UniProtKB - A6JFQ6 (CLVS1_RAT)
Protein
Clavesin-1
Gene
Clvs1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).By similarity1 Publication
Miscellaneous
Binding to PtdIns(3,5)P2 is not required for localization.By similarity
GO - Molecular functioni
- phosphatidylinositol-3,5-bisphosphate binding Source: UniProtKB
- phosphatidylinositol bisphosphate binding Source: GO_Central
GO - Biological processi
- lysosome organization Source: UniProtKB
Keywordsi
Ligand | Lipid-binding |
Enzyme and pathway databases
Reactomei | R-RNO-432720, Lysosome Vesicle Biogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Clavesin-11 PublicationAlternative name(s): Retinaldehyde-binding protein 1-like 1 |
Gene namesi | |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1564200, Clvs1 |
Subcellular locationi
Golgi apparatus
- trans-Golgi network membrane 1 Publication; Peripheral membrane protein 1 Publication
Endosome
- Early endosome membrane By similarity; Peripheral membrane protein By similarity
Other locations
- clathrin-coated vesicle 1 Publication
Endosome
- early endosome membrane Source: UniProtKB-SubCell
- endosome Source: UniProtKB
Golgi apparatus
- trans-Golgi network Source: UniProtKB
Other locations
- clathrin-coated vesicle Source: UniProtKB
Keywords - Cellular componenti
Cytoplasmic vesicle, Endosome, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000389619 | 1 – 354 | Clavesin-1Add BLAST | 354 |
Proteomic databases
PaxDbi | A6JFQ6 |
PeptideAtlasi | A6JFQ6 |
PRIDEi | A6JFQ6 |
Expressioni
Tissue specificityi
Expressed in brain with no expression detected in non-neuronal tissues (at protein level).1 Publication
Interactioni
Subunit structurei
Forms a complex with clathrin heavy chain and gamma-adaptin.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000009744 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 118 – 279 | CRAL-TRIOPROSITE-ProRule annotationAdd BLAST | 162 |
Domaini
The CRAL-TRIO domain is required for targeting to the membrane and for binding PtdIns(3,5)P2.By similarity
Phylogenomic databases
eggNOGi | KOG1471, Eukaryota |
InParanoidi | A6JFQ6 |
OrthoDBi | 1182715at2759 |
PhylomeDBi | A6JFQ6 |
Family and domain databases
CDDi | cd00170, SEC14, 1 hit |
Gene3Di | 3.40.525.10, 1 hit |
InterProi | View protein in InterPro IPR028634, Clavesin-1 IPR001251, CRAL-TRIO_dom IPR036865, CRAL-TRIO_dom_sf IPR011074, CRAL/TRIO_N_dom IPR036273, CRAL/TRIO_N_dom_sf |
PANTHERi | PTHR10174:SF72, PTHR10174:SF72, 1 hit |
Pfami | View protein in Pfam PF00650, CRAL_TRIO, 1 hit PF03765, CRAL_TRIO_N, 1 hit |
SMARTi | View protein in SMART SM01100, CRAL_TRIO_N, 1 hit SM00516, SEC14, 1 hit |
SUPFAMi | SSF46938, SSF46938, 1 hit SSF52087, SSF52087, 1 hit |
PROSITEi | View protein in PROSITE PS50191, CRAL_TRIO, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
A6JFQ6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGPVSVLPKP QSISTWEGDL AKMTHLQAGL SPDTIEKARL ELNENPDVLH
60 70 80 90 100
QDIQQVRDMI ITRPDIGFLR TDDAFILRFL RARKFHQADA FRLLAQYFQY
110 120 130 140 150
RQLNLDMFKN FKADDPGIKR ALIDGFPGVL ENRDHYGRKI LLLFAANWDQ
160 170 180 190 200
SRNSFTDILR AILLSLEVLI EDPELQINGF ILIIDWSNFS FKQASKLTPS
210 220 230 240 250
ILKLAIEGLQ DSFPARFGGV HFVNQPWYIH ALYTLIKPFL KDKTRKRIFL
260 270 280 290 300
HGNNLNSLHQ LIHPEFLPSE FGGTLPPYDM GTWARTLLGP DYSDENDYTH
310 320 330 340 350
TSYNAMYVKH TCSNLERECS PKPMKRSQSV VEAGTLKHEE KGENENTQPL
LALD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF1LRF3 | F1LRF3_RAT | Clavesin-1 | Clvs1 | 332 | Annotation score: | ||
A0A0G2K5H2 | A0A0G2K5H2_RAT | Clavesin-1 | Clvs1 | 352 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473984 Genomic DNA Translation: EDM11652.1 |
RefSeqi | NP_001102439.1, NM_001108969.1 |
Genome annotation databases
GeneIDi | 366311 |
KEGGi | rno:366311 |
UCSCi | RGD:1564200, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473984 Genomic DNA Translation: EDM11652.1 |
RefSeqi | NP_001102439.1, NM_001108969.1 |
3D structure databases
SMRi | A6JFQ6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000009744 |
Proteomic databases
PaxDbi | A6JFQ6 |
PeptideAtlasi | A6JFQ6 |
PRIDEi | A6JFQ6 |
Genome annotation databases
GeneIDi | 366311 |
KEGGi | rno:366311 |
UCSCi | RGD:1564200, rat |
Organism-specific databases
CTDi | 157807 |
RGDi | 1564200, Clvs1 |
Phylogenomic databases
eggNOGi | KOG1471, Eukaryota |
InParanoidi | A6JFQ6 |
OrthoDBi | 1182715at2759 |
PhylomeDBi | A6JFQ6 |
Enzyme and pathway databases
Reactomei | R-RNO-432720, Lysosome Vesicle Biogenesis |
Miscellaneous databases
PROi | PR:A6JFQ6 |
Family and domain databases
CDDi | cd00170, SEC14, 1 hit |
Gene3Di | 3.40.525.10, 1 hit |
InterProi | View protein in InterPro IPR028634, Clavesin-1 IPR001251, CRAL-TRIO_dom IPR036865, CRAL-TRIO_dom_sf IPR011074, CRAL/TRIO_N_dom IPR036273, CRAL/TRIO_N_dom_sf |
PANTHERi | PTHR10174:SF72, PTHR10174:SF72, 1 hit |
Pfami | View protein in Pfam PF00650, CRAL_TRIO, 1 hit PF03765, CRAL_TRIO_N, 1 hit |
SMARTi | View protein in SMART SM01100, CRAL_TRIO_N, 1 hit SM00516, SEC14, 1 hit |
SUPFAMi | SSF46938, SSF46938, 1 hit SSF52087, SSF52087, 1 hit |
PROSITEi | View protein in PROSITE PS50191, CRAL_TRIO, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CLVS1_RAT | |
Accessioni | A6JFQ6Primary (citable) accession number: A6JFQ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 2009 |
Last sequence update: | December 15, 2009 | |
Last modified: | December 2, 2020 | |
This is version 52 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |