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Entry version 51 (31 Jul 2019)
Sequence version 1 (24 Jul 2007)
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Protein
Submitted name:

NOL8 protein

Gene

NOL8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
NOL8 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOL8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A6H8Z4

PRoteomics IDEntifications database

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PRIDEi
A6H8Z4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni155 – 236DisorderedSequence analysisAdd BLAST82
Regioni367 – 402DisorderedSequence analysisAdd BLAST36
Regioni431 – 465DisorderedSequence analysisAdd BLAST35
Regioni522 – 798DisorderedSequence analysisAdd BLAST277
Regioni812 – 842DisorderedSequence analysisAdd BLAST31
Regioni864 – 914DisorderedSequence analysisAdd BLAST51
Regioni938 – 958DisorderedSequence analysisAdd BLAST21
Regioni1003 – 1037DisorderedSequence analysisAdd BLAST35
Regioni1072 – 1099DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi180 – 214PolarSequence analysisAdd BLAST35
Compositional biasi367 – 393PolarSequence analysisAdd BLAST27
Compositional biasi440 – 455PolarSequence analysisAdd BLAST16
Compositional biasi573 – 601PolarSequence analysisAdd BLAST29
Compositional biasi624 – 642PolyampholyteSequence analysisAdd BLAST19
Compositional biasi681 – 709PolyampholyteSequence analysisAdd BLAST29
Compositional biasi718 – 735PolyampholyteSequence analysisAdd BLAST18
Compositional biasi742 – 759PolyampholyteSequence analysisAdd BLAST18
Compositional biasi827 – 842PolyampholyteSequence analysisAdd BLAST16
Compositional biasi871 – 897PolyampholyteSequence analysisAdd BLAST27
Compositional biasi1011 – 1034PolyampholyteSequence analysisAdd BLAST24

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4365 Eukaryota
ENOG410Y5CN LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293312

Database of Orthologous Groups

More...
OrthoDBi
442365at2759

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A6H8Z4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVLNKTKWK GGTLQIQLAK ESFLHRLAQE REAAKAKKEE STTGNANLLE
60 70 80 90 100
KTGGVDFHMK AVPGTEVPGH KNWVVSKFGR VLPVLHLKNQ HKRKIIKYDP
110 120 130 140 150
SKYCHNLKKI GEDFSNTIPI SSLTWELEGG NDPMSKKRRG EFSDFHGPPK
160 170 180 190 200
KIIKVQKDES STGSLAMSTR PRRVIERPPL TQQQAAQKRT CDSITPSKSS
210 220 230 240 250
PVPVSDTQKL KNLPFKTSGL EPAKKRNSIS DDDTDSEDEL RMMIAKEENL
260 270 280 290 300
QRTTQPSINE SESDPFEVVR DDFKSGVHKL HSLIGLGIKN RVSCHDSDDD
310 320 330 340 350
IMRNDREYDS GDTDEIIAMK KNVAKVKNST EFSQMEKSTK KTSFKNRENC
360 370 380 390 400
ELSDHCIKLQ KRKSNVESAL SHGLKSLNRK SPSHSSSSED ADSASELADS
410 420 430 440 450
EGGEEYNAVM KNCLRVNLTL ADLEQLAGSD LKVPNEDTKS DGPETTTQCK
460 470 480 490 500
FDRGSKSPKT PTGLRRGRQC IRPAEIVASL LEGEENTCGK QKPKENNLKP
510 520 530 540 550
KFQAFKGVGC LYEKESMKKS LKDSVASNNK DQNSMKHEDP SIISMEDGSP
560 570 580 590 600
YVNGSLGEVT PCQHAKKANG PNYIQPQKRQ ATFESQDRKA VSPSSSEKRS
610 620 630 640 650
KNPISRPLEG KKSLSLSAKT HNIGFDKDSC HSTTKTEASQ EERSDSSGLT
660 670 680 690 700
SLKKSPKVSS KDTREIKTDF SLSISNSSDV SAKDKHAEDN EKRLAALEAR
710 720 730 740 750
QKAKEVQKKL VHNALANLDG HPEDKPTHII FSSDSECETE ETSTQEQSHP
760 770 780 790 800
GEEWVKESMG KTSGKLFDSS DDDESDSEDD SNRFKIKPQF EGRAGQKLMD
810 820 830 840 850
LQSHFGTDDR FRMDSRFLET DSEEEQEEVN EKKTAEEEEL AEEKKKALNV
860 870 880 890 900
VQSVLQINLS NSTNRGSVAA KKFKDIIHYD PTKQDHATYE RKRDDKPKES
910 920 930 940 950
KAKRKKKREE AEKLPEVSKE MYYNIAMDLK EIFQTTKYTS EKEEGTPWNE
960 970 980 990 1000
DCGKEKPEEI QDPAALTSDA EQPSGFTFSF FDSDTKDIKE ETYRVETVKP
1010 1020 1030 1040 1050
GKIVWQEDPR LQDSSSEEED VTEETDHRNS SPGEASLLEK ETTRFFFFSK
1060 1070 1080 1090
NDERLQGSDL FWRGVGSNMS RNSWEAGTTN LRMDCRKKHK DAKRKMKPK
Length:1,099
Mass (Da):123,792
Last modified:July 24, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC3C7FE69A39E6F03
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BC146810 mRNA Translation: AAI46811.1

NCBI Reference Sequences

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RefSeqi
NP_001243323.1, NM_001256394.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55035

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146810 mRNA Translation: AAI46811.1
RefSeqiNP_001243323.1, NM_001256394.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiA6H8Z4
PRIDEiA6H8Z4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi55035

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55035

Phylogenomic databases

eggNOGiKOG4365 Eukaryota
ENOG410Y5CN LUCA
HOGENOMiHOG000293312
OrthoDBi442365at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NOL8 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55035

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA6H8Z4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6H8Z4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: July 31, 2019
This is version 51 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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