UniProtKB - A6MFL5 (NGFV1_DEMVE)
Venom nerve growth factor 1
Functioni
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons as well as basal forebrain cholinergic neurons in the brain. Its relevance in the snake venom is not clear. However, it has been shown to inhibit metalloproteinase-dependent proteolysis of platelet glycoprotein Ib alpha, suggesting a metalloproteinase inhibition to prevent metalloprotease autodigestion and/or protection against prey proteases (By similarity).
Binds a lipid between the two protein chains in the homodimer. The lipid-bound form promotes histamine relase from mouse mast cells, contrary to the lipid-free form (By similarity).
By similarityGO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- lipid binding Source: UniProtKB-KW
- metalloendopeptidase inhibitor activity Source: UniProtKB
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Growth factor, Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor, Toxin |
Ligand | Lipid-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Venom nerve growth factor 1Short name: v-NGF-1 Short name: vNGF-1 |
Organismi | Demansia vestigiata (Lesser black whip snake) (Demansia atra) |
Taxonomic identifieri | 412038 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Elapidae › Notechinae › Demansia |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
PropeptideiPRO_5000254119 | 19 – 125 | By similarityAdd BLAST | 107 | |
ChainiPRO_5000254120 | 126 – 242 | Venom nerve growth factor 1Add BLAST | 117 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 139 ↔ 203 | By similarity | ||
Glycosylationi | 147 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 181 ↔ 231 | By similarity | ||
Disulfide bondi | 191 ↔ 233 | By similarity |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinExpressioni
Tissue specificityi
Interactioni
Subunit structurei
Homodimer; non-covalently linked.
By similarityGO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 26 – 69 | DisorderedSequence analysisAdd BLAST | 44 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 27 – 49 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 50 – 65 | Basic and acidic residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Keywords - Domaini
SignalFamily and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR020408, Nerve_growth_factor-like IPR002072, Nerve_growth_factor-rel IPR020425, Nerve_growth_factor_bsu IPR019846, Nerve_growth_factor_CS IPR020433, Venom_nerve_growth_factor |
PANTHERi | PTHR11589, PTHR11589, 1 hit |
Pfami | View protein in Pfam PF00243, NGF, 1 hit |
PIRSFi | PIRSF001789, NGF, 1 hit |
PRINTSi | PR00268, NGF PR01913, NGFBETA PR01917, VENOMNGF |
SMARTi | View protein in SMART SM00140, NGF, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00248, NGF_1, 1 hit PS50270, NGF_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MSMLCYTLII AFLIGIWAAP KSEDNVPLGS PATSDLSDTS CAQTHKALKT
60 70 80 90 100
SRNTDQRHPA PKKAEDQELG SAANIIVDPK LFQKRRFQSP RVLFSTQPPP
110 120 130 140 150
LSRDEQSVEF LENEDALNRN IRSKRENHPV NDHGEYSVCD SVSVWVNKTT
160 170 180 190 200
ATDIKGKPVT VMVDVNLNNH VYKQYFFETK CKNPNPVPSG CRGIDSRHWN
210 220 230 240
SYCTTTQSFV KALTKEGNQA SWRFIRIDTA CVCVISRKTG NF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ917526 mRNA Translation: ABK63555.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ917526 mRNA Translation: ABK63555.1 |
3D structure databases
SMRi | A6MFL5 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR020408, Nerve_growth_factor-like IPR002072, Nerve_growth_factor-rel IPR020425, Nerve_growth_factor_bsu IPR019846, Nerve_growth_factor_CS IPR020433, Venom_nerve_growth_factor |
PANTHERi | PTHR11589, PTHR11589, 1 hit |
Pfami | View protein in Pfam PF00243, NGF, 1 hit |
PIRSFi | PIRSF001789, NGF, 1 hit |
PRINTSi | PR00268, NGF PR01913, NGFBETA PR01917, VENOMNGF |
SMARTi | View protein in SMART SM00140, NGF, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00248, NGF_1, 1 hit PS50270, NGF_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NGFV1_DEMVE | |
Accessioni | A6MFL5Primary (citable) accession number: A6MFL5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | July 24, 2007 | |
Last modified: | September 29, 2021 | |
This is version 47 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program | |
Annotation program | Chordata Protein Annotation Program |