMETSLGM DTSLGLQSPS
310 320 330 340 350
QTFCLPQTPE FSKSFSSRNT QTLESNPSPE LGDISITPVQ SPTNLLTLSP
360 370 380 390 400
APSQEKNENE NLDEIKTNLS KPLDVHQILI GNQDPPLLPV EIPDIHPLLA
410 420 430 440 450
CIDPLGQEEQ PGSENANLRN KSLSLEDQGI FENGIESSSD LADITTWVED
460 470 480 490 500
TYLPPIFSSL QDLDQPESPS AKKAKDTSAI KVNQVQEKSC VIKGHSDQVR
510 520 530 540 550
KNKHKASEPI QGAPKAKIQP KNPECLLERE VVVGSATVSN SASVNKAKHS
560 570 580 590 600
SNKPHKAASS RISKTKSHGQ EKTKGNRKNS SKKSEESKQS GKKVKVEEKQ
610 620 630 640 650
TIPNMKRKKN QPELSQKTLK KPRSSLGMHM LESVQVFHAL GKKIDMKTGF
660 670 680 690 700
SSSRTLGSSS NTQNRQPFPA LKPWLDIQHE GKGPEKIQVK AQKLDGSAEK
710 720 730 740 750
ECTSPSHSEL PPPGKVKLIP LPFLTLDQPQ ARHVSRRPNP LASRRPAVAY
760 770 780 790 800
PARPDSTNSA QSNAVNPSRP APTNTSLTGP ATPAQPISAK ATQPSSANPT
810 820 830 840 850
QPTVPQSAAS RPSAYKTSSC SSLQREPVST AVTSLRSLPK PQNQFLIQDF
860 870 880 890 900
SLQPRPWRKP TVPEPVMSTP ITEEQRPERE AMKRKAQQER ENAAKYTSLG
910 920
KVQFFIERER DMEIAEYYGY TI
Length:922
Mass (Da):100,170
Last modified:April 5, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i866A70E766774B03
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK125975 mRNA No translation available.
AC092653 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS46338.1

NCBI Reference Sequences

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RefSeqi
NP_001073943.1, NM_001080474.1
XP_005264359.1, XM_005264302.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000409561; ENSP00000387124; ENSG00000187833

Database of genes from NCBI RefSeq genomes

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GeneIDi
388960

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:388960

UCSC genome browser

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UCSCi
uc002sjr.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125975 mRNA No translation available.
AC092653 Genomic DNA No translation available.
CCDSiCCDS46338.1
RefSeqiNP_001073943.1, NM_001080474.1
XP_005264359.1, XM_005264302.3

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiA6NCI8, 3 interactors
STRINGi9606.ENSP00000387124

PTM databases

iPTMnetiA6NCI8
PhosphoSitePlusiA6NCI8

Polymorphism and mutation databases

BioMutaiC2orf78

Proteomic databases

PaxDbiA6NCI8
PRIDEiA6NCI8
ProteomicsDBi838

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409561; ENSP00000387124; ENSG00000187833
GeneIDi388960
KEGGihsa:388960
UCSCiuc002sjr.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
388960

GeneCards: human genes, protein and diseases

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GeneCardsi
C2orf78
HGNCiHGNC:34349 C2orf78
neXtProtiNX_A6NCI8
OpenTargetsiENSG00000187833

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IVAP Eukaryota
ENOG41115RW LUCA
GeneTreeiENSGT00390000014208
HOGENOMiHOG000060273
InParanoidiA6NCI8
OMAiYRASAHQ
OrthoDBi669317at2759
PhylomeDBiA6NCI8
TreeFamiTF337929

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
388960

Protein Ontology

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PROi
PR:A6NCI8

Gene expression databases

BgeeiENSG00000187833 Expressed in 6 organ(s), highest expression level in right testis

Family and domain databases

InterProiView protein in InterPro
IPR040292 C2orf78-like
IPR027898 DUF4629
PANTHERiPTHR31466 PTHR31466, 1 hit
PfamiView protein in Pfam
PF15442 DUF4629, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCB078_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NCI8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: April 5, 2011
Last modified: May 8, 2019
This is version 70 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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