UniProtKB - A6NCI4 (VWA3A_HUMAN)
Protein
von Willebrand factor A domain-containing protein 3A
Gene
VWA3A
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: von Willebrand factor A domain-containing protein 3A |
Gene namesi | Name:VWA3A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000175267.14 |
HGNCi | HGNC:27088, VWA3A |
neXtProti | NX_A6NCI4 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 146177 |
OpenTargetsi | ENSG00000175267 |
PharmGKBi | PA162408933 |
Miscellaneous databases
Pharosi | A6NCI4, Tdark |
Polymorphism and mutation databases
BioMutai | VWA3A |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000324623 | 25 – 1184 | von Willebrand factor A domain-containing protein 3AAdd BLAST | 1160 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 709 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | A6NCI4 |
PaxDbi | A6NCI4 |
PeptideAtlasi | A6NCI4 |
PRIDEi | A6NCI4 |
ProteomicsDBi | 833 [A6NCI4-1] 834 [A6NCI4-2] 835 [A6NCI4-3] 836 [A6NCI4-4] |
PTM databases
GlyGeni | A6NCI4, 1 site |
iPTMneti | A6NCI4 |
PhosphoSitePlusi | A6NCI4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000175267, Expressed in right uterine tube and 159 other tissues |
ExpressionAtlasi | A6NCI4, baseline and differential |
Genevisiblei | A6NCI4, HS |
Organism-specific databases
HPAi | ENSG00000175267, Tissue enhanced (brain, fallopian tube) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 126967, 1 interactor |
IntActi | A6NCI4, 1 interactor |
STRINGi | 9606.ENSP00000374049 |
Miscellaneous databases
RNActi | A6NCI4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 511 – 708 | VWFA 1PROSITE-ProRule annotationAdd BLAST | 198 | |
Domaini | 959 – 1131 | VWFA 2PROSITE-ProRule annotationAdd BLAST | 173 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 333 – 357 | Sequence analysisAdd BLAST | 25 |
Keywords - Domaini
Coiled coil, Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502QTDG, Eukaryota |
GeneTreei | ENSGT00940000159290 |
HOGENOMi | CLU_008839_0_0_1 |
InParanoidi | A6NCI4 |
OMAi | CSSQEWV |
OrthoDBi | 580729at2759 |
PhylomeDBi | A6NCI4 |
TreeFami | TF328978 |
Family and domain databases
Gene3Di | 3.40.50.410, 3 hits |
InterProi | View protein in InterPro IPR002035, VWF_A IPR036465, vWFA_dom_sf |
Pfami | View protein in Pfam PF13768, VWA_3, 3 hits |
SMARTi | View protein in SMART SM00327, VWA, 1 hit |
SUPFAMi | SSF53300, SSF53300, 3 hits |
PROSITEi | View protein in PROSITE PS50234, VWFA, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: A6NCI4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKKYRKISIG CFAMATQTSH VFHGQENMFL ENHCIRRNTG RDSKKPLKQK
60 70 80 90 100
NMNGLGQNSD NGLLVTHVNQ TQDLLRLQGS ETQSSDWEDS EDWLSAHSLK
110 120 130 140 150
CQKLTLADLI SQGTEVLEEG TNVVQKICFS TQIIRHFESK LSDTIEVYQE
160 170 180 190 200
RIQWLTENSK KAFGLIKGAR VSILIDVSAI SSGPQKEEFQ KDLMSLIDEQ
210 220 230 240 250
LSHKEKLFVL SFGTNAGSLW PDPMEVSAST LQELKLWVKT LQPDGGSNLL
260 270 280 290 300
QALKKIFTLK GLDSLVAIMR SCPDQPSEIL SDYIQQSTMG RDLIIHFITY
310 320 330 340 350
RCDDQMPPAV LKNLAEAVRG YYHCYSPKME HYTSRDMDEL LAEIQKAQSL
360 370 380 390 400
LSHVQALQHS SPCEALTCTM EEISTEITNG PLISLLPKPP KHDAPLTIEF
410 420 430 440 450
PNLDKTSAEW LKVNGLKAKK LSLYQVLAPN AFSPVEEFVP ILQKTVSSTI
