UniProtKB - A6N8N6 (A6N8N6_CHICK)
Protein
Insulin-like growth factor-binding protein 3
Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Functioni
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.ARBA annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- insulin-like growth factor binding Source: InterPro
Keywordsi
Molecular function | Growth factor bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Insulin-like growth factor-binding protein 3ARBA annotation |
Organismi | Gallus gallus (Chicken)Imported |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedARBA annotationInteractioni
GO - Molecular functioni
- insulin-like growth factor binding Source: InterPro
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000020311 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 121 – 140 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 181 – 203 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 181 – 198 | PolarSequence analysisAdd BLAST | 18 |
Phylogenomic databases
eggNOGi | ENOG502QWC0, Eukaryota |
OrthoDBi | 979270at2759 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR012211, IGFBP-3 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF3, PTHR11551:SF3, 1 hit |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01979, IGFBPFAMILY3 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A6N8N6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVSRPGVLWA VAAAALALVG RRALPAPVVR CEPCDARALQ QCKPLQPDCA
60 70 80 90 100
ERVREPGCGC CLTCALRLGQ PCGIYTERCG AGLNCQPRQE EARPLQALLE
110 120 130 140 150
GRGFCTNATA GDKLRAFLLP GPHAAGNSSD SEEDRSTSSL ENQAIPSLHR
160 170 180 190 200
VPDSNLPPQH IRIDIIRKEQ AKNTQRYKVE YDSQSTDTLN FSSESKQETE
210 220 230 240 250
YGPCRREMED TLNHLKILNV LSPRGFHIPN CDKKGFYKKK QCRPSKGRKR
260 270 280
GYCWCVDKYG QPLPGYDGKG KGDVHCYNLG SK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF624351 mRNA Translation: ABR21209.1 |
RefSeqi | NP_001094504.1, NM_001101034.1 |
Genome annotation databases
GeneIDi | 420790 |
KEGGi | gga:420790 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF624351 mRNA Translation: ABR21209.1 |
RefSeqi | NP_001094504.1, NM_001101034.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000020311 |
Genome annotation databases
GeneIDi | 420790 |
KEGGi | gga:420790 |
Organism-specific databases
CTDi | 3486 |
Phylogenomic databases
eggNOGi | ENOG502QWC0, Eukaryota |
OrthoDBi | 979270at2759 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR012211, IGFBP-3 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF3, PTHR11551:SF3, 1 hit |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01979, IGFBPFAMILY3 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A6N8N6_CHICK | |
Accessioni | A6N8N6Primary (citable) accession number: A6N8N6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 24, 2007 |
Last sequence update: | July 24, 2007 | |
Last modified: | February 10, 2021 | |
This is version 98 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |