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Protein

Alpha-conotoxin-like Lp1.10

Gene
N/A
Organism
Conus leopardus (Leopard cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin-like Lp1.101 Publication
OrganismiConus leopardus (Leopard cone)
Taxonomic identifieri101306 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusLithoconus

Organism-specific databases

ConoServeri574 Lp1.10 precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_0000370659‹1 – 271 PublicationAdd BLAST›27
PeptideiPRO_000037066028 – 44Alpha-conotoxin-like Lp1.101 PublicationAdd BLAST17

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 36By similarity
Disulfide bondi31 ↔ 44By similarity
Modified residuei44Cysteine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Structurei

3D structure databases

ProteinModelPortaliA6M938
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is I (CC-C-C). Alpha4/7 pattern.Curated

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Family and domain databases

InterProiView protein in InterPro
IPR009958 Conotoxin_a-typ
PfamiView protein in Pfam
PF07365 Toxin_8, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6M938-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40 
VVLGPASDGR NAAANVKAPD LIALTVRNDC CHNAPCRNNH PGICG
Length:45
Mass (Da):4,596
Last modified:July 24, 2007 - v1
Checksum:i1A1E6709665EA269
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ359144 Genomic DNA Translation: ABD48795.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ359144 Genomic DNA Translation: ABD48795.1

3D structure databases

ProteinModelPortaliA6M938
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri574 Lp1.10 precursor

Family and domain databases

InterProiView protein in InterPro
IPR009958 Conotoxin_a-typ
PfamiView protein in Pfam
PF07365 Toxin_8, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCA1A_CONLE
AccessioniPrimary (citable) accession number: A6M938
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: July 24, 2007
Last modified: September 12, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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