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Entry version 105 (08 May 2019)
Sequence version 1 (24 Jul 2007)
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Protein
Submitted name:

CD109 antigen

Gene

Cd109

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CD109 antigenImported
Submitted name:
CD109 antigen, isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cd109Imported
ORF Names:mCG_15224Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2445221 Cd109

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501429700722 – 1442Sequence analysisAdd BLAST1421

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000046186 Expressed in 151 organ(s), highest expression level in ear

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini470 – 601A2M_N_2InterPro annotationAdd BLAST132
Domaini695 – 786A2MInterPro annotationAdd BLAST92
Domaini1311 – 1395A2M_recepInterPro annotationAdd BLAST85

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1366 Eukaryota
ENOG410XRED LUCA

KEGG Orthology (KO)

More...
KOi
K06530

Identification of Orthologs from Complete Genome Data

More...
OMAi
TWLKGRQ

Database of Orthologous Groups

More...
OrthoDBi
354230at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02897 A2M_2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
2.60.40.690, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009048 A-macroglobulin_rcpt-bd
IPR036595 A-macroglobulin_rcpt-bd_sf
IPR011625 A2M_N_BRD
IPR041813 A2M_TED
IPR011626 Alpha-macroglobulin_TED
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR001599 Macroglobln_a2
IPR019742 MacrogloblnA2_CS
IPR002890 MG2
IPR041555 MG3
IPR008930 Terpenoid_cyclase/PrenylTrfase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00207 A2M, 1 hit
PF07703 A2M_BRD, 1 hit
PF07677 A2M_recep, 1 hit
PF01835 MG2, 1 hit
PF17791 MG3, 1 hit
PF07678 TED_complement, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit
SM01361 A2M_recep, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48239 SSF48239, 1 hit
SSF49410 SSF49410, 1 hit
SSF81296 SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00477 ALPHA_2_MACROGLOBULIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A6MDD3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSRRLLSAA HLLCLCAVAL AAPGSRFLVT APGIIRPGAN VTIGVDLLEN
60 70 80 90 100
SPPQVLVKAQ VFKIASNKSR SILEAEGVFH RGHFKTLVLP ALPLSSADKI
110 120 130 140 150
YELHINGQSE NEIVFSNRTR LTFESKSISV LIQTDKAFYK PKQEVKFRVL
160 170 180 190 200
TLCSDLKPYR TSVDIFIKDP KSNVIQQWFS QKGDLGVVSK TFQLSSNPIF
210 220 230 240 250
GDWSIQVQVN DQQYYQSFQV LEYVLPKFEV TVQTPLYCSL KSKQLNGSVI
260 270 280 290 300
AKYTYGKPVK GSLSLTFLPL SFWGKKKNIT KSFEINGFAN FSFDNYEMKK
310 320 330 340 350
VMNLKPLTDV SEGSYENVDP SFPGPAEIIA TVTESLTGIS RMASTNVFFK
360 370 380 390 400
QHDYIIEIFD YTTVLKPSLN FTATVKVSRS DGNQLTPEEI ENDLVTVVTQ
410 420 430 440 450
RKNNHPESQR DQEMDYIQTV NYTIPQNGII KIEFPVMSIS GELQLKAYFL
460 470 480 490 500
DGTSSVTVHS MFTSPSKTYI QLKTRDEYIK VGSPFDLMVS GNRQFKDLSY
510 520 530 540 550
MVISKGQLVA AGKQSSRTFS LTPEASWAPK ACIIAYYIAE DGEIINDILK
560 570 580 590 600
IPVQLVFENK VKLFWSKPTV KPSDKVSLRI SATQSDSLVG IVAVDKSVTL
610 620 630 640 650
MENSNSITME TMVHELELYN TEYYLGMFMN SFAVFQECGL WVLTDATLIR
660 670 680 690 700
DSIDEVYDTE EYSERFAEEN EANLVDFEDA SSVNNVHVRK NFPETWIWLD
710 720 730 740 750
AYMGSKIYEE FEVTVPDSIT SWVASAFVIS EDLGFGLTTV PAELQAFQPF
760 770 780 790 800
FLFLNLPYSV IRGEEFALEV SIVNYLKDTI KVVILIEESD SFDILMTSND
810 820 830 840 850
TNGTIYRKTV QVPRDNGVTL VFPIKPTHLG EIPITVTAAS PTASDAVTQT
860 870 880 890 900
IVVKPEGIEK SYSKSVLLDL TDSNVESKQQ SMRFSFPPDT VIGSERVQIT
910 920 930 940 950
AIGDILGSSI NGLSSLIRMP YGCGEQNMIY FAPNIYILDY LTKQKQLTVN
960 970 980 990 1000
LKEKALSYMR QGYQRELLYQ REDGSFSAFG DIDSSGSTWL SAFVLRCFLE
1010 1020 1030 1040 1050
ADYYIDIDQD VLHRTYTWLN AHKKFNGEFW EPGRVIHSEL QGGTKSPVTL
1060 1070 1080 1090 1100
TAYIVTSVLG YKKYQPNIDV QDSIKFLEFE FSRGISDNYT LAIISYALST
1110 1120 1130 1140 1150
VGSPKAEEAL NLLMQRSEKE GDTQFWLSSG PALSGSWQPR SVDIEIAAYA
1160 1170 1180 1190 1200
LLAHTLHHVS EGIPVMRWLI QQRNSLGGFV STQDTVVALK ALSEFSALVH
1210 1220 1230 1240 1250
KENTDIQLTV TGPGIPRSIH FRIDSQNLFL LHQEELHALD PITVNVSAHG
1260 1270 1280 1290 1300
SGFAICQLNV DYNVKGSGSS KRRRSTENQE VFDLDVIVNN EDDISHLNLN
1310 1320 1330 1340 1350
VCTSHLGSER TGMVLMEVNL LSGFSASSDS IPLSETLKKV EYDNGKLNLY
1360 1370 1380 1390 1400
LDSVNESQFC VNIPTVRDYK VSNIRDGSVS VMDYYEPRRQ AVRSYNTQVK
1410 1420 1430 1440
LSSCYLSPDT NCKSHTDGAT DSLRRSSSLL VFCSVLLYFV QH
Length:1,442
Mass (Da):161,659
Last modified:July 24, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2B9671B8EA5BAA7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ832284 mRNA Translation: ABI30218.1
CH466522 Genomic DNA Translation: EDL26409.1

NCBI Reference Sequences

More...
RefSeqi
NP_694738.1, NM_153098.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
235505

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:235505

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ832284 mRNA Translation: ABI30218.1
CH466522 Genomic DNA Translation: EDL26409.1
RefSeqiNP_694738.1, NM_153098.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi235505
KEGGimmu:235505

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
135228
MGIiMGI:2445221 Cd109

Phylogenomic databases

eggNOGiKOG1366 Eukaryota
ENOG410XRED LUCA
KOiK06530
OMAiTWLKGRQ
OrthoDBi354230at2759

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000046186 Expressed in 151 organ(s), highest expression level in ear

Family and domain databases

CDDicd02897 A2M_2, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.690, 1 hit
InterProiView protein in InterPro
IPR009048 A-macroglobulin_rcpt-bd
IPR036595 A-macroglobulin_rcpt-bd_sf
IPR011625 A2M_N_BRD
IPR041813 A2M_TED
IPR011626 Alpha-macroglobulin_TED
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR001599 Macroglobln_a2
IPR019742 MacrogloblnA2_CS
IPR002890 MG2
IPR041555 MG3
IPR008930 Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF00207 A2M, 1 hit
PF07703 A2M_BRD, 1 hit
PF07677 A2M_recep, 1 hit
PF01835 MG2, 1 hit
PF17791 MG3, 1 hit
PF07678 TED_complement, 1 hit
SMARTiView protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit
SM01361 A2M_recep, 1 hit
SUPFAMiSSF48239 SSF48239, 1 hit
SSF49410 SSF49410, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00477 ALPHA_2_MACROGLOBULIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA6MDD3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6MDD3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: May 8, 2019
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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