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Entry version 103 (08 May 2019)
Sequence version 1 (24 Jul 2007)
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Protein

Coiled-coil domain-containing protein 88B

Gene

CCDC88B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4+ and the CD8+ compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processStress response

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 88B
Alternative name(s):
Brain leucine zipper domain-containing protein
Gipie1 Publication
Hook-related protein 31 Publication
Short name:
HkRP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC88B
Synonyms:BRLZ
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26757 CCDC88B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611205 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6NC98

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
283234

Open Targets

More...
OpenTargetsi
ENSG00000168071

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162381820

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC88B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003174541 – 1476Coiled-coil domain-containing protein 88BAdd BLAST1476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei436PhosphoserineCombined sources1
Modified residuei596PhosphoserineCombined sources1
Modified residuei1348PhosphoserineBy similarity1
Modified residuei1379PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A6NC98

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A6NC98

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A6NC98

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A6NC98

PRoteomics IDEntifications database

More...
PRIDEi
A6NC98

ProteomicsDB human proteome resource

More...
ProteomicsDBi
811
812 [A6NC98-2]
813 [A6NC98-3]
814 [A6NC98-4]
815 [A6NC98-5]
816 [A6NC98-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6NC98

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A6NC98

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in endothelium (at protein level) (PubMed:21289099). Expressed in NK cells (at protein level) (PubMed:25762780).2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By endoplasmic reticulum stress.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168071 Expressed in 108 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A6NC98 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A6NC98 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA026652

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:25762780). Interacts with DOCK8 (PubMed:25762780). Interacts (via C-terminus) with intact microtubules (PubMed:25762780). Interacts with dynein-dynactin motor complex (PubMed:25762780). Interacts (via C-terminus) with HSPA5 (PubMed:21289099).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
129505, 3 interactors

Protein interaction database and analysis system

More...
IntActi
A6NC98, 42 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000349238

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A6NC98

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili253 – 481Sequence analysisAdd BLAST229
Coiled coili720 – 1303Sequence analysisAdd BLAST584

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi35 – 44Poly-Glu10

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CCDC88 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1265 Eukaryota
KOG3595 Eukaryota
KOG4643 Eukaryota
ENOG410YFRJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162048

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6NC98

Identification of Orthologs from Complete Genome Data

More...
OMAi
ACRLATQ

Database of Orthologous Groups

More...
OrthoDBi
59187at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A6NC98

TreeFam database of animal gene trees

More...
TreeFami
TF320231

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036872 CH_dom_sf
IPR008636 Hook-like_fam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05622 HOOK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: A6NC98-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGGKGPRLR DFLSGSLATW ALGLAGLVGE AEDSEGEEEE EEEEPPLWLE
60 70 80 90 100
KRFLRLSDGA LLLRVLGIIA PSSRGGPRML RGLDGPAAWR VWNLNHLWGR
110 120 130 140 150
LRDFYQEELQ LLILSPPPDL QTLGFDPLSE EAVEQLEGVL RLLLGASVQC
160 170 180 190 200
EHRELFIRHI QGLSLEVQSE LAAAIQEVTQ PGAGVVLALS GPDPGELAPA
210 220 230 240 250
ELEMLSRSLM GTLSKLARER DLGAQRLAEL LLEREPLCLR PEAPSRAPAE
260 270 280 290 300
GPSHHLALQL ANAKAQLRRL RQELEEKAEL LLDSQAEVQG LEAEIRRLRQ
310 320 330 340 350
EAQALSGQAK RAELYREEAE ALRERAGRLP RLQEELRRCR ERLQAAEAYK
360 370 380 390 400
SQLEEERVLS GVLEASKALL EEQLEAARER CARLHETQRE NLLLRTRLGE
410 420 430 440 450
AHAELDSLRH QVDQLAEENV ELELELQRSL EPPPGSPGEA PLAGAAPSLQ
460 470 480 490 500
DEVREAEAGR LRTLERENRE LRGLLQVLQG QPGGQHPLLE APREDPVLPV
510 520 530 540 550
LEEAPQTPVA FDHSPQGLVQ KARDGGPQAL DLAPPALDSV LEASAECPQA
560 570 580 590 600
PDSDPQEAES PLQAAAMDPQ ASDWSPQESG SPVETQESPE KAGRRSSLQS
610 620 630 640 650
PASVAPPQGP GTKIQAPQLL GGETEGREAP QGELVPEAWG LRQEGPEHKP
660 670 680 690 700
GPSEPSSVQL EEQEGPNQGL DLATGQAEAR EHDQRLEGTV RDPAWQKPQQ
710 720 730 740 750
KSEGALEVQV WEGPIPGESL ASGVAEQEAL REEVAQLRRK AEALGDELEA
760 770 780 790 800
QARKLEAQNT EAARLSKELA QARRAEAEAH REAEAQAWEQ ARLREAVEAA
810 820 830 840 850
GQELESASQE REALVEALAA AGRERRQWER EGSRLRAQSE AAEERMQVLE
860 870 880 890 900
SEGRQHLEEA ERERREKEAL QAELEKAVVR GKELGDRLEH LQRELEQAAL
910 920 930 940 950
ERQEFLREKE SQHQRYQGLE QRLEAELQAA ATSKEEALME LKTRALQLEE
960 970 980 990 1000
ELFQLRQGPA GLGPKKRAEP QLVETQNVRL IEVERSNAML VAEKAALQGQ
1010 1020 1030 1040 1050
LQHLEGQLGS LQGRAQELLL QSQRAQEHSS RLQAEKSVLE IQGQELHRKL
1060 1070 1080 1090 1100
EVLEEEVRAA RQSQEETRGQ QQALLRDHKA LAQLQRRQEA ELEGLLVRHR
1110 1120 1130 1140 1150
DLKANMRALE LAHRELQGRH EQLQAQRASV EAQEVALLAE RERLMQDGHR
1160 1170 1180 1190 1200
QRGLEEELRR LQSEHDRAQM LLAELSRERG ELQGERGELR GRLARLELER
1210 1220 1230 1240 1250
AQLEMQSQQL RESNQQLDLS ACRLTTQCEL LTQLRSAQEE ENRQLLAEVQ
1260 1270 1280 1290 1300
ALSRENRELL ERSLESRDHL HREQREYLDQ LNALRREKQK LVEKIMDQYR
1310 1320 1330 1340 1350
VLEPVPLPRT KKGSWLADKV KRLMRPRREG GPPGGLRLGA DGAGSTESLG
1360 1370 1380 1390 1400
GPPETELPEG READGTGSPS PAPMRRAQSS LCLRDETLAG GQRRKLSSRF
1410 1420 1430 1440 1450
PVGRSSESFS PGDTPRQRFR QRHPGPLGAP VSHSKGPGVG WENSAETLQE
1460 1470
HETDANREGP EVQEPEKRPL TPSLSQ
Length:1,476
Mass (Da):164,809
Last modified:July 24, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4DB82F199F224EFC
GO
Isoform 2 (identifier: A6NC98-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     987-1034: NAMLVAEKAA...AQEHSSRLQA → VSVGPQWALG...WARGWGCPMQ
     1035-1476: Missing.

Show »
Length:1,034
Mass (Da):114,101
Checksum:i4AC0150AD38D33D6
GO
Isoform 3 (identifier: A6NC98-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-351: Missing.
     352-403: QLEEERVLSG...LRTRLGEAHA → MGGAGALGGA...NPAGRGPCGK
     955-972: LRQGPAGLGPKKRAEPQL → VMPARLGAGGHATLPSIP
     973-1476: Missing.

Note: No experimental confirmation available.
Show »
Length:621
Mass (Da):67,018
Checksum:i60AF1EBA3536FC8D
GO
Isoform 4 (identifier: A6NC98-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1019-1136: Missing.

Note: No experimental confirmation available.
Show »
Length:1,358
Mass (Da):151,121
Checksum:iE01A73698162233C
GO
Isoform 5 (identifier: A6NC98-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-864: Missing.
     865-872: REKEALQA → MKNRGLRE
     1320-1476: VKRLMRPRRE...KRPLTPSLSQ → GPLPRHPCAG...GTVAWADLEP

Note: No experimental confirmation available.
Show »
Length:696
Mass (Da):79,003
Checksum:i5F432467BDA55721
GO
Isoform 6 (identifier: A6NC98-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1337: Missing.
     1338-1367: LGADGAGSTESLGGPPETELPEGREADGTG → MPCAARSRSSWRRSWTNTACWSLCPCPGPR

Show »
Length:139
Mass (Da):15,345
Checksum:i4B20F3982CB8BAB3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BY33H7BY33_HUMAN
Coiled-coil domain-containing prote...
CCDC88B
712Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC03417 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti291L → W in BAC03417 (PubMed:11230166).Curated1
Sequence conflicti943T → I in AAI41867 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038523193D → E. Corresponds to variant dbSNP:rs647152Ensembl.1
Natural variantiVAR_038524639W → R. Corresponds to variant dbSNP:rs685870Ensembl.1
Natural variantiVAR_038525886D → A3 PublicationsCorresponds to variant dbSNP:rs1318165Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0354051 – 1337Missing in isoform 6. 1 PublicationAdd BLAST1337
Alternative sequenceiVSP_0309561 – 864Missing in isoform 5. 1 PublicationAdd BLAST864
Alternative sequenceiVSP_0309571 – 351Missing in isoform 3. 1 PublicationAdd BLAST351
Alternative sequenceiVSP_030958352 – 403QLEEE…GEAHA → MGGAGALGGAGGVQGAAGRA AGGCPRALRPAARDPAREPA AANPAGRGPCGK in isoform 3. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_030959865 – 872REKEALQA → MKNRGLRE in isoform 5. 1 Publication8
Alternative sequenceiVSP_030960955 – 972LRQGP…AEPQL → VMPARLGAGGHATLPSIP in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_030961973 – 1476Missing in isoform 3. 1 PublicationAdd BLAST504
Alternative sequenceiVSP_030962987 – 1034NAMLV…SRLQA → VSVGPQWALGRCPVQCECGS TVDPGLGGIPCSVSVDSQWA RGWGCPMQ in isoform 2. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_0309631019 – 1136Missing in isoform 4. 1 PublicationAdd BLAST118
Alternative sequenceiVSP_0309641035 – 1476Missing in isoform 2. 1 PublicationAdd BLAST442
Alternative sequenceiVSP_0309651320 – 1476VKRLM…PSLSQ → GPLPRHPCAGPRAPSACGMR PWQAGSGGNSAQGSRWGEAL SHSALGTPLGNDSDSAIQAP WGRPSPTAKDLVWDGRTPLR PCRNTKQMPTERALRYRNRR NVPSPHPSASDTVGTAGLGV QPSRHWSVSGGPRQPKSSGS QGPQGESLDKEAWALRSSTV SAGARRWSWDECVDRGDGWP PRAAPGWSSGSSRWLPLRQR SLGDPPAEGGWQELAREPPA LSRWEAESQCWGTVAWADLE P in isoform 5. 1 PublicationAdd BLAST157
Alternative sequenceiVSP_0354061338 – 1367LGADG…ADGTG → MPCAARSRSSWRRSWTNTAC WSLCPCPGPR in isoform 6. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL136799 mRNA Translation: CAB66733.2
AK090436 mRNA Translation: BAC03417.1 Different initiation.
AK095289 mRNA No translation available.
AP003774 Genomic DNA No translation available.
BC040232 mRNA Translation: AAH40232.1
BC141866 mRNA Translation: AAI41867.1
AY491401 mRNA Translation: AAR83719.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS8072.2 [A6NC98-1]

NCBI Reference Sequences

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RefSeqi
NP_115627.6, NM_032251.5 [A6NC98-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000301897; ENSP00000301897; ENSG00000168071 [A6NC98-6]
ENST00000356786; ENSP00000349238; ENSG00000168071 [A6NC98-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
283234

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:283234

UCSC genome browser

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UCSCi
uc001nzy.4 human [A6NC98-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136799 mRNA Translation: CAB66733.2
AK090436 mRNA Translation: BAC03417.1 Different initiation.
AK095289 mRNA No translation available.
AP003774 Genomic DNA No translation available.
BC040232 mRNA Translation: AAH40232.1
BC141866 mRNA Translation: AAI41867.1
AY491401 mRNA Translation: AAR83719.1
CCDSiCCDS8072.2 [A6NC98-1]
RefSeqiNP_115627.6, NM_032251.5 [A6NC98-1]

3D structure databases

SMRiA6NC98
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129505, 3 interactors
IntActiA6NC98, 42 interactors
STRINGi9606.ENSP00000349238

PTM databases

iPTMnetiA6NC98
PhosphoSitePlusiA6NC98

Polymorphism and mutation databases

BioMutaiCCDC88B

Proteomic databases

EPDiA6NC98
jPOSTiA6NC98
MaxQBiA6NC98
PaxDbiA6NC98
PRIDEiA6NC98
ProteomicsDBi811
812 [A6NC98-2]
813 [A6NC98-3]
814 [A6NC98-4]
815 [A6NC98-5]
816 [A6NC98-6]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
283234
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301897; ENSP00000301897; ENSG00000168071 [A6NC98-6]
ENST00000356786; ENSP00000349238; ENSG00000168071 [A6NC98-1]
GeneIDi283234
KEGGihsa:283234
UCSCiuc001nzy.4 human [A6NC98-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
283234
DisGeNETi283234

GeneCards: human genes, protein and diseases

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GeneCardsi
CCDC88B

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0201630
HGNCiHGNC:26757 CCDC88B
HPAiHPA026652
MIMi611205 gene
neXtProtiNX_A6NC98
OpenTargetsiENSG00000168071
PharmGKBiPA162381820

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1265 Eukaryota
KOG3595 Eukaryota
KOG4643 Eukaryota
ENOG410YFRJ LUCA
GeneTreeiENSGT00940000162048
InParanoidiA6NC98
OMAiACRLATQ
OrthoDBi59187at2759
PhylomeDBiA6NC98
TreeFamiTF320231

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CCDC88B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
283234

Protein Ontology

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PROi
PR:A6NC98

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000168071 Expressed in 108 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiA6NC98 baseline and differential
GenevisibleiA6NC98 HS

Family and domain databases

Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR036872 CH_dom_sf
IPR008636 Hook-like_fam
PfamiView protein in Pfam
PF05622 HOOK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC88B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6NC98
Secondary accession number(s): A5D8Y5
, B5MDM2, Q05BL2, Q6RUV3, Q8N1Q6, Q8NF44, Q9H0H1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 24, 2007
Last modified: May 8, 2019
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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