Tbpl2

Functionⁱ

Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity).By similarity

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

DNA-templated transcription, initiation Source: InterPro
multicellular organism development Source: UniProtKB-KW
negative regulation of transcription, DNA-templated Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: TATA box-binding protein-like protein 2 Short name: TBP-like protein 2 Alternative name(s): TATA box-binding protein-related factor 3 Short name: TBP-related factor 3
Gene namesⁱ	Name:Tbpl2By similarity Synonyms:Tbp2, Trf3By similarity
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 3

Organism-specific databases

Rat genome database More...RGDⁱ	1596837 Tbpl2

RGDⁱ

1596837 Tbpl2

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000318121	1 – 344	TATA box-binding protein-like protein 2Add BLAST		344

Proteomic databases

PaxDbⁱ	A6H909
PRIDEⁱ	A6H909

Interactionⁱ

Subunit structureⁱ

Interacts with TAF3.By similarity

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000039739

STRINGⁱ

10116.ENSRNOP00000039739

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A6H909
SMRⁱ	A6H909
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TBP family.Sequence analysis

Phylogenomic databases

eggNOGⁱ	KOG3302 Eukaryota COG2101 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00410000025389
HOGENOMⁱ	HOG000105164
HOVERGENⁱ	HBG044997
InParanoidⁱ	A6H909
KEGG Orthology (KO) More...KOⁱ	K03120
OMAⁱ	MTPVSEC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ENY
PhylomeDBⁱ	A6H909

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd04516 TBP_eukaryotes, 1 hit
Gene3Dⁱ	3.30.310.10, 2 hits
HAMAPⁱ	MF_00408 TATA_bind_prot_arch, 1 hit
InterProⁱ	View protein in InterPro IPR000814 TBP IPR030491 TBP_CS IPR012295 TBP_dom_sf IPR033710 TBP_eukaryotic
PANTHERⁱ	PTHR10126 PTHR10126, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00352 TBP, 2 hits
PRINTSⁱ	PR00686 TIFACTORIID
PROSITEⁱ	View protein in PROSITE PS00351 TFIID, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

A6H909-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEEDMYVDIF LDPYTFQDDF PPATSQLFSP GAPLDVHPLN PSNPETVFHS 
        60         70         80         90        100
HLGAVKKAPS DFSSVDLSFL PDELTQENKD RTVTGNKVTN EESFRTQDWQ 
       110        120        130        140        150
SQLQLPDEQG SGLNLNSNSS PDTQSCLCSH DADSNQLSSE TPNSNALPVV 
       160        170        180        190        200
LISSMTPMNP VTECSGIVPQ LQNVVSTANL ACKLDLRKIA LNAKNTEYNP 
       210        220        230        240        250
KRFAAVIMRI REPRTTALIF SSGKVVCTGA KSEDESRLAA RKYARVVQKL 
       260        270        280        290        300
GFPVRFFNFK IQNMVASCDV KFPIRLEILA LTHRQFSSYE PELFPGLIYK 
       310        320        330        340 
MVKPQVVLLI FASGKVVLTG AKERSEIYEA FENMYPILES FKKV

Length:344

Mass (Da):38,355

Last modified:July 24, 2007 - v1

Checksum:ⁱCAA7FFAC7482F732

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AAHX01020401 Genomic DNA No translation available. BK005774 mRNA Translation: DAA06034.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001092831.1, NM_001099361.1
UniGeneⁱ	Rn.217494

Genome annotation databases

Ensemblⁱ	ENSRNOT00000050371; ENSRNOP00000039739; ENSRNOG00000033682
GeneIDⁱ	680050
KEGGⁱ	rno:680050
UCSC genome browser More...UCSCⁱ	RGD:1596837 rat

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A6H909	TATA-box-binding protein		CAEEL		340	UniRef50_P32085
TATA-box-binding protein		XENTR		297
TATA box-binding protein-like protein 2		TAKRU		322
CRE-TBP-1 protein		CAERE		338
Protein CBR-TBP-1		CAEBR		337
+133

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AAHX01020401 Genomic DNA No translation available. BK005774 mRNA Translation: DAA06034.1
RefSeqⁱ	NP_001092831.1, NM_001099361.1
UniGeneⁱ	Rn.217494

3D structure databases

ProteinModelPortalⁱ	A6H909
SMRⁱ	A6H909
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000039739

STRINGⁱ

10116.ENSRNOP00000039739

Proteomic databases

PaxDbⁱ	A6H909
PRIDEⁱ	A6H909

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000050371; ENSRNOP00000039739; ENSRNOG00000033682
GeneIDⁱ	680050
KEGGⁱ	rno:680050
UCSCⁱ	RGD:1596837 rat

Organism-specific databases

CTDⁱ	387332
RGDⁱ	1596837 Tbpl2

Phylogenomic databases

eggNOGⁱ	KOG3302 Eukaryota COG2101 LUCA
GeneTreeⁱ	ENSGT00410000025389
HOGENOMⁱ	HOG000105164
HOVERGENⁱ	HBG044997
InParanoidⁱ	A6H909
KOⁱ	K03120
OMAⁱ	MTPVSEC
OrthoDBⁱ	EOG091G0ENY
PhylomeDBⁱ	A6H909

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:A6H909

PROⁱ

PR:A6H909

Family and domain databases

CDDⁱ	cd04516 TBP_eukaryotes, 1 hit
Gene3Dⁱ	3.30.310.10, 2 hits
HAMAPⁱ	MF_00408 TATA_bind_prot_arch, 1 hit
InterProⁱ	View protein in InterPro IPR000814 TBP IPR030491 TBP_CS IPR012295 TBP_dom_sf IPR033710 TBP_eukaryotic
PANTHERⁱ	PTHR10126 PTHR10126, 1 hit
Pfamⁱ	View protein in Pfam PF00352 TBP, 2 hits
PRINTSⁱ	PR00686 TIFACTORIID
PROSITEⁱ	View protein in PROSITE PS00351 TFIID, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TBPL2_RAT
Accessionⁱ	A6H909Primary (citable) accession number: A6H909
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
	Last sequence update:	July 24, 2007
	Last modified:	September 12, 2018
	This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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UniProtKB - A6H909 (TBPL2_RAT)

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TATA box-binding protein-like protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