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Entry version 64 (11 Dec 2019)
Sequence version 1 (24 Jul 2007)
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Protein
Submitted name:

LRRK1 protein

Gene

LRRK1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
A6H8V9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
LRRK1 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRK1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A6H8V9

PRoteomics IDEntifications database

More...
PRIDEi
A6H8V9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 180RocInterPro annotationAdd BLAST180
Domaini596 – 879Protein kinaseInterPro annotationAdd BLAST284

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1142 – 1164DisorderedSequence analysisAdd BLAST23
Regioni1195 – 1253DisorderedSequence analysisAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1195 – 1228PolarSequence analysisAdd BLAST34

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0192 Eukaryota
KOG0619 Eukaryota
COG4886 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113392

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032171 COR
IPR011009 Kinase-like_dom_sf
IPR027417 P-loop_NTPase
IPR000719 Prot_kinase_dom
IPR020859 ROC_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16095 COR, 1 hit
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit
SSF52540 SSF52540, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS51424 ROC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

A6H8V9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
PRQGKSTLLE ILQTGRAPQV VHGEATIRTT KWELQRPAGS RAKVESVEFN
60 70 80 90 100
VWDIGGPASM ATVNQCFFTD KALYVVVWNL ALGEEAVANL QFWLLNIEAK
110 120 130 140 150
APNAVVLVVG THLDLIEAKF RVERIATLRA YVLALCRSPS GSRATGFPDI
160 170 180 190 200
TFKHLHEISC KSLEGQEGLR QLIFHVTCSM KDVGSTIGCQ RLAGRLIPRS
210 220 230 240 250
YLSLQEAVLA EQQRRSRDDD VQYLTDRQLE QLVEQTPDND IKDYEDLQSA
260 270 280 290 300
ISFLIETGTL LHFPDTSHGL RNLYFLDPIW LSECLQRIFN IKGSRSVAKN
310 320 330 340 350
GVIRAEDLRM LLVGTGFTQQ TEEQYFQFLA KFEIALPVAN DSYLLPHLLP
360 370 380 390 400
SKPGLDTHGM RHPTANTIQR VFKMSFVPVG FWQRFIARML ISLAEMDLQL
410 420 430 440 450
FENKKNTKSR NRKVTIYSFT GNQRNRCSTF RVKRNQTIYW QEGLLVTFDG
460 470 480 490 500
GYLSVESSDV NWKKKKSGGM KIVCQSEVRD FSAMAFITDH VNSLIDQWFP
510 520 530 540 550
ALTATESDGT PLMEQYVPCP VCETAWAQHT DPSEKSEDVQ YFDMEDCVLT
560 570 580 590 600
AIERDFISCP RHPDLPVPLQ ELVPELFMTD FPARLFLENS KLEHSEDEGS
610 620 630 640 650
VLGQGGSGTV IYRARYQGQP VAVKRFHIKK FKNFANVPAD TMLRHLRATD
660 670 680 690 700
AMKNFSEFRQ EASMLHALQH PCIVALIGIS IHPLCFALEL APLSSLNTVL
710 720 730 740 750
SENARDSSFI PLGHMLTQKI AYQIASGLAY LHKKNIIFCD LKSDNILVWS
760 770 780 790 800
LDVKEHINIK LSDYGISRQS FHEGALGVEG TPGYQAPEIR PRIVYDEKVD
810 820 830 840 850
MFSYGMVLYE LLSGQRPALG HHQLQIAKKL SKGIRPVLGQ PEEVQFRRLQ
860 870 880 890 900
ALMMECWDTK PEKRPLALSV VSQMKDPTFA TFMYELCCGK QTAFFSSQGQ
910 920 930 940 950
EYTVVFWDGK EESRNYTVVN TEKGLMEVQR MCCPGMKVSC QLQVQRSLWT
960 970 980 990 1000
ATEDQKIYIY TLKGMCPLNT PQQALDTPAV VTCFLAVPVI KKNSYLVLAG
1010 1020 1030 1040 1050
LADGLVAVFP VVRGTPKDSC SYLCSHTANR SKFSIADEDA RQNPYPVKAM
1060 1070 1080 1090 1100
EVVNSGSEVW YSNGPGLLVI DCASLEICRR LEPYMAPSMV TSVVCSSEGR
1110 1120 1130 1140 1150
GEEVVWCLDD KANSLVMYHS TTYQLCARYF CGVPSPLRDM FPVRPLDTEP
1160 1170 1180 1190 1200
PAASHTANPK VPEGDSIADV SIMYSEELGT QILIHQESLT DYCSMSSYSS
1210 1220 1230 1240 1250
SPPRQAARSP SSLPSSPASS SSVPFSTDCE DSDMLHTPGA ASDRSEHDLT
1260 1270 1280 1290 1300
PMDGETFSQH LQAVKILAVR DLIWVPRRGG DVIVIGLEKD SEAQRGRVIA
1310 1320 1330 1340 1350
VLKARELTPH GVLVDAAVVA KDTVVCTFEN ENTEWCLAVW RGWGAREFDI
1360
FYQSYEELGR LEACTRKRR
Length:1,369
Mass (Da):153,627
Last modified:July 24, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAE90CE09C88370D9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC146769 mRNA Translation: AAI46770.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146769 mRNA Translation: AAI46770.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiA6H8V9
PRIDEiA6H8V9

Phylogenomic databases

eggNOGiKOG0192 Eukaryota
KOG0619 Eukaryota
COG4886 LUCA
HOGENOMiHOG000113392

Enzyme and pathway databases

SignaLinkiA6H8V9

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LRRK1 human

Family and domain databases

InterProiView protein in InterPro
IPR032171 COR
IPR011009 Kinase-like_dom_sf
IPR027417 P-loop_NTPase
IPR000719 Prot_kinase_dom
IPR020859 ROC_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF16095 COR, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF50978 SSF50978, 1 hit
SSF52540 SSF52540, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS51424 ROC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA6H8V9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6H8V9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: December 11, 2019
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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