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Protein

Sodium channel protein

Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei127 – 149HelicalUniRule annotationAdd BLAST23
Transmembranei253 – 273HelicalUniRule annotationAdd BLAST21
Transmembranei388 – 416HelicalUniRule annotationAdd BLAST29
Transmembranei721 – 739HelicalUniRule annotationAdd BLAST19
Transmembranei751 – 769HelicalUniRule annotationAdd BLAST19
Transmembranei781 – 798HelicalUniRule annotationAdd BLAST18
Transmembranei838 – 861HelicalUniRule annotationAdd BLAST24
Transmembranei914 – 939HelicalUniRule annotationAdd BLAST26
Transmembranei1204 – 1223HelicalUniRule annotationAdd BLAST20
Transmembranei1244 – 1260HelicalUniRule annotationAdd BLAST17
Transmembranei1272 – 1293HelicalUniRule annotationAdd BLAST22
Transmembranei1321 – 1347HelicalUniRule annotationAdd BLAST27
Transmembranei1443 – 1469HelicalUniRule annotationAdd BLAST27
Transmembranei1528 – 1546HelicalUniRule annotationAdd BLAST19
Transmembranei1558 – 1576HelicalUniRule annotationAdd BLAST19
Transmembranei1588 – 1608HelicalUniRule annotationAdd BLAST21
Transmembranei1645 – 1673HelicalUniRule annotationAdd BLAST29
Transmembranei1748 – 1771HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliA6N7T7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 422Ion_transInterPro annotationAdd BLAST293
Domaini478 – 667Na_trans_cytoplInterPro annotationAdd BLAST190
Domaini720 – 943Ion_transInterPro annotationAdd BLAST224
Domaini953 – 1199Na_trans_assocInterPro annotationAdd BLAST247
Domaini1203 – 1478Ion_transInterPro annotationAdd BLAST276
Domaini1527 – 1781Ion_transInterPro annotationAdd BLAST255

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili413 – 451Sequence analysisAdd BLAST39

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG410XNP6 LUCA
HOVERGENiHBG053100

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR008053 Na_channel_a5su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit
PRINTSiPR00170 NACHANNEL
PR01666 NACHANNEL5

Sequencei

Sequence statusi: Complete.

