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Protein

LL-diaminopimelate aminotransferase

Gene

dapL

Organism
Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. LL-diaminopimelate aminotransferase (dapL)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei15SubstrateUniRule annotation1
Binding sitei42Substrate; via amide nitrogenUniRule annotation1
Binding sitei72Pyridoxal phosphateUniRule annotation1
Binding sitei109SubstrateUniRule annotation1
Binding sitei132Pyridoxal phosphateUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Binding sitei186Pyridoxal phosphateUniRule annotation1
Binding sitei186SubstrateUniRule annotation1
Binding sitei217Pyridoxal phosphateUniRule annotation1
Binding sitei256Pyridoxal phosphateUniRule annotation1
Binding sitei291Pyridoxal phosphateUniRule annotation1
Binding sitei291SubstrateUniRule annotation1
Binding sitei387SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciBVUL435590:G1G59-4142-MONOMER
UniPathwayi
UPA00034;UER00466

Names & Taxonomyi

Protein namesi
Recommended name:
LL-diaminopimelate aminotransferaseUniRule annotation (EC:2.6.1.83UniRule annotation)
Short name:
DAP-ATUniRule annotation
Short name:
DAP-aminotransferaseUniRule annotation
Short name:
LL-DAP-aminotransferaseUniRule annotation
Gene namesi
Name:dapLUniRule annotation
Ordered Locus Names:BVU_4005
OrganismiBacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154)
Taxonomic identifieri435590 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000002861 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003422161 – 409LL-diaminopimelate aminotransferaseAdd BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei248N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi435590.BVU_4005

Structurei

3D structure databases

ProteinModelPortaliA6L7E4
SMRiA6L7E4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni108 – 109Pyridoxal phosphate bindingUniRule annotation2
Regioni245 – 247Pyridoxal phosphate bindingUniRule annotation3

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107QSS Bacteria
COG0436 LUCA
HOGENOMiHOG000223061
KOiK10206
OMAiTGTRCAF

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01642 DapL_aminotrans_1, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR019942 DapL/ALD1
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR43144 PTHR43144, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03542 DAPAT_plant, 1 hit

Sequencei

Sequence statusi: Complete.

A6L7E4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALVNEHFLK LPNNYLFSDI AKKVNAFKVS HPKTDLIRLG IGDVTRPLPQ
60 70 80 90 100
TSIEAMYKAV DELANKETFH GYGPEQGYDF LIDAVIRNDY APRGVYLEPG
110 120 130 140 150
EVFISDGAKS DTGNIGDILR HDNSIGVTDP IYPVYIDSNV MCGRAGILED
160 170 180 190 200
GRWSNVVYLP CLSENNFVPE IPDRRIDILY LCYPNNPTGT VISKAELKKW
210 220 230 240 250
VNYALENDTL ILYDAAYEAY IQDPDIPHSI YEIKGAKKVA IEFRSFSKTA
260 270 280 290 300
GFTGVRCGYT VVPKELTAAT LEGERIPLNR MWNRRQCTKF NGTSYITQRG
310 320 330 340 350
AEAIYTPEGK KQVKAIIQYY MANARIMKEA LESTGLKVFG GENAPYLWVK
360 370 380 390 400
APGEVSSWKF FEQMLYEANV VGTPGVGFGP SGEGYIRLTA FGERADCEEA

MKRIRKWLL
Length:409
Mass (Da):45,916
Last modified:July 24, 2007 - v1
Checksum:i6E6A882F5EC4F7DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000139 Genomic DNA Translation: ABR41608.1
RefSeqiWP_012055981.1, NC_009614.1

Genome annotation databases

EnsemblBacteriaiABR41608; ABR41608; BVU_4005
GeneIDi5304964
KEGGibvu:BVU_4005
PATRICifig|435590.9.peg.4114

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000139 Genomic DNA Translation: ABR41608.1
RefSeqiWP_012055981.1, NC_009614.1

3D structure databases

ProteinModelPortaliA6L7E4
SMRiA6L7E4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi435590.BVU_4005

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR41608; ABR41608; BVU_4005
GeneIDi5304964
KEGGibvu:BVU_4005
PATRICifig|435590.9.peg.4114

Phylogenomic databases

eggNOGiENOG4107QSS Bacteria
COG0436 LUCA
HOGENOMiHOG000223061
KOiK10206
OMAiTGTRCAF

Enzyme and pathway databases

UniPathwayi
UPA00034;UER00466

BioCyciBVUL435590:G1G59-4142-MONOMER

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01642 DapL_aminotrans_1, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR019942 DapL/ALD1
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR43144 PTHR43144, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03542 DAPAT_plant, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDAPAT_BACV8
AccessioniPrimary (citable) accession number: A6L7E4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 24, 2007
Last modified: October 10, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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