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Protein

WD repeat-containing protein 35

Gene

Wdr35

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-RNO-5610787 Hedgehog 'off' state
R-RNO-5620924 Intraflagellar transport

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 35
Alternative name(s):
Naofen
Gene namesi
Name:Wdr35
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1564116 Wdr35

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004054061 – 1170WD repeat-containing protein 35Add BLAST1170

Proteomic databases

PaxDbiA6N6J5
PeptideAtlasiA6N6J5
PRIDEiA6N6J5

Expressioni

Tissue specificityi

Expressed at high levels in testis and at lower levels in the brain (at protein level). Also present in other tissues, including heart, uterus, spinal cord, ovary, liver, kidney, lung, pancreas and stomach.1 Publication

Gene expression databases

BgeeiENSRNOG00000028783 Expressed in 10 organ(s), highest expression level in testis
GenevisibleiA6N6J5 RN

Interactioni

Subunit structurei

Component of the IFT complex A (IFT-A). Interacts with IFT43 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042019

Structurei

3D structure databases

ProteinModelPortaliA6N6J5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati12 – 51WD 1Add BLAST40
Repeati69 – 108WD 2Add BLAST40
Repeati113 – 152WD 3Add BLAST40
Repeati154 – 193WD 4Add BLAST40
Repeati491 – 528WD 5Add BLAST38

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2041 Eukaryota
ENOG410XNSQ LUCA
GeneTreeiENSGT00610000085970
HOGENOMiHOG000255527
HOVERGENiHBG079343
InParanoidiA6N6J5
KOiK19674
OMAiQYYVQGR
OrthoDBiEOG091G014X
PhylomeDBiA6N6J5

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR011990 TPR-like_helical_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR017233 WDR35
PANTHERiPTHR16517:SF1 PTHR16517:SF1, 1 hit
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PIRSFiPIRSF037536 WD_repeat_p35, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

A6N6J5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFFYLSKKIA VPNNVKLKCI SWNKDQGFIA CGGEDGLLKV LRLETQTDDS
60 70 80 90 100
KLRGLAAPSN LSMNQNLEGH SGAVQVVTWN EQYQKLTTSD QNGLIIVWML
110 120 130 140 150
YKGSWYEEMI NNRNKSVVRS MSWNADGQKI CIVYEDGAVI VGSVDGNRIW
160 170 180 190 200
GKDLKGIQLC HVTWSADSKI LLFGMANGEI HIYDNQGNFI MKMKLNCLVN
210 220 230 240 250
VTGAISIAGI HWYHGTEGYV EPDCPCLAIC FDNGRCQIMR HENDQNPVLI
260 270 280 290 300
DTGMYVVGIQ WNHIGSVLAV AGSQKVVTQD KDVNIVQFYT PFGEHLGTLK
310 320 330 340 350
VPGKQMCSLS WEGGGLKIAL AVDSFIYFAN IRPDYKWGYC SNTVVYAYTR
360 370 380 390 400
PDRPEYCVVF WDTKNNEKYV KYVKSLISIT TCGDFCILAT KADENHPQFV
410 420 430 440 450
LVLCNSIGTP LDPKYIDLVP LFVAMTKTHV IAASKEALYT WQYRVAKKLT
460 470 480 490 500
ALEINQITRS RKEGRERIYH VDDVPSGSVD GVFDYSKAIQ GTRDPICAIT
510 520 530 540 550
ASDKTLIVGR ESGVIQRYSF PNVALIQKYS LDCRACQLSL NCNSSRLAII
560 570 580 590 600
DIAGVLTFFD LDTRVTDSTG QQVVGELLKL ERKDVWDMKW AKDNPDLFAM
610 620 630 640 650
MEKTRMYVFR NLDPEEPIQT SGYICNFEDL EIKSVLLDEI LKNPEHPSKD
660 670 680 690 700
YIMNFEIRSL RDSRALIEKV GIEDASQFIE DNPHPRLWRL LAEAALQKLD
710 720 730 740 750
LYTAQQAFVR CKDYQGIKFV KRLGNLQSES MKQAEVIAYF GRFEEAERMY
760 770 780 790 800
LDMDRRDLAI GLRLKLGDWF RVLQLLKTGS GDADDSLLEQ AHNAIGDYFA
810 820 830 840 850
DRQKWMNAVQ YYVKGRNQER LAECYYMLED YEGLENLANS LPENHKLLPE
860 870 880 890 900
IAQMFVRVGM CEQAVSAFLK CNQPKAAVDT CVHLNQWNKA VELAKSHSMK
910 920 930 940 950
EIGSLLARYA SHLLEKNKTL DAIELYRKAS YFFDAAKLMY KIADEEAKKR
960 970 980 990 1000
TKPLRVKKLY VLSALLIEQY HEQMKNAQRG KVKGKNSEAT SALAGLLEEE
1010 1020 1030 1040 1050
VLSTTSRFTD NAWRGAEAYH FFILAQRQLY EGYVDTALKT ALHLRDYEDI
1060 1070 1080 1090 1100
IPSVEIYSLL ALCACASRAF GTCSKAFIKL ESLETLSAEQ KQQYEDLALE
1110 1120 1130 1140 1150
IFTKHTPKDN RKSELNSLLE GGEGKLPTCI ATGSPIIEYQ FWVCKVCKHY
1160 1170
VLAQEISNYN FCPLCHSSVE
Length:1,170
Mass (Da):132,779
Last modified:July 24, 2007 - v1
Checksum:i70792ECD36111DEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF613262 mRNA Translation: ABR22620.1
CH473947 Genomic DNA Translation: EDM03084.1
RefSeqiNP_001092810.1, NM_001099340.1
UniGeneiRn.14574

Genome annotation databases

EnsembliENSRNOT00000051970; ENSRNOP00000042019; ENSRNOG00000028783
GeneIDi503018
KEGGirno:503018

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF613262 mRNA Translation: ABR22620.1
CH473947 Genomic DNA Translation: EDM03084.1
RefSeqiNP_001092810.1, NM_001099340.1
UniGeneiRn.14574

3D structure databases

ProteinModelPortaliA6N6J5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042019

Proteomic databases

PaxDbiA6N6J5
PeptideAtlasiA6N6J5
PRIDEiA6N6J5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000051970; ENSRNOP00000042019; ENSRNOG00000028783
GeneIDi503018
KEGGirno:503018

Organism-specific databases

CTDi57539
RGDi1564116 Wdr35

Phylogenomic databases

eggNOGiKOG2041 Eukaryota
ENOG410XNSQ LUCA
GeneTreeiENSGT00610000085970
HOGENOMiHOG000255527
HOVERGENiHBG079343
InParanoidiA6N6J5
KOiK19674
OMAiQYYVQGR
OrthoDBiEOG091G014X
PhylomeDBiA6N6J5

Enzyme and pathway databases

ReactomeiR-RNO-5610787 Hedgehog 'off' state
R-RNO-5620924 Intraflagellar transport

Miscellaneous databases

PROiPR:A6N6J5

Gene expression databases

BgeeiENSRNOG00000028783 Expressed in 10 organ(s), highest expression level in testis
GenevisibleiA6N6J5 RN

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR011990 TPR-like_helical_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR017233 WDR35
PANTHERiPTHR16517:SF1 PTHR16517:SF1, 1 hit
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PIRSFiPIRSF037536 WD_repeat_p35, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWDR35_RAT
AccessioniPrimary (citable) accession number: A6N6J5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: July 24, 2007
Last modified: September 12, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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