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Protein

Coiled-coil domain-containing protein 88B

Gene

CCDC88B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4+ and the CD8+ compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099).By similarity2 Publications

GO - Molecular functioni

  • dynein light intermediate chain binding Source: GO_Central
  • microtubule binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 88B
Alternative name(s):
Brain leucine zipper domain-containing protein
Gipie1 Publication
Hook-related protein 31 Publication
Short name:
HkRP3
Gene namesi
Name:CCDC88B
Synonyms:BRLZ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000168071.21
HGNCiHGNC:26757 CCDC88B
MIMi611205 gene
neXtProtiNX_A6NC98

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi283234
OpenTargetsiENSG00000168071
PharmGKBiPA162381820

Polymorphism and mutation databases

BioMutaiCCDC88B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003174541 – 1476Coiled-coil domain-containing protein 88BAdd BLAST1476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei436PhosphoserineCombined sources1
Modified residuei596PhosphoserineCombined sources1
Modified residuei1348PhosphoserineBy similarity1
Modified residuei1379PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA6NC98
MaxQBiA6NC98
PaxDbiA6NC98
PRIDEiA6NC98
ProteomicsDBi811
812 [A6NC98-2]
813 [A6NC98-3]
814 [A6NC98-4]
815 [A6NC98-5]
816 [A6NC98-6]

PTM databases

iPTMnetiA6NC98
PhosphoSitePlusiA6NC98

Expressioni

Tissue specificityi

Expressed in endothelium (at protein level) (PubMed:21289099). Expressed in NK cells (at protein level) (PubMed:25762780).2 Publications

Inductioni

By endoplasmic reticulum stress.1 Publication

Gene expression databases

BgeeiENSG00000168071 Expressed in 108 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_CCDC88B
ExpressionAtlasiA6NC98 baseline and differential
GenevisibleiA6NC98 HS

Organism-specific databases

HPAiHPA026652

Interactioni

Subunit structurei

Homodimer (PubMed:25762780). Interacts with DOCK8 (PubMed:25762780). Interacts (via C-terminus) with intact microtubules (PubMed:25762780). Interacts with dynein-dynactin motor complex (PubMed:25762780). Interacts (via C-terminus) with HSPA5 (PubMed:21289099).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi129505, 3 interactors
IntActiA6NC98, 42 interactors
STRINGi9606.ENSP00000349238

Structurei

3D structure databases

ProteinModelPortaliA6NC98
SMRiA6NC98
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili253 – 481Sequence analysisAdd BLAST229
Coiled coili720 – 1303Sequence analysisAdd BLAST584

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 44Poly-Glu10

Sequence similaritiesi

Belongs to the CCDC88 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1265 Eukaryota
KOG3595 Eukaryota
KOG4643 Eukaryota
ENOG410YFRJ LUCA
GeneTreeiENSGT00690000101702
HOVERGENiHBG104809
InParanoidiA6NC98
OMAiEFQHQRY
OrthoDBiEOG091G01AJ
PhylomeDBiA6NC98
TreeFamiTF320231

