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Entry version 55 (16 Jan 2019)
Sequence version 1 (24 Jul 2007)
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Protein
Submitted name:

Putative CoA-substrate-specific enzyme activase

Gene

Cbei_2405

Organism
Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
CBEI290402:G1G93-2513-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Putative CoA-substrate-specific enzyme activaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:Cbei_2405Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiClostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri290402 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000565 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
290402.Cbei_2405

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
A6LW33

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 255BcrAD_BadFGInterPro annotationAdd BLAST250
Domaini321 – 575BcrAD_BadFGInterPro annotationAdd BLAST255
Domaini672 – 890DUF2229InterPro annotationAdd BLAST219

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili816 – 843Sequence analysisAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG4105CIZ Bacteria
COG1924 LUCA
COG3580 LUCA
COG3581 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000261965

Identification of Orthologs from Complete Genome Data

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OMAi
VCYPAKL

Database of Orthologous Groups

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OrthoDBi
8032at2

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002731 ATPase_BadF
IPR018709 CoA_activase_DUF2229
IPR010327 FldB/FldC_alpha/beta

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01869 BcrAD_BadFG, 2 hits
PF09989 DUF2229, 1 hit
PF06050 HGD-D, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A6LW33-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MINYKIGLDI GSTTVKLVVL NNENILIYSK YKRHFSDIRS TIIDLIKECY
60 70 80 90 100
DELGNVNCKI NITGSGGLSV SKWLNLGFVQ EVIACSKTVE TIIPETDVVI
110 120 130 140 150
ELGGEDAKIT YFRGGIEQRM NGSCAGGTGA FIDQMAILLN TDAMGLNEYA
160 170 180 190 200
KEYKVIYPIA SRCGVFAKTD VQPLINEGAK KSDIAASIFQ AVVNQTIGGL
210 220 230 240 250
ACGKPIRGNV AFLGGPLFFL SELRERFIET LNLKDEQIIA PENSQLFVAM
260 270 280 290 300
GAALLSTKEK STSLKNIVDK ISDISNIKDD TEPRLEPLFK DKEDYNKFKE
310 320 330 340 350
RHDKNVVKKG ELKEYKGQAF LGIDAGSTTT KVALIGENSE LLYSYYGSNE
360 370 380 390 400
GNPLNKVVEI MKDLYEKLPE TIEIANSSVT GYGEALIKAA LHIDIGEIET
410 420 430 440 450
IAHYKAADHF LPGVDFILDI GGQDMKCIKI KNDAIDGILL NEACSSGCGS
460 470 480 490 500
FIESFAKSLD MKVEDFAKEA LKSKAPVDLG SRCTVFMNSR VKQSQKEGAE
510 520 530 540 550
ISDISAGLSY SVIKNALFKV IKLRDEKDIG EKVIVQGGTF YNEAVLRSFE
560 570 580 590 600
LISGREAVRP DISGLMGAFG CALIAKERYI EGEKSTLLPR DGIDQFEMTA
610 620 630 640 650
SFRRCGKCGN NCLLTVNKFS TDEEFISGNR CERGLGIEKS KENKLPNLFD
660 670 680 690 700
YKYKRTFAYK PLKEEEAKRG VIGIPRVLNM YENYPFWFTL LTNLGFSVKL
710 720 730 740 750
SAPSSKKIYE LGIETIPSES ACYPAKLAHG HIMNLINRGI KNIFYPCISY
760 770 780 790 800
EKKEFMDAQN HYNCPMVTSY PEAIKNNMDE LKENNINFME PFLSLDNEKE
810 820 830 840 850
LIKRIVDEFK AFDVSMQEAK IAVEEASKER ESFKKDIQKK GEEVISYLRE
860 870 880 890 900
NNKKGIVLSG RPYHVDPEIN HGIPDIINSF DMAVLTEDSV SHLGILKDKL
910 920 930 940 950
RVVDQWMYHS RLYRAAAFVA DEPCVDMIQL NSFGCGLDAV TTDQVSEIIS
960 970 980 990 1000
SKGKIYTVLK IDEGNNLGAA KIRIRSLKAA MGERERKNYK PVEEQVVYKN
1010 1020 1030 1040 1050
PVFTPEMRKK HTILCPQMSP IHFDLIETAV NASGYNLEVL PSMDMKAVDE
1060 1070 1080 1090 1100
GLKYVNNDAC YPSIIVIGQI IEALKSGKYD LNNTSVIISQ TGGGCRATNY
1110 1120 1130 1140 1150
IGFLKMALKH AGFEQVPVIS LNAVGLEKQP GFKITPKLLH KAIMALVYGD
1160 1170 1180 1190 1200
LFMRVLYRTR PYEKVKGSAN DIYKKWNEKV KLNLVNGSKR EFNNNIKEII
1210 1220 1230 1240 1250
QEFDELPLLN VKKPKVGVVG EILVKFHPTA NNDIVGILEN EGAEAVVPDL
1260 1270 1280 1290 1300
LDFFFYSAFD ADFKAKYLAG SKLSKNLCNM AISYIETYRK TMKKQLEKSV
1310 1320 1330 1340 1350
RFSKPKHIKE LAGMASPILS LGNQTGEGWF LTAEMIELIE SGTSNIVCLQ
1360 1370 1380 1390 1400
PFACLPNHVT GKGMIKALKE RYPKSNIVAI DYDPGASNVN QLNRIKLMLS
1410 1420 1430
VAFKNLGDEL KYHKKQNESI VEQQFHNEAG LTLEDNI
Length:1,437
Mass (Da):160,374
Last modified:July 24, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i04AE52B9B7D3FBD6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
CP000721 Genomic DNA Translation: ABR34563.1

NCBI Reference Sequences

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RefSeqi
WP_012058619.1, NC_009617.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ABR34563; ABR34563; Cbei_2405

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cbe:Cbei_2405

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000721 Genomic DNA Translation: ABR34563.1
RefSeqiWP_012058619.1, NC_009617.1

3D structure databases

ProteinModelPortaliA6LW33
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290402.Cbei_2405

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR34563; ABR34563; Cbei_2405
KEGGicbe:Cbei_2405

Phylogenomic databases

eggNOGiENOG4105CIZ Bacteria
COG1924 LUCA
COG3580 LUCA
COG3581 LUCA
HOGENOMiHOG000261965
OMAiVCYPAKL
OrthoDBi8032at2

Enzyme and pathway databases

BioCyciCBEI290402:G1G93-2513-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR002731 ATPase_BadF
IPR018709 CoA_activase_DUF2229
IPR010327 FldB/FldC_alpha/beta
PfamiView protein in Pfam
PF01869 BcrAD_BadFG, 2 hits
PF09989 DUF2229, 1 hit
PF06050 HGD-D, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA6LW33_CLOB8
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6LW33
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: January 16, 2019
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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