A6N7T7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGSTTLQ ESREGLPEEE
60 70 80 90 100
APRPQLDLQA SKKLPDLYGN PPQELIGEPL EDLDPFYSTQ KTFIVPNKGK
110 120 130 140 150
TIFRFSATNA LYVLSPFHPI RRAAVKILVH SLFNTLIMCT ILTNCVFMAQ
160 170 180 190 200
HDPPPWTKYV EHTFTAIYTF ESLVKILARG SCLHAFTFLR GPWNWLDFSV
210 220 230 240 250
IIMAYVSENI KLGNLSALRT FRVLRALKTI SVIPGLKTIV GALIQSVKKL
260 270 280 290 300
ADVMVLTVFC LSVFALIGLQ LFMGNLRHKR VRNFTALNGI NGSVEADGLV
310 320 330 340 350
WESLDLYLSD PENYLLKNGT SDVLLCGNSS DAGTCLEGYR CLKAGENPDH
360 370 380 390 400
GYTSFDSFAW AFLALFRLMT QDCWERLYQQ TLRSAGKIYM IFFMLVIFLG
410 420 430 440 450
SFYLVNLILA VVAMAYEEQN QATIAETEEK EKRFQEAMEM LKKEHEALTI
460 470 480 490 500
RGADTVSRSS LEMSPLAPVN SHERRSKRRK RMSSGTEECG EDRLPKSDSE
510 520 530 540 550
DGPRAMNHLS LTRGLSRTSM KPRSSRGSIF TFRRRDLGSE ADFADDENST
560 570 580 590 600
AGESESHHTS LLVPWPLRRT SAQGQPSPGT SAPGHALHGK KNSTVDCNGV
610 620 630 640 650
VSLLGAGDPE ATSPGSHLLR PVMLEHPPDT TTPSEEPGGP QMLTSQAPCV
660 670 680 690 700
DGFEEPGARQ RALSAVSVLT SALEELEESR HKCPPCWNRL AQRYLIWECC
710 720 730 740 750
PLWMSIKQGV KLVVMDPXTD LTITXCIVLN TLFMALEHYN MTSEFEEMLQ
760 770 780 790 800
VGNLVFTGIF TAEMTFKIIA LDPYYYFQQG WNIFDSIIVI LSLMELGLSR
810 820 830 840 850
MSNLSVLRSF RLLRVFKLAK SWPTLNTLIK IIGNSVGALG NLTLVLAIIV
860 870 880 890 900
FIFAVVGMQL FGKNYSELRD SDSGLLPRWH MMDFFHAFLX IFRILCGEWI
910 920 930 940 950
ETMWDCMEVS GQSLCLLVFL LVMVIGNLVV LNLFLALLLS SFSADNLTAP
960 970 980 990 1000
DEDGEMNNLQ LALARIQRGL RFVKRTTWDF CCGILRRRPK KPAALATHSQ
1010 1020 1030 1040 1050
LPSCITAPRS PPPPEVEKVP PARKETRFEE DKRPGQGTPG DSEPVCVPIA
1060 1070 1080 1090 1100
VAESDTEDQE EDEENSLGTE EESSKQESQV VSGGHEPYQE PRAWSQVSET
1110 1120 1130 1140 1150
TSSEAGASTS QADWQQEQKT EPQAPGCGET PEDSYSEGST ADMTNTADLL
1160 1170 1180 1190 1200
EQIPDLGEDV KDPEDCFTEG CVRRCPCCMV DTTQSPGKVW WRLRKTCYHI
1210 1220 1230 1240 1250
VEHSWFETFI IFMILLSSGA LAFEDIYLEE RKTIKVLLEY ADKMFTYVFV
1260 1270 1280 1290 1300
LEMLLKWVAY GFKKYFTNAW CWLDFLIVDV SLVSLVANTL GFAEMGPIKS
1310 1320 1330 1340 1350
LRTLRALRPL RALSRFEGMR VVVNALVGAI PSIMNVLLVC LIFWLIFSIM
1360 1370 1380 1390 1400
GVNLFAGKFG RCINQTEGDL PLNYTIVNNK SECESFNVTG ELYWTKVKVN
1410 1420 1430 1440 1450
FDNVGAGYLA LLQVATFKGW MDIMYAAVDS RGYEEQPQWE DNLYMYIYFV
1460 1470 1480 1490 1500
VFIIFGSFFT LNLFIGVIID NFNQQKKKLG GQDIFMTEEQ KKYYNAMKKL
1510 1520 1530 1540 1550
GSKKPQKPIP RPLNKYQGFI FDIVTKQAFD VTIMFLICLN MVTMMVETDD
1560 1570 1580 1590 1600
QSPEKVNILA KINLLFVAIF TGECIVKMAA LRHYYFTNSW NIFDFVVVIL
1610 1620 1630 1640 1650
SIVGTVLSDI IQKYFFSPTL FRVIRLARIG RILRLIRGAK GIRTLLFALM
1660 1670 1680 1690 1700
MSLPALFNIG LLLFLVMFIY SIFGMANFAY VKWEAGIDDM FNFQTFANSM
1710 1720 1730 1740 1750
LCLFQITTSA GWDGLLSPIL NTGPPYCDPN LPNSNGSRGN CGSPAVGILF
1760 1770 1780 1790 1800
FTTYIIISFL IVVNMYIAII LENFSVATEE STEPLSEDDF DMFYEIWEKF
1810 1820 1830 1840 1850
DPEATQFIEY LALSDFADAL SEPLRIAKPN QISLINMDLP MVSGDRIHCM
1860 1870 1880 1890 1900
DILFAFTKRV LGESGEMDAL KIQMEEKFMA ANPSKISYEP ITTTLRRKHE
1910 1920 1930 1940 1950
EVSATVIQRA FRRHLLQRSV KHASFLFRQQ AGGSGLSDED APEREGLIAY
1960 1970 1980 1990 2000
MMNGNFSRRS APLSSSSISS TSFPPSYDSV TRATSDNLPV RASDYSRSED
2010
LADFPPSPDR DRESIV
Length:2,016
Mass (Da):226,964
Last modified:July 24, 2007 - v1
Checksum:i0C2F491E5383B4EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF618549 mRNA Translation: ABR14545.1

Similar proteinsi

Entry informationi

Entry nameiA6N7T7_RAT
AccessioniPrimary (citable) accession number: A6N7T7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: February 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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