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UniProtKB - A6H909 (TBPL2_RAT)
Protein
TATA box-binding protein-like 2
Gene
Tbpl2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity).
By similarityGO - Molecular functioni
- DNA binding Source: RGD
- general transcription initiation factor activity Source: GO_Central
- RNA polymerase II general transcription initiation factor activity Source: GO_Central
GO - Biological processi
- DNA-templated transcription, initiation Source: GO_Central
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: TATA box-binding protein-like 2Short name: TBP-like 2 Alternative name(s): TATA box-binding protein-related factor 3 Short name: TBP-related factor 3 |
Gene namesi | |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1596837, Tbpl2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000318121 | 1 – 344 | TATA box-binding protein-like 2Add BLAST | 344 |
Proteomic databases
PaxDbi | A6H909 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000033682, Expressed in female gonad and 1 other tissue |
Interactioni
Subunit structurei
Interacts with TAF3.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000039739 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 78 – 143 | DisorderedSequence analysisAdd BLAST | 66 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 87 – 143 | Polar residuesSequence analysisAdd BLAST | 57 |
Sequence similaritiesi
Belongs to the TBP family.Sequence analysis
Phylogenomic databases
eggNOGi | KOG3302, Eukaryota |
GeneTreei | ENSGT00940000159561 |
HOGENOMi | CLU_060161_1_2_1 |
InParanoidi | A6H909 |
OMAi | MEQEETY |
OrthoDBi | 1219067at2759 |
PhylomeDBi | A6H909 |
Family and domain databases
CDDi | cd04516, TBP_eukaryotes, 1 hit |
Gene3Di | 3.30.310.10, 2 hits |
HAMAPi | MF_00408, TATA_bind_prot_arch, 1 hit |
InterProi | View protein in InterPro IPR000814, TBP IPR030491, TBP_CS IPR012295, TBP_dom_sf IPR033710, TBP_eukaryotic |
PANTHERi | PTHR10126, PTHR10126, 1 hit |
Pfami | View protein in Pfam PF00352, TBP, 2 hits |
PRINTSi | PR00686, TIFACTORIID |
PROSITEi | View protein in PROSITE PS00351, TFIID, 2 hits |
i Sequence
Sequence statusi: Complete.
A6H909-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEEDMYVDIF LDPYTFQDDF PPATSQLFSP GAPLDVHPLN PSNPETVFHS
60 70 80 90 100
HLGAVKKAPS DFSSVDLSFL PDELTQENKD RTVTGNKVTN EESFRTQDWQ
110 120 130 140 150
SQLQLPDEQG SGLNLNSNSS PDTQSCLCSH DADSNQLSSE TPNSNALPVV
160 170 180 190 200
LISSMTPMNP VTECSGIVPQ LQNVVSTANL ACKLDLRKIA LNAKNTEYNP
210 220 230 240 250
KRFAAVIMRI REPRTTALIF SSGKVVCTGA KSEDESRLAA RKYARVVQKL
260 270 280 290 300
GFPVRFFNFK IQNMVASCDV KFPIRLEILA LTHRQFSSYE PELFPGLIYK
310 320 330 340
MVKPQVVLLI FASGKVVLTG AKERSEIYEA FENMYPILES FKKV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAHX01020401 Genomic DNA No translation available. BK005774 mRNA Translation: DAA06034.1 |
RefSeqi | NP_001092831.1, NM_001099361.1 |
Genome annotation databases
Ensembli | ENSRNOT00000050371; ENSRNOP00000039739; ENSRNOG00000033682 |
GeneIDi | 680050 |
KEGGi | rno:680050 |
UCSCi | RGD:1596837, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAHX01020401 Genomic DNA No translation available. BK005774 mRNA Translation: DAA06034.1 |
RefSeqi | NP_001092831.1, NM_001099361.1 |
3D structure databases
SMRi | A6H909 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000039739 |
Proteomic databases
PaxDbi | A6H909 |
Genome annotation databases
Ensembli | ENSRNOT00000050371; ENSRNOP00000039739; ENSRNOG00000033682 |
GeneIDi | 680050 |
KEGGi | rno:680050 |
UCSCi | RGD:1596837, rat |
Organism-specific databases
CTDi | 387332 |
RGDi | 1596837, Tbpl2 |
Phylogenomic databases
eggNOGi | KOG3302, Eukaryota |
GeneTreei | ENSGT00940000159561 |
HOGENOMi | CLU_060161_1_2_1 |
InParanoidi | A6H909 |
OMAi | MEQEETY |
OrthoDBi | 1219067at2759 |
PhylomeDBi | A6H909 |
Miscellaneous databases
PROi | PR:A6H909 |
Gene expression databases
Bgeei | ENSRNOG00000033682, Expressed in female gonad and 1 other tissue |
Family and domain databases
CDDi | cd04516, TBP_eukaryotes, 1 hit |
Gene3Di | 3.30.310.10, 2 hits |
HAMAPi | MF_00408, TATA_bind_prot_arch, 1 hit |
InterProi | View protein in InterPro IPR000814, TBP IPR030491, TBP_CS IPR012295, TBP_dom_sf IPR033710, TBP_eukaryotic |
PANTHERi | PTHR10126, PTHR10126, 1 hit |
Pfami | View protein in Pfam PF00352, TBP, 2 hits |
PRINTSi | PR00686, TIFACTORIID |
PROSITEi | View protein in PROSITE PS00351, TFIID, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | TBPL2_RAT | |
Accessioni | A6H909Primary (citable) accession number: A6H909 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | July 24, 2007 | |
Last modified: | September 29, 2021 | |
This is version 85 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families