460 470 480 490 500
HEKAMIQFEW HDGTVKNIHV DPPFLYKYQQ QLSRAMRMYE RRIEWLSLAS
510 520 530 540 550
RRIWGTVCEK RVVVLLDISA TNSMYIIHIQ HSLRLLLEEQ LSNKDCFNLI
560 570 580 590 600
AFGSTIESWR PEMVPVSHNN LQSAWRWALN LRCRGSRNVL SALRKAVEVD
610 620 630 640 650
FKDKDKHQSQ GIYLFTGGIP DQDMPTLSAY MAEACGGCDL QLNVCLFYVG
660 670 680 690 700
EPKMDTTPPA RYASHTDTAA AYKEVTRAAG GRFHWFGDTG IYESDDINSI
710 720 730 740 750
MSEMEKALNY SQKCAFLMAS LKNHSGKVLG SSALPKEKPK TLQLRSQPKK
760 770 780 790 800
LCPPRPTVPL GARMSIKDDP DREKSPPLKS LKWRPLSSRV GISPAAAQPT
810 820 830 840 850
KEGMMELRRK TKSREAETSL LLFYTEKGND VGSVYKKYPQ GRGLRRTSSS
860 870 880 890 900
IDLPRKDTVC SSQEWVAKYG LKKLKLEISR CMGPNCTHQK SGQRSASAKH
910 920 930 940 950
CSIFPSVEIH GVVRHIQWTP REMEVYIRHL EKVLRRYVQR LQWLLSGSRR
960 970 980 990 1000
LFGTVLESKV CILLDTSGSM GPYLQQVKTE LVLLIWEQLR KCCDSFNLLS
1010 1020 1030 1040 1050
FAESFQSWQD TLVETTDAAC HEAMQWVTHL QAQGSTSILQ ALLKAFSFHD
1060 1070 1080 1090 1100
LEGLYLLTDG KPDTSCSLVL NEVQKLREKR DVKVHTISLN CSDRAAVEFL
1110 1120 1130 1140 1150
RKLASFTGGR YHCPVGEDTL SKIHSLLTKG FINEKDPTLP PFEGDDLRIL
1160 1170 1180
AQEITKARSF LWQAQSFRSQ LQKKNDAEPK VTLS
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BUS3 | H3BUS3_HUMAN | von Willebrand factor A domain-cont... | VWA3A | 746 | Annotation score: | ||
H7BXL8 | H7BXL8_HUMAN | von Willebrand factor A domain-cont... | VWA3A | 429 | Annotation score: | ||
H3BTG8 | H3BTG8_HUMAN | von Willebrand factor A domain-cont... | VWA3A | 147 | Annotation score: | ||
H3BTX3 | H3BTX3_HUMAN | von Willebrand factor A domain-cont... | VWA3A | 31 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 885 | N → S in AAH38400 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1005 | F → L in AAQ62968 (Ref. 1) Curated | 1 | |
Sequence conflicti | 1005 | F → L in BAC04176 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1005 | F → L in BAC87526 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1005 | F → L in EAW50598 (Ref. 4) Curated | 1 | |
Sequence conflicti | 1005 | F → L in AAH38400 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1005 | F → L in AAI09296 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059738 | 464 | T → I. Corresponds to variant dbSNP:rs1369695824Ensembl. | 1 | |
Natural variantiVAR_057020 | 657 | T → I1 PublicationCorresponds to variant dbSNP:rs1105929Ensembl. | 1 | |
Natural variantiVAR_057021 | 1165 | Q → P. Corresponds to variant dbSNP:rs16972517Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_032318 | 1 – 922 | Missing in isoform 3. 1 PublicationAdd BLAST | 922 | |
Alternative sequenceiVSP_032319 | 1 – 898 | Missing in isoform 4. 1 PublicationAdd BLAST | 898 | |
Alternative sequenceiVSP_032320 | 7 – 382 | Missing in isoform 2. 1 PublicationAdd BLAST | 376 | |
Alternative sequenceiVSP_032321 | 899 – 945 | KHCSI…LQWLL → MEVYIRHLEKVLRRYVQRLQ WLLSGPVLCSRTWYRQSMDR GVMMTAA in isoform 4. 1 PublicationAdd BLAST | 47 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY360464 mRNA Translation: AAQ62968.1 AK093467 mRNA Translation: BAC04176.1 AK128606 mRNA Translation: BAC87526.1 AC009019 Genomic DNA No translation available. CH471249 Genomic DNA Translation: EAW50598.1 BC038400 mRNA Translation: AAH38400.1 BC109295 mRNA Translation: AAI09296.1 |