Family and domain databases

Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR036872 CH_dom_sf
IPR008636 Hook-like_fam
PfamiView protein in Pfam
PF05622 HOOK, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: A6NC98-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGGKGPRLR DFLSGSLATW ALGLAGLVGE AEDSEGEEEE EEEEPPLWLE
60 70 80 90 100
KRFLRLSDGA LLLRVLGIIA PSSRGGPRML RGLDGPAAWR VWNLNHLWGR
110 120 130 140 150
LRDFYQEELQ LLILSPPPDL QTLGFDPLSE EAVEQLEGVL RLLLGASVQC
160 170 180 190 200
EHRELFIRHI QGLSLEVQSE LAAAIQEVTQ PGAGVVLALS GPDPGELAPA
210 220 230 240 250
ELEMLSRSLM GTLSKLARER DLGAQRLAEL LLEREPLCLR PEAPSRAPAE
260 270 280 290 300
GPSHHLALQL ANAKAQLRRL RQELEEKAEL LLDSQAEVQG LEAEIRRLRQ
310 320 330 340 350
EAQALSGQAK RAELYREEAE ALRERAGRLP RLQEELRRCR ERLQAAEAYK
360 370 380 390 400
SQLEEERVLS GVLEASKALL EEQLEAARER CARLHETQRE NLLLRTRLGE
410 420 430 440 450
AHAELDSLRH QVDQLAEENV ELELELQRSL EPPPGSPGEA PLAGAAPSLQ
460 470 480 490 500
DEVREAEAGR LRTLERENRE LRGLLQVLQG QPGGQHPLLE APREDPVLPV
510 520 530 540 550
LEEAPQTPVA FDHSPQGLVQ KARDGGPQAL DLAPPALDSV LEASAECPQA
560 570 580 590 600
PDSDPQEAES PLQAAAMDPQ ASDWSPQESG SPVETQESPE KAGRRSSLQS
610 620 630 640 650
PASVAPPQGP GTKIQAPQLL GGETEGREAP QGELVPEAWG LRQEGPEHKP
660 670 680 690 700
GPSEPSSVQL EEQEGPNQGL DLATGQAEAR EHDQRLEGTV RDPAWQKPQQ
710 720 730 740 750
KSEGALEVQV WEGPIPGESL ASGVAEQEAL REEVAQLRRK AEALGDELEA
760 770 780 790 800
QARKLEAQNT EAARLSKELA QARRAEAEAH REAEAQAWEQ ARLREAVEAA
810 820 830 840 850
GQELESASQE REALVEALAA AGRERRQWER EGSRLRAQSE AAEERMQVLE
860 870 880 890 900
SEGRQHLEEA ERERREKEAL QAELEKAVVR GKELGDRLEH LQRELEQAAL
910 920 930 940 950
ERQEFLREKE SQHQRYQGLE QRLEAELQAA ATSKEEALME LKTRALQLEE
960 970 980 990 1000
ELFQLRQGPA GLGPKKRAEP QLVETQNVRL IEVERSNAML VAEKAALQGQ
1010 1020 1030 1040 1050
LQHLEGQLGS LQGRAQELLL QSQRAQEHSS RLQAEKSVLE IQGQELHRKL
1060 1070 1080 1090 1100
EVLEEEVRAA RQSQEETRGQ QQALLRDHKA LAQLQRRQEA ELEGLLVRHR
1110 1120 1130 1140 1150
DLKANMRALE LAHRELQGRH EQLQAQRASV EAQEVALLAE RERLMQDGHR
1160 1170 1180 1190 1200
QRGLEEELRR LQSEHDRAQM LLAELSRERG ELQGERGELR GRLARLELER
1210 1220 1230 1240 1250
AQLEMQSQQL RESNQQLDLS ACRLTTQCEL LTQLRSAQEE ENRQLLAEVQ
1260 1270 1280 1290 1300
ALSRENRELL ERSLESRDHL HREQREYLDQ LNALRREKQK LVEKIMDQYR
1310 1320 1330 1340 1350
VLEPVPLPRT KKGSWLADKV KRLMRPRREG GPPGGLRLGA DGAGSTESLG
1360 1370 1380 1390 1400
GPPETELPEG READGTGSPS PAPMRRAQSS LCLRDETLAG GQRRKLSSRF
1410 1420 1430 1440 1450
PVGRSSESFS PGDTPRQRFR QRHPGPLGAP VSHSKGPGVG WENSAETLQE
1460 1470
HETDANREGP EVQEPEKRPL TPSLSQ
Length:1,476
Mass (Da):164,809
Last modified:July 24, 2007 - v1
Checksum:i4DB82F199F224EFC
GO
Isoform 2 (identifier: A6NC98-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     987-1034: NAMLVAEKAA...AQEHSSRLQA → VSVGPQWALG...WARGWGCPMQ
     1035-1476: Missing.

