UniProtKB - A6H8Z2 (F221B_HUMAN)
Protein
Protein FAM221B
Gene
FAM221B
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Protein FAM221B |
Gene namesi | Name:FAM221B Synonyms:C9orf128 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30762, FAM221B |
neXtProti | NX_A6H8Z2 |
VEuPathDBi | HostDB:ENSG00000204930.9 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000204930 |
PharmGKBi | PA134925958 |
Miscellaneous databases
Pharosi | A6H8Z2, Tdark |
Genetic variation databases
BioMutai | FAM221B |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000309264 | 1 – 402 | Protein FAM221BAdd BLAST | 402 |
Proteomic databases
MassIVEi | A6H8Z2 |
PaxDbi | A6H8Z2 |
PeptideAtlasi | A6H8Z2 |
PRIDEi | A6H8Z2 |
ProteomicsDBi | 786 [A6H8Z2-1] 787 [A6H8Z2-2] 788 [A6H8Z2-3] |
PTM databases
iPTMneti | A6H8Z2 |
PhosphoSitePlusi | A6H8Z2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000204930, Expressed in testis and 76 other tissues |
ExpressionAtlasi | A6H8Z2, baseline and differential |
Genevisiblei | A6H8Z2, HS |
Organism-specific databases
HPAi | ENSG00000204930, Tissue enhanced (blood, testis) |
Interactioni
Binary interactionsi
Hide detailsA6H8Z2
Isoform 3 [A6H8Z2-3]
With | #Exp. | IntAct |
---|---|---|
DMWD [G5E9A7] | 3 | EBI-25843965,EBI-10976677 |
LMNA [P02545] | 3 | EBI-25843965,EBI-351935 |
SPRED1 [Q7Z699] | 3 | EBI-25843965,EBI-5235340 |
Protein-protein interaction databases
BioGRIDi | 134170, 23 interactors |
IntActi | A6H8Z2, 23 interactors |
Miscellaneous databases
RNActi | A6H8Z2, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the FAM221 family.Curated
Phylogenomic databases
eggNOGi | ENOG502R7X0, Eukaryota |
GeneTreei | ENSGT00770000120611 |
HOGENOMi | CLU_053868_0_0_1 |
InParanoidi | A6H8Z2 |
OMAi | CSCFESN |
OrthoDBi | 973186at2759 |
PhylomeDBi | A6H8Z2 |
TreeFami | TF328347 |
Family and domain databases
InterProi | View protein in InterPro IPR026755, Fam221a/b |
PANTHERi | PTHR31214, PTHR31214, 1 hit |
Pfami | View protein in Pfam PF14753, FAM221, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: A6H8Z2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEAHEIIEEP HITMDAEKHP PSKDPSAEDL QENHISESFL KPSTSETPLE
60 70 80 90 100
PHTSESPLVP SPSQIPLEAH SPETHQEPSI SETPSETPTY EASLDSPISV
110 120 130 140 150
VPEKHLTLPP QSRDYVCLSS SDTLKEDLSS ESSSNEVPWT RRSTHLSESE
160 170 180 190 200
SLPEHCLSGP SSQVQVDTTE KQEEEAGEVE KGVDASDSTA HTAQPGHQLG
210 220 230 240 250
NTARPVFPAR QTELVEVAKA MHREEFGAQV NNLFQWEKDA ALNAIQTGLY
260 270 280 290 300
IGWRCPHYLW DCFRIGDESR CFCGHLLREH RIISDISVPC KVSQCRCFMF
310 320 330 340 350
CFIPSRPEEV GEFWLKRRAT FDPKAWRAQC RCKHSHEEHA ATGPHPCRHH
360 370 380 390 400
GCCCGCFESN FLCAACDRRW EEHETFFDTQ KTRQRGGRPR GTDTVSNWHR
PL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8W8N9 | F8W8N9_HUMAN | Protein FAM221B | FAM221B | 301 | Annotation score: | ||
C9JPK8 | C9JPK8_HUMAN | Protein FAM221B | FAM221B | 90 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061598 | 34 | H → R1 PublicationCorresponds to variant dbSNP:rs13294256Ensembl. | 1 | |
Natural variantiVAR_061599 | 41 | K → E1 PublicationCorresponds to variant dbSNP:rs13294245Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035486 | 1 – 246 | Missing in isoform 2. 1 PublicationAdd BLAST | 246 | |