CCDSi | CCDS45441.1 [A6NCI4-1] |
RefSeqi | NP_775886.3, NM_173615.4 [A6NCI4-1] |
Genome annotation databases
Ensembli | ENST00000389398; ENSP00000374049; ENSG00000175267 [A6NCI4-1] ENST00000563755; ENSP00000456513; ENSG00000175267 [A6NCI4-4] |
GeneIDi | 146177 |
KEGGi | hsa:146177 |
UCSCi | uc010bxe.2, human [A6NCI4-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY360464 mRNA Translation: AAQ62968.1 AK093467 mRNA Translation: BAC04176.1 AK128606 mRNA Translation: BAC87526.1 AC009019 Genomic DNA No translation available. CH471249 Genomic DNA Translation: EAW50598.1 BC038400 mRNA Translation: AAH38400.1 BC109295 mRNA Translation: AAI09296.1 |
CCDSi | CCDS45441.1 [A6NCI4-1] |
RefSeqi | NP_775886.3, NM_173615.4 [A6NCI4-1] |
3D structure databases
SMRi | A6NCI4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126967, 1 interactor |
IntActi | A6NCI4, 1 interactor |
STRINGi | 9606.ENSP00000374049 |
PTM databases
GlyGeni | A6NCI4, 1 site |
iPTMneti | A6NCI4 |
PhosphoSitePlusi | A6NCI4 |
Polymorphism and mutation databases
BioMutai | VWA3A |
Proteomic databases
jPOSTi | A6NCI4 |
PaxDbi | A6NCI4 |
PeptideAtlasi | A6NCI4 |
PRIDEi | A6NCI4 |
ProteomicsDBi | 833 [A6NCI4-1] 834 [A6NCI4-2] 835 [A6NCI4-3] 836 [A6NCI4-4] |
Protocols and materials databases
Antibodypediai | 51004, 30 antibodies |
Genome annotation databases
Ensembli | ENST00000389398; ENSP00000374049; ENSG00000175267 [A6NCI4-1] ENST00000563755; ENSP00000456513; ENSG00000175267 [A6NCI4-4] |
GeneIDi | 146177 |
KEGGi | hsa:146177 |
UCSCi | uc010bxe.2, human [A6NCI4-1] |
Organism-specific databases
CTDi | 146177 |
DisGeNETi | 146177 |
EuPathDBi | HostDB:ENSG00000175267.14 |
GeneCardsi | VWA3A |
HGNCi | HGNC:27088, VWA3A |
HPAi | ENSG00000175267, Tissue enhanced (brain, fallopian tube) |
neXtProti | NX_A6NCI4 |
OpenTargetsi | ENSG00000175267 |
PharmGKBi | PA162408933 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTDG, Eukaryota |
GeneTreei | ENSGT00940000159290 |
HOGENOMi | CLU_008839_0_0_1 |
InParanoidi | A6NCI4 |
OMAi | CSSQEWV |
OrthoDBi | 580729at2759 |
PhylomeDBi | A6NCI4 |
TreeFami | TF328978 |
Enzyme and pathway databases
PathwayCommonsi | A6NCI4 |
Miscellaneous databases
BioGRID-ORCSi | 146177, 4 hits in 842 CRISPR screens |
ChiTaRSi | VWA3A, human |
GenomeRNAii | 146177 |
Pharosi | A6NCI4, Tdark |
PROi | PR:A6NCI4 |
RNActi | A6NCI4, protein |
Gene expression databases
Bgeei | ENSG00000175267, Expressed in right uterine tube and 159 other tissues |
ExpressionAtlasi | A6NCI4, baseline and differential |
Genevisiblei | A6NCI4, HS |
Family and domain databases
Gene3Di | 3.40.50.410, 3 hits |
InterProi | View protein in InterPro IPR002035, VWF_A IPR036465, vWFA_dom_sf |
Pfami | View protein in Pfam PF13768, VWA_3, 3 hits |
SMARTi | View protein in SMART SM00327, VWA, 1 hit |
SUPFAMi | SSF53300, SSF53300, 3 hits |
PROSITEi | View protein in PROSITE PS50234, VWFA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VWA3A_HUMAN | |
Accessioni | A6NCI4Primary (citable) accession number: A6NCI4 Secondary accession number(s): A4QMU8 Q8N9W1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | March 18, 2008 | |
Last modified: | December 2, 2020 | |
This is version 98 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations