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Protein

Modulator of macroautophagy TMEM150B

Gene

TMEM150B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux (PubMed:25929859). Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner (PubMed:25929859). May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival (PubMed:25929859).1 Publication

GO - Biological processi

  • autophagy Source: UniProtKB-KW
  • regulation of autophagy Source: GO_Central

Keywordsi

Biological processAutophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Modulator of macroautophagy TMEM150BCurated
Alternative name(s):
Protein DRAM-31 Publication
Transmembrane protein 150BImported
Transmembrane protein 224Imported
Gene namesi
Name:TMEM150BImported
Synonyms:TMEM224Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000180061.9
HGNCiHGNC:34415 TMEM150B
neXtProtiNX_A6NC51

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicCurated7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 51ExtracellularCuratedAdd BLAST23
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Topological domaini73 – 84CytoplasmicCuratedAdd BLAST12
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 116ExtracellularCuratedAdd BLAST11
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 155CytoplasmicCuratedAdd BLAST18
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Topological domaini177 – 185ExtracellularCurated9
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
Topological domaini207 – 233CytoplasmicBy similarityAdd BLAST27

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180061
PharmGKBiPA165394503

Polymorphism and mutation databases

BioMutaiTMEM150B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003492841 – 233Modulator of macroautophagy TMEM150BAdd BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA6NC51
PRIDEiA6NC51
ProteomicsDBi800

Expressioni

Tissue specificityi

Highly expressed in the colon and lung with comparatively high levels also detectable in the lymph nodes, placenta, duodenum, peripheral blood mononuclear cells and spleen (PubMed:25929859).1 Publication

Inductioni

Is not markedly up- or down-regulated by DNA damage, nutrient deprivation or by exposure to TNF-alpha and IFN-gamma (PubMed:25929859).1 Publication

Gene expression databases

BgeeiENSG00000180061 Expressed in 89 organ(s), highest expression level in small intestine Peyer's patch
ExpressionAtlasiA6NC51 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000320757

Structurei

3D structure databases

ProteinModelPortaliA6NC51
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DRAM/TMEM150 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4320 Eukaryota
ENOG4111KNB LUCA
GeneTreeiENSGT00730000110794
HOGENOMiHOG000251588
InParanoidiA6NC51
KOiK21846
OMAiFQEKNQR
OrthoDBiEOG091G0GEU
PhylomeDBiA6NC51
TreeFamiTF314508

Family and domain databases

InterProiView protein in InterPro
IPR019402 Frag1/DRAM/Sfk1
PfamiView protein in Pfam
PF10277 Frag1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A6NC51-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWGYLSLMPV FLAVWAISGV WIVFAIAVTN RTVDLSKGFP YISICGSFPP
60 70 80 90 100
QSCIFSQVLN MGAALAAWIC IVRYHQLRDW GVRRWPNQLI LWTGLLCALG
110 120 130 140 150
TSVVGNFQEK NQRPTHLAGA FLAFILGNVY FWLQLLLWRL KRLPQPGAAW
160 170 180 190 200
IGPLRLGLCS VCTILIVAMI VLHACSLRSV SAACEWVVAM LLFALFGLLA
210 220 230
VDFSALESCT LCVQPWPSLS PPPASPISLP VQL
Length:233
Mass (Da):25,701
Last modified:July 24, 2007 - v1
Checksum:iF818C4617E8AA9F8
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EM00K7EM00_HUMAN
Modulator of macroautophagy TMEM150...
TMEM150B
134Annotation score:
K7EKL2K7EKL2_HUMAN
Modulator of macroautophagy TMEM150...
TMEM150B
152Annotation score:
K7EKW5K7EKW5_HUMAN
Modulator of macroautophagy TMEM150...
TMEM150B
84Annotation score:
K7ENI3K7ENI3_HUMAN
Modulator of macroautophagy TMEM150...
TMEM150B
63Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046343199L → F2 PublicationsCorresponds to variant dbSNP:rs7246479Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020922 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72362.1
BC171904 mRNA Translation: AAI71904.1
CCDSiCCDS42629.1
RefSeqiNP_001078957.1, NM_001085488.2
NP_001268940.1, NM_001282011.1
XP_005258869.1, XM_005258812.3
XP_011525154.1, XM_011526852.2
XP_011525155.1, XM_011526853.2
XP_011525156.1, XM_011526854.2
XP_011525157.1, XM_011526855.2
XP_011525158.1, XM_011526856.2
XP_016882156.1, XM_017026667.1
UniGeneiHs.382625

Genome annotation databases

EnsembliENST00000326652; ENSP00000320757; ENSG00000180061
GeneIDi284417
KEGGihsa:284417
UCSCiuc010yfu.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020922 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72362.1
BC171904 mRNA Translation: AAI71904.1
CCDSiCCDS42629.1
RefSeqiNP_001078957.1, NM_001085488.2
NP_001268940.1, NM_001282011.1
XP_005258869.1, XM_005258812.3
XP_011525154.1, XM_011526852.2
XP_011525155.1, XM_011526853.2
XP_011525156.1, XM_011526854.2
XP_011525157.1, XM_011526855.2
XP_011525158.1, XM_011526856.2
XP_016882156.1, XM_017026667.1
UniGeneiHs.382625

3D structure databases

ProteinModelPortaliA6NC51
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000320757

Polymorphism and mutation databases

BioMutaiTMEM150B

Proteomic databases

PaxDbiA6NC51
PRIDEiA6NC51
ProteomicsDBi800

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326652; ENSP00000320757; ENSG00000180061
GeneIDi284417
KEGGihsa:284417
UCSCiuc010yfu.3 human

Organism-specific databases

CTDi284417
EuPathDBiHostDB:ENSG00000180061.9
GeneCardsiTMEM150B
HGNCiHGNC:34415 TMEM150B
neXtProtiNX_A6NC51
OpenTargetsiENSG00000180061
PharmGKBiPA165394503
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4320 Eukaryota
ENOG4111KNB LUCA
GeneTreeiENSGT00730000110794
HOGENOMiHOG000251588
InParanoidiA6NC51
KOiK21846
OMAiFQEKNQR
OrthoDBiEOG091G0GEU
PhylomeDBiA6NC51
TreeFamiTF314508

Miscellaneous databases

GenomeRNAii284417
PROiPR:A6NC51

Gene expression databases

BgeeiENSG00000180061 Expressed in 89 organ(s), highest expression level in small intestine Peyer's patch
ExpressionAtlasiA6NC51 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR019402 Frag1/DRAM/Sfk1
PfamiView protein in Pfam
PF10277 Frag1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT150B_HUMAN
AccessioniPrimary (citable) accession number: A6NC51
Secondary accession number(s): B7ZW71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 24, 2007
Last modified: November 7, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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