Alternative sequenceiVSP_035487 | 247 | T → M in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_036643 | 248 – 340 | GLYIG…HEEHA → DRIRNSSSGILAPAHLHCDC LYLALSTKPPWCKGALALQA ISIKTEEAKPKATSRQALDP DRLWVSTLAGAAPITYGTVS GLGMSPDAFVDTC in isoform 3. 1 PublicationAdd BLAST | 93 | |
Alternative sequenceiVSP_036644 | 341 – 402 | Missing in isoform 3. 1 PublicationAdd BLAST | 62 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX648702 mRNA No translation available. AL133410 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58330.1 BC146808 mRNA Translation: AAI46809.1 AI809547 mRNA No translation available. |
CCDSi | CCDS43799.2 [A6H8Z2-1] |
RefSeqi | NP_001012448.2, NM_001012446.3 [A6H8Z2-1] |
Genome annotation databases
Ensembli | ENST00000388950; ENSP00000373602; ENSG00000204930 [A6H8Z2-3] ENST00000423537; ENSP00000415299; ENSG00000204930 [A6H8Z2-1] |
GeneIDi | 392307 |
KEGGi | hsa:392307 |
UCSCi | uc003zyj.3, human [A6H8Z2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX648702 mRNA No translation available. AL133410 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58330.1 BC146808 mRNA Translation: AAI46809.1 AI809547 mRNA No translation available. |
CCDSi | CCDS43799.2 [A6H8Z2-1] |
RefSeqi | NP_001012448.2, NM_001012446.3 [A6H8Z2-1] |
3D structure databases
SMRi | A6H8Z2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 134170, 23 interactors |
IntActi | A6H8Z2, 23 interactors |
PTM databases
iPTMneti | A6H8Z2 |
PhosphoSitePlusi | A6H8Z2 |
Genetic variation databases
BioMutai | FAM221B |
Proteomic databases
MassIVEi | A6H8Z2 |
PaxDbi | A6H8Z2 |
PeptideAtlasi | A6H8Z2 |
PRIDEi | A6H8Z2 |
ProteomicsDBi | 786 [A6H8Z2-1] 787 [A6H8Z2-2] 788 [A6H8Z2-3] |
Protocols and materials databases
Antibodypediai | 5672, 41 antibodies |
Genome annotation databases
Ensembli | ENST00000388950; ENSP00000373602; ENSG00000204930 [A6H8Z2-3] ENST00000423537; ENSP00000415299; ENSG00000204930 [A6H8Z2-1] |
GeneIDi | 392307 |
KEGGi | hsa:392307 |
UCSCi | uc003zyj.3, human [A6H8Z2-1] |
Organism-specific databases
CTDi | 392307 |
GeneCardsi | FAM221B |
HGNCi | HGNC:30762, FAM221B |
HPAi | ENSG00000204930, Tissue enhanced (blood, testis) |
neXtProti | NX_A6H8Z2 |
OpenTargetsi | ENSG00000204930 |
PharmGKBi | PA134925958 |
VEuPathDBi | HostDB:ENSG00000204930.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502R7X0, Eukaryota |
GeneTreei | ENSGT00770000120611 |
HOGENOMi | CLU_053868_0_0_1 |
InParanoidi | A6H8Z2 |
OMAi | CSCFESN |
OrthoDBi | 973186at2759 |
PhylomeDBi | A6H8Z2 |
TreeFami | TF328347 |
Enzyme and pathway databases
PathwayCommonsi | A6H8Z2 |
Miscellaneous databases
BioGRID-ORCSi | 392307, 5 hits in 871 CRISPR screens |
GenomeRNAii | 392307 |
Pharosi | A6H8Z2, Tdark |
PROi | PR:A6H8Z2 |
RNActi | A6H8Z2, protein |
Gene expression databases
Bgeei | ENSG00000204930, Expressed in testis and 76 other tissues |
ExpressionAtlasi | A6H8Z2, baseline and differential |
Genevisiblei | A6H8Z2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026755, Fam221a/b |
PANTHERi | PTHR31214, PTHR31214, 1 hit |
Pfami | View protein in Pfam PF14753, FAM221, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F221B_HUMAN | |
Accessioni | A6H8Z2Primary (citable) accession number: A6H8Z2 Secondary accession number(s): Q5TCW2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | September 23, 2008 | |
Last modified: | February 10, 2021 | |
This is version 92 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families