Show »
Length:1,034
Mass (Da):114,101
Checksum:i4AC0150AD38D33D6
GO
Isoform 3 (identifier: A6NC98-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-351: Missing.
     352-403: QLEEERVLSG...LRTRLGEAHA → MGGAGALGGA...NPAGRGPCGK
     955-972: LRQGPAGLGPKKRAEPQL → VMPARLGAGGHATLPSIP
     973-1476: Missing.

Note: No experimental confirmation available.
Show »
Length:621
Mass (Da):67,018
Checksum:i60AF1EBA3536FC8D
GO
Isoform 4 (identifier: A6NC98-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1019-1136: Missing.

Note: No experimental confirmation available.
Show »
Length:1,358
Mass (Da):151,121
Checksum:iE01A73698162233C
GO
Isoform 5 (identifier: A6NC98-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-864: Missing.
     865-872: REKEALQA → MKNRGLRE
     1320-1476: VKRLMRPRRE...KRPLTPSLSQ → GPLPRHPCAG...GTVAWADLEP

Note: No experimental confirmation available.
Show »
Length:696
Mass (Da):79,003
Checksum:i5F432467BDA55721
GO
Isoform 6 (identifier: A6NC98-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1337: Missing.
     1338-1367: LGADGAGSTESLGGPPETELPEGREADGTG → MPCAARSRSSWRRSWTNTACWSLCPCPGPR

Show »
Length:139
Mass (Da):15,345
Checksum:i4B20F3982CB8BAB3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BY33H7BY33_HUMAN
Coiled-coil domain-containing prote...
CCDC88B
712Annotation score:

Sequence cautioni

The sequence BAC03417 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti291L → W in BAC03417 (PubMed:11230166).Curated1
Sequence conflicti943T → I in AAI41867 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038523193D → E. Corresponds to variant dbSNP:rs647152Ensembl.1
Natural variantiVAR_038524639W → R. Corresponds to variant dbSNP:rs685870Ensembl.1
Natural variantiVAR_038525886D → A3 PublicationsCorresponds to variant dbSNP:rs1318165Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0354051 – 1337Missing in isoform 6. 1 PublicationAdd BLAST1337
Alternative sequenceiVSP_0309561 – 864Missing in isoform 5. 1 PublicationAdd BLAST864
Alternative sequenceiVSP_0309571 – 351Missing in isoform 3. 1 PublicationAdd BLAST351
Alternative sequenceiVSP_030958352 – 403QLEEE…GEAHA → MGGAGALGGAGGVQGAAGRA AGGCPRALRPAARDPAREPA AANPAGRGPCGK in isoform 3. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_030959865 – 872REKEALQA → MKNRGLRE in isoform 5. 1 Publication8
Alternative sequenceiVSP_030960955 – 972LRQGP…AEPQL → VMPARLGAGGHATLPSIP in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_030961973 – 1476Missing in isoform 3. 1 PublicationAdd BLAST504
Alternative sequenceiVSP_030962987 – 1034NAMLV…SRLQA → VSVGPQWALGRCPVQCECGS TVDPGLGGIPCSVSVDSQWA RGWGCPMQ in isoform 2. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_0309631019 – 1136Missing in isoform 4. 1 PublicationAdd BLAST118
Alternative sequenceiVSP_0309641035 – 1476Missing in isoform 2. 1 PublicationAdd BLAST442
Alternative sequenceiVSP_0309651320 – 1476VKRLM…PSLSQ → GPLPRHPCAGPRAPSACGMR PWQAGSGGNSAQGSRWGEAL SHSALGTPLGNDSDSAIQAP WGRPSPTAKDLVWDGRTPLR PCRNTKQMPTERALRYRNRR NVPSPHPSASDTVGTAGLGV QPSRHWSVSGGPRQPKSSGS QGPQGESLDKEAWALRSSTV SAGARRWSWDECVDRGDGWP PRAAPGWSSGSSRWLPLRQR SLGDPPAEGGWQELAREPPA LSRWEAESQCWGTVAWADLE P in isoform 5. 1 PublicationAdd BLAST157
Alternative sequenceiVSP_0354061338 – 1367LGADG…ADGTG → MPCAARSRSSWRRSWTNTAC WSLCPCPGPR in isoform 6. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136799 mRNA Translation: CAB66733.2
AK090436 mRNA Translation: BAC03417.1 Different initiation.
AK095289 mRNA No translation available.
AP003774 Genomic DNA No translation available.
BC040232 mRNA Translation: AAH40232.1
BC141866 mRNA Translation: AAI41867.1
AY491401 mRNA Translation: AAR83719.1
CCDSiCCDS8072.2 [A6NC98-1]
RefSeqiNP_115627.6, NM_032251.5 [A6NC98-1]
UniGeneiHs.98564

Genome annotation databases

EnsembliENST00000301897; ENSP00000301897; ENSG00000168071 [A6NC98-6]
ENST00000356786; ENSP00000349238; ENSG00000168071 [A6NC98-1]
GeneIDi283234
KEGGihsa:283234
UCSCiuc001nzy.4 human [A6NC98-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136799 mRNA Translation: CAB66733.2
AK090436 mRNA Translation: BAC03417.1 Different initiation.
AK095289 mRNA No translation available.
AP003774 Genomic DNA No translation available.
BC040232 mRNA Translation: AAH40232.1
BC141866 mRNA Translation: AAI41867.1
AY491401 mRNA Translation: AAR83719.1
CCDSiCCDS8072.2 [A6NC98-1]
RefSeqiNP_115627.6, NM_032251.5 [A6NC98-1]
UniGeneiHs.98564

3D structure databases

ProteinModelPortaliA6NC98
SMRiA6NC98
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129505, 3 interactors
IntActiA6NC98, 42 interactors
STRINGi9606.ENSP00000349238

PTM databases

iPTMnetiA6NC98
PhosphoSitePlusiA6NC98

Polymorphism and mutation databases

BioMutaiCCDC88B

Proteomic databases

EPDiA6NC98
MaxQBiA6NC98
PaxDbiA6NC98
PRIDEiA6NC98
ProteomicsDBi811
812 [A6NC98-2]
813 [A6NC98-3]
814 [A6NC98-4]
815 [A6NC98-5]
816 [A6NC98-6]

Protocols and materials databases

DNASUi283234
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301897; ENSP00000301897; ENSG00000168071 [A6NC98-6]
ENST00000356786; ENSP00000349238; ENSG00000168071 [A6NC98-1]
GeneIDi283234
KEGGihsa:283234
UCSCiuc001nzy.4 human [A6NC98-1]

Organism-specific databases

CTDi283234
DisGeNETi283234
EuPathDBiHostDB:ENSG00000168071.21
GeneCardsiCCDC88B
H-InvDBiHIX0201630
HGNCiHGNC:26757 CCDC88B
HPAiHPA026652
MIMi611205 gene
neXtProtiNX_A6NC98
OpenTargetsiENSG00000168071
PharmGKBiPA162381820
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1265 Eukaryota
KOG3595 Eukaryota
KOG4643 Eukaryota
ENOG410YFRJ LUCA
GeneTreeiENSGT00690000101702
HOVERGENiHBG104809
InParanoidiA6NC98
OMAiEFQHQRY
OrthoDBiEOG091G01AJ
PhylomeDBiA6NC98
TreeFamiTF320231

Miscellaneous databases

ChiTaRSiCCDC88B human
GenomeRNAii283234
PROiPR:A6NC98
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168071 Expressed in 108 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_CCDC88B
ExpressionAtlasiA6NC98 baseline and differential
GenevisibleiA6NC98 HS

Family and domain databases

Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR036872 CH_dom_sf
IPR008636 Hook-like_fam
PfamiView protein in Pfam
PF05622 HOOK, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCC88B_HUMAN
AccessioniPrimary (citable) accession number: A6NC98
Secondary accession number(s): A5D8Y5
, B5MDM2, Q05BL2, Q6RUV3, Q8N1Q6, Q8NF44, Q9H0H1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 24, 2007
Last modified: November 7, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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